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■ Abbreviation / Long Form : NTCP / Na+/taurocholate cotransporting polypeptide

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Total Number of Papers: 126
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Abbreviation:   NTCP  (>> Co-occurring Abbreviation)
Long Form:   Na+/taurocholate cotransporting polypeptide
 Abbreviation Variation
 Long Form Variation
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No. Year Title Co-occurring Abbreviation
2022 Establishment of a monoclonal antibody against human NTCP that blocks HBV infection. aa, ECLs, HBV, HDV, mAb, NA
2022 Human Organic Anion Transporting Polypeptides 1B1, 1B3, and 2B1 Are Involved in the Hepatic Uptake of Phenolsulfonphthalein. MRP2, OATP1B1, OCT1
2022 Ilexsaponin A1 Ameliorates Diet-Induced Nonalcoholic Fatty Liver Disease by Regulating Bile Acid Metabolism in Mice. BA, BSEP, BSH, FXR, HFD, NAFLD, TC
2021 Bile Salt and FGF19 Signaling in the Early Phase of Human Liver Regeneration. CT, FGF19, FXR, IL-6, LR, STAT3
2021 Characterization of Novel Fluorescent Bile Salt Derivatives for Studying Human Bile Salt and Organic Anion Transporters. ASBT, BSEP, OATP, OATPs
2021 Concentration of Na+-taurocholate-cotransporting polypeptide expressed after in vitro-transcribed mRNA transfection determines susceptibility of hepatoma cells for hepatitis B virus. HBV
2021 Distinct Bile Acid Profiles in Patients With Chronic Hepatitis B Virus Infection Reveal Metabolic Interplay Between Host, Virus and Gut Microbiome. BAs, BSEP, BSH, CHB, CHB, HBV, hdhA
2021 Evaluation for Potential Drug-Drug Interaction of MT921 Using In Vitro Studies and Physiologically-Based Pharmacokinetic Models. ASBT, DDI, OAT, OATP, PBPK
2021 Functional and Pharmacological Comparison of Human and Mouse Na+/Taurocholate Cotransporting Polypeptide (NTCP). hNTCP, mNtcp
10  2021 Genetically edited hepatic cells expressing the NTCP-S267F variant are resistant to hepatitis B virus infection. HBV, HLCs
11  2021 Glycyrrhetinic Acid Protects alpha-Naphthylisothiocyanate- Induced Cholestasis Through Regulating Transporters, Inflammation and Apoptosis. ANIT, BSEP, FXR, GA, GL, MRP2, NF-kappaB, Nrf2, TNF-alpha
12  2021 Hepatitis D Virus Entry Inhibitors Based on Repurposing Intestinal Bile Acid Reabsorption Inhibitors. ASBT, BARIs
13  2021 Histone acetylation of bile acid transporter genes plays a critical role in cirrhosis. BA, FXR, HDAC1, HSCs, MCRS1, NSL
14  2021 Identification of Novel HBV/HDV Entry Inhibitors by Pharmacophore- and QSAR-Guided Virtual Screening. QSAR
15  2021 Impact on Bile Acid Concentrations by Alveolar Echinococcosis and Treatment with Albendazole in Mice. ABZ, AE, AKR, BSEP
16  2021 Kinsenoside Alleviates 17alpha-Ethinylestradiol-Induced Cholestatic Liver Injury in Rats by Inhibiting Inflammatory Responses and Regulating FXR-Mediated Bile Acid Homeostasis. BSEP, EE, EIC, KD
17  2021 Perfluoroalkyl Carboxylic Acids Interact with the Human Bile Acid Transporter NTCP. ---
18  2020 A clinically relevant polymorphism in the Na+/taurocholate cotransporting polypeptide (NTCP) occurs at a rheostat position. TCA
19  2020 Four-And-A-Half LIM-Domain Protein 2 (FHL2) Deficiency Aggravates Cholestatic Liver Injury. Bax, Bcl-2, BDL, DCA, FHL2, HSCs, WT
20  2020 Inhibition of Hepatic Bile Acid Uptake by Myrcludex B Promotes Glucagon-Like Peptide-1 Release and Reduces Obesity. OATP
21  2020 Interindividual Diversity in Expression of Organic Anion Uptake Transporters in Normal and Cirrhotic Human Liver. OATPs
22  2020 Long-term trans-inhibition of the hepatitis B and D virus receptor NTCP by taurolithocholic acid. TLC
23  2020 OATP1B3 Expression and Function is Modulated by Coexpression with OCT1, OATP1B1, and NTCP. CCK-8, HEK293, OATP, OCT
24  2020 Picroside II alleviates liver injury induced by alpha-naphthylisothiocyanate through AMPK-FXR pathway. AMPK, ANIT, BSEP, PIC, UGT1A1
25  2020 Protective effects of n-Butanol extract and iridoid glycosides of Veronica ciliata Fisch. Against ANIT-induced cholestatic liver injury in mice. ALP, AST, BE, BSEP, CAT, DBIL, GGT, i.g, IG, IL-6, MDA, MRP2, NF-kappaB, SOD, TBA, TBIL, TNF-alpha, UCDA
26  2020 Selective hepatitis B and D virus entry inhibitors from the group of pentacyclic lupane-type betulin-derived triterpenoids. ---
27  2020 Tanshinone ⅡA may alleviate rifampin-induced cholestasis by regulating the expression and function of NTCP. RFP, Tan IIA, TCA
28  2020 The Lipid Raft Component Stomatin Interacts with the Na+ Taurocholate Cotransporting Polypeptide (NTCP) and Modulates Bile Salt Uptake. CLCC1
29  2020 Woolly Monkey-HBV Infection in Squirrel Monkeys as a Surrogate Nonhuman Primate Model of HBV Infection. AAV-HBV, HBV, WMHBV
30  2019 An effective antidotal combination of polymyxin B and methylprednisolone for alpha-amanitin intoxication. i.p, MP, OATP1B3, PolB, RNAPII
31  2019 Homo- and heterodimerization is a common feature of the solute carrier family SLC10 members. ASBT
32  2019 NTCP deficiency in mice protects against obesity and hepatosteatosis. ---
33  2019 Quantitative Contribution of Six Major Transporters to the Hepatic Uptake of Drugs: "SLC-Phenotyping" Using Primary Human Hepatocytes. ft, OATP, PHHs, SLCs
34  2019 Synthesis, pharmacological evaluation, and mechanistic study of adefovir mixed phosphonate derivatives bearing cholic acid and l-amino acid moieties for the treatment of HBV. ADV, HBV, hOAT1, NAs
35  2019 Uremic solutes modulate hepatic bile acid handling and induce mitochondrial toxicity. BSEP, CKD, CYP7A1, MRP3, OATP1B1, TCA
36  2018 Calnexin Depletion by Endoplasmic Reticulum Stress During Cholestasis Inhibits the Na+-Taurocholate Cotransporting Polypeptide. DDC, ER, FXR, mRNA, MS, RT-PCR, TCA, UPR
37  2018 Development of a mechanistic biokinetic model for hepatic bile acid handling to predict possible cholestatic effects of drugs. BSEP, DILI
38  2018 Na+ -taurocholate cotransporting polypeptide inhibition has hepatoprotective effects in cholestasis in mice. ALP, BDL, BSs, PL
39  2017 N-Glycosylation of the Na+-Taurocholate Cotransporting Polypeptide (NTCP) Determines Its Trafficking and Stability and Is Required for Hepatitis B Virus Infection. HBV
40  2017 Paeoniflorin ameliorates cholestasis via regulating hepatic transporters and suppressing inflammation in ANIT-fed rats. ALP, ANIT, AST, BSEP, CYP7A1, DBIL, gamma-GT, IL-1beta, MRP2, NF-kappaB, TBA, TBIL
41  2016 Down-regulation of NTCP expression by cyclin D1 in hepatitis B virus-related hepatocellular carcinoma has clinical significance. HBV, HCC
42  2016 Inhibition of Hepatobiliary Transport Activity by the Antibacterial Agent Fusidic Acid: Insights into Factors Contributing to Conjugated Hyperbilirubinemia/Cholestasis. BSEP
43  2016 Live Cell Imaging Confocal Microscopy Analysis of HBV Myr-PreS1 Peptide Binding and Uptake in NTCP-GFP Expressing HepG2 Cells. ---
44  2016 Organic Anion Transporting Polypeptides Contribute to the Disposition of Perfluoroalkyl Acids in Humans and Rats. ASBT, OATPs, PFBS, PFCAs, PFHxS, PFOS, PFSAs
45  2015 Comparative Localization and Functional Activity of the Main Hepatobiliary Transporters in HepaRG Cells and Primary Human Hepatocytes. BSEP, HHs, MDR1, MRP2
46  2015 Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na(+) -taurocholate cotransporting polypeptide knockout mice. BAs
47  2015 Interleukin 6 inhibits HBV entry through NTCP down regulation. HBV
48  2015 Investigations of the total flavonoids extracted from flowers of Abelmoschus manihot (L.) Medic against alpha-naphthylisothiocyanate-induced cholestatic liver injury in rats. ALP, ANIT, AST, BSEP, DBIL, GGT, GST, LDH, MDA, MRP2, NO, RT-PCR, SOD, TBA, TBIL, TNF-alpha
49  2015 Irbesartan, an FDA approved drug for hypertension and diabetic nephropathy, is a potent inhibitor for hepatitis B virus entry by disturbing Na(+)-dependent taurocholate cotransporting polypeptide activity. cccDNA, HBeAg, HBV, TALEN
50  2015 Na+/Taurocholate Cotransporting Polypeptide and Apical Sodium-Dependent Bile Acid Transporter Are Involved in the Disposition of Perfluoroalkyl Sulfonates in Humans and Rats. ASBT, PFASs, PFBS, PFHxS, PFOS
51  2015 Quantitative bile acid profiling by liquid chromatography quadrupole time-of-flight mass spectrometry: monitoring hepatitis B therapy by a novel Na(+)-taurocholate cotransporting polypeptide inhibitor. BAs, LC-QTOF-MS
52  2015 Stable Human Hepatoma Cell Lines for Efficient Regulated Expression of Nucleoside/Nucleotide Analog Resistant and Vaccine Escape Hepatitis B Virus Variants and Woolly Monkey Hepatitis B Virus. CHB, HBV, NAs, WMHBV
53  2015 The effect of Na+/taurocholate cotransporting polypeptide (NTCP) c.800C > T polymorphism on rosuvastatin pharmacokinetics in Chinese healthy males. ---
54  2015 The Na(+)-Taurocholate Cotransporting Polypeptide Traffics with the Epidermal Growth Factor Receptor. EGFR, PKC
55  2014 Binding of hepatitis B virus to its cellular receptor alters the expression profile of genes of bile acid metabolism. BA, HBV
56  2014 Electrophysiological characterization of human Na⁺/taurocholate cotransporting polypeptide (hNTCP) heterologously expressed in Xenopus laevis oocytes. hNTCP, hNTCP, NMDG, TCA
57  2014 HBV: Stowaway of NTCP. HBV
58  2014 Interaction of digitalis-like compounds with liver uptake transporters NTCP, OATP1B1, and OATP1B3. CHO-NTCP, DLCs, OATP, TCA
59  2014 Kinetics of the bile acid transporter and hepatitis B virus receptor Na+/taurocholate cotransporting polypeptide (NTCP) in hepatocytes. HBV, myr-preS1
60  2014 Organic anion uptake by hepatocytes. ---
61  2014 Role of protein kinase C isoforms in bile formation and cholestasis. aPKCzeta, cPKCalpha, MAPK, MRP2, nPKCdelta, PI3K, PKC
62  2014 The impact of solute carrier (SLC) drug uptake transporter loss in human and rat cryopreserved hepatocytes on clearance predictions. OATPs, OCTs, SLC
63  2014 Transport of the soy isoflavone daidzein and its conjugative metabolites by the carriers SOAT, NTCP, OAT4, and OATP2B1. DAI, IF, SOAT
64  2013 A mechanistic framework for in vitro-in vivo extrapolation of liver membrane transporters: prediction of drug-drug interaction between rosuvastatin and cyclosporine. AUC, BCRP, IVIVE, PBPK, tmax
65  2013 Clinical application of transcriptional activators of bile salt transporters. BS, BSEP
66  2013 Effects of ginsenosides on the expression of cytochrome P450s and transporters involved in cholesterol metabolism. MRP
67  2013 Hepatocellular organic anion-transporting polypeptides (OATPs) and multidrug resistance-associated protein 2 (MRP2) are inhibited by silibinin. BSEP, MRP2, OATPs
68  2013 Mechanistic background and clinical applications of indocyanine green fluorescence imaging of hepatocellular carcinoma. HCC, ICG, OATP8
69  2013 Quantitative assessment of the contribution of sodium-dependent taurocholate co-transporting polypeptide (NTCP) to the hepatic uptake of rosuvastatin, pitavastatin and fluvastatin. ---
70  2013 Structural basis of the alternating-access mechanism in a bile acid transporter. ASBT, ASBTYf
71  2012 Anticholestatic effects of bezafibrate in patients with primary biliary cirrhosis treated with ursodeoxycholic acid. IgM, MDR3, MRP2, PBC, PPARs, PXR, UDCA
72  2012 Characterization of ursodeoxycholic and norursodeoxycholic acid as substrates of the hepatic uptake transporters OATP1B1, OATP1B3, OATP2B1 and NTCP. HEK, norUDCA, UDCA
73  2012 Endogenous bile acid disposition in rat and human sandwich-cultured hepatocytes. BAs, BSEP, CTL, GCA, GCDCA, SCH, TCA, TCDCA, TRO
74  2012 Expression and transport function of drug uptake transporters in differentiated HepaRG cells. OATPs
75  2012 Monitoring bile acid transport in single living cells using a genetically encoded Forster resonance energy transfer sensor. BAS, FRET, OSTalphabeta
76  2012 Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells. BA, BSEP, CPZ, MDR3, mRNA, MRP4, NAC, ROS
77  2012 Pharmaceutical excipients influence the function of human uptake transporting proteins. CrEL, HPCD, OATP, TA
78  2012 Protein kinase Cdelta differentially regulates cAMP-dependent translocation of NTCP and MRP2 to the plasma membrane. MRP2, PKCdelta
79  2012 The SLC10 carrier family: transport functions and molecular structure. ASBT, SLCs, SOAT
80  2011 CLA-enriched diet containing t10,c12-CLA alters bile acid homeostasis and increases the risk of cholelithiasis in mice. BA, BSEP, CYP7A1
81  2011 Genetic polymorphisms in Na+-taurocholate co-transporting polypeptide (NTCP) and ileal apical sodium-dependent bile acid transporter (ASBT) and ethnic comparisons of functional variants of NTCP among Asian populations. ASBT
82  2011 Interaction of fluvastatin with the liver-specific Na+ -dependent taurocholate cotransporting polypeptide (NTCP). CHO-NTCP
83  2010 Differential effect of genetic variants of Na(+)-taurocholate co-transporting polypeptide (NTCP) and organic anion-transporting polypeptide 1B1 (OATP1B1) on the uptake of HMG-CoA reductase inhibitors. OATP1B1
84  2010 Evaluation of the endothelin receptor antagonists ambrisentan, darusentan, bosentan, and sitaxsentan as substrates and inhibitors of hepatobiliary transporters in sandwich-cultured human hepatocytes. BSEP, ERAs, MRP2, OATP
85  2010 Hepatic transport mechanisms of cholyl-L-lysyl-fluorescein. ABCB11, CLF, OATP1B3
86  2010 Hepatic uptake of the magnetic resonance imaging contrast agent Gd-EOB-DTPA: role of human organic anion transporters. BSP, Gd-EOB-DTPA, HEK
87  2010 Inhibition of Na+-taurocholate Co-transporting polypeptide-mediated bile acid transport by cholestatic sulfated progesterone metabolites. ICP, PHH, PM4-S
88  2010 Nitric oxide mimics transcriptional and post-translational regulation during alpha-tocopherol cytoprotection against glycochenodeoxycholate-induced cell death in hepatocytes. CYP7A1, GCDCA, HO-1, NO, ROS, TC
89  2010 Transporter studies with the 3-O-sulfate conjugate of 17alpha-ethinylestradiol: assessment of human liver drug transporters. BCRP, HEK
90  2009 Disodium ascorbyl phytostanol phosphate (FM-VP4), a modified phytostanol, is a highly active hypocholesterolaemic agent that affects the enterohepatic circulation of both cholesterol and bile acids in mice. ABC, CYP7A1, FXR, HMG-CoAR, LXR, NPC1L1, SR-BI
91  2008 Bile acid transporters in health and disease. BSEP
92  2008 Thyroid hormone transporters in the brain. MCT8, oatp
93  2007 Bile acid transporters: structure, function, regulation and pathophysiological implications. ASBT, BSEP, IBABP, MRPs, OATPs, Ost
94  2006 Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics. HMG-CoA, OATP
95  2006 Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity. BSEP, CAR, ERalpha, FXR, PXR
96  2006 PKCzeta is required for microtubule-based motility of vesicles containing the ntcp transporter. MTs
97  2006 The solute carrier family SLC10: more than a family of bile acid transporters regarding function and phylogenetic relationships. ASBT, SLC10, SLC10A3, SOAT
98  2006 Uptake of ursodeoxycholate and its conjugates by human hepatocytes: role of Na(+)-taurocholate cotransporting polypeptide (NTCP), organic anion transporting polypeptide (OATP) 1B1 (OATP-C), and oatp1B3 (OATP8). GUDC, OATP, TUDC, UDCA
99  2006 Vectorial transport of unconjugated and conjugated bile salts by monolayers of LLC-PK1 cells doubly transfected with human NTCP and BSEP or with rat Ntcp and Bsep. BSEP
100  2005 Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis. BSEP, CYP7A1, FXR, SHP