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Abbreviation : 25-HC
Long Form : 25-hydroxycholesterol
No. Year Title Co-occurring Abbreviation
2022 25-Hydroxycholesterol-Induced Oxiapoptophagy in L929 Mouse Fibroblast Cell Line. ---
2022 Assessment of FDA-Approved Drugs as a Therapeutic Approach for Niemann-Pick Disease Type C1 Using Patient-Specific iPSC-Based Model Systems. iPSCs, NPC1, PCs
2022 Ch25h and 25-HC prevent liver steatosis through regulation of cholesterol metabolism and inflammation. CH25H, HFD, LXRalpha, NAFLD, SREBP-2
2022 Coxiella burnetii Sterol-Modifying Protein Stmp1 Regulates Cholesterol in the Intracellular Niche. CCV
2022 Hepatic Reduction in Cholesterol 25-Hydroxylase Aggravates Diet-induced Steatosis. CH25H, CYP7A1, HFD, WT
2022 Senolysis induced by 25-hydroxycholesterol targets CRYAB in multiple cell types. ---
2022 Transcription of cytochrome P450 46A1 in NIH3T3 cells is negatively regulated by FBS. 24S-HC, 27HC, CH25H, Cyp46A1, IGF-II
2021 25-Hydroxycholesterol Inhibits Kaposi's Sarcoma Herpesvirus and Epstein-Barr Virus Infections and Activates Inflammatory Cytokine Responses. CH25H, IFN, IL-8, ISGs, LANA, miRNAs, PBMCs, RNA-Seq, SARS-CoV-2
2021 25-Hydroxycholesterol mitigates hepatic ischemia reperfusion injury via mediating mitophagy. 3-MA, I/R
10  2021 25-Hydroxycholesterol protecting from cerebral ischemia-reperfusion injury through the inhibition of STING activity. MCAO, STING
11  2021 25-Hydroxycholesterol suppress IFN-γ-induced inflammation in microglia by disrupting lipid raft formation and caveolin-mediated signaling endosomes. BBB, IFN-gamma
12  2021 25-Hydroxycholesterol-Conjugated EK1 Peptide with Potent and Broad-Spectrum Inhibitory Activity against SARS-CoV-2, Its Variants of Concern, and Other Human Coronaviruses. CH25H, CoV, VOCs
13  2021 A Proinflammatory Stimulus Disrupts Hippocampal Plasticity and Learning via Microglial Activation and 25-Hydroxycholesterol. CH25H, KO, LPS, LTP
14  2021 A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. SREBP, TM
15  2021 Antiviral Actions of 25-Hydroxycholesterol in Fish Vary With the Virus-Host Combination. CH25H, CyHV-3, IPNV, Para, SVCV, VHSV
16  2021 Cholesterol 25-hydroxylase inhibits Senecavirus A replication by enzyme activity-dependent and independent mechanisms. CH25H-M, SVA
17  2021 Cholesterol 25-hydroxylase suppresses porcine deltacoronavirus infection by inhibiting viral entry. CH25H, PDCoV
18  2021 Cholesterol-25-Hydroxylase Suppresses Seneca Valley Virus Infection via Producing 25-Hydroxycholesterol to Block Adsorption Procedure. CH25H, SVV
19  2021 Immune-related oxysterol modulates neuromuscular transmission via non-genomic liver X receptor-dependent mechanism. LXRs, ROS, SVs
20  2021 Insulin-induced genes INSIG1 and INSIG2 mediate oxysterol-dependent activation of the PERK-eIF2α-ATF4 axis. ATF4, INSIGs
21  2021 Lung-selective 25-hydroxycholesterol nanotherapeutics as a suppressor of COVID-19-associated cytokine storm. ARDS, COVID-19, DDAB, SARS-CoV-2
22  2021 Modulation of Antiviral Immunity and Therapeutic Efficacy by 25-Hydroxycholesterol in Chronically SIV-Infected, ART-Treated Rhesus Macaques. ART, CH25H, RMs
23  2021 Testicular 25-hydroxycholesterol: An alternate substrate for steroidogenesis in reptiles. FSH, LC, TMCM
24  2021 The cholesterol metabolite 25-hydroxycholesterol restrains the transcriptional regulator SREBP2 and limits intestinal IgA plasma cell differentiation. CH25H, IgA, PC
25  2021 Tumor Necrosis Factor-alpha utilizes MAPK/NFkappaB pathways to induce cholesterol-25 hydroxylase for amplifying pro-inflammatory response via 25-hydroxycholesterol-integrin-FAK pathway. ATF2, C25H, FAK, TNF
26  2020 25-Hydroxycholesterol amplifies microglial IL-1beta production in an apoE isoform-dependent manner. AD, APOE4, CH25H, DAM, LPS, TLR4
27  2020 25-Hydroxycholesterol Induces Death Receptor-mediated Extrinsic and Mitochondria-dependent Intrinsic Apoptosis in Head and Neck Squamous Cell Carcinoma Cells. ---
28  2020 25-Hydroxycholesterol promotes vascular calcification via activation of endoplasmic reticulum stress. CVC, ERS, VSMCs
29  2020 25-Hydroxycholesterol protects against myocardial ischemia-reperfusion injury via inhibiting PARP activity. IR
30  2020 Aggregation of 25-hydroxycholesterol in a complex biomembrane. Differences with cholesterol. ---
31  2020 Cholesterol 25-hydroxylase (CH25H) as a promoter of adipose tissue inflammation in obesity and diabetes. ATMs, BMDMs, CH25H, DIO, HFD, IR, VAT
32  2020 Cholesterol 25-hydroxylase inhibits encephalomyocarditis virus replication through enzyme activity-dependent and independent mechanisms. EMCV, ISG
33  2020 Cholesterol 25-Hydroxylase inhibits SARS-CoV-2 and other coronaviruses by depleting membrane cholesterol. ACAT, CH25H, COVID-19, ISGs, MERS-CoV
34  2020 Cholesterol 25-hydroxylase promotes efferocytosis and resolution of lung inflammation. AM, CH25H, LXR
35  2020 Cholesterol 25-hydroxylase protects against experimental colitis in mice by modulating epithelial gut barrier function. CH25H, DSS
36  2020 Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion. CH25H, IFN, VSV
37  2020 Cholesterol metabolism regulation mediated by SREBP-2, LXRalpha and miR-33a in rainbow trout (Oncorhynchus mykiss) both in vivo and in vitro. LXRs, SREBPs
38  2020 EHMT2 Inhibition Induces Cell Death in Human Non-Small Cell Lung Cancer by Altering the Cholesterol Biosynthesis Pathway. EHMT2, NSCLC
39  2020 Esterification of 4beta-hydroxycholesterol and other oxysterols in human plasma occurs independently of LCAT. 24S-HC, 27HC, 4betaHC, 5,6alpha-EC, 5,6betaEC, 7-KC, 7alphaHC, CT, FED, FLD
40  2020 High Glucose Induces Lipid Accumulation via 25-Hydroxycholesterol DNA-CpG Methylation. DNMT1, HG
41  2020 Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins. CDCs, IFN
42  2020 Multifaceted Functions of CH25H and 25HC to Modulate the Lipid Metabolism, Immune Responses, and Broadly Antiviral Activities. CH25H, EBOV, HIV, NiV, RVFV, ZIKV
43  2020 Multiple Roles of 25-Hydroxycholesterol in Lipid Metabolism, Antivirus Process, Inflammatory Response, and Cell Survival. ---
44  2020 Oxysterol 25-hydroxycholesterol as a metabolic pathophysiological factors of osteoarthritis induces apoptosis in primary rat chondrocytes. CH25H
45  2020 Oxysterol 25-hydroxycholesterol as a metabolic pathophysiological factors of osteoarthritis induces apoptosis in primary rat chondrocytes. CH25H
46  2020 Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol. ACAT, CH25H
47  2020 Spermine synthesis inhibitor blocks 25-hydroxycholesterol-induced- apoptosis via SREBP2 upregulation in DLD-1 cell spheroids. ---
48  2020 Sterol metabolism modulates susceptibility to HIV-1 Infection. HESN, ISG, MDMs, PBMCs, pDCs
49  2019 25-HC promotes hepatocellular carcinoma metastasis through up-regulation of TLR4 dependent FABP4. FABP4, HCC, TLR4
50  2019 Cholesterol 25-Hydroxylase inhibits bovine parainfluenza virus type 3 replication through enzyme activity-dependent and -independent ways. BPIV3, gRNA, ISG
51  2019 Cholesterol 25-hydroxylase negatively regulates porcine intestinal coronavirus replication by the production of 25-hydroxycholesterol. CH25H, CH25H-M, PEDV, TGEV
52  2019 Cholesterol 25-hydroxylase suppresses rabies virus infection by inhibiting viral entry. CH25H, ISG, RABV
53  2019 Cholesterol-25-hydroxylase Is a Chicken ISG That Restricts ALV-J Infection by Producing 25-hydroxycholesterol. ALV-J, chCH25H, hpi, IFN-alpha, ISGs, PBMC
54  2019 Exogenous Addition of 25-Hydroxycholesterol Reduces Level of Very Long-Chain Fatty Acids in X-Linked Adrenoleukodystrophy. CH25H, iPSCs, LXR, VLCFAs, X-ALD
55  2019 Fish Cholesterol 25-Hydroxylase Inhibits Virus Replication via Regulating Interferon Immune Response or Affecting Virus Entry. CH25H, FA, IFN, LPS, RGNNV, SGIV
56  2019 Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response. FAK
57  2019 Lipid Exchange Factors at Membrane Contact Sites in African Swine Fever Virus Infection. ACBD3, ASF, ASFV, ITZ, MCSs, ORP4, OSBP, PI4Kbeta, VFs
58  2019 Macrophage Migration Inhibitory Factor Promotes Chemotaxis of Astrocytes through Regulation of Cholesterol 25-Hydroxylase Following Rat Spinal Cord Injury. CH25H, CNS
59  2019 Mining for Oxysterols in Cyp7b1-/- Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5. 24S,25-EC, 26HC, INSIG, LC-MS, MSn, SPG5, SREBP-2, WT
60  2019 Mitochondrial oxysterol biosynthetic pathway gives evidence for CYP7B1 as controller of regulatory oxysterols. 24HC, 26HC, 26HC, CDCA
61  2019 Modulation of cell proteome by 25-hydroxycholesterol and 27-hydroxycholesterol: A link between cholesterol metabolism and antiviral defense. 27HC, JAM-A
62  2019 Oxysterols and apolipoproteins in multiple sclerosis: a 5 year follow-up study. 27HC, 7-KC, 7alphaHC, HCs, MS, PMS, RRMS, SP-MS
63  2019 Porcine Reproductive and Respiratory Syndrome Virus E Protein Degrades Porcine Cholesterol 25-Hydroxylase via the Ubiquitin-Proteasome Pathway. CH25H, pCH25H, PRRSV
64  2019 The Oxysterol 25-Hydroxycholesterol Inhibits Replication of Murine Norovirus. 22-S-HC, HSV-1, MNV
65  2019 The Oxysterol Synthesising Enzyme CH25H Contributes to the Development of Intestinal Fibrosis. CD, CH25H
66  2018 25-Hydroxycholesterol activates the expression of cholesterol 25-hydroxylase in an LXR-dependent mechanism. CH25H, LXR
67  2018 25-Hydroxycholesterol and 27-hydroxycholesterol inhibit human rotavirus infection by sequestering viral particles into late endosomes. 27HC, HRV, OSBP, VAP-A
68  2018 25-Hydroxycholesterol Production by the Cholesterol-25-Hydroxylase Interferon-Stimulated Gene Restricts Mammalian Reovirus Infection. CH25H, ISGs, ISVPs
69  2018 25-Hydroxycholesterol protects against acute lung injury via targeting MD-2. ALI, LPS, MD-2
70  2018 25-hydroxycholesterol reduces inflammation, viral load and cell death in ZIKV-infected U-87 MG glial cell line. ZIKV
71  2018 Activation of liver X receptor plays a central role in antiviral actions of 25-hydroxycholesterol. 25HC3S, CH25H, HSV-1, IFN, LXR
72  2018 Antiviral effect of 25-hydroxycholesterol against porcine reproductive and respiratory syndrome virus in vitro. PRRSV
73  2018 Effect of 25-hydroxycholesterol in viral membrane fusion: Insights on HIV inhibition. HIV-FP
74  2018 Evaluation of 4beta-Hydroxycholesterol and 25-Hydroxycholesterol as Endogenous Biomarkers of CYP3A4: Study with CYP3A-Humanized Mice. 4betaHC, CYP3A
75  2018 Regulating Innate and Adaptive Immunity for Controlling SIV Infection by 25-Hydroxycholesterol. CH25H, LPS
76  2018 Theonellamide A, a marine-sponge-derived bicyclic peptide, binds to cholesterol in aqueous DMSO: Solution NMR-based analysis of peptide-sterol interactions using hydroxylated sterol. Chol, DMSO, TNM-A, TNMs
77  2017 25-Hydroxycholesterol and inflammation in Lovastatin-deregulated mevalonate pathway. MK, MKD, MVK
78  2017 25-Hydroxycholesterol promotes migration and invasion of lung adenocarcinoma cells. ADC, IL-1beta
79  2017 25-hydroxycholesterol promotes RANKL-induced osteoclastogenesis through coordinating NFATc1 and Sp1 complex in the transcription of miR-139-5p. BMMs, M-CSF, NFATc1, RANKL
80  2017 25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model. CH25H, ZIKV
81  2017 Biophysical Properties and Antiviral Activities of Measles Fusion Protein Derived Peptide Conjugated with 25-Hydroxycholesterol. MV
82  2017 Cholesterol 25-hydroxylase acts as a host restriction factor on pseudorabies virus replication. CH25H, PRV
83  2017 Cholesterol 25-Hydroxylase Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication through Enzyme Activity-Dependent and -Independent Mechanisms. CH25H, CH25H-M, nsp1alpha, PRRSV, siRNA
84  2017 Cholesterol 25-hydroxylase is an interferon-inducible factor that protects against porcine reproductive and respiratory syndrome virus infection. CH25H, PRRSV
85  2017 Interferon-independent antiviral activity of 25-hydroxycholesterol in a teleost fish. CH25H, IFNs, LPS, SVCV
86  2017 Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation. AIM2, CH25H, IL-1beta, LPS
87  2017 Purification and identification of 25-hydroxycholesterol in a reptile: Seasonal variation and hormonal regulation. FSH, HPLC, MS, TMCM
88  2017 Viral MicroRNAs Repress the Cholesterol Pathway, and 25-Hydroxycholesterol Inhibits Infection. CH25H, CoA, HHV-8, HUVECs, KSHV, miRNAs, siRNAs
89  2016 25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome. CCALD, CH25H, LXR, ROS, VLCFA, X-ALD
90  2016 25-Hydroxycholesterol Inhibition of Lassa Virus Infection through Aberrant GP1 Glycosylation. CH25H, ISG, LASV, siRNA
91  2016 Characterization of Glycoprotein-Mediated Entry of Severe Fever with Thrombocytopenia Syndrome Virus. DC-SIGN, DC-SIGNR, GPs, SFTS, SFTSV, SFTSV, VSV
92  2016 Immune oxysterols: Role in mycobacterial infection and inflammation. ---
93  2016 Mass spectrometry profiling of oxysterols in human sperm identifies 25-hydroxycholesterol as a marker of sperm function. ---
94  2016 RORalpha and 25-Hydroxycholesterol Crosstalk Regulates Lipid Droplet Homeostasis in Macrophages. CH25H, LD
95  2015 A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol. 25-HCTL
96  2015 Armand-Frappier Outstanding Student Award--The emerging role of 25-hydroxycholesterol in innate immunity. ---
97  2015 Identification of Cholesterol 25-Hydroxylase as a Novel Host Restriction Factor and a Part of the Primary Innate Immune Responses against Hepatitis C Virus Infection. CH25H, HCV
98  2015 Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation. CH25H, hCH25H, HCV
99  2015 Lysophosphatidylcholine promotes SREBP-2 activation via rapid cholesterol efflux and SREBP-2-independent cytokine release in human endothelial cells. IL-6, LPC, SREBP-2
100  2015 MicroRNAs regulate the immunometabolic response to viral infection in the liver. HCV, miRNAs