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■ Abbreviation / Long Form : Nrf2 / nuclear factor erythroid 2-related factor 2

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Abbreviation:   Nrf2  (>> Co-occurring Abbreviation)
Long Form:   nuclear factor erythroid 2-related factor 2
 Abbreviation Variation
 Long Form Variation
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No. Year Title Co-occurring Abbreviation
2021 (-)-Loliolide Isolated from Sargassum horneri Suppressed Oxidative Stress and Inflammation by Activating Nrf2/HO-1 Signaling in IFN-γ/TNF-α-Stimulated HaCaT Keratinocytes. HO-1, IFN, IL, MAPK, MDC, NF-kappaB, RANTES, ROS, S. horneri, TARC, TNF, TSLP
2021 (E)-N-(2-(3, 5-Dimethoxystyryl) phenyl) furan-2-carboxamide (BK3C231) induces cytoprotection in CCD18-Co human colon fibroblast cells through Nrf2/ARE pathway activation. 4NQO, ARE, GCLC, GST, HO-1, NQO1
2021 1-O-Hexyl-2,3,5-Trimethylhydroquinone Ameliorates the Development of Preeclampsia through Suppression of Oxidative Stress and Endothelial Cell Apoptosis. ET-1, HO-1, HTHQ, HUVECs, PE, ROS, SBP, sEng, sFlt-1, VEGF
2021 15-Deoxy-Δ12,14-prostaglandin J2 Upregulates VEGF Expression via NRF2 and Heme Oxygenase-1 in Human Breast Cancer Cells. COX-2, HO-1, VEGF
2021 18β-Glycyrrhetinic acid inhibits IL-1β-induced inflammatory response in mouse chondrocytes and prevents osteoarthritic progression by activating Nrf2. 18beta-GA, COX-2, DMM, ECM, HO-1, IL-1beta, IL-6, iNOS, MMP-13, NF-kappaB, NO, OA, PGE2, TNF-alpha
2021 4-Acetylantroquinonol B ameliorates nonalcoholic steatohepatitis by suppression of ER stress and NLRP3 inflammasome activation. 4-AAQB, AST, ER, MCD, NAFLD, NAS, NLRP3, SIRT1, TM
2021 A combination of herbal compound (SPTC) along with exercise or metformin more efficiently alleviated diabetic complications through down-regulation of stress oxidative pathway upon activating Nrf2-Keap1 axis in AGE rich diet-induced type 2 diabetic mice. ---
2021 A Nature-Inspired Nrf2 Activator Protects Retinal Explants from Oxidative Stress and Neurodegeneration. OS
2021 A Network Pharmacology-Based Approach to Investigating the Mechanisms of Fushen Granule Effects on Intestinal Barrier Injury in Chronic Renal Failure. COX-2, FSG, GO, HO-1, KEGG, MDA
10  2021 A New Peracetylated Oleuropein Derivative Ameliorates Joint Inflammation and Destruction in a Murine Collagen-Induced Arthritis Model via Activation of the Nrf-2/Ho-1 Antioxidant Pathway and Suppression of MAPKs and NF-κB Activation. CIA, COMP, HO-1, MAPK, NF-kappaB, OL, SLE
11  2021 A Novel Nrf2 Pathway Inhibitor Sensitizes Keap1-Mutant Lung Cancer Cells to Chemotherapy. ROS, TBHP
12  2021 A review on herbal Nrf2 activators with preclinical evidence in cardiovascular diseases. CVDs, Keap1, ROS
13  2021 Acidic fibroblast growth factor attenuates type 2 diabetes-induced demyelination via suppressing oxidative stress damage. aFGF, Keap1, SC, T2DM
14  2021 Activation of Cellular Antioxidant Defense System by Naturally Occurring Dibenzopyrone Derivatives Confers Neuroprotection against Oxidative Insults. ---
15  2021 Activation of kelch-like ECH-associated protein 1/nuclear factor erythroid 2-related factor 2/antioxidant response element pathway by curcumin enhances the anti-oxidative capacity of corneal endothelial cells. ARE, CECs, Keap1
16  2021 Activation of Nrf2 by Electrophiles Is Largely Independent of the Selenium Status of HepG2 Cells. GPX1, Se, SELENOW
17  2021 Activation of Nrf2 Pathway by Dimethyl Fumarate Attenuates Renal Ischemia-Reperfusion Injury. DMF, HO-1, IRI, NQO1
18  2021 Activation of Nrf2 signaling pathway by natural and synthetic chalcones: a therapeutic road map for oxidative stress. ---
19  2021 Activation of the Nrf2/HO-1 signaling pathway by dimethyl fumarate ameliorates complete Freund's adjuvant-induced arthritis in rats. CAT, CCP, CFA, CRP, DMF, GPx, MDA, MPO, RF, SOD
20  2021 Adaptive and Constitutive Activations of Malic Enzymes Confer Liver Cancer Multilayered Protection Against Reactive Oxygen Species. MEs, ROS
21  2021 Advances of natural activators for Nrf2 signaling pathway on cholestatic liver injury protection: a review. ---
22  2021 Adverse Effects of Oxidative Stress on Bone and Vasculature in Corticosteroid-Associated Osteonecrosis: Potential Role of Nuclear Factor Erythroid 2-Related Factor 2 in Cytoprotection. ON, ONFH
23  2021 AITC inhibits fibroblast-myofibroblast transition via TRPA1-independent MAPK and NRF2/HO-1 pathways and reverses corticosteroids insensitivity in human lung fibroblasts. AITC, alpha-SMA, ERK, FMT, HO, MAPK, TGF-beta1, TRPA1
24  2021 Akt / GSK3β / Nrf2 / HO-1 pathway activation by flurbiprofen protects the hippocampal neurons in a rat model of glutamate excitotoxicity. ---
25  2021 Albumin Reduces Oxidative Stress and Neuronal Apoptosis via the ERK/Nrf2/HO-1 Pathway after Intracerebral Hemorrhage in Rats. ICH
26  2021 Aldo-Keto Reductases and Cancer Drug Resistance. AKRs
27  2021 Algae-derived polysaccharides supplementation ameliorates heat stress-induced impairment of bursa of Fabricius via modulating NF-κB signaling pathway in broilers. ADP, GST, HO-1, HS, IkappaBalpha, IL, INF-gamma, MDA, NF-kappaB, T-AOC, TNF-alpha
28  2021 Allisartan isoproxil attenuates oxidative stress and inflammation through the SIRT1/Nrf2/NF‑κB signalling pathway in diabetic cardiomyopathy rats. ARB, BNP, DCM, SIRT1
29  2021 Allopurinol ameliorates liver injury in type 1 diabetic rats through activating Nrf2. ALP, AST, HO-1, Keap1, MDA, NAFLD, SOD, STZ
30  2021 Aloin protects mice from diet-induced non-alcoholic steatohepatitis via activation of Nrf2/HO-1 signaling. CDAAH, HO-1, IL, KO, NASH
31  2021 Alpha lipoic acid priming enhances the hepatoprotective effect of adipose derived stem cells in CCl4 induced hepatic injury in-vitro. ADSCs, AFP, ALA, ALAT, ALB, ALP, CK8, CYP2E1, HGF, HO-1, IGF, IL-6, LDH, SOD, TNF-alpha, VEGF
32  2021 Alpha-lipoic acid supplementation increases the efficacy of exercise- and diet-induced obesity treatment and induces immunometabolic changes in female mice and women. ALA, VAT
33  2021 Altered adipokine levels are associated with dimethyl fumarate treatment in multiple sclerosis patients. DMF, FABP4, MS
34  2021 Amelioration effect of black seed oil against high-fat diet-induced obesity in rats through Nrf2/HO-1 pathway. BSO, HFD, HO-1
35  2021 Ameliorative effect of betanin on experimental cisplatin-induced liver injury; the novel impact of miRNA-34a on the SIRT1/PGC-1α signaling pathway. BET, CIS, miRNA-34a, PGC-1alpha, SIRT1
36  2021 Ameliorative effects and mechanisms of salvianic acid A on retinal iron overload in vivo and in vitro. NF-kappaB, SAA
37  2021 Ameliorative effects of astaxanthin on brain tissues of alzheimer's disease-like model: cross talk between neuronal-specific microRNA-124 and related pathways. AD, ATX, DMSO, MWM
38  2021 An Update on the Role of Nrf2 in Respiratory Disease: Molecular Mechanisms and Therapeutic Approaches. ALI, ARDS, ARE, COPD, IPF, Keap1
39  2021 Anti-allergic activities of Umbelliferone against histamine- and Picryl chloride-induced ear edema by targeting Nrf2/iNOS signaling in mice. H and E, i.p, IgE, iNOS, PiCl, UMB
40  2021 Anti-fibrotic activity of sitagliptin against concanavalin A-induced hepatic fibrosis. Role of Nrf2 activation/NF-κB inhibition. Con A, NF-kappaB
41  2021 Anti-inflammatory effect of resveratrol attenuates the severity of diabetic neuropathy by activating the Nrf2 pathway. DPN
42  2021 Anti-inflammatory effects of Fritillaria thunbergii Miquel extracts in LPS-stimulated murine macrophage RAW 264.7 cells. EAFM, HO-1, NO
43  2021 Anti-Inflammatory Effects of Rosmarinic Acid-Loaded Nanovesicles in Acute Colitis through Modulation of NLRP3 Inflammasome. DSS, HO-1, NLRP3, RA, UC
44  2021 Anti-inflammatory effects of thymoquinone and its protective effects against several diseases. COX-2, NF-kappabeta
45  2021 Anti-Interleukin-16 Neutralizing Antibody Treatment Alleviates Sepsis-Induced Cardiac Injury and Dysfunction via the Nuclear Factor Erythroid-2 Related Factor 2 Pathway in Mice. AIF, CK-MB, CLP, cTnT, IL, LDH, NAb, PARP
46  2021 Anti-nociceptive effect of Portulaca oleracea L. ethanol extracts attenuated zymosan-induced mouse joint inflammation via inhibition of Nrf2 expression. NLRP3
47  2021 Antidepressant effect of catalpol on corticosterone-induced depressive-like behavior involves the inhibition of HPA axis hyperactivity, central inflammation and oxidative damage probably via dual regulation of NF-κB and Nrf2. CORT, HPA, NF-kappaB
48  2021 Antidepressant mechanism of catalpol: Involvement of the PI3K/Akt/Nrf2/HO-1 signaling pathway in rat hippocampus. CUMS, HO-1, PI3K, TrkB
49  2021 Antiepileptic Effects of Cicadae Periostracum on Mice and Its Antiapoptotic Effects in H2O2-Stimulated PC12 Cells via Regulation of PI3K/Akt/Nrf2 Signaling Pathways. CAT, CPM, EB, GSH-Px, HO-1, MOMP, PI3K, ROS, SOD, TCM
50  2021 Antinociceptive effects of oleuropein in experimental models of neuropathic pain in male rats. CBS, CCI, CSE
51  2021 Antioxidant activity and laxative effects of tannin-enriched extract of Ecklonia cava in loperamide-induced constipation of SD rats. DPPH, Lop, pRISMCs, ROS, SOD, TEE
52  2021 Antioxidant Activity of Novel Casein-Derived Peptides with Microbial Proteases as Characterized via Keap1-Nrf2 Pathway in HepG2 Cells. CAT, DPPH, GSH-Px, Keap1, MDA, ROS, SOD
53  2021 Antioxidant ameliorative effect of caffeic acid on the ectopic endometrial cells separated from patients with endometriosis. HO-1, NQO1, ROS
54  2021 Antioxidant and Anti-Inflammatory Activities of Zingiber montanum Oil in HepG2 Cells and Lipopolysaccharide-Stimulated RAW 264.7 Macrophages. HO-1, IL, LPS, MAPK, STAT3, ZMO
55  2021 Antioxidant and Anti-Inflammatory Effects of Bischofia javanica (Blume) Leaf Methanol Extracts through the Regulation of Nrf2 and TAK1. IL, LPS, MAPK, MBJ, NF-kappaB, NO
56  2021 Antioxidant Effects of Elderberry Anthocyanins in Human Colon Carcinoma Cells: A Study on Structure-Activity Relationships. CAT, Cy, Cy-3-glc, cy-3-rut, Cy-3-sam, Cy-3-sam-5-glc, DCF, GPx, HO-1, PCA, PGA, ROS, SOD
57  2021 Antioxidative and Anti-inflammatory Effects of Kojic Acid in Aβ-Induced Mouse Model of Alzheimer's Disease. AD, BACE1, HO1, i.c.v, KA
58  2021 Apigenin Attenuates Acetaminophen-Induced Hepatotoxicity by Activating AMP-Activated Protein Kinase/Carnitine Palmitoyltransferase I Pathway. AMPK, API, MPO, NAPQI, ROS
59  2021 Apigenin exerts chemopreventive effects on lung injury induced by SiO2 nanoparticles through the activation of Nrf2. APG, ROS
60  2021 Apolipoprotein E deficiency induces a progressive increase in tissue iron contents with age in mice. AD, APOE, KO, p-ERK, TfR1
61  2021 Apolipoprotein E Polymorphism and Oxidative Stress in Human Peripheral Blood Cells: Can Physical Activity Reactivate the Proteasome System through Epigenetic Mechanisms? AD, AOC, APOE
62  2021 Aqueous extract prepared from steamed red amaranth (Amaranthus gangeticus L.) leaves protected human lens cells against high glucose induced glycative and oxidative stress. AGEs, MMP, ROS
63  2021 Arsenic Trioxide Combining Leflunomide Activates Nrf2-ARE-HO-1 Signaling Pathway and Protects Heart Xenografts. FOXP3, HO-1, ICAM-1
64  2021 Arsenite induces tissue factor synthesis through Nrf2 activation in cultured human aortic smooth muscle cells. HASMCs, TF
65  2021 Arsenite Inhibits Tissue-Type Plasminogen Activator Synthesis through NRF2 Activation in Cultured Human Vascular Endothelial EA.hy926 Cells. PAI-1, ROS, tPA
66  2021 Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of hepatic encephalopathy via induction of Nrf2/HO-1 and mitigation of NF-κB/MAPK signaling pathways. ASH, ELISA, GS, HE, HO, iNOS, PCR, TAA
67  2021 Association of Nuclear Factor Erythroid-2-Related Actor 2 Gene Polymorphisms with Diabetic Nephropathy in Chinese Patients. DN, T2DM
68  2021 Astaxanthin prevents mitochondrial impairment in the dopaminergic SH-SY5Y cell line exposed to glutamate-mediated excitotoxicity: Role for the Nrf2/HO-1/CO-BR axis. AST, BR, BVR, Glu, HO-1, MMP
69  2021 Astaxanthin provides neuroprotection in an experimental model of traumatic brain injury via the Nrf2/HO-1 pathway. ATX, c-caspase-3, FST, NQO1, NSSs, SOD1, TBI
70  2021 Astragaloside IV Synergizing with Ferulic Acid Ameliorates Pulmonary Fibrosis by TGF-β1/Smad3 Signaling. Ast, ELISA, FA, HE, IPF, MDA, miR-29, NC group, ROS, SOD, TGF-beta1
71  2021 ATDC binds to KEAP1 to drive NRF2-mediated tumorigenesis and chemoresistance in pancreatic cancer. ATDC, Keap1, ROS
72  2021 Atrial natriuretic peptide protects vertebral endplate chondrocytes against H2O2‑induced apoptosis and oxidative stress through activation of the Nrf2/HO‑1 signaling pathway. ANP, EPCs, MDA, NO, SOD
73  2021 Auranofin-Mediated NRF2 Induction Attenuates Interleukin 1 Beta Expression in Alveolar Macrophages. AFN, AMs, BSO, IL, LPS, MH-S, NF-kappaB
74  2021 Autophagy Controls Nrf2-Mediated Dichotomy in Pressure Overloaded Hearts. ATG, CR, ERK, KO, PO
75  2021 Azilsartan ameliorates ventricular hypertrophy in rats suffering from pressure overload-induced cardiac hypertrophy by activating the Keap1-Nrf2 signalling pathway. AAC, Ang, mRNA, NRCM, siRNA
76  2021 Bariatric surgery can acutely modulate ER-stress and inflammation on subcutaneous adipose tissue in non-diabetic patients with obesity. AMPK, BMI, CALR, EIF2AK3, ERS, GCN2, MCP-1, PGC1alpha, RYGB, TNF-alpha
77  2021 Beneficial effects of octreotide in alcohol-induced neuropathic pain. Role of H 2S, BDNF, TNF-α and Nrf2. BDNF, CBS, CSE, TNF-alpha
78  2021 Benzyl isothiocyanates modulate inflammation, oxidative stress, and apoptosis via Nrf2/HO-1 and NF-κB signaling pathways on indomethacin-induced gastric injury in rats. BITC, HO-1, HSP70, IND, MDA, MPO, NF-kappaB, NO, PGE2, TNF-alpha
79  2021 Betanin Prevents Experimental Abdominal Aortic Aneurysm Progression by Modulating the TLR4/NF-κB and Nrf2/HO-1 Pathways. AAA, HO-1, MMPs, NF-kappaB, TLR4
80  2021 Betulin ameliorates 7,12-dimethylbenz(a)anthracene-induced rat mammary cancer by modulating MAPK and AhR/Nrf-2 signaling pathway. BE, DMBA
81  2021 Bicyclol Alleviates Signs of BDL-Induced Cholestasis by Regulating Bile Acids and Autophagy-Mediated HMGB1/p62/Nrf2 Pathway. BDL, HMGB1
82  2021 Biochanin A protects SH-SY5Y cells against isoflurane-induced neurotoxicity by suppressing oxidative stress and apoptosis. BCA, CAT, HO-1, MDA, SOD, TUNEL
83  2021 Biotechnologically-Produced Myconoside and Calceolarioside E Induce Nrf2 Expression in Neutrophils. CDDO-Me
84  2021 Bird evolution by insulin resistance. GLUT4, PT, ROS
85  2021 Bisphenol A Modulates Autophagy and Exacerbates Chronic Kidney Damage in Mice. ATG5, Atg7, BPA, CKD, HO-1, NQO1
86  2021 Bisphenol A stabilizes Nrf2 via Ca2+ influx by direct activation of the IP3 receptor. BPA, PLC
87  2021 Borassus flabellifer Linn haustorium methanol extract mitigates fluoride-induced apoptosis by enhancing Nrf2/Haeme oxygenase 1 -dependent glutathione metabolism in intestinal epithelial cells. Apaf-1, BHE, HO1
88  2021 Bortezomib alleviates myocardial ischemia reperfusion injury via enhancing of Nrf2/HO-1 signaling pathway. CAT, HO-1, LVEF, LVFS, MDA, MIRI, ROS
89  2021 Brazilin prevents against myocardial ischemia-reperfusion injury through the modulation of Nrf2 via the PKC signaling pathway. CK-MB, HO-1, LDH, MDA, MIRI, PKC, ROS, SOD, TTC, TUNEL
90  2021 Cadmium exposure induces rat proximal tubular cells injury via p62-dependent Nrf2 nucleus translocation mediated activation of AMPK/AKT/mTOR pathway. AMPK, Cd, CDDO-ME, rPT
91  2021 Cadmium induced oxystress alters Nrf2-Keap1 signaling and triggers apoptosis in piscine head kidney macrophages. Cd, HKM, HKSI, HO-1, Keap1, ROS
92  2021 Camu-Camu Fruit Extract Inhibits Oxidative Stress and Inflammatory Responses by Regulating NFAT and Nrf2 Signaling Pathways in High Glucose-Induced Human Keratinocytes. AP-1, MAPK, NF-kappaB, NFAT, NQO1, ROS
93  2021 Capacity of Trolox to improve the development and quality of metabolically compromised bovine oocytes and embryos invitro during different windows of development. PA, ROS, TR
94  2021 Cardamonin Attenuates Inflammation and Oxidative Stress in Interleukin-1β-Stimulated Osteoarthritis Chondrocyte through the Nrf2 Pathway. COX-2, ERK, HO-1, iNOS, MMPs, mTOR, NF-kappaB, NO, NQO1, OA, PGE2
95  2021 Cardamonin protects nucleus pulposus cells against IL-1β-induced inflammation and catabolism via Nrf2/NF-κB axis. CAR, COX-2, IL-1beta, IL-6, iNOS, IVDD, MMP-13, NF-kappaB, NO, NP, PGE2, TNF-alpha
96  2021 Cardioprotective Effect of Glycyrrhizin on Myocardial Remodeling in Diabetic Rats. Cx43, GLC, RAGE, TGF-beta
97  2021 Carnosic Acid Attenuates an Early Increase in ROS Levels during Adipocyte Differentiation by Suppressing Translation of Nox4 and Inducing Translation of Antioxidant Enzymes. DCFH-DA, DHE, GST, HO-1, NADPH, NF-kappaB, ROS
98  2021 Carnosic acid depends on glutathione to promote mitochondrial protection in methylglyoxal-exposed SH-SY5Y cells. ATP, BSO, CA, gamma-GCL, MG, MMP, PI3K
99  2021 Carotenoid Extract Derived from Euglena gracilis Overcomes Lipopolysaccharide-Induced Neuroinflammation in Microglia: Role of NF-κB and Nrf2 Signaling Pathways. EAE, HO-1
100  2021 Carvacrol hinders the progression of hepatic fibrosis via targeting autotaxin and thioredoxin in thioacetamide-induced liver fibrosis in rat. ALP, alpha-SMA, AST, ATX, DB, GGT, IL-1beta, iNOS, MDA, MMP-3 and 9, NF-kappaB, NOx, TAA, TB, TP, Trx, UDCA