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■ Abbreviation / Long Form : Nrf2 / nuclear factor erythroid 2-related factor 2

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Abbreviation:   Nrf2  (>> Co-occurring Abbreviation)
Long Form:   nuclear factor erythroid 2-related factor 2
 Abbreviation Variation
 Long Form Variation
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No. Year Title Co-occurring Abbreviation
2023 17β-estradiol plays the anti-osteoporosis role via a novel ESR1-Keap1-Nrf2 axis-mediated stress response activation and Tmem119 upregulation. BMSCs, Keap1
2023 3',4'-Dihydroxyflavone mitigates inflammatory responses by inhibiting LPS and TLR4/MD2 interaction. AP-1, DHF, IRF3, LPS, MD2, NF-kappaB, NO, PGE2, STAT1, TLR4
2023 6-Gingerol attenuates sepsis-induced acute lung injury by suppressing NLRP3 inflammasome through Nrf2 activation. ALI, BALF, HO-1, IL, LPS, MDA, PPI, SOD, TNF-alpha
2023 A Multifunctional (-)-Meptazinol-Serotonin Hybrid Ameliorates Oxidative Stress-Associated Apoptotic Neuronal Death and Memory Deficits via Activating the Nrf2/Antioxidant Enzyme Pathway. AChE, AD, HO-1, Keap1, Mep-S, NQO-1, SOD
2023 A novel type lavandulyl flavonoid from Sophora flavescens as potential anti-hepatic injury agent that inhibit TLR2/NF-κB signaling pathway. ALP, AST, COX-2, HO-1, IL-1beta, IL-6, KM, MTS, SOD2, TCM, TLR2, TNF-alpha
2023 Acacetin alleviates neuroinflammation and oxidative stress injury via the Nrf2/HO-1 pathway in a mouse model of spinal cord injury. BMS, HO-1, IL, Keap1, SCI, TNF-alpha
2023 Activating transcription factor-2 supports the antioxidant capacity and ability of human mesenchymal stem cells to prevent asthmatic airway inflammation. AA2G, ATF2, CREB, MSCs
2023 Activation of the Keap1/Nrf2 Pathway as an Adaptive Response to an Electrophilic Metabolite of Morphine. Keap1, MO
2023 Advances and challenges in therapeutic targeting of NRF2. ---
10  2023 Adverse effects of pristine and aged polystyrene microplastics in mice and their Nrf2-mediated defense mechanisms with tissue specificity. HO-1, MPs, UV
11  2023 Ameliorative effects of different doses of selenium against fluoride-triggered apoptosis and oxidative stress-mediated renal injury in rats through the activation of Nrf2/HO-1/NQO1 signaling pathway. CAT, HO-1, MDA, NQO1, ROS, SCr, Se
12  2023 An updated patent review of Nrf2 activators (2020-present). BBB, Keap1-Nrf2-ARE
13  2023 Anesthetic propofol inhibits ferroptosis and aggravates distant cancer metastasis via Nrf2 upregulation. CTCs, ROS
14  2023 Annexin A5 ameliorates traumatic brain injury-induced neuroinflammation and neuronal ferroptosis by modulating the NF-ĸB/HMGB1 and Nrf2/HO-1 pathways. ---
15  2023 Anti-Inflammatory Effect of Dimethyl Fumarate Associates with the Inhibition of Thioredoxin Reductase 1 in RAW 264.7 Cells. DAMPs, DMF, MS, NO, PAMPs, TXNRD1
16  2023 Antidiabetic drug sitagliptin blocks cyclophosphamide cerebral neurotoxicity by activating Nrf2 and suppressing redox cycle imbalance, inflammatory iNOS/NO/NF-κB response and caspase-3/Bax activation in rats. AChE, CAT, CYP, GPx, IL-1beta, IL-6, iNOS, MDA, NF-kappaB, NO, SOD, STG, TNF-alpha
17  2023 Baicalein limits osteoarthritis development by inhibiting chondrocyte ferroptosis. DMM, HO-1, IL-1beta, KO, OA, WT
18  2023 Benzo[a]pyrene treatment modulates Nrf2/Keap1 axis and changes the metabolic profile in rat lung cancer. ATF6, CHOP, ER, HO1, Keap1, MDA, PINK1, PPP, SOD, TCA
19  2023 Berberine hydrochloride alleviates imatinib mesylate - induced cardiotoxicity through the inhibition of Nrf2-dependent ferroptosis. Ber, FTH1, GPX4, HO-1, IMA, LIP, MDA, MMP, NQO1, ROS, TfR
20  2023 Bifidobacterium bifidum Ameliorates DSS-Induced Colitis in Mice by Regulating AHR/NRF2/NLRP3 Inflammasome Pathways through Indole-3-lactic Acid Production. AhR, DSS, NLRP3
21  2023 Bisphenol S exposure promotes cell apoptosis and mitophagy in murine osteocytes by regulating mtROS signaling. BPS, LC3, MMP, mtROS, PINK, ROS
22  2023 Camptothecin improves sorafenib sensitivity by inhibiting Nrf2‑ARE pathway in hepatocellular carcinoma. CPT, HCC, NQO1
23  2023 Carnosol inhibits KGN cells oxidative stress and apoptosis and attenuates polycystic ovary syndrome phenotypes in mice through Keap1-mediated Nrf2/HO-1 activation. HO-1, Keap1, PCOS, ROS, ZnPP
24  2023 Cell-Permeable PROTAC Degraders against KEAP1 Efficiently Suppress Hepatic Stellate Cell Activation through the Antioxidant and Anti-Inflammatory Pathway. HO-1, KKP1
26  2023 Cerium oxide nanoparticles protect against chondrocytes and cartilage explants from oxidative stress via Nrf2/HO-1 pathway in temporomandibular joint osteoarthritis. CNPs, HO-1, ROS
27  2023 Clustered Cobalt Nanodots Initiate Ferroptosis by Upregulating Heme Oxygenase 1 for Radiotherapy Sensitization. Co, HMOX1, Keap1, SLC40A1
28  2023 Combined carvacrol and cilostazol ameliorate ethanol-induced liver fibrosis in rats: Possible role of SIRT1/Nrf2/HO-1 pathway. 4Hyp, ALF, alpha-SMA, HO-1, HSCs, IL, SIRT1, TGF
29  2023 Costunolide alleviates hyperglycaemia-induced diabetic cardiomyopathy via inhibiting inflammatory responses and oxidative stress. Cos, DCM, HG, NF-kappaB
30  2023 Curcumin attenuates AFB1-induced duck liver injury by inhibiting oxidative stress and lysosomal damage. AFB1, MDA
31  2023 Cycloartenyl Ferulate Is the Predominant Compound in Brown Rice Conferring Cytoprotective Potential against Oxidative Stress-Induced Cytotoxicity. alpha-T, CAF, gammaT, HO-1
32  2023 Deciphering the protective effect of Buzhong Yiqi Decoction on osteoporotic fracture through network pharmacology and experimental validation. BZYQD, HO-1, IL, MAPK, NF-kappaB, OPF, SOD, TNF-alpha
33  2023 Downregulation of Nrf2 in the Hippocampus Contributes to Postoperative Cognitive Dysfunction in Aged Rats by Sensitizing Oxidative Stress and Neuroinflammation. POCD, ROS
34  2023 Druggable Biomarkers Altered in Clear Cell Renal Cell Carcinoma: Strategy for the Development of Mechanism-Based Combination Therapy. ccRCC, miRS, MSC, PBRM1, SLM, TP, VHL
35  2023 Echinacoside from Cistanche tubulosa ameliorates alcohol-induced liver injury and oxidative stress by targeting Nrf2. ALD, AML12, AST, ECH, GCLC, HE, HO-1
36  2023 Effect of Lactobacillus plantarum KSFY01 on the exercise capacity of D-galactose-induced oxidative stress-aged mice. AST, BUN, CK, L. plantarum KSFY01, LD, LDH, MDA, MG
37  2023 Effects and mechanism of gastrodin supplementation on exercise-induced fatigue in mice. ---
38  2023 Effects of Clostridium butyricum on growth performance, meat quality, and intestinal health of broilers. NF-kappaB, T-SOD, VH
39  2023 Effects of continuous prenatal and postnatal global system for mobile communications electromagnetic waves (GSM-EMW) exposure on the oxidative stress biomarkers in female rat liver. CAT, GPx, GSM-EMW, ICAM-1, OS, PND, RF-EMR
40  2023 Effects of curcumin and melatonin treatment in the cerebral cortex of adult rats. MDA, NO, SOD
41  2023 Effects of dietary pretreated Chinese herbal medicine supplementation on production performance, egg quality, uterine histopathological changes, and antioxidant capacity in late-phase laying hens. CAT, GPX1, GSH-Px, MDA, PCHM
42  2023 Effects of Dietary Supplementation of Chinese Yam Polysaccharide on Carcass Composition, Meat Quality, and Antioxidant Capacity in Broilers. CAT, CYP, GPx, GPX1, GST, HO-1, MDA, SOD1, T-AOC, T-SOD
43  2023 Effects of dietary supplementation with quercetagetin on nutrient digestibility, intestinal morphology, immunity, and antioxidant capacity of broilers. ARE, GSH-Px, HO-1, IgG, Keap1, NQO-1, QG, SOD, SOD1, T-AOC
44  2023 Effects of in ovo feeding of chlorogenic acid on antioxidant capacity of postnatal broilers. 4CGA, CAT, CGA, DNMT3A, GPx, GSR, GSS, HO1, MDA, SOD
45  2023 Efficacy of Artemisia annua Linné in improving cognitive impairment in a chronic cerebral hypoperfusion-induced vascular dementia animal model. AA, BCCAO, Keap1, NVU, SIRT, VaD
46  2023 EGR1 is crucial for the chlorogenic acid-provided promotion on liver regeneration and repair after APAP-induced liver injury. APAP-CYS, CGA, ChIP-seq, Egr-1, ERK, KO, WT
47  2023 Elabela-APJ axis attenuates cerebral ischemia/reperfusion injury by inhibiting neuronal ferroptosis. ELA, I/R
48  2023 Estradiol protects hair cells from cisplatin-induced ototoxicity via Nrf2 activation. ---
49  2023 Evaluation of the oxidative toxicity induced by lead, manganese, and cadmium using genetically modified nrf2a-mutant zebrafish. Cd, Mn, WT
50  2023 Exploring the cardioprotective effects of canagliflozin against cisplatin-induced cardiotoxicity: Role of iNOS/NF-κB, Nrf2, and Bax/cytochrome C/Bcl-2 signals. CA, CDDP, NF-kappaB, PI3K
51  2023 Fenoldopam Mesylate Enhances the Survival of Mesenchymal Stem Cells Under Oxidative Stress and Increases the Therapeutic Function in Acute Kidney Injury. AKI, FD, FD-MSCs, MSCs
52  2023 Ferroptosis contribute to neonicotinoid imidacloprid-evoked pyroptosis by activating the HMGB1-RAGE/TLR4-NF-κB signaling pathway. HMGB1, IMI, NF-kappaB, NLRP3, RAGE, TEM
53  2023 Ferroptosis-modulating small molecules for targeting drug-resistant cancer: Challenges and opportunities in manipulating redox signaling. GPx
54  2023 FGF4 improves hepatocytes ferroptosis in autoimmune hepatitis mice via activation of CISD3. AIH, CISD3, Con A, Fer-1, FGF4, HO-1, rFGF4
55  2023 FOXO6 transcription inhibition of CTRP3 promotes OGD/R-triggered cardiac microvascular endothelial barrier disruption via SIRT1/Nrf2 signaling. CTRP3, FOXO6, HCMECs, OGD/R, SIRT1, ZO-1
56  2023 Free radicals, antioxidants, nuclear factor-E2-related factor-2 and liver damage. NOD, ROS
57  2023 G0S2 ameliorates oxidized low-density lipoprotein-induced vascular endothelial cell injury by regulating mitochondrial apoptosis. AMPK, CAT, cyt c, G0S2, HAEC, HO-1, LDH, MDA, ox-LDL, ROS, SIRT1, SOD
58  2023 Genistein Protects against Acetaldehyde-Induced Oxidative Stress and Hepatocyte Injury in Chronic Alcohol-Fed Mice. ALD, HO-1
59  2023 Gestational Diabetes Mellitus (GDM), Hypothyroidism, and Gene Variants (Keap1 Rs11085735) in Patients with Preeclampsia. AST, GDM, Keap1, PCR
60  2023 Health Benefits of Coffee Consumption for Cancer and Other Diseases and Mechanisms of Action. AhR, NR4A1
61  2023 Hepatoprotective effect of taxifolin on cyclophosphamide-induced oxidative stress, inflammation, and apoptosis in mice: Involvement of Nrf2/HO-1 signaling. ALP, CAT, CP, HO-1, IL-1beta, LDH, MDA, NO, SOD, TA, TNF-alpha
62  2023 Hydropersulfides (RSSH) attenuate doxorubicin-induced cardiotoxicity while boosting its anticancer action. DOX, PGC-1alpha, ROS, RSSH
63  2023 Hypothalamic paraventricular nucleus hydrogen sulfide exerts antihypertensive effects in spontaneously hypertensive rats via the Nrf2 pathway. (AAV)-CBS, AAV, IL, PVN, ROS, SHR, WKY
64  2023 Identifying new biomarkers of aggressive Group 3 and SHH medulloblastoma using 3D hydrogel models, single cell RNA sequencing and 3D OrbiSIMS imaging. MB, scRNA-seq, SLRPs, TCA
65  2023 Incorporation of paclitaxel in mesenchymal stem cells using nanoengineering upregulates antioxidant response, CXCR4 expression and enhances tumor homing. MSCs, PTX, ROS
66  2023 Inhibitors of Keap1-Nrf2 protein-protein interaction reduce estrogen responsive gene expression and oxidative stress in estrogen receptor-positive breast cancer. ER, PPI
67  2023 Investigating the functional role of SETD6 in lung adenocarcinoma. LUAD, NF-kappaB, SETD6
68  2023 Is Nuclear Factor Erythroid 2-Related Factor 2 a Target for the Intervention of Cytokine Storms? ---
69  2023 Isosinensetin alleviates estrogen deficiency-induced osteoporosis via suppressing ROS-mediated NF-κB/MAPK signaling pathways. Iss, MAPK, micro-CT, NF-kappaB, NFATc1, OP, RANKL, ROS
70  2023 Ketamine Attenuates Airway Inflammation via Inducing Inflammatory Cells Apoptosis and Activating Nrf2 Pathway in a Mixed-Granulocytic Murine Asthma Model. BALF, LPS, Mcl-1, OVA
71  2023 Kynureninase Upregulation Is a Prominent Feature of NFR2-Activated Cancers and Is Associated with Tumor Immunosuppression and Poor Prognosis. Keap1, KYNU, PDAC
72  2023 Lactiplantibacillus plantarum P101 alleviates alcoholic liver injury by modulating the Nrf2/HO-1 pathway in mice. HO-1, L. plantarum
73  2023 Leptin alleviated ovarian ischemia-reperfusion injury in rats via modulation of Sirt-1/Nrf2 and TLR4/NF-kB/caspase-3 signaling pathways. AMH, COX-2, IR, OVIR, SIRT1, TLR4
74  2023 Linagliptin counteracts rotenone's toxicity in non-diabetic rat model of Parkinson's disease: Insights into the neuroprotective roles of DJ-1, SIRT-1/Nrf-2 and implications of HIF1-α. DPP-4, HIF-1alpha, HO-1, IL-6, PD, SIRT-1, TNF-alpha
75  2023 Lipoxin A4 alleviates inflammation in Aspergillus fumigatus-stimulated human corneal epithelial cells by Nrf2/HO-1 signaling pathway. A. fumigatus, CCK-8, ELISA, HCECs, HO-1, LXA4, qRT-PCR
76  2023 Lyciumbarbarum polysaccharides ameliorate canine acute liver injury by reducing oxidative stress, protecting mitochondrial function, and regulating metabolic pathways. 9-HODE, ATP, CAT, ECH, LBPs, PE, SQSTM1
77  2023 Lycopene ameliorates DEHP exposure-induced renal pyroptosis through the Nrf2/Keap-1/NLRP3/Caspase-1 axis. KIM-1, NGAL
78  2023 Melatonin attenuates high glucose‑induced endothelial cell pyroptosis by activating the Nrf2 pathway to inhibit NLRP3 inflammasome activation. HG, HUVECs, NLRP3
79  2023 Metabolic reprogramming by immune-responsive gene 1 up-regulation improves donor heart preservation and function. HDAC, HO1, IRG1, PGD, SOD1, VPA
80  2023 Modulation of p38 MAPK and Nrf2/HO-1/NLRP3 inflammasome signaling and pyroptosis outline the anti-neuroinflammatory and remyelinating characters of Clemastine in EAE rat model. ASC, CLM, EAE, GSDMD, HO-1, MAPK, MS, NLRP3
81  2023 Mogroside-rich extract from Siraitia grosvenorii fruits protects against heat stress-induced intestinal damage by ameliorating oxidative stress and inflammation in mice. CAT, GPX1, IFN-gamma, IL-10, MGE, NF-kB, OCLD, SOD, TFF3, TLR4, TNF-alpha, ZO-1
82  2023 Molecular Characterization of Spodoptera frugiperda Heme Oxygenase and Its Involvement in Susceptibility to Chlorantraniliprole. CncC, HO
83  2023 Molecular Mechanism of Fucoidan Nanoparticles as Protector on Endothelial Cell Dysfunction in Diabetic Rats' Aortas. ACh, cGMP, GPx, MDA, NO, ROS, SOD, STZ
84  2023 Moschus exerted protective activity against H2O2-induced cell injury in PC12 cells through regulating Nrf-2/ARE signaling pathways. AD, MDA, MMP, ROS
85  2023 Naringin mitigates LPS-induced intestinal barrier injury in mice. CAT, D-LA, DAO, GPx, IL-1beta, JAM2, Keap1, LPS, MDA, MUC2, NF-kappaB, p38 MAPK, SOD, TLR4, TNF-alpha, ZO-1
86  2023 Netrin-1 Alleviates Early Brain Injury by Regulating Ferroptosis via the PPARγ/Nrf2/GPX4 Signaling Pathway Following Subarachnoid Hemorrhage. CoQ10-FSP1, EBI, GPX4, NTN-1, PPARgamma, SAH
87  2023 Neuroprotective Effects of Erinacine A on an Experimental Model of Traumatic Optic Neuropathy. C-cas-3, Cas8, EA, FVEP, HO-1, IL, iNOS, ONs, pRIP1, RGC, SOD1, TNF, TNFR1, TUNEL
88  2023 Neuroprotective Effects of Pulicaria incisa Infusion on Human Neuroblastoma Cells and Hippocampal Neurons. CREB, Pi, ROS
89  2023 Neuroprotective Efficacy of Europinidin in Streptozotocin-Induced Memory Impairment by Modulation of Oxidative Stress, Inflammatory Mediators, and Cholinesterase Activity in Rats. IL-1beta, TNF-alpha
90  2023 New advances in Nrf2-mediated analgesic drugs. ---
91  2023 Nicotinamide Mononucleotide Ameliorates Silica-Induced Lung Injury through the Nrf2-Regulated Glutathione Metabolism Pathway in Mice. NMN
92  2023 Nrf2 Activation: Involvement in Central Nervous System Traumatic Injuries. A Promising Therapeutic Target of Natural Compounds. CNS, SCI, TBI
93  2023 NRF2 and its targets in skeletal muscle repair and regeneration. DMD, HO-1
94  2023 Nrf2 Expression Is Decreased in LRRK2 Transgenic Mouse Brain and LRRK2 Overexpressing SH-SY5Y Cells. GSK-3beta, LRRK2, PD
95  2023 NRF2 in Cancer: Cross-Talk with Oncogenic Pathways and Involvement in Gammaherpesvirus-Driven Carcinogenesis. HSF1, mTOR, mut, ROS
96  2023 Nrf2 is expressed more extensively in neurons than in astrocytes following an acute epileptic seizure in rats. ---
97  2023 Nrf2 Is Involved in Hyperglycemia-Induced Abnormal Lung Development Through Both Antioxidation-Dependent and Antioxidation-Independent Activation. GDM, PGDM
98  2023 Nrf2 regulates the expression of NOX1 in TNF-α-induced A549 cells. MDA, NOX1, T-AOC, TNF-alpha
99  2023 Nuclear factor erythroid 2-related factor 2-mediated signaling and metabolic associated fatty liver disease. MAFLD