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■ Abbreviation / Long Form : RTX / raltitrexed

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Total Number of Papers: 39
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Abbreviation:   RTX  (>> Co-occurring Abbreviation)
Long Form:   raltitrexed
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No. Year Title Co-occurring Abbreviation
2021 Inhibition of Human Uracil DNA Glycosylase Sensitizes a Large Fraction of Colorectal Cancer Cells to 5-Fluorodeoxyuridine and Raltitrexed but Not Fluorouracil. FdU, FU, hUNG
2021 Thymidylate synthase is essential for efficient HIV-1 replication in macrophages. MDMs, siRNA, TS
2020 A Peptidic Thymidylate-Synthase Inhibitor Loaded on Pegylated Liposomes Enhances the Antitumour Effect of Chemotherapy Drugs in Human Ovarian Cancer Cells. 5-FU, OC
2020 Exposure-response analysis of Raltitrexed assessing liver toxicity. 5-FU, BSA, PK
2020 Formulation of Folate-Modified Raltitrexed-Loaded Nanoparticles for Colorectal Cancer Theranostics. CRC, FA, LbL, NIR, NPs
2020 Thymidylate synthase inhibitor raltitrexed can induce high levels of DNA damage in MYCN-amplified neuroblastoma cells. ---
2019 Enhancing chemoradiation of colorectal cancer through targeted delivery of raltitrexed by hyaluronic acid coated nanoparticles. HA
2019 MYC predetermines the sensitivity of gastrointestinal cancer to antifolate drugs through regulating TYMS transcription. TYMS
2018 Biomolecular study of human thymidylate synthase conformer-selective inhibitors: New chemotherapeutic approach. hTS, IF, PDPA, TS
10  2016 Enhanced electrochemical sensing of leukemia cells using drug/lipid co-immobilized on the conducting polymer layer. FR, PC, Rct
11  2016 Raltitrexed Inhibits HepG2 Cell Proliferation via G0/G1 Cell Cycle Arrest. CDK2, TS
12  2015 Inhibition of thymidylate synthase by 2',2'-difluoro-2'-deoxycytidine (Gemcitabine) and its metabolite 2',2'-difluoro-2'-deoxyuridine. dFdU, TS
13  2014 Raltitrexed's effect on the development of neural tube defects in mice is associated with DNA damage, apoptosis, and proliferation. NTDs, RPA2, TS
14  2014 [Pharmacokinetics behavior of raltitrexed in rats after repeatedly injected with Huangqi injection]. CL
15  2013 Intestinal absorption of raltitrexed and evaluation of the effects of absorption enhancers. BCRP, MRP
16  2013 [Pharmacokinetics behavior of raltitrexed in rats after single injected with astragali radix]. RA
17  2011 Effect of the thymidylate synthase inhibitors on dUTP and TTP pool levels and the activities of DNA repair glycosylases on uracil and 5-fluorouracil in DNA. 5-FU, TS, UNG
18  2010 Oxaliplatin plus dual inhibition of thymidilate synthase during preoperative pelvic radiotherapy for locally advanced rectal carcinoma: long-term outcome. 5-FU, CRM, LFA, OXA, RT, TRG
19  2010 Synthesis and biological activity of raltitrexed-carrier conjugates. BSA
20  2009 Modulation of thymidilate synthase and p53 expression by HDAC inhibitor vorinostat resulted in synergistic antitumor effect in combination with 5FU or raltitrexed. 5FU-FA, CRC, TS
21  2008 DNA damage and homologous recombination signaling induced by thymidylate deprivation. BER, HR, TS
22  2008 Induction of intrachromosomal homologous recombination in human cells by raltitrexed, an inhibitor of thymidylate synthase. DSB, TS
23  2007 A preclinical evaluation of pemetrexed and irinotecan combination as second-line chemotherapy in pancreatic cancer. DCT, GEM, OXP, PMX
24  2006 An evaluation of thymidine phosphorylase as a means of preventing thymidine rescue from the thymidylate synthase inhibitor raltitrexed. CEA, Thd, TP
25  2006 Biweekly oxaliplatin, raltitrexed, 5-fluorouracil and folinic acid combination chemotherapy during preoperative radiation therapy for locally advanced rectal cancer: a phase I-II study. CT, FA, FU, LARC, OXA, RDs, RT, TRG
26  2006 Effects of antifolate drugs on the cellular uptake of radiofolates in vitro and in vivo. MTX, PMX
27  2005 Study on brain targeting of raltitrexed following intranasal administration in rats. DTI, i.n, i.v, OB
28  2004 Raltitrexed increases tumorigenesis as a single agent yet exhibits anti-tumor synergy with 5-fluorouracil in ApcMin/+ mice. FUra, TS
29  2004 The roles of thymidylate synthase and p53 in regulating Fas-mediated apoptosis in response to antimetabolites. 5-FU
30  2003 Oxaliplatin plus raltitrexed in the treatment of patients with advanced colorectal cancer: a phase II study. ACC, FA, OXA
31  2003 Thymidine and hypoxanthine protection patterns of the folic acid-enhanced synergies for combinations of trimetrexate plus a polyglutamylatable inhibitor of purine or thymidylate synthesis against human ileocecal HCT-8 cells. FPGS, GARFT, HX, TS
32  2002 Effects of antifolates on the binding of 5-fluoro-2'-deoxyuridine monophosphate to thymidylate synthase. FdUMP, MTA, NTX, TS
33  2002 Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism. 5-FU, dTMP, dUMP, FdUMP, LV, TS
34  2002 The raltitrexed-vinorelbine combination: a phase I pharmacokinetic and pharmacodynamic trial in advanced breast cancer. 5-FU, MTD, TS, VRB
35  2001 Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors. 5-FU, GDF, TK, TS
36  2000 Balb/c mice as a preclinical model for raltitrexed-induced gastrointestinal toxicity. MTD, TS
37  2000 Leucovorin rescue from raltitrexed (tomudex)-induced antiproliferative effects: in vitro cell line and in vivo mouse studies. LV, TS
38  2000 Modulation of RTX cytotoxicity by thymidine and dipyridamole in vitro: implications for chemotherapy. DP, TS
39  1998 Modeling of the time-dependency of in vitro drug cytotoxicity and resistance. PD