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■ Abbreviation / Long Form : PGC-1alpha / PPARgamma coactivator-1alpha

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Total Number of Papers: 220
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Abbreviation:   PGC-1alpha  (>> Co-occurring Abbreviation)
Long Form:   PPARgamma coactivator-1alpha
 Abbreviation Variation
 Long Form Variation
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No. Year Title Co-occurring Abbreviation
2022 Galangin Reverses H2O2-Induced Dermal Fibroblast Senescence via SIRT1-PGC-1α/Nrf2 Signaling. HO-1, Nrf2, SIRT1
2022 Ginseng polysaccharide attenuates red blood cells oxidative stress injury by regulating red blood cells glycolysis and liver gluconeogenesis. GPS, MET, PG, WBV
2022 Molecular mechanism of benzo [a] pyrene regulating lipid metabolism via aryl hydrocarbon receptor. AhR, BaP, FABP4, MCP-1, NF-kappaB, PPARalpha, PPARgamma, TNF-alpha, WAT
2022 Paternal diabetes programs sex-dependent placental alterations and fetal overgrowth. PPAR
2022 rhEPO Upregulates the PPARγ Pathway in Long-term Cultured Primary Nerve Cells via PI3K/Akt to Delay Cell Senescence. PPARgamma, rhEPO
2022 Targeting PPARs Signaling Pathways in Cardiotoxicity by Natural Compounds. AMPK, HO-1, NCs, NF-kappaB, Nrf2, PPARs
2022 The Symbiotic Effect of a New Nutraceutical with Yeast β-Glucan, Prebiotics, Minerals, and Silybum marianum (Silymarin) for Recovering Metabolic Homeostasis via Pgc-1α, Il-6, and Il-10 Gene Expression in a Type-2 Diabetes Obesity Model. HFD, IL-10, IL-6, T2D
2022 Tyrosol Ameliorates the Symptoms of Obesity, Promotes Adipose Thermogenesis, and Modulates the Composition of Gut Microbiota in HFD Fed Mice. BAT, DIO2, EVOO, HFD, iWAT, PPARalpha, PRDM16, TC, TG
2022 Upregulation of PGC-1α Attenuates Oxygen-Glucose Deprivation-Induced Hippocampal Neuronal Injury. OGD, ROS, VaD
10  2021 A novel HSF1 activator ameliorates non-alcoholic steatohepatitis by stimulating mitochondrial adaptive oxidation. AMPK, HSF1, MAFLD, NASH
11  2021 Abnormal levels of mitochondrial proteins in plasma neuronal extracellular vesicles in major depressive disorder. CypD, LETM1, MDD, Mfn2, MPs, NAD, NDEVs, NMNAT2, SARM1, SNPH, SSRI, TFAM
12  2021 Advances in PPARs Molecular Dynamics and Glitazones as a Repurposing Therapeutic Strategy through Mitochondrial Redox Dynamics against Neurodegeneration. AD, PPARs
13  2021 Combination of Peroxisome Proliferator-activated Receptor Gamma (PPARγ) Agonist and PPAR Gamma Co-Activator 1α (PGC-1α) Activator Ameliorates Cognitive Deficits, Oxidative Stress, and Inflammation in Rodent Model of Parkinson's Disease. MPTP, PD, PPARgamma
14  2021 DMEP induces mitochondrial damage regulated by inhibiting Nrf2 and SIRT1/PGC-1alpha signaling pathways in HepG2 cells. AST, DMEP, HO-1, IL-1beta, IL-6, MDA, mtDNA, NAC, NF-kappaB, NRF1, Nrf2, ROS, SIRT1, TNF-alpha
15  2021 Dual Role of Phenyl Amides from Hempseed on BACE 1, PPARγ, and PGC-1α in N2a-APP Cells. AD, BACE 1, CAFT, CUMT, PPARgamma
16  2021 Effect of DEHP and DnOP on mitochondrial damage and related pathways of Nrf2 and SIRT1/PGC-1α in HepG2 cells. AST, DEHP, HO-1, LC3II, MDA, NRF1, Nrf2, SIRT1
17  2021 Effect of dietary leucine supplementation on skeletal muscle fiber type transformation in weaning piglets. AdipoR1, LD, LDH, p-AMPK, SDH
18  2021 Low Birth Weight Disturbs the Intestinal Redox Status and Mitochondrial Morphology and Functions in Newborn Piglets. CAT, Ccox IV, cyt c, GPx, HO-1, LBW, NBW, V/C, ZO-1
19  2021 Melatonin rescues the mice brain against cisplatin-induced neurodegeneration, an insight into antioxidant and anti-inflammatory effects. IL-1beta, MWM, NF-kappaB, Nrf2, PSD-95, SNAP23, TNF-alpha
20  2021 Microglial PGC-1α protects against ischemic brain injury by suppressing neuroinflammation. AIS, MCAO, ULK1
21  2021 NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1α pathway. BCCAO, CCH
22  2021 PGC-1α Protects against Hepatic Ischemia Reperfusion Injury by Activating PPARα and PPARγ and Regulating ROS Production. A/R, I/R, PPARs, ROS
23  2021 Pioglitazone Inhibits Diabetes-Induced Atrial Mitochondrial Oxidative Stress and Improves Mitochondrial Biogenesis, Dynamics, and Function Through the PPAR-gamma/PGC-1alpha Signaling Pathway. AF, MMP, ROS, siRNA
24  2021 Polygonum multiflorum Thunb. Hot Water Extract Reverses High-Fat Diet-Induced Lipid Metabolism of White and Brown Adipose Tissues in Obese Mice. ADRB3, BAT, CD36, ChREBP, CPT1B, DGAT2, FABP4, HFD, HSL, PPARgamma, WAT
25  2021 Positive regulation of TFEB and mitophagy by PGC-1alpha to alleviate LPS-induced acute lung injury in rats. ALI, LPS
26  2021 Regulation of Peroxisome Proliferator-Activated Receptor Pathway During Torpor in the Garden Dormouse, Eliomys quercinus. L-FABP, PPAR, PUFAs
27  2021 SIRT1/PGC-1alpha/PPAR-gamma Correlate With Hypoxia-Induced Chemoresistance in Non-Small Cell Lung Cancer. EGFR, HIF, NSCLC, PPARgamma, SIRT1, TKIs
28  2020 Citri Reticulatae Pericarpium protects against isoproterenol-induced chronic heart failure via activation of PPARγ. ANP, BNP, CRP, CVDs, HE, HF, ISO, NRVMs, PPARgamma, QLQX, qRT-PCR
29  2020 Garcinol promotes hepatic gluconeogenesis by inhibiting P300/CBP-associated factor in late-pregnant sows. BW, FOXO1, siRNA
30  2020 Glucocorticoid Receptor Activation Restores Learning Memory by Modulating Hippocampal Plasticity in a Mouse Model of Brain Vitamin B12 Deficiency. GR
31  2020 Melanoma-Time to fast or time to feast? An interplay between PPARs, metabolism and immunity. AMPK, mTOR, PPARs
32  2020 Metabolic disturbance in Korean red ginseng-induced "Shanghuo" (excessive heat). AMP, AMPK, KRG, NRF1, SDH
33  2020 Minutes of PPAR-gamma agonism and neuroprotection. PPARgamma
34  2020 PPAR gamma agonist leriglitazone improves frataxin-loss impairments in cellular and animal models of Friedreich Ataxia. CNS, DRG, FRDA, FXN, ISC, PPARgamma
35  2020 Research on the mechanism of microwave-toughened starch on glucolipid metabolism in mice. beta3-AR, HFD, HFP, HFR, MTT, PPARgamma, RS, UCP1
36  2020 Rice Bran Phenolic Extract Confers Protective Effects against Alcoholic Liver Disease in Mice by Alleviating Mitochondrial Dysfunction via the PGC-1alpha-TFAM Pathway Mediated by microRNA-494-3p. ALD, RBPE
37  2020 Roflupram exerts neuroprotection via activation of CREB/PGC-1alpha signalling in experimental models of Parkinson's disease. CREB, PD
38  2020 Shikonin Attenuates Hepatic Steatosis by Enhancing Beta Oxidation and Energy Expenditure via AMPK Activation. AMPK, CPT1
39  2020 Short chain fatty acids could prevent fat deposition in pigs via regulating related hormones and genes. ACC, CPT-1alpha, FAS, FFAR2, G6PC, GLP-1, LDL-C, LIPE, PYY, SCFAs, SIRT1, SREBP-1c, TC, TG
40  2020 The Novel Role of PPAR Alpha in the Brain: Promising Target in Therapy of Alzheimer's Disease and Other Neurodegenerative Disorders. AD, APP, PPAR-alpha, PPREs, RXR
41  2020 Vitamin D supplementation improves SIRT1, Irisin, and glucose indices in overweight or obese type 2 diabetic patients: a double-blind randomized placebo-controlled clinical trial. BMI, FBS, HOMA-IR, IR, QUICKI, SIRT1, T2D, VD
42  2020 Whole-transcriptome Analysis of Fully Viable Energy Efficient Glycolytic-null Cancer Cells Established by Double Genetic Knockout of Lactate Dehydrogenase A/B or Glucose-6-Phosphate Isomerase. ACAA2, DEGs, DKO, HMGCS2, KO, LDH, TXNIP, WT
43  2019 Adiponectin/SIRT1 Axis Induces White Adipose Browning After Vertical Sleeve Gastrectomy of Obese Rats with Type 2 Diabetes. AMPK, PPAR, SG, SIRT1, UCP1, WAT
44  2019 Arginine promotes porcine type I muscle fibres formation through improvement of mitochondrial biogenesis. Arg, cyt c, MyHC I, NRF1, ROT
45  2019 Berberine hydrochloride protects against cytokine-induced inflammation through multiple pathways in undifferentiated C2C12 myoblast cells. BBR, NF-kappaB, SAPK/JNK, SIRT-1
46  2019 Carnosine decreases retinal ganglion cell death in a mouse model of optic nerve crushing. GFAP, mtTFA, NF-kappaB, ONC, PPAR, RGC
47  2019 Exploiting the Therapeutic Potential of Endogenous Immunomodulatory Systems in Multiple Sclerosis-Special Focus on the Peroxisome Proliferator-Activated Receptors (PPARs) and the Kynurenines. CNS, EAE, IDO, MS, PPARs, Th1, Th17, Th2, Trp
48  2019 FOXO1 inhibition prevents renal ischemia-reperfusion injury via cAMP-response element binding protein/PPAR-gamma coactivator-1alpha-mediated mitochondrial biogenesis. CREB, FOXO1, I/R
49  2019 Hepatic stearoyl CoA desaturase 1 deficiency increases glucose uptake in adipose tissue partially through the PGC-1alpha-FGF21 axis in mice. FGF21, GLUT1, SCD1
50  2019 High-fat diet induces mouse liver steatosis with a concomitant decline in energy metabolism: attenuation by eicosapentaenoic acid (EPA) or hydroxytyrosol (HT) supplementation and the additive effects upon EPA and HT co-administration. AMPK, CD, EPA, HFD, HT, n-3 LCPUFA, NRF-2, OS
51  2019 Isovitexin-Mediated Regulation of Microglial Polarization in Lipopolysaccharide-Induced Neuroinflammation via Activation of the CaMKKbeta/AMPK-PGC-1alpha Signaling Axis. IL-10, IVX, PPARgamma
52  2019 Mechanisms of Adiponectin Action: Implication of Adiponectin Receptor Agonism in Diabetic Kidney Disease. AdipoR, AMPK, DKD, PPAR, S1P
53  2019 PGC-1alpha induced browning promotes involution and inhibits lactation in mammary glands. ---
54  2019 Potential role of ALDH3A2 on the lipid and glucose metabolism regulated by (-)-hydroxycitric acid in chicken embryos. ALDH3A2, CPT1A, PEPCK, PPARalpha
55  2019 Taxifolin ameliorates DEHP-induced cardiomyocyte hypertrophy via attenuating mitochondrial dysfunction and glycometabolism disorder in chicken. ANP, ATP, beta-MHC, DEHP, IGF1, IL-6, JAK, PI3K, PPARs, STAT3, TAX, WB
56  2018 Adiponectin/AdiopR1 signal inactivation contributes to impaired angiogenesis in mice of advanced age. AdipoR1, APN, Bcl-2, C-caspase-8, p-AMPK-alpha, PPARgamma
57  2018 Chronic cold exposure results in subcutaneous adipose tissue browning and altered global metabolism in Qinghai-Tibetan plateau pika (Ochotona curzoniae). BAT, sWAT, UCP1
58  2018 CREB-upregulated lncRNA MEG3 promotes hepatic gluconeogenesis by regulating miR-302a-3p-CRTC2 axis. ceRNA, CREB, CRTC2, G6PC, lncRNA, MEG3, PEPCK, PKA
59  2018 Current understanding and future perspectives of the roles of sirtuins in the reprogramming and differentiation of pluripotent stem cells. iPSCs, MET, MSCs
60  2018 Dietary nucleotides supplementation during the suckling period improves the antioxidative ability of neonates with intrauterine growth retardation when using a pig model. CON, eSOD, GPx, IUGR, MDA, NBW, NRF1, NT, T-AOC, T-SOD
61  2018 Docosahexaenoic acid-thyroid hormone combined protocol as a novel approach to metabolic stress disorders: Relation to mitochondrial adaptation via liver PGC-1alpha and sirtuin1 activation. DHA
62  2018 Effects of visfatin on brown adipose tissue energy regulation using T37i cells. BAT, NMN, PRDM-16, RIP140, UCP1
63  2018 Grape pomace extract induced beige cells in white adipose tissue from rats and in 3T3-L1 adipocytes. eWAT, GPE, HFD, PPARgamma, PRDM16, SHR, UCP1, VEGFA, WKY
64  2018 IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity. APP, CTR, eWAT, HF, KO, UCP1
65  2018 MH84 improves mitochondrial dysfunction in a mouse model of early Alzheimer's disease. AD, APP, CS, PPARgamma
66  2018 Mild hyperbaric oxygen inhibits the growth-related decline in skeletal muscle oxidative capacity and prevents hyperglycemia in rats with type 2 diabetes mellitus. LETO, Myf5, MyoG, OLETF, T2DM
67  2018 New wine into old wineskins: PGC-1alpha and NF-kappaB in obesity and acute pancreatitis. ---
68  2018 Obesity causes PGC-1alpha deficiency in the pancreas leading to marked IL-6 upregulation via NF-kappaB in acute pancreatitis. IL-6, KO, NF-kappaB
69  2018 Peroxisome Proliferator-Activated Receptor gamma and PGC-1alpha in Cancer: Dual Actions as Tumor Promoter and Suppressor. PPARgamma
70  2018 Peroxisome proliferator-activated receptor gamma coactivator-1alpha is a predictor of lymph node metastasis and poor prognosis in human colorectal cancer. DFS, OS, PPARgamma
71  2018 Resveratrol Improves the Energy Sensing and Glycolipid Metabolism of Blunt Snout Bream Megalobrama amblycephala Fed High-Carbohydrate Diets by Activating the AMPK-SIRT1-PGC-1alpha Network. ACCalpha, AMP, ATP, CPT I, FAS, FBPase, GLUT2, p-AMPKalpha, SIRT1
72  2018 Salvianolic Acid B Improves Mitochondrial Function in 3T3-L1 Adipocytes Through a Pathway Involving PPARgamma Coactivator-1alpha (PGC-1alpha). ECAR, MTG, OCR, PFKFB2, Sal B, UCP2
73  2018 Sirtuins in Neuroendocrine Regulation and Neurological Diseases. FOXO, NAD, PPARgamma, SIRT1, SIRT2
74  2018 Transcription factor scleraxis vitally contributes to progenitor lineage direction in wound healing of adult tendon in mice. ECM, Sca-1, Scx, SOX9, TGF-beta
75  2017 Cinnamaldehyde Ameliorates Diet-Induced Obesity in Mice by Inducing Browning of White Adipose Tissue. CA, HFD, PPARgamma, PRDM16, UCP1
76  2017 Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity. Drp1, ETC, MB, mtDNA, NRF1
77  2017 Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity. AMPK, CTLs, dLNs, mTOR, ROS
78  2017 PPARgamma coactivator-1alpha (PGC-1alpha) protects neuroblastoma cells against amyloid-beta (Abeta) induced cell death and neuroinflammation via NF-kappaB pathway. ---
79  2017 Secretory phospholipase A2 group IIA modulates insulin sensitivity and metabolism. BAT, PLA2G2A, SIRT1, UCP1
80  2017 Supranutritional selenium intake from enriched milk casein impairs hepatic insulin sensitivity via attenuated IRS/PI3K/AKT signaling and decreased PGC-1alpha expression in male Sprague-Dawley rats. IRS, PI3K, Se
81  2017 Unlike PPARgamma, neither other PPARs nor PGC-1alpha is elevated in the cerebrospinal fluid of patients with multiple sclerosis. CSF, MS, PPARgamma
82  2016 Association of combined genetic variations in PPARgamma, PGC-1alpha, and LXRalpha with coronary artery disease and severity in Thai population. CAD, LXRalpha, PPARgamma
83  2016 Concerted action of histone methyltransferases G9a and PRMT-1 regulates PGC-1alpha-RIG-I axis in IFNgamma treated glioma cells. HMTs, PRMT1, RIG-I
84  2016 Delta-9-tetrahydrocannabinol protects against MPP+ toxicity in SH-SY5Y cells by restoring proteins involved in mitochondrial biogenesis. Delta9-THC, PD, PPARgamma
85  2016 Effects of flavonoid-rich Chinese bayberry (Morella rubra Sieb. et Zucc.) fruit extract on regulating glucose and lipid metabolism in diabetic KK-A(y) mice. G6Pase, PEPCK
86  2016 Evaluation of the Role of JNK1 in the Hippocampus in an Experimental Model of Familial Alzheimer's Disease. AD, JNKs, MAPK
87  2016 Mitochondrial Biogenesis Inhibitors for Anticancer Therapy: A Review of Recent Patents. ERalpha, ERRs
88  2016 Mulberry anthocyanin extract ameliorates insulin resistance by regulating PI3K/AKT pathway in HepG2 cells and db/db mice. FOXO1, G6Pase, GSK-3beta, GYS2, MAE, PEPCK, PI3K
89  2016 PGC-1 alpha interacts with microRNA-217 to functionally regulate breast cancer cell proliferation. ---
90  2016 PPARgamma-coactivator-1alpha gene transfer reduces neuronal loss and amyloid-beta generation by reducing beta-secretase in an Alzheimer's disease model. AD, PPARgamma
91  2016 Regulation of Ketone Body Metabolism and the Role of PPARalpha. AMPK, FGF21, PPARalpha
92  2015 Activating mitochondrial function and haemoglobin expression with EH-201, an inducer of erythropoietin in neuronal cells, reverses memory impairment. KA, SD
93  2015 Conjugated linoleic acid (CLA) stimulates mitochondrial biogenesis signaling by the upregulation of PPARgamma coactivator 1alpha (PGC-1alpha) in C2C12 cells. AMPK, c9,t11, CLA, Cyt C, NRF1, PPARdelta, t10,c12, VDAC
94  2015 Folate- and vitamin B12-deficient diet during gestation and lactation alters cerebellar synapsin expression via impaired influence of estrogen nuclear receptor alpha. ERalpha, MPP
95  2015 Moderate ethanol administration accentuates cardiomyocyte contractile dysfunction and mitochondrial injury in high fat diet-induced obesity. ---
96  2015 Mulberry anthocyanin extract regulates glucose metabolism by promotion of glycogen synthesis and reduction of gluconeogenesis in human HepG2 cells. FOXO1, G6Pase, GSK-3beta, GYS2, MAE, PEPCK, PI3K
97  2015 PGC-1alpha regulates the expression and activity of IRF-1. COX-2, IRF-1, PP2A, S727P, TNF-alpha
98  2015 Sirtuin 1 signaling and alcoholic fatty liver disease. AFLD, AMPK, NF-kappaB, SIRT1, SREBP-1
99  2015 Vinegar decreases blood pressure by down-regulating AT1R expression via the AMPK/PGC-1alpha/PPARgamma pathway in spontaneously hypertensive rats. ACE, AMPK, AT1R, SHRs, SVAREC
100  2014 17beta-estradiol prevents cardiac diastolic dysfunction by stimulating mitochondrial function: a preclinical study in a mouse model of a human hypertrophic cardiomyopathy mutation. HCM, IVRT, MDA, NRF1, PPARalpha