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■ Abbreviation / Long Form : WKYs / Wistar-Kyoto rats

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Total Number of Papers: 149
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Abbreviation:   WKYs  (>> Co-occurring Abbreviation)
Long Form:   Wistar-Kyoto rats
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No. Year Title Co-occurring Abbreviation
2021 Aging Additively Influences Insulin- and Insulin-Like Growth Factor-1-Mediated Endothelial Dysfunction and Antioxidant Deficiency in Spontaneously Hypertensive Rats. IGF-1, MDA, NO, PI3K, SHRs, TAC
2021 Extracellular Uridine Nucleotides-Induced Contractions Were Increased in Femoral Arteries of Spontaneously Hypertensive Rats. SHRs, UDP, UTP
2021 Inhibition of miR-135a-5p attenuates vascular smooth muscle cell proliferation and vascular remodeling in hypertensive rats. FNDC5, SHRs, VSMCs
2021 PET-CT and RNA sequencing reveal novel targets for acupuncture-induced lowering of blood pressure in spontaneously hypertensive rats. MA, PVH, SHRs
2020 Central Blockade of E-Prostanoid 3 Receptor Ameliorated Hypertension Partially by Attenuating Oxidative Stress and Inflammation in the Hypothalamic Paraventricular Nucleus of Spontaneously Hypertensive Rats. EP3, Fra-LI, MAP, MAPK, NE, PGE2, PVN, SHRs
2020 Comparison of pancreatic microcirculation profiles in spontaneously hypertensive rats and Wistar-kyoto rats by laser doppler and wavelet transform analysis. SHRs
2020 Defective Function of the Blood-Brain Barrier in a Stroke-Prone Spontaneously Hypertensive Rat: Evaluation in an In Vitro Cell Culture Model. BBB, BECs, SHRSP
2020 High-salt intake accelerates functional and histological renal damage associated with renal tissue overexpression of (pro)renin receptors and AT1 receptors in spontaneously hypertensive rats. BUN, SHRs
2020 Selective blocking of CXCR2 prevents and reverses atrial fibrillation in spontaneously hypertensive rats. AF, SHRs
10  2020 The Characterization of Ground Raspberry Seeds and the Physiological Response to Supplementation in Hypertensive and Normotensive Rats. COX, iNOS, RBS, SHRs, TCP, TP
11  2020 Therapeutic effects of losartan on prostatic hyperplasia in spontaneously hypertensive rats. bFGF, IL-6, MDA, PBR, SHRs, TUNEL
12  2019 Gene-Level Regulation of Acupuncture Therapy in Spontaneously Hypertensive Rats: A Whole Transcriptome Analysis. BP, DEGs, GO, HR, MAP, RVLM, SBP, SHRs
13  2019 Long-term treatment with kefir probiotics ameliorates cardiac function in spontaneously hypertensive rats. CNS, HR, MAP, PLB, PVN, RVLM, SERCA2a, SHR, TH
14  2019 Restoration of Cdk5, TrkB and Soluble N-ethylmaleimide-Sensitive Factor Attachment Protein Receptor Proteins after Chronic Methylphenidate Treatment in Spontaneous Hypertensive Rats, a Model for Attention-Deficit Hyperactivity Disorder. ADHD, Cdk5, MPH, SHRs, SNAP-25, STX1A, TrkB
15  2019 The cytokine alterations/abnormalities and oxidative damage in the pancreas during hypertension development. ELISA, SHRs
16  2018 Functional changes of the SCN in spontaneous hypertension but not after the induction of hypertension. 2K1C, SCN, SHRs
17  2018 Hydrogen Sulfide Attenuates Hypertensive Inflammation via Regulating Connexin Expression in Spontaneously Hypertensive Rats. Cxs, SHR
18  2018 miRNA profiling in the hippocampus of attention-deficit/hyperactivity disorder rats. ADHD, miRNAs, SHRs
19  2018 miRNA Profiling of Exosomes from Spontaneous Hypertensive Rats Using Next-Generation Sequencing. DE, SHRs
20  2018 Spontaneously hypertensive rats exhibit higher sensitivity to ethanol-induced hypotensive effects: Role of NMDA receptors and nitric oxide in rostral ventrolateral medulla. BP, i.p, NOS, RVLM, SHRs
21  2018 Vasoactivity of retinal veins: A potential involvement of endothelin-1 (ET-1) in the pathogenesis of retinal vein occlusion (RVO). ET-1, HIF-1, RVO, SHR
22  2017 Altered mitochondrial function, capacitative calcium entry and contractions in the aorta of hypertensive rats. CCE, SHRs, SOCs, STIM1
23  2017 ANTXR2 Knock-Out Does Not Result in the Development of Hypertension in Rats. ANTXR2, GWASs, SHRs, WT
24  2017 Comparative Analysis of Renin-Angiotensin System (RAS)-Related Gene Expression Between Hypertensive and Normotensive Rats. RAS
25  2017 Excessively low salt diet damages the heart through activation of cardiac (pro) renin receptor, renin-angiotensin-aldosterone, and sympatho-adrenal systems in spontaneously hypertensive rats. SHRs
26  2017 Heart-bound adiponectin, not serum adiponectin, inversely correlates with cardiac hypertrophy in stroke-prone spontaneously hypertensive rats. SHRs
27  2017 Increased role of E prostanoid receptor-3 in prostacyclin-evoked contractile activity of spontaneously hypertensive rat mesenteric resistance arteries. EP3, SHRs, TP
28  2017 Involvement of Epithelial Na+ Channel in the Elevated Myogenic Response in Posterior Cerebral Arteries from Spontaneously Hypertensive Rats. ENaC, Nedd4-2, PCAs, SHRs, W/L
29  2017 Rg3-enriched Korean Red Ginseng enhances blood pressure stability in spontaneously hypertensive rats. DBP, KRG, REKRG, SBP, SHRs
30  2017 Therapeutic ultrasound plus pulsed electromagnetic field improves recovery from peripheral arterial disease in hypertension. p-Akt, p-eNOS, PEMF, SHRs, TUS, VEGF
31  2017 Vascular Remodelling Relates to an Elevated Oscillatory Shear Index and Relative Residence Time in Spontaneously Hypertensive Rats. CFD, OSI, RRT, SHRs
32  2016 Aerobic exercise of low to moderate intensity corrects unequal changes in BK(Ca) subunit expression in the mesenteric arteries of spontaneously hypertensive rats. Ca, MAs, SHR, VSMCs
33  2016 Attenuation of blood pressure in spontaneously hypertensive rats by acupuncture was associated with reduction oxidative stress and improvement from endothelial dysfunction. DHE, ROS, SHRs
34  2016 Enhancing hepatic fibrosis in spontaneously hypertensive rats fed a choline-deficient diet: a follow-up report on long-term effects of oxidative stress in non-alcoholic fatty liver disease. CD, NAFLD, SHRs, TBARS
35  2016 Functional inhibition of urea transporter UT-B enhances endothelial-dependent vasodilatation and lowers blood pressure via L-arginine-endothelial nitric oxide synthase-nitric oxide pathway. eNOS, SHRs, UTs
36  2016 Hypomethylation of Agtrap is associated with long-term inhibition of left ventricular hypertrophy in prehypertensive losartan-treated spontaneously hypertensive rats. LVH, LVM/BW, SBP, SHRs
37  2016 Inhibition of endoplasmic reticulum stress improves coronary artery function in the spontaneously hypertensive rats. ER, SHRs
38  2016 Long-term antihypertensive effects of far-infrared ray irradiated from wooden board in spontaneously hypertensive rats. BP, FIR, SHRs
39  2016 Reduced capacity of autonomic and baroreflex control associated with sleep pattern in spontaneously hypertensive rats with a nondipping profile. BP, lQS, SHRs
40  2016 Rescue of hypertension-related impairment of angiogenesis by therapeutic ultrasound. eNOS, HIF-1alpha, p-Akt, SHRs, TUS, VEGF
41  2016 Resveratrol ameliorates renal injury in spontaneously hypertensive rats by inhibiting renal micro-inflammation. beta2-MG, Ccr, CKD, Col I, FN, ICAM-1, IL-6, MCP-1, NF-kappaB, PAI-1, RSV, SHR, TGF-beta1
42  2015 Arterial Hypertension Aggravates Innate Immune Responses after Experimental Stroke. ICAM-1, SHRs, VCAM-1
43  2015 Exercise training reverses alterations in Kv and BKCa channel molecular expression in thoracic aorta smooth muscle cells from spontaneously hypertensive rats. SHR-SED, SHRs
44  2015 Sympathetic Hyperactivity, Sleep Fragmentation, and Wake-Related Blood Pressure Surge During Late-Light Sleep in Spontaneously Hypertensive Rats. BP, SHRs, WBPS, ZT
45  2014 Acanthopanax divaricatus var. chiisanensis reduces blood pressure via the endothelial nitric oxide synthase pathway in the spontaneously hypertensive rat model. AD, AE, Ang II, BP, eNOS, HC, SHRs, SN, WN
46  2014 Anti-hypertensive effect of radiofrequency renal denervation in spontaneously hypertensive rats. BP, HR, RDN, RF, SHRs
47  2014 Hydrogen sulfide alleviates myocardial collagen remodeling in association with inhibition of TGF-beta/Smad signaling pathway in spontaneously hypertensive rats. CFs, CVF, MMP, SHRs, TbetaRI, TGF-beta1, TIMP
48  2014 Improving erectile function of spontaneously hypertensive rats by silencing ROCK2. eNOS, mRNA, ROCK2, SHRs, siRNA
49  2014 Profilin-1 promotes the development of hypertension-induced artery remodeling. IL-6, iNOS, SHRs
50  2013 Administration of telmisartan reduced systolic blood pressure and oxidative stress probably through the activation of PI3K/Akt/eNOS pathway and NO release in spontaneously hypertensive rats. NO, SBP, SHRs
51  2013 Blockade of central orexin 2 receptors reduces arterial pressure in spontaneously hypertensive rats. HR, MAP, OX1R, RVLM, SHRs
52  2013 Effect of farnesyltransferase inhibition on cardiac remodeling in spontaneously hypertensive rats. FT, IVSd, RWT, SHRs
53  2013 Effects of enalapril on the expression of cardiac angiotensin-converting enzyme and angiotensin-converting enzyme 2 in spontaneously hypertensive rats. ACE2, mRNA, RAS, SHRs
54  2013 Exercise training at MLSS decreases weight gain and increases aerobic capacity in obese Zucker rats. BW, MLSS, OZRs
55  2013 Profilin-1 promotes the development of hypertension-induced cardiac hypertrophy. eNOS, NO, SHRs
56  2013 Vascular VPO1 expression is related to the endothelial dysfunction in spontaneously hypertensive rats. eNOS, HOCl, ROS, SHRs, VPO1
57  2012 Importance of stress receptor-mediated mechanisms in the amygdala on visceral pain perception in an intrinsically anxious rat. CeA, CRD, CRF, GR, IBS, MR, VMR
58  2012 Rosuvastatin-attenuated heart failure in aged spontaneously hypertensive rats via PKCalpha/beta2 signal pathway. BNP, CaMKII, CcO, EM, PLB, PPI-1, RyR2, SBP, SERCA-2, SHRs
59  2010 Effects of suboptimal doses of the AT1 receptor blocker, telmisartan, with the angiotensin-converting enzyme inhibitor, ramipril, on cerebral arterioles in spontaneously hypertensive rat. ACEIs, ARBs, CBF, RAM, SHRs, TEL
60  2010 Hypertensive hypertrophied myocardium is vulnerable to infarction and refractory to erythropoietin-induced protection. EPO, SHRSPs
61  2010 Renin inhibition mitigates anti-angiogenesis in spontaneously hypertensive rats. L-NAME, MAP, SHRs
62  2010 Response acquisition with signaled delayed reinforcement in a rodent model of ADHD. SHRs
63  2010 Striatal volume changes in a rat model of childhood attention-deficit/hyperactivity disorder. ADHD, SHRs
64  2009 AT(1) receptor blockers increase insulin-like growth factor-I production by stimulating sensory neurons in spontaneously hypertensive rats. Ang II, cAMP, CGRP, CPZ, DRG, IGF-I, MABP, mRNA, SHRs, VR1
65  2009 Intrarenal aminopeptidase N inhibition restores defective angiontesin II type 2-mediated natriuresis in spontaneously hypertensive rats. Ang, SHRs
66  2009 Seed-specific expression of truncated OsGAD2 produces GABA-enriched rice grains that influence a decrease in blood pressure in spontaneously hypertensive rats. CaMBD, GABA, GAD, SHRs
67  2008 Effects of atorvastatin on calcium-regulating proteins: a possible mechanism to repair cardiac dysfunction in spontaneously hypertensive rats. PLB, SERCA2a, SHRs
68  2008 Genotoxic studies in hypertensive and normotensive rats treated with amiodarone. SHR
69  2008 Glucosyl hesperidin prevents endothelial dysfunction and oxidative stress in spontaneously hypertensive rats. G-hesperidin, SHRs
70  2008 Intrarenal angiotensin III infusion induces natriuresis and angiotensin type 2 receptor translocation in Wistar-Kyoto but not in spontaneously hypertensive rats. AM, Ang, RI, SHRs
71  2008 Voltage gated K+ channel expression in arteries of Wistar-Kyoto and spontaneously hypertensive rats. SHRs, SMAs, TAs
72  2007 Angiotensin AT1 receptor antagonists exert anti-inflammatory effects in spontaneously hypertensive rats. CCR2, MCP-1, SHRs
73  2007 Differential splicing patterns of L-type calcium channel Cav1.2 subunit in hearts of Spontaneously Hypertensive Rats and Wistar Kyoto Rats. SHRs
74  2007 Monocytes from spontaneously hypertensive rats show increased store-operated and second messenger-operated calcium influx mediated by transient receptor potential canonical Type 3 channels. SHRs, siRNA, TRPC3
75  2007 Phospholipase C expression and activity in smooth muscle cells of renal arterioles and aorta of young, spontaneously hypertensive rats during culture. PLC, SHRs, VSMCs
76  2007 Spontaneously hypertensive rats are highly vulnerable to AMPA-induced brain lesions. AMPA, NMDA, SHRs
77  2007 Vasodilator effects of fasudil, a Rho-kinase inhibitor, on retinal arterioles in stroke-prone spontaneously hypertensive rats. SHRSPs
78  2006 Early onset of a decreased intracellular magnesium and phosphate concentration in smooth muscle cell of SHR. SHRs
79  2005 A role for muscarinic receptors or rho-kinase in hypertension associated rat bladder dysfunction? SHRs
80  2005 Inhibition of NF-kappaB induces regression of cardiac hypertrophy, independent of blood pressure control, in spontaneously hypertensive rats. IKKbeta, NF, PDTC, SHRs
81  2005 Relation between QRS amplitude and left ventricular mass in the initial stage of exercise-induced left ventricular hypertrophy in rats. LVH, LVM, SHRs, SP, SWIM
82  2004 Differential cardiovascular responses to stressors in hypertensive and normotensive rats. SD, SHRs
83  2004 Prolonged tissue PO2 reduction after contraction in spinotrapezius muscle of spontaneously hypertensive rats. RBC, SHRs
84  2004 [Changes of neuronal nitric oxide synthase-immunopositive neurons in the central amygdaloid nucleus of spontaneously hypertensive rats]. nNOS, SHRs
85  2003 EEG power spectra changes and forebrain ischemia in rats. SHRs
86  2003 Effect of beta-adrenoceptor antagonist and angiotensin-converting enzyme inhibitor on hypertension-associated changes in adenylyl cyclase type V messenger RNA expression in spontaneously hypertensive rats. AC, LVH, mRNA, RAS, SHRs
87  2003 Measurement of oxidative stress in stroke-prone spontaneously hypertensive rat brain using in vivo electron spin resonance spectroscopy. SHRSPs
88  2003 Rapid proliferation of prostatic epithelial cells in spontaneously hypertensive rats: a model of spontaneous hypertension and prostate hyperplasia. BrdU, PECs, SHRs
89  2002 Early myocardial fibrosis is associated with depletion of vasoactive intestinal peptide in rat heart. SHRs, VIP
90  2002 Induction of heme oxygenase-1 and stimulation of cGMP production by hemin in aortic tissues from hypertensive rats. BP, CO, HO, sGC, SHRs
91  2001 Altered growth response to prostaglandin E2 and its receptor signaling in mesangial cells from stroke-prone spontaneously hypertensive rats. ERK, MCs, PG, SHRSPs
92  2001 Designing potent derivatives of ovokinin(2-7), an anti-hypertensive peptide derived from ovalbumin. SHRs
93  2001 Potentiation by endothelin-1 of vasoconstrictor response in stroke-prone spontaneously hypertensive rats. SHRSPs
94  2000 Angiotensin II-induced cardiomyocyte hypertrophy and cardiac fibrosis in stroke-prone spontaneously hypertensive rats. ACEIs, AT1R, ICVF, LV, LVH, LVW, SBP, SHRSPs
95  2000 Etiologic factors in femoral head osteonecrosis in growing rats. SHRs
96  2000 Increased ganglionic responses to substance P in hypertensive rats due to upregulation of NK(1) receptors. SHRs, SP
97  1999 Acute hemodynamic effects of ethanol in conscious spontaneously hypertensive and normotensive rats. CO, HR, MAP, SHRs, SV, TPR
98  1999 Angiotensinogen gene-activating elements regulate blood pressure in the brain. AGE, ODNs, SHRs
99  1999 Chronic endothelin-1 improves nitric oxide-dependent flow-induced dilation in resistance arteries from normotensive and hypertensive rats. ET-1, L-NAME, SHRs
100  1999 Effect of pregnancy on insulin metabolism in spontaneously hypertensive rats. SHRs