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■ Abbreviation / Long Form : Nrf2 / nuclear factor-like 2

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Total Number of Papers: 52
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Abbreviation:   Nrf2  (>> Co-occurring Abbreviation)
Long Form:   nuclear factor-like 2
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No. Year Title Co-occurring Abbreviation
2021 Esomeprazole attenuates inflammatory and fibrotic response in lung cells through the MAPK/Nrf2/HO1 pathway. HO1, IPF, MAPK, PPIs, TGF-beta
2021 Loss of FCHSD1 leads to amelioration of chronic obstructive pulmonary disease. FCHSD1, SIRT1
2021 Overexpression of Kininogen-1 aggravates oxidative stress and mitochondrial dysfunction in DOX-induced cardiotoxicity. 4-HNE, COX4, DOX, HO-1, KNG1, NMCMs
2021 TGR5 protects against cholestatic liver disease via suppressing the NF-κB pathway and activating the Nrf2/HO-1 pathway. BA, BDL, CLD, NF-kappaB, TLR4
2020 Curcumin reverses diabetic nephropathy in streptozotocin-induced diabetes in rats by inhibition of PKCβ/p66Shc axis and activation of FOXO-3a. DM, MnSOD, NF-kappaB, PKCbetaII, ROS, TGF-beta1
2020 Identification of heme oxygenase-1 from golden pompano (Trachinotus ovatus) and response of Nrf2/HO-1 signaling pathway to copper-induced oxidative stress. CAT, GSH-Px, HO-1, Keap1, NQO1, ORF, SOD, UTR
2020 Non-Esterified Fatty Acid-Induced Reactive Oxygen Species Mediated Granulosa Cells Apoptosis Is Regulated by Nrf2/p53 Signaling Pathway. ERS, GCs, NAC, NEB, NEFA, ROS
2020 Organophosphate-pesticides induced survival mechanisms and APE1-mediated Nrf2 regulation in non-small-cell lung cancer cells. AIF, APE1, BER, CP, MCP, NSCLC, OPPs, OS, TF
2020 Orosomucoid 1 Attenuates Doxorubicin-Induced Oxidative Stress and Apoptosis in Cardiomyocytes via Nrf2 Signaling. 4-HNE, DOX, HO-1, ORM1
10  2019 Differential induction of nuclear factor-like 2 signature genes with toll-like receptor stimulation. LPS, NAC, PKC, PMA, PRDXs, ROS, TLRs, TXN
11  2019 Effects of daphnetin on lipid metabolism, insulin resistance and oxidative stress in OA‑treated HepG2 cells. DAP, NAFLD, OA, PI3K, PNPLA3, PPARalpha, ROS, TG
12  2019 Effects of Dietary Apple Polyphenols Supplementation on Hepatic Fat Deposition and Antioxidant Capacity in Finishing Pigs. APPs, CPT1b, CYP7A1, HSL, Keap1, LDLR, PPARalpha
13  2019 Essential element Cu and non-essential element Hg exposures have different toxicological effects in the liver of large yellow croaker. MTs, NF-kappaB, ROS
14  2019 Ilexgenin A inhibits mitochondrial fission and promote Drp1 degradation by Nrf2-induced PSMB5 in endothelial cells. AS, Drp1, IA, PA, PSMB5, ROS
15  2019 Low expression of pentraxin 3 and nuclear factor-like 2 implying a relatively longer overall survival time in gliomas. IHC, PBTs, PTX3, WHO
16  2019 MiR-153 regulates cardiomyocyte apoptosis by targeting Nrf2/HO-1 signaling. HO-1, I/R, miRNAs, OGD/R, ROS
17  2019 Neuroprotective mechanisms of dieckol against glutamate toxicity through reactive oxygen species scavenging and nuclear factor-like 2/heme oxygenase-1 pathway. DEK, HO-1, ROS
18  2019 Pre-hypoxia exposure inhibited copper toxicity by improving energy metabolism, antioxidant defence and mitophagy in the liver of the large yellow croaker Larimichthys crocea. FOXO3, HIF-1alpha, ROS
19  2019 Protective effect of 3,5‑dicaffeoyl‑epi‑quinic acid against UVB‑induced photoaging in human HaCaT keratinocytes. CQA
20  2019 Protective role of luteolin against bisphenol A-induced renal toxicity through suppressing oxidative stress, inflammation, and upregulating Nrf2/ARE/ HO-1 pathway. ARE, BPA, HO-1, LUT, OS
21  2019 The molecular mechanism of Nrf2-Keap1 signaling pathway in the antioxidant defense response induced by BaP in the scallop Chlamys farreri. BaP, C. farreri, CAT, GPx, JNK, Keap1, MAPKs, PKC, qRT-PCR, RNAi, SOD
22  2019 Toxicological effects of waterborne Zn on the proximal and distal intestines of large yellow croaker Larimichthys crocea. LPO, NF-kappaB, PC, ROS
23  2019 Zinc supplementation inhibits the high glucose‑induced EMT of peritoneal mesothelial cells by activating the Nrf2 antioxidant pathway. EMT, HG, HPMCs, NQO1, PF, PMCs, Zn
24  2018 Astaxanthin-Rich Haematococcus pluvialis Algal Hepatic Modulation in D-Galactose-Induced Aging in Rats: Role of Nrf2. ATX, CAT, D-gal, GST, IL-6, MPO, NF-kB
25  2018 Effect of dimethyl fumarate on heme oxygenase-1 expression in experimental allergic encephalomyelitis in rats. DMF, EAE, HO-1
26  2018 Effects of extracts from soothing-liver and invigorating-spleen formulas on the injury induced by oxidative stress in the hepatocytes of rats with non-alcoholic fatty liver disease induced by high-fat diet. GSH-Px, HFD, HO-1, IG, ISG, Keap1, MDA, NAFLD, NQO1, SLG, SOD, TEM
27  2018 Ethyl pyruvate can alleviate alcoholic liver disease through inhibiting Nrf2 signaling pathway. AST, EP, FFA, SOD, TG, VLDLR
28  2018 Exogenous Pancreatic Kallikrein Improves Diabetic Cardiomyopathy in Streptozotocin-Induced Diabetes. CAT, DCM, eNOS, GPX1, NF-kappaB, PKK, PLN, SERCA2, SOD, STZ
29  2018 Gastrodin protects MC3T3-E1 osteoblasts from dexamethasone-induced cellular dysfunction and promotes bone formation via induction of the NRF2 signaling pathway. ALP, CCK-8, DEX, GC
30  2018 Glutathione homeostasis is significantly altered by quercetin via the Keap1/Nrf2 and MAPK signaling pathways in rats. ERK, GCL, GR, GST, MAPKs
31  2018 Mechanical stretch induced transcriptomic profiles in cardiac myocytes. NRVM
32  2018 Olfactory ensheathing cells transplantation attenuates chronic cerebral hypoperfusion induced cognitive dysfunction and brain damages by activating Nrf2/HO-1 signaling pathway. CCH, CNS, HO-1, OECs
33  2018 Protective effects of total flavonoids from Clinopodium chinense (Benth.) O. Ktze on myocardial injury in vivo and in vitro via regulation of Akt/Nrf2/HO-1 pathway. A/R, HO-1, ISO, PI, ROS, SD
34  2017 alpha-lipoic acid ameliorates n-3 highly-unsaturated fatty acids induced lipid peroxidation via regulating antioxidant defenses in grass carp (Ctenopharyngodon idellus). CAT, GST, HSI, HUFAs, Keap1, KI, LA, MDA, SOD
35  2017 Discovery and Mechanistic Elucidation of a Class of Protein Disulfide Isomerase Inhibitors for the Treatment of Glioblastoma. Bru-seq, Egr-1, ER, PDI, SLC7A11
36  2017 Effects of dietary supplementation with a mixed blueberry and grape extract on working memory in aged beagle dogs. DNMP, PEGB
37  2017 Genetic alterations in Krebs cycle and its impact on cancer pathogenesis. EMT, HIF1, PDH3, ROS
38  2017 Nicotinamide mononucleotide attenuates brain injury after intracerebral hemorrhage by activating Nrf2/HO-1 signaling pathway. cICH, HO-1, ICH, NMN
39  2016 Apigetrin from Scutellaria baicalensis Georgi Inhibits Neuroinflammation in BV-2 Microglia and Exerts Neuroprotective Effect in HT22 Hippocampal Cells. ABTS, COX-2, IL-6, iNOS, LPS, NF-kappaB, NO, PGE2, ROS, TNF-alpha
40  2016 Bio-assay guided identification of hepatoprotective polyphenols from Penthorum chinense Pursh on t-BHP induced oxidative stress injured L02 cells. BCL-2, HO-1, Keap1, PARP, ROS, SOD2, TBHP
41  2016 Glutamate ameliorates copper-induced oxidative injury by regulating antioxidant defences in fish intestine. AHR, ASA, Glu, GPx, GR, GST, T-SOD
42  2016 Increase in antioxidant activity by sheep/goat whey protein through nuclear factor-like 2 (Nrf2) is cell type dependent. CAT, GCS, GST, HO-1, SOD
43  2015 Bardoxolone methyl prevents insulin resistance and the development of hepatic steatosis in mice fed a high-fat diet. BM, FOXO1, G6Pase, GTT, HF, IR, IST, LC, PTP1B, STAT3
44  2015 Ebselen by modulating oxidative stress improves hypoxia-induced macroglial Muller cell and vascular injury in the retina. GFAP, OIR, ROS
45  2015 Effects of glutamate on growth, antioxidant capacity, and antioxidant-related signaling molecule expression in primary cultures of fish enterocytes. Glu
46  2014 Anti-inflammatory potential of peat moss extracts in lipopolysaccharide-stimulated RAW 264.7 macrophages. HO-1, LPS, NF-kappaB, NO, PME, RT-PCR
47  2014 Phase II enzyme induction by a carotenoid, lutein, in a PC12D neuronal cell line. ---
48  2013 Sulforaphane enhances the ability of human retinal pigment epithelial cell against oxidative stress, and its effect on gene expression profile evaluated by microarray analysis. RPE, SF, Trx1
49  2012 Inhibition of IGF-IR increases chemosensitivity in human colorectal cancer cells through MRP-2 promoter suppression. IGF-IR, MDR, MRP2
50  2012 Nuclear factor-E2 (Nrf2) is regulated through the differential activation of ERK1/2 and PKC alpha/betaII by Gymnasterkoreayne B. GKB, QR
51  2012 Preconditioning with Ginkgo biloba (EGb 761®) provides neuroprotection through HO1 and CRMP2. CRMP2, HO1, NMDA, t-BuOOH, TFM, tMCAO
52  2009 Nitric oxide activation of Keap1/Nrf2 signaling in human colon carcinoma cells. Keap1