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■ Abbreviation / Long Form : PDE5 / phosphodiesterase type 5

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Total Number of Papers: 1413
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Abbreviation:   PDE5  (>> Co-occurring Abbreviation)
Long Form:   phosphodiesterase type 5
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No. Year Title Co-occurring Abbreviation
2022 A Comprehensive Review of the Pharmacologic Perspective on Loop Diuretic Drug Interactions with Therapeutically Used Drugs. ACE inhibitors, DOAJ, NSAIDs
2022 Absorption, distribution, metabolism, and excretion of [14C]TPN729 after oral administration to rats. ED
2022 Adverse Events Associated With Coprescription of Phosphodiesterase Type 5 Inhibitors and Oral Organic Nitrates in Male Patients With Ischemic Heart Disease : A Case-Crossover Study. ICD-10, IHD, OR
2022 Ameliorative Sexual Behavior and Phosphodiesterase-5 Inhibitory Effects of Spondias mangifera Fruit Extract in Rodents: In Silico, In Vitro, and In Vivo Study. SMFE
2022 An update on the management algorithms of priapism during the last decade. IP, NIP, SP
2022 Aphrodisiac Performance of Bioactive Compounds from Mimosa pudica Linn.: In Silico Molecular Docking and Dynamics Simulation Approach. ED, MD
2022 Blockading a new NSCLC immunosuppressive target by pluripotent autologous tumor vaccines magnifies sequential immunotherapy. ATVs, CTLs, iNOS, PD-L1, TCM
2022 Combination therapy of doxorubicin and Sildenafil inhibits the growth of pediatric rhabdomyosarcoma. ROS
2022 Diet, herbs and erectile function: A good friendship! ACE, AChE, ADA
10  2022 Effect of Antioxidants Supplementation on Erectile Dysfunction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. CIs, ED, IIEF, SMDs
11  2022 Effects of phosphodiesterase 5 inhibition on cardiovascular function in resistant hypertension: A systematic review. BP, RH
12  2022 Effects of sildenafil on symptoms and exercise capacity for heart failure with reduced ejection fraction and pulmonary hypertension (the SilHF study): a randomized placebo-controlled multicentre trial. HFrEF, IQR, PASP, PHT, SilHF
13  2022 Effects of Tadalafil on skeletal muscle tissue: exploring interactions and novel mechanisms of action. ---
14  2022 Evaluating the efficacy of intraplaque injection of dexamethasone with oral tadalafil in the chordee patients with Peyronie disease. PD
15  2022 Gosha-Jinki-Gan Improved Erectile Dysfunction Caused by Anti-Cancer Agent Oxaliplatin by Decreasing Transcriptional Expression of Phosphodiesterase-5 in Rats. ED, eNOS, GJG, ICP, MAP, NADPH, nNOS
16  2022 How do phosphodiesterase-5 inhibitors affect cancer? A focus on glioblastoma multiforme. cGMP, CNS, GBM, TME
17  2022 In vitro inhibition of phosphodiesterase type 4 enhances rat corpus cavernosum nerve-mediated relaxation induced by gasotransmitters. cAMP, CC, cGMP, EFS, NO
18  2022 Mirodenafil ameliorates skin fibrosis in bleomycin-induced mouse model of systemic sclerosis. BLM, SSc, TGF
19  2022 Modulation of SIRT1 expression improves erectile function in aged rats. cGMP, dUTP, FOXO3a, ICP, MAP, MDA, NAM, NO, SIRT1, SOD, TdT
20  2022 Nitric Oxide Signalling in Descending Vasa Recta after Hypoxia/Re-Oxygenation. AKI, DVR, sGC
21  2022 Pharmacokinetics, mass balance, and metabolism of [14C]TPN171, a novel PDE5 inhibitor, in humans for the treatment of pulmonary arterial hypertension. CYP3A4, ED, FDA, PAH, UGT1A9
22  2022 Phosphodiesterase 5 inhibitor mirodenafil ameliorates Alzheimer-like pathology and symptoms by multimodal actions. AD, cGMP, CREB, DKK1, GR, GSK-3beta
23  2022 Phosphodiesterase 5 inhibitor sildenafil potentiates the antitumor activity of cisplatin by ROS-mediated apoptosis: a role of deregulated glucose metabolism. cyt c, GLUT1, HIF-1alpha, HKII, LDHA, OXPHOS, PDK1, PKM2, ROS
24  2022 Phosphodiesterase-5 Inhibitory Activity of Canthin-6-One Alkaloids and the Roots of Eurycoma longifolia and Eurycoma harmandiana. EH, EL
25  2022 Plantain peels restore sexual performance, hormonal imbalance, and modulate nitric oxide production and key enzymes of penile function in paroxetine-sexually impaired male rats. ACE, AChE, ADA, ED, FSH, LH, PAR, TBARS
26  2022 ROCK and PDE-5 Inhibitors for the Treatment of Dementia: Literature Review and Meta-Analysis. ROCK
27  2022 Sex-specific effects of daily tadalafil on diabetic heart kinetics in RECOGITO, a randomized, double-blind, placebo-controlled trial. T2DM
28  2022 Sildenafil (Viagra) Aggravates the Development of Experimental Abdominal Aortic Aneurysm. AAA, SMC
29  2022 Tadalafil and Steroid Hormones Interactions in Adipose, Bone and Prostate Tissues: Focus on Translational Perspectives. AR, BPH, Cyp19a1, ED, ERbeta
30  2021 A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects. PAH
31  2021 Antinociceptive Effect of Lodenafil Carbonate in Rodent Models of Inflammatory Pain and Spinal Nerve Ligation-Induced Neuropathic Pain. cGMP, L-NAME, NO
32  2021 Assessment of Combination Therapies vs Monotherapy for Erectile Dysfunction: A Systematic Review and Meta-analysis. AEs, ED, IIEF, PRISMA, WMD
33  2021 Beneficial Effects of Human Umbilical Cord Blood Mononuclear Cells on Persistent Erectile Dysfunction After Treatment of 5-Alpha Reductase Inhibitor in Rats. 5ARI, CC, EFS, eNOS, HIF, HUCB, MNCs, nNOS
34  2021 Beyond Antimuscarinics: A Review of Pharmacological and Interventional Options for Overactive Bladder Management in Men. BTX-A, CI, MIRA, OAB, PRISMA, RCTs
35  2021 Bilateral Sequential Non-arteritic Anterior Ischemic Optic Neuropathy (NAION). HVF, NAION
36  2021 Cardiac Effects of Phosphodiesterase-5 Inhibitors: Efficacy and Safety. ---
37  2021 Cerebrovascular Reactivity Measures Are Associated With Post-traumatic Headache Severity in Chronic TBI; A Retrospective Analysis. CVR, fMRI, HIT-6, PPTH, TBI, TCVI
38  2021 Combined Effects of Oligopeptides Isolated from Panax ginseng C.A. Meyer and Ostrea gigas Thunberg on Sexual Function in Male Mice. cGMP, NO
39  2021 Compliance with Testosterone Replacement Therapy in Patients with Testosterone Deficiency Syndrome: A 10-Year Observational Study in Korea. TDS, TRT
40  2021 Cyclic GMP in Liver Cirrhosis-Role in Pathophysiology of Portal Hypertension and Therapeutic Implications. cGMP, eNOS, PH, sGC
41  2021 Dapagliflozin reduces systolic blood pressure and modulates vasoactive factors. ANP, BP, cGMP, MNC, T2D
42  2021 Diets supplemented with raw and roasted pumpkin (Cucurbita pepo L) seeds improved some biochemical parameters associated with erectile function in rats. AChE, ADA, MDA
43  2021 Diketopiperazine-Based, Flexible Tadalafil Analogues: Synthesis, Crystal Structures and Biological Activity Profile. ---
44  2021 Eco-friendly stability-indicating RP-HPTLC method for sildenafil analysis, characterization and biological evaluation of its oxidized stress degradation product. EP, ICH, PEI, RP-HPTLC, SDL N-oxide, SLD
45  2021 Effect of phosphodiesterase type 5 inhibitors on sperm motility and acrosome reaction: An in vitro study. ---
46  2021 Efficacy Evaluation of Plant Products in the Treatment of Erectile Dysfunction Related to Diabetes. STZ
47  2021 Endothelin receptor antagonists for pulmonary arterial hypertension. CENTRAL, CI, ERAs, NYHA, OR, WHO
48  2021 Exosomal miRNAs as Potential Biomarkers to Monitor Phosphodiesterase 5 Inhibitor Induced Anti-Fibrotic Effects on CCl4 Treated Rats. miRNAs
49  2021 First molecular modelling report on tri-substituted pyrazolines as phosphodiesterase 5 (PDE5) inhibitors through classical and machine learning based multi-QSAR analysis. cGMP
50  2021 Functional nitrergic innervation of smooth muscle structures in the mucosa of pig lower urinary tract. CGRP, EFS, MM, nNOS, NO, SMC-LP, TH
51  2021 Health benefits and phenolic compounds of Moringa oleifera leaves: A comprehensive review. ACE, KIM-1, MO
52  2021 Impacts of caffeine on resistant chicken's performance and cardiovascular gene expression. ADORA1, BW, PH, SERT
53  2021 Inhibition of Phosphodiesterase 5 Promotes the Aromatase-Mediated Estrogen Biosynthesis in Osteoblastic Cells by Activation of cGMP/PKG/SHP2 Pathway. cGMP, PKG
54  2021 Is Tadalafil an Effective Treatment Option for Interstitial Cystitis/Painful Bladder Syndrome? A Report of a Challenging Case. cGMP, CPP, IC/PBS, NO
55  2021 Lead and mercury 28day exposure at small concentrations reduces smooth muscle relaxation by decreasing cGMP. ---
56  2021 New Approaches in Oncology for Repositioning Drugs: The Case of PDE5 Inhibitor Sildenafil. cGMP
57  2021 Novel synthesized attapulgite nanoparticles-based hydrophobic monolithic column for in-tube solid-phase microextraction of thiosildenafil, pseudovardenafil, and norneosildenafil in functional foods. ATP, EDMA, SPME, VBIMBr
58  2021 On the Viability of Tadalafil-Based 18F-Radiotracers for In Vivo Phosphodiesterase 5 (PDE5) PET Imaging. cGMP, NO, PET
59  2021 Osthole alleviates pulmonary vascular remodeling by modulating microRNA-22-3p mediated lipid metabolic reprogramming. cGMP, CPT1A, FAS, HDL-C, HK2, IDH3alpha, IR, ND1, PAH, PLA2, TC, TG
60  2021 Over-expression of PDE5 in Oral Squamous Cell Carcinoma - Effect of Sildenafil Citrate. OSCC, SC
61  2021 Pathological Significance of Macrophages in Erectile Dysfunction Including Peyronie's Disease. ED, PD
62  2021 PDE-5 inhibitors in selected herbal supplements from the Ghanaian market for better erectile function as tested by a bioassay. ED, HTS
63  2021 Recent applications of phosphodiesterase (PDE5) inhibition assays for detecting adulterated sexual enhancement products. ED
64  2021 Relaxation effects of Eriobotrya japonica toward tracheal smooth muscle via action mechanism on histamine-1 receptor and phosphodiesterase-5 enzyme. ---
65  2021 Retrospective Observational Real-World Outcome Study to Evaluate Safety Among Patients With Erectile Dysfunction (ED) With Co-Possession of Tadalafil and Anti-Hypertensive Medications (anti-HTN). anti-HTN, CI, ED, IRRs
66  2021 Significant Increase of Erectile Dysfunction in Men With Post-stroke: A Comprehensive Review. CI, ED, IIEF-5, RR, SMD
67  2021 Sildenafil 4.0-Integrated Synthetic Chemistry, Formulation and Analytical Strategies Effecting Immense Therapeutic and Societal Impact in the Fourth Industrial Era. ---
68  2021 Sildenafil prevents HDACi-induced Epstein-Barr virus reactivation through the PKG pathway in NK/T cell lymphoma; potential implications for HDACi-mediated fatal complications. HDAC, NK
69  2021 Sildenafil-Mediated Neuroprotection from Adult to Neonatal Brain Injury: Evidence, Mechanisms, and Future Translation. ---
70  2021 Structural Determination, Biological Function, and Molecular Modelling Studies of Sulfoaildenafil Adulterated in Herbal Dietary Supplement. ---
71  2021 Tadalafil Reversed H-89 - and Scopolamine - Induced Spatial Learning Impairments in Male Rats. AD, MWM
72  2021 Tadalafil Reverses the Effect of Three-Dimensional Cell Culture System on Stem Cell Features in A549 and SK-MES-1. CCK, CSC, EMT, qPCR
73  2021 Tadalafil treatment improves cardiac, renal and lower urinary tract dysfunctions in rats with heart failure. DM, EFS, HF, LUTS, LV
74  2021 The effect of pharmacotherapy on prostate volume, prostate perfusion and prostate-specific antigen (prostate morphometric parameters) in patients with lower urinary tract symptoms and benign prostatic obstruction. A systematic review and meta-analysis. 5ARI, PRISMA, PSA, RCTs, SMD, TPV, TZV
75  2021 The effect of phosphodiesterase-5 inhibitors on uteroplacental and fetal cerebral perfusion in pregnancies with fetal growth restriction: A systematic review and meta-analysis. CIs, FGR, WMDs
76  2021 The Effect of Phosphodiesterase-type 5 Inhibitors on Erectile Function: An Overview of Systematic Reviews. CI, ED, WMD
77  2021 The PDE5 inhibitor udenafil ameliorates nonalcoholic fatty liver disease by improving mitochondrial function. NAFLD, TG
78  2021 The Potential Role of Sildenafil in Cancer Management through EPR Augmentation. ABC, ED, EPR, ROS
79  2021 Use of sildenafil and other phosphodiesterase type 5 inhibitors among pregnant women in Scandinavia. ---
80  2021 Visual Side Effects Linked to Sildenafil Consumption: An Update. cGMP, CTs, ED, ERG, IOP, NAION
81  2020 A meta-analysis of efficacy and safety of PDE5 inhibitors in the treatment of ureteral stent-related symptoms. CI, MD, OR, RCTs
82  2020 A new approach at diabetic foot treatment: Phosphodiesterase 5 inhibitors. DF, DM
83  2020 A synthetic mimic of phosphodiesterase type 5 based on corona phase molecular recognition of single-walled carbon nanotubes. ---
84  2020 Addressing male sexual and reproductive health in the wake of COVID-19 outbreak. DIC, ED, ICUs
85  2020 Aging-Related Increase of cGMP Disrupts Mitochondrial Homeostasis in Leydig Cells. ---
86  2020 Alterations in the phosphodiesterase type 5 pathway and oxidative stress correlate with erectile function in spontaneously hypertensive rats. alpha1-AR, CCSM, ED, ES, NOS, SHR, WKY
87  2020 An MRTF-A-Sp1-PDE5 Axis Mediates Angiotensin-II-Induced Cardiomyocyte Hypertrophy. Ang II, MRTF-A, Sp1
88  2020 Assessment of preclinical effect of (+)-catechin hydrate on sexual function: An in silico and in vivo study. ---
89  2020 Changes in the expression and function of the PDE5 pathway in the obstructed urinary bladder. BPH/LUTS, NOS, OAB, PBOO, SNP
90  2020 Chronic inhibition of phosphodiesterase 5 with tadalafil affords cardioprotection in a mouse model of metabolic syndrome: role of nitric oxide. I/R, LV, MetS, NO
91  2020 Could Oral Phosphodiesterase 5 Inhibitors Have a Potential Adjuvant Role in Combating COVID-19 Infection? COVID-19
92  2020 Design and synthesis of pyrazolo[3,4-d]pyrimidinone derivatives: Discovery of selective phosphodiesterase-5 inhibitors. ---
93  2020 Design, synthesis and biological evaluation of new 2-aminothiazole scaffolds as phosphodiesterase type 5 regulators and COX-1/COX-2 inhibitors. ---
94  2020 Development of novel phosphodiesterase 5 inhibitors for the therapy of Alzheimer's disease. AD, CREB, NO
95  2020 Direct-To-Consumer Internet Prescription Platforms Overlook Crucial Pathology Found During Traditional Office Evaluation of Young Men With Erectile Dysfunction. DTC, ED
96  2020 Discovery of Evodiamine Derivatives as Highly Selective PDE5 Inhibitors Targeting a Unique Allosteric Pocket. EVO
97  2020 Discovery of Novel Agents on Spindle Assembly Checkpoint to Sensitize Vinorelbine-Induced Mitotic Cell Death Against Human Non-Small Cell Lung Cancers. Bcl-2, BUBR1, NSCLC
98  2020 Discovery of trisubstituted pyrazolines as a novel scaffold for the development of selective phosphodiesterase 5 inhibitors. COX-2
99  2020 Dual Pharmacological Targeting of HDACs and PDE5 Inhibits Liver Disease Progression in a Mouse Model of Biliary Inflammation and Fibrosis. cGMP, CLD, HDACs, HSC, PKG, TGF-beta
100  2020 Effect of daily tadalafil on reported outcomes in patients with erectile dysfunction and depressive symptoms: STROBE, a case-control study. ED, IIEF, LUTS, SDS