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■ Abbreviation / Long Form : ROCK2 / Rho-associated coiled-coil containing protein kinase 2

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Total Number of Papers: 61
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Abbreviation:   ROCK2  (>> Co-occurring Abbreviation)
Long Form:   Rho-associated coiled-coil containing protein kinase 2
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No. Year Title Co-occurring Abbreviation
2021 Belumosudil for Chronic Graft-versus-Host Disease (cGVHD) After 2 or More Prior Lines of Therapy: The ROCKstar Study. AEs, cGVHD, DOR, ORR, STAT3, STAT5
2021 circNSUN2 promotes the malignant biological behavior of colorectal cancer cells via the miR‑181a‑5p/ROCK2 axis. circNSUN2, circRNAs, CRC, miR
2021 CircUSP36 knockdown alleviates oxidized low‑density lipoprotein‑induced cell injury and inflammatory responses in human umbilical vein endothelial cells via the miR‑20a‑5p/ROCK2 axis. AS, circRNAs, ELISA, HUVECs, RIP
2021 Effect of Naoluoxintong on the NogoA/RhoA/ROCK pathway by down-regulating DNA methylation in MCAO rats. IS, MCAO, MCAO/R, NgR, NLXT, Nogo-A, rCBF, RhoA, RT-PCR, TCM
2021 Knockdown of XIST Attenuates Cerebral Ischemia/Reperfusion Injury Through Regulation of miR-362/ROCK2 Axis. FISH, I/R, lncRNAs, MCAO/R, OGD/R, XIST
2021 Perspectives on ROCK2 as a Therapeutic Target for Alzheimer's Disease. AD, EC
2021 ROCK2 Inhibition With Belumosudil (KD025) for the Treatment of Chronic Graft-Versus-Host Disease. cGVHD, CS, LOTs, ORR
2021 VEGF-Induced Endothelial Podosomes via ROCK2-Dependent Thrombomodulin Expression Initiate Sprouting Angiogenesis. 3DPs, VEGF
2020 ADAM17-regulated CX3CL1 expression produced by bone marrow endothelial cells promotes spinal metastasis from hepatocellular carcinoma. ADAM17, AKT1, BMECs, CX3CL1, CXCR3, HCC, MAPK, PIK3CA, PTK2, RhoA
10  2020 Circular RNA circ_HN1 facilitates gastric cancer progression through modulation of the miR-302b-3p/ROCK2 axis. circ_HN1, GC, qRT-PCR, RIP
11  2020 Ghrelin suppresses migration of macrophages via inhibition of ROCK2 under chronic intermittent hypoxia. CIH
12  2020 Long non-coding RNA EGFR-AS1 sponges micorRNA-381 to upregulate ROCK2 in bladder cancer. BC, EGFR-AS1, miR
13  2020 Long non-coding RNA TTN-AS1 promotes tumorigenesis of ovarian cancer through modulating the miR-139-5p/ROCK2 axis. lncRNA, miR-139-5p, OC, qRT-PCR, TTN-AS1
14  2020 Mechanism of delayed encephalopathy after acute carbon monoxide poisoning. DEACMP, LINGO-1, RhoA
15  2020 miR-506 regulates cell proliferation and apoptosis by affecting RhoA/ROCK signaling pathway in hepatocellular carcinoma cells. HCC, miR-506, qRT-PCR, Rac1
16  2020 ROCK2 mediates osteosarcoma progression and TRAIL resistance by modulating O-GlcNAc transferase degradation. TRAIL
17  2020 Serine-threonine kinase ROCK2 regulates germinal center B cell positioning and cholesterol biosynthesis. GC, IRF8, SREBP2
18  2020 Upregulation of miR-496 Rescues Propofol-induced Neurotoxicity by Targeting Rho Associated Coiled-coil Containing Protein Kinase 2 (ROCK2) in Prefrontal Cortical Neurons. PFC, TUNEL
19  2019 Atorvastatin suppresses vascular hypersensitivity and remodeling induced by transient adventitial administration of lipopolysaccharide in rats. ELISA, GAPDH, IL-6, LPS, MLC, MYPT1, TNF-alpha, VSMCs
20  2019 Expression of miR-133a-5p and ROCK2 in Heart in Methamphetamine-Induced Rats and Intervention of Rhynchophylline. CPP
21  2019 LINC01638 lncRNA mediates the postoperative distant recurrence of bladder cancer by upregulating ROCK2. ---
22  2019 microRNA-138-5p as a Worse Prognosis Biomarker in Pediatric, Adolescent, and Young Adult Osteosarcoma. OS
23  2019 MicroRNA-466 inhibits cancer cell migration and invasion in hepatocellular carcinoma by indirectly mediating the downregulation of ROCK2. HCC
24  2019 miR-185-5p targets ROCK2 and inhibits cell migration and invasion of hepatocellular carcinoma. HCC, miR-185, miRNA, RT-qPCR
25  2019 ROCK2 Confers Acquired Gemcitabine Resistance in Pancreatic Cancer Cells by Upregulating Transcription Factor ZEB1. GR cells, PDAC, ZEB1
26  2019 ROCK2 deprivation leads to the inhibition of tumor growth and metastatic potential in osteosarcoma cells through the modulation of YAP activity. NSG, OS, PDXs, YAP
27  2019 ROCK2 promotes osteosarcoma growth and metastasis by modifying PFKFB3 ubiquitination and degradation. PFKFB3
28  2019 Urotensin-#receptor antagonist SB-706375 protected isolated rat heart from ischaemia-reperfusion injury by attenuating myocardial necrosis via RhoA/ROCK/RIP3 signalling pathway. CK-MB, cTnI, hU-II, I/R, LDH, RIP3, ROCK1, UTR
29  2018 Deletion of long noncoding RNA EFNA3 aggravates hypoxia-induced injury in PC-12 cells by upregulation of miR-101a. FITC, lncRNAs, PI
30  2018 GLP-1 attenuates Ang II-induced proliferation and migration in rat aorta smooth muscle cells via inhibition of the RhoA/ROCK2 signaling pathway. Ang II, GLP-1, RASMCs
31  2018 MiR-455-3p suppresses renal fibrosis through repression of ROCK2 expression in diabetic nephropathy. DN, ECM, EMT, HG, HMC, miRNAs, PAS, PCNA, STZ, TGF-beta1
32  2018 Overexpression of Rho-Associated Coiled-Coil Containing Protein Kinase 2 Is Correlated with Clinical Progression and Poor Prognosis in Breast Cancer. CI, HR, IRS
33  2018 The interaction of Lin28A/Rho associated coiled-coil containing protein kinase2 accelerates the malignancy of ovarian cancer. IP, OC
34  2018 The selective ROCK2 inhibitor KD025 reduces IL-17 secretion in human peripheral blood mononuclear cells independent of IL-1 and IL-6. IL-1ra, PBMCs, STAT3
35  2017 Clinicopathologic significance of ROCK2 expression in oral squamous cell carcinomas. alpha-SMA, CAF, OSCCs
36  2017 Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction. Ang II, CTGF, FGF-2, LV
37  2017 LncRNA H19 promotes epithelial-mesenchymal transition (EMT) by targeting miR-484 in human lung cancer cells. EMT, JNK, lncRNA, miR-484
38  2017 Long non-coding RNA MALAT1 for promoting metastasis and proliferation by acting as a ceRNA of miR-144-3p in osteosarcoma cells. ceRNA, lncRNAs, MALAT1, miR-144-3p, ROCK1
39  2017 Megakaryocytic Smad4 Regulates Platelet Function through Syk and ROCK2 Expression. Syk
40  2017 MicroRNA-139-5p Inhibits Cell Proliferation and Invasion by Targeting RHO-Associated Coiled-Coil-Containing Protein Kinase 2 in Ovarian Cancer. miR-139-5p, OC, qRT-PCR
41  2016 Polymorphisms and haplotype of ROCK2 associate with high altitude essential hypertension in native high altitude Ladakhi Indian population: a preliminary study. HAEH
42  2016 Upregulation of ROCK2 in gastric cancer cell promotes tumor cell proliferation, metastasis and invasion. CCK-8, GC
43  2016 [Effect of antepartum taurine supplementation in regulating the activity of Rho family factors and promoting the proliferation of neural stem cells in neonatal rats with fetal growth restriction]. FABP7, FGR, RhoA
44  2015 Autocrine motility factor receptor promotes the proliferation of human acute monocytic leukemia THP-1 cells. AMFR, Bcl, si
45  2015 Estradiol attenuates the TGF-beta1-induced conversion of primary TAFs into myofibroblasts and inhibits collagen production and myofibroblast contraction by modulating the Smad and Rho/ROCK signaling pathways. alpha-SMA, PD, RhoA, TAFs
46  2015 Recombinant Nogo-66 via soluble expression with SUMO fusion in Escherichia coli inhibits neurite outgrowth in vitro. CGCs, CNS, CRMP2, E. coli, MLC, NgR, SUMO
47  2015 Rotenone inhibits primary murine myotube formation via Raf-1 and ROCK2. CI, OXPHOS, PA, ROT
48  2014 Antenatal taurine improves neuronal regeneration in fetal rats with intrauterine growth restriction by inhibiting the Rho-ROCK signal pathway. IUGR, PCNA, Rho A
49  2014 Characterization of a modified ROCK2 protein that allows use of N6-ATP analogs for the identification of novel substrates. AS
50  2014 Downregulation of ROCK2 through nanocomplex sensitizes the cytotoxic effect of temozolomide in U251 glioma cells. CLSM, FCM, TMZ
51  2014 Prostaglandin E(2)-dependent blockade of actomyosin and stress fibre formation is mediated through S1379 phosphorylation of ROCK2. MLC
52  2014 Tubers from patients with tuberous sclerosis complex are characterized by changes in microtubule biology through ROCK2 signalling. TSC
53  2014 [Suppression of hepatocellular carcinoma invasion and metastasis by Rho-kinase inhibitor Fasudil through inhibition of BTBD7-ROCK2 signaling pathway]. BTBD7, MMP-2, RhoC
54  2013 CD99 suppresses osteosarcoma cell migration through inhibition of ROCK2 activity. ---
55  2012 IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction. IL-17A, IL-17RA, NF-kappaB
56  2012 Inhibition of angiotensin II-induced contraction of human airway smooth muscle cells by angiotensin-(1-7) via downregulation of the RhoA/ROCK2 signaling pathway. ACE2, Ang II, AT1R, HASMCs, RAS
57  2011 MicroRNA-138 suppresses epithelial-mesenchymal transition in squamous cell carcinoma cell lines. EZH2
58  2011 Protein kinase C and rho activated coiled coil protein kinase 2 (ROCK2) modulate Alzheimer's APP metabolism and phosphorylation of the Vps10-domain protein, SorL1. AD, APP, PKC, ROCKs, TGN
59  2010 Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice. IRF4
60  2009 ROCK2 allelic variants are not associated with pre-eclampsia susceptibility in the Finnish population. SNPs
61  2006 Gene profile for differentiation of vascular adventitial myofibroblasts. AFs, EDN1, MFs, NOX4, NQO1