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■ Abbreviation / Long Form : PI3K / PI3 kinase

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Total Number of Papers: 202
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Abbreviation:   PI3K  (>> Co-occurring Abbreviation)
Long Form:   PI3 kinase
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No. Year Title Co-occurring Abbreviation
2021 Diverse mechanisms activate the PI 3-kinase/mTOR pathway in melanomas: implications for the use of PI 3-kinase inhibitors to overcome resistance to inhibitors of BRAF and MEK. ---
2021 Genetic and Physiological Effects of Insulin on Human Urate Homeostasis. FeU, INS, INSR, IRS-1, PTK, SU
2021 The G2A Receptor Deficiency Aggravates Atherosclerosis in Rats by Regulating Macrophages and Lipid Metabolism. ---
2021 The PI3-Kinase p110β Isoform Controls Severity of Cocaine-Induced Sequelae and Alters the Striatal Transcriptome. mPFC
2021 Toll receptors remodel epithelia by directing planar-polarized Src and PI3K activity. ---
2020 Combined targeting of G protein-coupled receptor and EGF receptor signaling overcomes resistance to PI3K pathway inhibitors in PTEN-null triple negative breast cancer. EGFR, TNBC
2020 The Hypoxia Tolerance of the Goldfish (Carassius auratus) Heart: The NOS/NO System and Beyond. NO, NOS, p-Akt, SERCA2a
2019 ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion. EMT
2019 Efficacy results of a phase 2 trial of first-line idelalisib plus ofatumumab in chronic lymphocytic leukemia. CI, CLL, ORR, PFS
10  2019 EGF receptor stimulation shifts breast cancer cell glucose metabolism toward glycolytic flux through PI3 kinase signaling. EGF, FDG, GLUT1, HK, MAPK
11  2019 Maternal and Post-weaning High-Fat Diets Produce Distinct DNA Methylation Patterns in Hepatic Metabolic Pathways within Specific Genomic Contexts. DMGs, DMRs, HF, MHF, PDE3, PHF, PI
12  2019 Oncogenic PIK3CA promotes cellular stemness in an allele dose-dependent manner. iPSCs
13  2019 PTEN: Bridging Endocytosis and Signaling. PIP
14  2018 AKT1 restricts the invasive capacity of head and neck carcinoma cells harboring a constitutively active PI3 kinase activity. ---
15  2018 Arterial Wall Stress Induces Phenotypic Switching of Arterial Smooth Muscle Cells in Vascular Remodeling by Activating the YAP/TAZ Signaling Pathway. HUASMCs, TAZ, YAP
16  2018 Continuous signaling of CD79b and CD19 is required for the fitness of Burkitt lymphoma B cells. BCR, BL, ITAM
17  2018 Dihydroartemisinin attenuates autoimmune thyroiditis by inhibiting the CXCR3/PI3K/AKT/NF-kappaB signaling pathway. AIT, CXCL10, DHA, NF, Th
18  2018 Distinct roles for phosphoinositide 3-kinases gamma and delta in malignant B cell migration. CLL
19  2018 Loss of Galphaq impairs regulatory B-cell function. p38 MAPK, PBMCs, WT
20  2018 Post-translational modifications of Beclin 1 provide multiple strategies for autophagy regulation. ---
21  2018 PTEN/PTENP1: 'Regulating the regulator of RTK-dependent PI3K/Akt signalling', new targets for cancer therapy. PTEN, RTKs
22  2018 RAPTOR up-regulation contributes to resistance of renal cancer cells to PI3K-mTOR inhibition. RCC
23  2018 Role of c-Jun terminal kinase (JNK) activation in influenza A virus-induced autophagy and replication. IAV, JNK, NS1
24  2018 Schwann-Cell-Specific Deletion of Phosphatidylinositol 4-Kinase Alpha Causes Aberrant Myelination. PI4KA, SCs
25  2018 TNFR2 mediated TNF-alpha signaling and NF-kappaB activation in hippocampus of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice. MPTP, NF-kappaB
26  2017 Evidence for an Additive Neurorestorative Effect of Simultaneously Administered CDNF and GDNF in Hemiparkinsonian Rats: Implications for Different Mechanism of Action. CDNF, DAergic, eIF2alpha, ER, GRP78, NTFs, PD, SN, SNpc, TH
27  2017 Functional screen analysis reveals miR-3142 as central regulator in chemoresistance and proliferation through activation of the PTEN-AKT pathway in CML. ADR, CML, miRNAs
28  2017 mTORC1 signalling mediates PI3K-dependent large lipid droplet accumulation in Drosophila ovarian nurse cells. IIS, mTOR, p-Akt
29  2017 Spatiotemporal expression of foxo4, foxo6a, and foxo6b in the developing brain and retina are transcriptionally regulated by PI3K signaling in zebrafish. FOXO
30  2017 The miR-23a~27a~24-2 microRNA cluster buffers transcription and signaling pathways during hematopoiesis. CLPs, MPPs
31  2016 Augmented O-GlcNAc signaling via glucosamine attenuates oxidative stress and apoptosis following contrast-induced acute kidney injury in rats. CI-AKI, NE, O-GlcNAc
32  2016 B7-H3 increases thymidylate synthase expression via the PI3k-Akt pathway. 5-FU, TS
33  2016 Cyclic Compressive Stress Regulates Apoptosis in Rat Osteoblasts: Involvement of PI3K/Akt and JNK MAPK Signaling Pathways. JNK, MAPKs
34  2016 Dual PI-3 kinase/mTOR inhibition impairs autophagy flux and induces cell death independent of apoptosis and necroptosis. DKI
35  2016 Ecological Trade-offs between Migration and Reproduction Are Mediated by the Nutrition-Sensitive Insulin-Signaling Pathway. ---
36  2016 Fluid shear stress suppresses TNF-alpha-induced apoptosis in MC3T3-E1 cells: Involvement of ERK5-AKT-FoxO3a-Bim/FasL signaling pathways. ERK5, ERK5, FOXO3a, FSS, MAPK
37  2016 Orexin-A Protects Human Neuroblastoma SH-SY5Y Cells Against 6-Hydroxydopamine-Induced Neurotoxicity: Involvement of PKC and PI3K Signaling Pathways. 6-OHDA, COX-2, MTT, Nrf2, PD
38  2016 Role of P2Y12 Receptor in Thrombosis. AC, ACS, cAMP, CKD, DM
39  2015 A phase 1 study of the sachet formulation of the oral dual PI3K/mTOR inhibitor BEZ235 given twice daily (BID) in patients with advanced solid tumors. MTD, PK
40  2015 Different concentrations of glucose regulate proliferation and osteogenic differentiation of osteoblasts via the PI3 kinase/Akt pathway. ALP
41  2015 Effects of phycocyanin on INS-1 pancreatic beta-cell mediated by PI3K/Akt/FoxO1 signaling pathway. GSIS, MG, PC
42  2015 Enhanced expression of Gialpha proteins contributes to the hyperproliferation of vascular smooth muscle cells from spontaneously hypertensive rats via MAP kinase- and PI3 kinase-independent pathways. MAPK, PT, SHR, VSMC, WKY
43  2015 EphrinA2 receptor (EphA2) is an invasion and intracellular signaling receptor for Chlamydia trachomatis. EphA2
44  2015 Fine-Tuning of PI3K/AKT Signalling by the Tumour Suppressor PTEN Is Required for Maintenance of Flight Muscle Function and Mitochondrial Integrity in Ageing Adult Drosophila melanogaster. IIS, mTORC1
45  2015 Glucose-dependent insulinotropic polypeptide directly induces glucose transport in rat skeletal muscle. GIP
46  2015 PIK3CA Mutation, Aspirin Use after Diagnosis and Survival of Colorectal Cancer. A Systematic Review and Meta-analysis of Epidemiological Studies. COX-2
47  2015 Rescue from Sexually Dimorphic Neuronal Cell Death by Estradiol and PI3 Kinase Activity. AIF, ER
48  2015 Reverse-D-4F Increases the Number of Endothelial Progenitor Cells and Improves Endothelial Progenitor Cell Dysfunctions in High Fat Diet Mice. EPCs, HDL, Rev-D4F, SDF-1alpha, TNF-alpha, VEGF
49  2015 ROCK activity and the Gbetagamma complex mediate chemotactic migration of mouse bone marrow-derived stromal cells. BMSCs, GPCR alphabeta, ROCK
50  2015 Stimulation of cardiomyogenesis from mouse embryonic stem cells by nuclear translocation of cardiotrophin-1. ANP, CT-1, ES, FGF-2, JAK2, l-NAME, NMPG, NO, PDGF-BB, ROS, siRNA, VEGF
51  2015 Wiskott-Aldrich Syndrome Interacting Protein Deficiency Uncovers the Role of the Co-receptor CD19 as a Generic Hub for PI3 Kinase Signaling in B Cells. WIP
52  2015 Zinc oxide nanoparticles induce lipoxygenase-mediated apoptosis and necrosis in human neuroblastoma SH-SY5Y cells. LOX, ROS, SNP, ZnO NPs
53  2014 Epidermal growth factor induces FoxO1 nuclear exclusion to activate MMP7-mediated metastasis of larynx carcinoma. EGFR, JNK, MAPK, MMP-7
54  2014 Functionally distinct PI 3-kinase pathways regulate myelination in the peripheral nervous system. ECM, NDRG1, S6RP
55  2014 IGF-1 and insulin exert opposite actions on ClC-K2 activity in the cortical collecting ducts. CCD, ENaC, IGF-1
56  2014 MAPK-induced Gab1 translocation to the plasma membrane depends on a regulated intramolecular switch. MAPK, PLC, PM, Ser552
57  2014 Palmitic acid suppresses apolipoprotein M gene expression via the pathway of PPARbeta/delta in HepG2 cells. apoM, HDL, IGF, PAF, PKC, TGF
58  2014 Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110alpha. PDAC
59  2014 Phospho-NHE3 forms membrane patches and interacts with beta-actin to sense and maintain constant direction during cell migration. FCCS, HEK, PIP3, pNHE3
60  2014 Plasticity versus specificity in RTK signalling modalities for distinct biological outcomes in motor neurons. MN, RTK
61  2014 Targeting PI3-kinase (PI3K), AKT and mTOR axis in lymphoma. mTOR
62  2013 A kinome-wide RNAi screen in Drosophila Glia reveals that the RIO kinases mediate cell proliferation and survival through TORC2-Akt signaling in glioblastoma. RTK
63  2013 Adenosine A2A receptor-dependent proliferation of pulmonary endothelial cells is mediated through calcium mobilization, PI3-kinase and ERK1/2 pathways. HLMVECs
64  2013 Aging impairs PI3K/Akt signaling and NO-mediated dilation in soleus muscle feed arteries. ACh, eNOS, NO, SFA, SNP
65  2013 Analysis of Snail1 function and regulation by Twist1 in palatal fusion. MES, Tgfbeta3
66  2013 CXCR4/CXCL12 mediate autocrine cell- cycle progression in NF1-associated malignant peripheral nerve sheath tumors. MPNSTs, NF1
67  2013 Differential regulation of chemotaxis: role of Gbetagamma in chemokine receptor-induced cell migration. ---
68  2013 Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinase beta isoform. ---
69  2013 Downregulation of PTEN expression in psoriatic lesions. PTEN, RT-PCR
70  2013 Effect of IRS4 levels on PI 3-kinase signalling. IRS-1
71  2013 Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis. ---
72  2013 Inhibitors of neutrophil recruitment identified using transgenic zebrafish to screen a natural product library. GFP, PIP3
73  2013 Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism. IIS, IRS
74  2013 Phosphatidylinositol 4-phosphate 5-kinase α negatively regulates nerve growth factor-induced neurite outgrowth in PC12 cells. NGF, PI, PIP5K
75  2013 Phosphoinositides play differential roles in regulating phototropin1- and phototropin2-mediated chloroplast movements in Arabidopsis. PI, PI4K, PLC
76  2013 PI 3-kinase independent role for AKT in F-actin regulation during outer segment phagocytosis by RPE cells. AKT, POS, RPE
77  2013 Pilus phase variation switches gonococcal adherence to invasion by caveolin-1-dependent host cell signaling. Cav1-pY14, IA, T4P
78  2013 Rapamycin inhibits IGF-1-mediated up-regulation of MDM2 and sensitizes cancer cells to chemotherapy. eIF4E, MDM2
79  2013 Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1. YAP
80  2013 Targeted next-generation sequencing of head and neck squamous cell carcinoma identifies novel genetic alterations in HPV+ and HPV- tumors. CNA, HNSCC
81  2013 TGF-beta1 up-regulates the expression of PDGF-beta receptor mRNA and induces a delayed PI3K-, AKT-, and p70(S6K) -dependent proliferative response in activated hepatic stellate cells. ECM, HSC, PDGF-beta, TGF-beta1
82  2013 The combination of novel targeted molecular agents and radiation in the treatment of pediatric gliomas. mTOR
83  2013 The Paradox of Akt-mTOR Interactions. ---
84  2012 A framework for identification of actionable cancer genome dependencies in small cell lung cancer. SCLC
85  2012 A novel function of FoxO transcription factors in thrombin-stimulated vascular smooth muscle cell proliferation. AP, FOXO, PAR, SMC
86  2012 Class I(A) PI3Kinase regulatory subunit, p85α, mediates mast cell development through regulation of growth and survival related genes. IPA, MCp, SCF
87  2012 In vivo cleaved CDCP1 promotes early tumor dissemination via complexing with activated β1 integrin and induction of FAK/PI3K/Akt motility signaling. CDCP1, FAK
88  2012 Inhibition of T-cell activation by PIK3IP1. PIK3IP1, PTEN
89  2012 Insulin activates Erk1/2 signaling in the dorsal vagal complex to inhibit glucose production. DVC, MBH
90  2012 Restoration of alveolar type II cell function contributes to simvastatin-induced attenuation of lung ischemia-reperfusion injury. AT, HMG-CoA, I/R, LBs, LIRI, SP-C
91  2012 T-cadherin attenuates insulin-dependent signalling, eNOS activation, and angiogenesis in vascular endothelial cells. EC, eNOS, InsRes, IR, mTOR, T-cad
92  2012 Translating PI3K-Delta Inhibitors to the Clinic in Chronic Lymphocytic Leukemia: The Story of CAL-101 (GS1101). CLL, CML, NHL
93  2012 Two PI 3-kinases and one PI 3-phosphatase together establish the cyclic waves of phagosomal PtdIns(3)P critical for the degradation of apoptotic cells. ---
94  2012 Upregulation of reggie-1/flotillin-2 promotes axon regeneration in the rat optic nerve in vivo and neurite growth in vitro. CSPG, RGCs
95  2011 Drosophila melanogaster as a model system for human brain cancers. EGFR, GBM
96  2011 ENTPD5, an endoplasmic reticulum UDPase, alleviates ER stress induced by protein overloading in AKT-activated cancer cells. ER
97  2011 Identification of novel synergistic targets for rational drug combinations with PI3 kinase inhibitors using siRNA synthetic lethality screening against GBM. GBM
98  2011 Inhibitory activity of flavonoids against class I phosphatidylinositol 3-kinase isoforms. HTRF, PIP3
99  2011 Interpreting mammalian target of rapamycin and cell growth inhibition in a genetically engineered mouse model of Nf1-deficient astrocytes. mTOR, NF1
100  2011 Novel inhibitors of AKT: assessment of a different approach targeting the pleckstrin homology domain. APLs, IPs, PH