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■ Abbreviation / Long Form : PA / pyrrolizidine alkaloid

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Total Number of Papers: 136
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Abbreviation:   PA  (>> Co-occurring Abbreviation)
Long Form:   pyrrolizidine alkaloid
 Abbreviation Variation
 Long Form Variation
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No. Year Title Co-occurring Abbreviation
2021 Hepatic sinusoidal obstruction syndrome caused by the ingestion of Gynura segetum in a patient with alcoholic cirrhosis: a case report. HSOS, PA-HSOS
2021 Prognostic factors for pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome: a multicenter study in China. HSCT, HSOS, PT
2020 Evaluation of pyrrolizidine alkaloid-induced genotoxicity using metabolically competent TK6 cell lines. BMD, DHP
2020 Hepatotoxic pyrrolizidine alkaloids induce DNA damage response in rat liver in a 28-day feeding study. ---
2020 In vitro biotransformation of pyrrolizidine alkaloids in different species: part II-identification and quantitative assessment of the metabolite profile of six structurally different pyrrolizidine alkaloids. ---
2020 Occurrence and Risk Assessment of Pyrrolizidine Alkaloids in Spices and Culinary Herbs from Various Geographical Origins. ---
2020 Occurrence of pyrrolizidine alkaloids in ragwort plants, soils and surface waters at the field scale in grassland. dw
2020 Pyrrolizidine alkaloids and beehive products: A review. ---
2020 Safety of medicinal comfrey cream preparations (Symphytum officinale s.l.): The pyrrolizidine alkaloid lycopsamine is poorly absorbed through human skin. PDE
10  2020 Soil Inoculation Alters Leaf Metabolic Profiles in Genetically Identical Plants. NMR
11  2020 Spread of Jacobaea vulgaris and Occurrence of Pyrrolizidine Alkaloids in Regionally Produced Honeys from Northern Germany: Inter- and Intra-Site Variations and Risk Assessment for Special Consumer Groups. PANO
12  2020 Tu-San-Qi (Gynura japonica): the culprit behind pyrrolizidine alkaloid-induced liver injury in China. HILI, HSOS
13  2020 [Clinicopathological analysis of 16 cases of pyrrolizidine alkaloids-associated hepatic sinusoidal obstruction syndrome]. HSOS
14  2019 Complementary and Integrative Medicine for Episodic Migraine: an Update of Evidence from the Last 3 Years. AAN, AHS, PT
15  2019 Development of a sensitive analytical method for determining 44 pyrrolizidine alkaloids in teas and herbal teas via LC-ESI-MS/MS. PANO
16  2019 Human CYP3A4-mediated toxification of the pyrrolizidine alkaloid lasiocarpine. ---
17  2019 In vitro metabolism of pyrrolizidine alkaloids - Metabolic degradation and GSH conjugate formation of different structure types. ---
18  2019 In vitro ovicidal effect of a Senecio brasiliensis extract and its fractions on Haemonchus contortus. ---
19  2019 Pyrrolizidine Alkaloids of Blue Heliotrope (Heliotropium amplexicaule) and Their Presence in Australian Honey. ---
20  2019 Reduction of Pyrrolizidine Alkaloid Levels in Comfrey (Symphytum officinale) Hairy Roots by RNAi Silencing of Homospermidine Synthase. DHS, HSS
21  2019 Structure-dependent hepato-cytotoxic potencies of selected pyrrolizidine alkaloids in primary rat hepatocyte culture. BROD, iREP
22  2019 Transfer of pyrrolizidine alkaloids between living plants: A disregarded source of contaminations. ---
23  2018 A Balanced Risk-Benefit Analysis to Determine Human Risks Associated with Pyrrolizidine Alkaloids (PA)-The Case of Herbal Medicinal Products Containing St. John's Wort Extracts (SJW). SJW, SJW
24  2018 Methyl Jasmonate Changes the Composition and Distribution Rather than the Concentration of Defence Compounds: a Study on Pyrrolizidine Alkaloids. MeJA
25  2018 Pyrrolizidine alkaloid-induced alterations of prostanoid synthesis in human endothelial cells. HUVEC, VOD
26  2018 Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety. ---
27  2018 Structure-dependent induction of apoptosis by hepatotoxic pyrrolizidine alkaloids in the human hepatoma cell line HepaRG: Single versus repeated exposure. ---
28  2017 A Balanced Risk-Benefit Analysis to Determine Human Risks Associated with Pyrrolizidine Alkaloids (PA)-The Case of Tea and Herbal Infusions. ---
29  2017 Immunoassay approach for diagnosis of exposure to pyrrolizidine alkaloids. ---
30  2017 In vitro biotransformation of pyrrolizidine alkaloids in different species. PartI: Microsomal degradation. ---
31  2016 The long persistence of pyrrolizidine alkaloid-derived DNA adducts in vivo: kinetic study following single and multiple exposures in male ICR mice. ---
32  2015 7-glutathione pyrrole adduct: a potential DNA reactive metabolite of pyrrolizidine alkaloids. dA, dG
33  2015 A field investigation into a suspected outbreak of pyrrolizidine alkaloid toxicosis in horses in western Queensland. ---
34  2015 Disturbance of gene expression in primary human hepatocytes by hepatotoxic pyrrolizidine alkaloids: A whole genome transcriptome analysis. ---
35  2015 Hepatotoxicity of Pyrrolizidine Alkaloids. ---
36  2015 Pyrrolizidine alkaloids in herbal teas for infants, pregnant or lactating women. ---
37  2015 Risk assessment on the use of herbal medicinal products containing pyrrolizidine alkaloids. ---
38  2015 UPLC TOF MS for sensitive quantification of naturally occurring pyrrolizidine alkaloids in Petasites hybridus extract (Ze 339). LOQ
39  2014 Chemical variation in Jacobaea vulgaris is influenced by the interaction of season and vegetation successional stage. ---
40  2014 Determination of pyrrolizidine alkaloids in tea, herbal drugs and honey. ---
41  2014 Structure-activity relationship in the passage of different pyrrolizidine alkaloids through the gastrointestinal barrier: ABCB1 excretes heliotrine and echimidine. Em, Hn, SC, Sk
42  2014 Tusanqi and hepatic sinusoidal obstruction syndrome. HSOS
43  2013 Lack of metabolic activation and predominant formation of an excreted metabolite of nontoxic platynecine-type pyrrolizidine alkaloids. PLA
44  2013 Structural screening by multiple reaction monitoring as a new approach for tandem mass spectrometry: presented for the determination of pyrrolizidine alkaloids in plants. MRM
45  2012 An outbreak of veno-occlusive liver disease in northern Ethiopia, clinical findings. VOLD
46  2012 Characteristic ion clusters as determinants for the identification of pyrrolizidine alkaloid N-oxides in pyrrolizidine alkaloid-containing natural products using HPLC-MS analysis. ---
47  2012 Distinct cell-specific expression of homospermidine synthase involved in pyrrolizidine alkaloid biosynthesis in three species of the boraginales. HSS
48  2012 The Role of Astrocytes in Metabolism and Neurotoxicity of the Pyrrolizidine Alkaloid Monocrotaline, the Main Toxin of Crotalaria retusa. MCT
49  2011 Assessment of neurotoxicity of monocrotaline, an alkaloid extracted from Crotalaria retusa in astrocyte/neuron co-culture system. CNS, DHMC, GFAP, MCT
50  2011 Effect of prednisone on transforming growth factor-beta1, connective tissue growth factor, nuclear factor-kappaBp65 and tumor necrosis factor-alpha expression in a murine model of hepatic sinusoidal obstruction syndrome induced by Gynura segetum. CTGF, HSOS, NF, RT-PCR, TGF, TNF
51  2011 Photoirradiation of dehydropyrrolizidine alkaloids--formation of reactive oxygen species and induction of lipid peroxidation. DHR, ESR, ROS
52  2011 Plants containing pyrrolizidine alkaloids: toxicity and problems. ---
53  2011 Pyrrolizidine alkaloid variation in shoots and roots of segregating hybrids between Jacobaea vulgaris and Jacobaea aquatica. SM
54  2011 Pyrrolizidine alkaloid-containing toxic plants (Senecio, Crotalaria, Cynoglossum, Amsinckia, Heliotropium, and Echium spp.). ---
55  2011 The relationship between structurally different pyrrolizidine alkaloids and western flower thrips resistance in F(2) hybrids of Jacobaea vulgaris and Jacobaea aquatica. WFT
56  2011 [Pyrrolizidine alkaloids and seneciosis in farm animals. Part 2: clinical signs, species-specific sensitivity, food residues, feed contamination, limit values]. ---
57  2010 Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum. HSOS
58  2010 Hepatic veno-occlusive disease associated with toxicity of pyrrolizidine alkaloids in herbal preparations. SCT, VOD
59  2010 Metabolism, genotoxicity, and carcinogenicity of comfrey. DHP
60  2009 Lycopsamine and cumambrin B from Eupatorium maculatum. ---
61  2009 NMR metabolomics of thrips (Frankliniella occidentalis) resistance in Senecio hybrids. NMR
62  2009 Protective mechanisms of N-acetyl-cysteine against pyrrolizidine alkaloid clivorine-induced hepatotoxicity. GPx, GST, NAC, ROS, Trx
63  2009 Pyrrolizidine alkaloid isoline-induced oxidative injury in various mouse tissues. CAT, GPx, GST, LPO
64  2008 Pyrrolizidine alkaloids in honey: risk analysis by gas chromatography-mass spectrometry. SCX-SPE
65  2008 The toxic effect of pyrrolizidine alkaloid clivorine on the human embryonic kidney 293 cells and its primary mechanism. HEK293, JNK
66  2007 In vitro metabolism of isoline, a pyrrolizidine alkaloid from Ligularia duciformis, by rodent liver microsomal esterase and enhanced hepatotoxicity by esterase inhibitors. TOCP
67  2007 Insect-synthesised retronecine ester alkaloids: precursors of the common arctiine (Lepidoptera) pheromone hydroxydanaidal. ---
68  2007 Tissue distribution, core biosynthesis and diversification of pyrrolizidine alkaloids of the lycopsamine type in three Boraginaceae species. ---
69  2006 Pyrrolizidine alkaloid level in Senecio bicolor (Wilid.) Tod, ssp. cineraria (DC.) from middle Europe. ---
70  2006 The shikonin derivatives and pyrrolizidine alkaloids in hairy root cultures of Lithospermum canescens (Michx.) Lehm. ACS, IBS
71  2005 Pyrrolizidine alkaloids from Anchusa strigosa and their antifeedant activity. ---
72  2004 Natural hybridization between Senecio jacobaea and Senecio aquaticus: molecular and chemical evidence. AFLPs
73  2004 Phenotypic plasticity of Senecio vulgaris from contrasting habitat types: growth and pyrrolizidine alkaloid formation. GDB
74  2004 Plant-derived pyrrolizidine alkaloid protects eggs of a moth (Utetheisa ornatrix) against a parasitoid wasp (Trichogramma ostriniae). ---
75  2004 Preventive activity of pyrrolizidine alkaloids from Seneciobrasiliensis (Asteraceae) on gastric and duodenal induced ulcer on mice and rats. ---
76  2004 Repeated evolution of the pyrrolizidine alkaloid-mediated defense system in separate angiosperm lineages. DHS, HSS
77  2004 Variation in pyrrolizidine alkaloid patterns of Senecio jacobaea. ---
78  2003 Are insect-synthesized retronecine esters (creatonotines) the precursors of the male courtship pheromone in the arctiid moth Estigmene acrea? ---
79  2003 Liver inflammation during monocrotaline hepatotoxicity. CINC-1, HPC, i.p, MCP-1, MCT, MIP-2, PTX, TNF-alpha
80  2003 Loss of gustatory responses to pyrrolizidine alkaloids after their extensive ingestion in the polyphagous caterpillar Estigmene acrea. ---
81  2003 Modes of cell death in rat liver after monocrotaline exposure. HPC, MCT, SEC
82  2002 Endothelial cell injury and fibrin deposition in rat liver after monocrotaline exposure. CVECs, MCT, SECs
83  2002 Temporal modulation of pyrrolizidine alkaloid intake and genetic variation in performance of Utetheisa ornatrix caterpillars. ---
84  2002 Toxic pyrrolyzidine alkaloids from three mongolian plants. a possible risk for cattle poisoning. ---
85  2001 Interplant alkaloid variation and Senecio vernalis toxicity in cattle. SCO, SCP, SKK
86  2001 Pyrrolizidine alkaloids from Ageratum houstonianum Mill. ---
87  2000 Characterization of rat liver microsomal metabolites of clivorine, an hepatotoxic otonecine-type pyrrolizidine alkaloid. DHR
88  2000 Induction of cytochrome P450 enzymes in the livers of rats treated with the pyrrolizidine alkaloid retrorsine. ---
89  2000 Variability in chemical constituents in Petasites hybridus from Austria. ---
90  1999 Interactions in sheep between tall fescue ergot alkaloids and hepatotoxic carbon tetrachloride and Senecio pyrrolizidine alkaloids. PRL, TR
91  1999 Pyrrolizidine alkaloids in human diet. ---
92  1999 Sexually transmitted chemical defense in a moth (Utetheisa ornatrix). ---
93  1998 Involvement of cytochrome P450 3A in the metabolism and covalent binding of 14C-monocrotaline in rat liver microsomes. SD
94  1998 Species differences in the hepatic microsomal enzyme metabolism of the pyrrolizidine alkaloids. FMO, SN
95  1998 The roles of CYP3A and CYP2B isoforms in hepatic bioactivation and detoxification of the pyrrolizidine alkaloid senecionine in sheep and hamsters. DHP, SN, TAO
96  1996 Male sex pheromone of a giant danaine butterfly,Idea leuconoe. ---
97  1995 A cytochrome P4502B form is the major bioactivation enzyme for the pyrrolizidine alkaloid senecionine in guinea pig. PB, SN
98  1994 Cost assessment of the production of pyrrolizidine alkaloids in ragwort (Senecio jacobaea L.). ---
99  1994 Genetic variation in constitutive and inducible pyrrolizidine alkaloid levels inCynoglossum officinale L. ---
100  1994 The effect of spironolactone treatment on the cytochrome P450-mediated metabolism of the pyrrolizidine alkaloid senecionine by hepatic microsomes from rats and guinea pigs. SPL