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■ Abbreviation / Long Form : SPEA / streptococcal pyrogenic exotoxin A

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Total Number of Papers: 61
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Abbreviation:   SPEA  (>> Co-occurring Abbreviation)
Long Form:   streptococcal pyrogenic exotoxin A
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No. Year Title Co-occurring Abbreviation
2019 Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant TFH cells. GAS, GC-TFH, HLA, RT
2019 Streptococcal Pyrogenic Exotoxin A-Stimulated Monocytes Mediate Regulatory T-Cell Accumulation through PD-L1 and Kynurenine. APCs, IDO, IL-10, MHC class II, PD-L1, SAgs, TCR
2017 Evaluation of the Potency, Neutralizing Antibody Response, and Stability of a Recombinant Fusion Protein Vaccine for Streptococcus pyogenes. GAS, SpeB
2017 Nasopharyngeal infection by Streptococcus pyogenes requires superantigen-responsive Vbeta-specific T cells. SAgs, TCR
2016 Vitamin D3 derivatives, alone or in combination with glucocorticoids, suppress streptococcal pyrogenic enterotoxin A-stimulated proliferation of peripheral blood mononuclear cells in patients with psoriasis. BBP, Con A, GC, PBMC, VD3
2014 Development of a recombinant fusion protein vaccine formulation to protect against Streptococcus pyogenes. GAS, SpeB
2010 A single, engineered protein therapeutic agent neutralizes exotoxins from both Staphylococcus aureus and Streptococcus pyogenes. SEB
2009 Detection of multiple superantigen genes in stools of patients with Kawasaki disease. KD, SAgs
2009 Superantigen-presentation by rat major histocompatibility complex class II molecules RT1.Bl and RT1.Dl. MHC, SEB
10  2008 Superantigens SPEA and SMEZ do not affect secretome expression in Streptococcus pyogenes. SEB, SMEZ, TSST-1
11  2008 Vaccine based on a ubiquitous cysteinyl protease and streptococcal pyrogenic exotoxin A protects against Streptococcus pyogenes sepsis and toxic shock. SpeB
12  2006 Development of serum IgM antibodies against superantigens of Staphylococcus aureus and Streptococcus pyogenes in Kawasaki disease. KD, SEA, TSST-1
13  2006 Intranasal exposure to bacterial superantigens induces airway inflammation in HLA class II transgenic mice. SEB, STAT
14  2004 Detection of circulating superantigens in an intensive care unit population. ICU, SIRS, TSST-1
15  2004 Post-proteomic identification of a novel phage-encoded streptodornase, Sda1, in invasive M1T1 Streptococcus pyogenes. GAS, SdaD
16  2003 Influences of linezolid, penicillin, and clindamycin, alone and in combination, on streptococcal pyrogenic exotoxin a release. GAS
17  2003 Mutational effects on protein folding stability and antigenicity: the case of streptococcal pyrogenic exotoxin A. ---
18  2003 Possible relationship between streptococcal pyrogenic exotoxin A and Kawasaki syndrome in patients older than six months of age. KS
19  2003 Prophage induction and expression of prophage-encoded virulence factors in group A Streptococcus serotype M3 strain MGAS315. GAS, MF4, Sdn, SpeK
20  2002 Genome sequence of a serotype M3 strain of group A Streptococcus: phage-encoded toxins, the high-virulence phenotype, and clone emergence. GAS, SSA
21  2002 Lethal shock induced by streptococcal pyrogenic exotoxin A in mice transgenic for human leukocyte antigen-DQ8 and human CD4 receptors: implications for development of vaccines and therapeutics. HLA, MHC, SAg
22  2002 [Antimicrobial sensitivity and characterization of Streptococcus pyogenes strains isoleated from a scarlatina outbreak]. GAS, MICs
23  2001 Complementation of a speA negative Streptococcus pyogenes with speA: effects on virulence and production of streptococcal pyrogenic exotoxin A. ---
24  2001 Enhanced susceptibility to superantigen-associated streptococcal sepsis in human leukocyte antigen-DQ transgenic mice. HLA
25  2001 Penicillin and clindamycin differentially inhibit the production of pyrogenic exotoxins A and B by group A streptococci. ---
26  2001 Structural features of a zinc binding site in the superantigen strepococcal pyrogenic exotoxin A (SpeA1): implications for MHC class II recognition. STSS
27  2000 Assay for superantigens. ELISA
28  2000 Dexamethasone and cyclosporin A affect the maturation of monocyte-derived dendritic cells differently. APCs, CyA, DCs, DEX, GCs, LPS, moDCs, SEA
29  2000 Pyrogenic toxin superantigen site specificity in toxic shock syndrome and food poisoning in animals. PTSAgs, SEs, SFP, TSS, TSST-1
30  2000 Relative neutralizing activity in polyspecific IgM, IgA, and IgG preparations against group A streptococcal superantigens. Ig
31  2000 Synergic activities of streptococcal pyrogenic exotoxin A and lipoteichoic acid in cytokine induction. LTA, sPGN, TSS
32  1999 Activation of mouse liver natural killer cells and NK1.1(+) T cells by bacterial superantigen-primed Kupffer cells. CD, IFN-gamma, IL-12, MNC, NK, SEB
33  1999 Invasive and noninvasive group A streptococcal isolates with different speA alleles in The Netherlands: genetic relatedness and production of pyrogenic exotoxins A and B. GAS
34  1999 Molecular analysis of the role of streptococcal pyrogenic Exotoxin A (SPEA) in invasive soft-tissue infection resulting from Streptococcus pyogenes. ---
35  1999 Relative avidities of human immunoglobulin G antibodies for streptococcal pyrogenic exotoxins A and B. IgG, IVIG
36  1999 Structural basis for the recognition of superantigen streptococcal pyrogenic exotoxin A (SpeA1) by MHC class II molecules and T-cell receptors. MHC, SEC
37  1999 The role of lipopolysaccharide, pro-inflammatory cytokines and bacterial superantigens in the transcriptional regulation of lymphotoxin alpha and beta in mouse splenocytes. Con A, IFN-gamma, IL-2, LPS, LTalpha, LTbeta, SEB, TNF, TSST-1
38  1998 Identification and characterization of staphylococcal enterotoxin types G and I from Staphylococcus aureus. IL-2, SSA
39  1998 Inhibition of IL-12 synthesis of peripheral blood mononuclear cells (PBMC) stimulated with a bacterial superantigen by pooled human immunoglobulin: implications for its effect on Kawasaki disease (KD). IFN-gamma, KD, PBMC, PHIG, TNF-alpha
40  1998 Streptococcal pyrogenic exotoxin A (SPE A) superantigen induced production of hematopoietic cytokines, IL-12 and IL-13 by human peripheral blood mononuclear cells. Con A, LPS, PBMC
41  1998 Streptococcal pyrogenic exotoxins A (SpeA) and C (SpeC) stimulate the production of inducible nitric oxide synthase (iNOS) protein in RAW 264.7 macrophages. iNOS, NO, rIFN gamma, TNF
42  1997 A clinical and bacteriologic investigation of invasive streptococcal infections in Japan on the basis of serotypes, toxin production, and genomic DNA fingerprints. PFGE
43  1997 Analysis of the interaction between the bacterial superantigen streptococcal pyrogenic exotoxin A (SpeA) and the human T-cell receptor. CDRs, PBMCs, STSS, TCR
44  1997 Analysis of toxicity of streptococcal pyrogenic exotoxin A mutants. PTSAgs, STSS
45  1997 Comparative effects of clindamycin and ampicillin on superantigenic activity of Streptococcus pyogenes. ---
46  1997 Exclusion of bioactive contaminations in Streptococcus pyogenes erythrogenic toxin A preparations by recombinant expression in Escherichia coli. TNF-alpha
47  1996 Analysis of the superantigenic activity of mutant and allelic forms of streptococcal pyrogenic exotoxin A. STSS
48  1996 Intravenous immune globulin affects cytokine production in T lymphocytes and monocytes/macrophages. PBMC
49  1996 Streptococcal pyrogenic exotoxin A release, distribution, and role in a murine model of fasciitis and multiorgan failure due to Streptococcus pyogenes. ---
50  1995 Superantigen binding to a T cell receptor beta chain of known three-dimensional structure. SAg, SEs, TCR
51  1994 Lymphokine production induced by streptococcal pyrogenic exotoxin-A is selectively down-regulated by pooled human IgG. IFN, IL
52  1994 Major histocompatibility complex class II binding site for streptococcal pyrogenic (erythrogenic) toxin A. ---
53  1994 [Toxic shock like syndrome due to S. pyogenes (TSLS)]. TSLS, TSLS
54  1993 Mutations affecting MHC class II binding of the superantigen streptococcal erythrogenic toxin A. ---
55  1993 Superantigens associated with staphylococcal and streptococcal toxic shock syndrome are potent inducers of tumor necrosis factor-beta synthesis. LPS, TNF, TNF-alpha, TSST-1
56  1992 Streptococcal pyrogenic exotoxin A and streptolysin O enhance polymorphonuclear leukocyte binding to gelatin matrixes. PMNL
57  1991 Fluid replacement protection of rabbits challenged subcutaneous with toxic shock syndrome toxins. TSS, TSST-1
58  1990 Activation of murine T cells by streptococcal pyrogenic exotoxin type A. Requirement for MHC class II molecules on accessory cells and identification of V beta elements in T cell receptor of toxin-reactive T cells. AC
59  1987 Cloning and expression of streptococcal pyrogenic exotoxin A and staphylococcal toxic shock syndrome toxin-1 in Bacillus subtilis. TSST-1
60  1986 Streptococcal pyrogenic exotoxin type A (scarlet fever toxin) is related to Staphylococcus aureus enterotoxin B. ---
61  1980 [Purification and characterization of erythrogenic toxins. I. Investigation of erythrogenic toxin A produced by Streptococcus pyogenes strain NY-5 (author's transl)]. ---