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Abbreviation : 2K1C
Long Form : 2-kidney, 1-clip
No. Year Title Co-occurring Abbreviation
2021 Exercise-Induced Modulation of Angiotensin II Responses in Femoral Veins From 2-Kidney-1-Clip Hypertensive Rats. Ang II, COX-1, COX-2, ET-1, ETA, NO
2021 Myrtus communis improves cognitive impairment in renovascular hypertensive rats. AChE, BBB, CD, DI, IL, MMP, MWM, RVH
2020 A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis. RAAS
2020 Anti-hypertensive effect of hydrogen peroxide acting centrally. Ang II, ATZ, i.c.v, SHRs
2020 Contribution of selected vasoactive systems to blood pressure regulation in two models of chronic kidney disease. BP, CKD, HanSD, NO, RAS, SNS, TGR
2020 Excessive dietary salt promotes aortic stiffness in murine renovascular hypertension. ABP
2019 Central Inhibition of Tumor Necrosis Factor Alpha Reduces Hypertension by Attenuating Oxidative Stress in the Rostral Ventrolateral Medulla in Renovascular Hypertensive Rats. RVLM
2019 Naringenin Ameliorates Renovascular Hypertensive Renal Damage by Normalizing the Balance of Renin-Angiotensin System Components in Rats. ACE
2019 Renal sensory nerves increase sympathetic nerve activity and blood pressure in 2-kidney 1-clip hypertensive mice. ABP, SNA
10  2018 Activation of Bone Marrow-Derived Cells Angiotensin (Ang) II Type 1 Receptor by Ang II Promotes Atherosclerotic Plaque Vulnerability. Ang, AT1R, BM
11  2018 Chios mastic gum decreases renin levels and ameliorates vascular remodeling in renovascular hypertensive rats. BP, CMG, CSA
12  2018 Chronic intermittent hypobaric hypoxia provides vascular protection in the aorta of the 2-kidney, 1-clip rat model of hypertension. CIHH, RVH
13  2018 Control of renal sympathetic nerve activity by neurotransmitters in the spinal cord in Goldblatt hypertension. BP, CTL, i.t, KYN, LOS, RSNA
14  2018 Enhanced angiotensin II induced sodium appetite in renovascular hypertensive rats. Ang II, i.c.v, WD
15  2018 Nitrite exerts antioxidant effects, inhibits the mTOR pathway and reverses hypertension-induced cardiac hypertrophy. ROS
16  2017 Cardiovascular phenotype in Smad3 deficient mice with renovascular hypertension. RAS, RVH, STK, WT
17  2017 Fenofibrate Attenuates Hypertension in Goldblatt Hypertensive Rats: Role of 20-Hydroxyeicosatetraenoic Acid in the Nonclipped Kidney. 20-HETE, BP
18  2017 Increased Expression of Macrophage Migration Inhibitory Factor in the Nucleus of the Solitary Tract Attenuates Renovascular Hypertension in Rats. MAP, MIF, NT, NTS
19  2017 Prorenin receptor mediates inflammation in renal ischemia. BP
20  2016 Antihypertensive activity of 80% methanol seed extract of Calpurnia aurea (Ait.) Benth. subsp. aurea (Fabaceae) is mediated through calcium antagonism induced vasodilation. ---
21  2016 Antihypertensive effects of fargesin in vitro and in vivo via attenuating oxidative stress and promoting nitric oxide release. Ang II, ET, NO, NOS, SBP
22  2016 Development of renal atrophy in murine 2 kidney 1 clip hypertension is strain independent. STK/CLK
23  2016 Direct vascular actions of quercetin in aorta from renal hypertensive rats. ---
24  2016 Hydrogen Sulfide Improves Myocardial Remodeling via Downregulated Angiotensin Ⅱ/AT1R Pathway in Renovascular Hypertensive Rats. Ang II, SOD
25  2016 Inhibition of PDE5 Restores Depressed Baroreflex Sensitivity in Renovascular Hypertensive Rats. BP, HR
26  2016 Prior renovascular hypertension does not predispose to atherosclerosis in mice. ASCVD, PCSK9
27  2016 Renal sympathetic denervation attenuates hypertension and vascular remodeling in renovascular hypertensive rats. RSD
28  2016 [Role of catestatin in 2K1C-induced renal hypertension in rats and the underlying mechanism]. BW, CHGA, CST, HPLC, NE, NO
29  2015 Aldosterone Contributes to Sympathoexcitation in Renovascular Hypertension. Ang II, CNS, MAP, PRA, RSNA
30  2015 Combined Aliskiren and L-arginine treatment reverses renovascular hypertension in an animal model. ALSK, L-Arg, RSNA, SBP
31  2015 Interplay between connexin40 and nitric oxide signaling during hypertension. 1K1C, Cxs, eNOS
32  2015 Morphological Identification of TRPC7 in Cardiomyocytes From Normal and Renovascular Hypertensive Rats. Ang II, PKC, TRPC7
33  2015 The Nuclear Factor kappaB Inhibitor Pyrrolidine Dithiocarbamate Prevents Cardiac Remodelling and Matrix Metalloproteinase-2 Up-Regulation in Renovascular Hypertension. MMP, PDTC
34  2014 Combined aliskiren and L-arginine treatment has antihypertensive effects and prevents vascular endothelial dysfunction in a model of renovascular hypertension. ALSK, BP, L-NAME
35  2014 Effects of Xin-Ji-Er-Kang formula on 2K1C-induced hypertension and cardiovascular remodeling in rats. Ang II, CSA, CVF, ED, eNOS, HW/BW, Hyp, JNK, LVEDP, LVSP, MDA, MH, NO, NOX2, PVCA, SBP, Sh-Op, SOD, VG, XJEK
36  2014 Swimming training promotes cardiac remodeling and alters the expression of mRNA and protein levels involved in calcium handling in hypertensive rats. ---
37  2014 The antihypertensive effects of sodium nitrite are not associated with circulating angiotensin converting enzyme inhibition. ACE, NO
38  2013 AT1 receptors prevent salt-induced vascular dysfunction in isolated middle cerebral arteries of 2 kidney-1 clip hypertensive rats. ACh, Ang II, HS, MCA, NS, PRA
39  2013 Atorvastatin and sildenafil lower blood pressure and improve endothelial dysfunction, but only atorvastatin increases vascular stores of nitric oxide in hypertension. NO, SBP
40  2013 Direct Renin Inhibitor Attenuates Left Ventricular Remodeling in Post-Myocardial Infarction Heart Failure Mice. AT1, MMP
41  2013 Effects of imperatorin, the active component from Radix Angelicae (Baizhi), on the blood pressure and oxidative stress in 2K,1C hypertensive rats. 8-iso-PGF2alpha, Ang II, CATA, ET, MBP, MDA, NADPH, NO, NOS, SOD, XOD
42  2013 Intermedin in paraventricular nucleus attenuates sympathetic activity and blood pressure via nitric oxide in hypertensive rats. CRLR, IMD, NO, PVN, RAMPs
43  2013 Peroxisome proliferator-activated receptor delta agonist, HPP593, prevents renal necrosis under chronic ischemia. PPARdelta
44  2013 PPARdelta binding to heme oxygenase 1 promoter prevents angiotensin II-induced adipocyte dysfunction in Goldblatt hypertensive rats. HO-1, Mest, PPARdelta, RAS, SnMP
45  2013 Prorenin receptor in distal nephron segments of 2-kidney, 1-clip goldblatt hypertensive rats. Ang II, PRR
46  2013 Reproductive dysfunction in female rats with renovascular hypertension. FSH, LH
47  2013 [Effects of qishenyiqi gutta pills on calcium/calmodulin dependent protein kinase II in rats with renal hypertension]. CaMKII, CVF, ELISA, LVMI, LVMI, ROS, SOD
48  2012 alpha-lipoic acid reduces hypertension and increases baroreflex sensitivity in renovascular hypertensive rats. BRS, HR, MAP
49  2012 Antihypertensive and antioxidant effects of a single daily dose of sodium nitrite in a model of renovascular hypertension. DHE, NO, ROS, SBP, SOD, TBARS
50  2012 Downregulation of alpha7 nicotinic acetylcholine receptor in two-kidney one-clip hypertensive rats. alpha7nAChR, TNF-alpha
51  2012 Influence of ovariectomy on cardiac oxidative stress in a renovascular hypertension model. BP, TRAP
52  2011 A novel vascular clip design for the reliable induction of 2-kidney, 1-clip hypertension in the rat. ---
53  2011 Raloxifene reduces blood pressure in hypertensive animals after ovarian hormone deprivation. ---
54  2011 Renovascular hypertension using a modified two-kidney, one-clip approach in mice is not dependent on the alpha1 or alpha2 Na-K-ATPase ouabain-binding site. ---
55  2010 Acute superoxide scavenging restores depressed baroreflex sensitivity in renovascular hypertensive rats. ---
56  2010 Angiotensin AT₂ receptor stimulation inhibits early renal inflammation in renovascular hypertension. cGMP, IL-6, NO, TGF-beta1, TNF-alpha
57  2010 Genistein prevents myocardial hypertrophy in 2-kidney 1-clip renal hypertensive rats by restoring eNOS pathway. AT2, eNOS, LVH, NO
58  2010 Matrix metalloproteinase inhibition improves cardiac dysfunction and remodeling in 2-kidney, 1-clip hypertension. MMPs
59  2009 Altered renal expression of aquaporin water channels and sodium transporters in rats with two-kidney, one-clip hypertension. AQP
60  2008 (Pro)renin receptor peptide inhibitor "handle-region" peptide does not affect hypertensive nephrosclerosis in Goldblatt rats. HRP
61  2007 Beta-1 adrenergic receptor antisense-oligodeoxynucleotides ameliorates left ventricular remodeling in 2-Kidney, 1-Clip rats. LV
62  2007 Calcitonin gene-related Peptide-mediated depressor effect and inhibiting vascular hypertrophy of rutaecarpine in renovascular hypertensive rats. CGRP, DRG, Rut, SBP, VR1
63  2007 Endogenous angiotensin II enhances atherogenesis in apoprotein E-deficient mice with renovascular hypertension through activation of vascular smooth muscle cells. 1K1C, AII, CM, SR-A, VSMC
64  2006 Connexin43-dependent mechanism modulates renin secretion and hypertension. ---
65  2006 Prevention of hypertension and organ damage in 2-kidney, 1-clip rats by tetradecylthioacetic acid. TTA
66  2006 [Effects of RNA interference targeting angiotensin 1a receptor on the blood pressure and cardiac hypertrophy of rats with 2K1C hypertension]. AT1a, DBP, LV/BW, RNAi, SBP
67  2005 Angiotensin type 2 receptor-mediated phosphorylation of eNOS in the aortas of mice with 2-kidney, 1-clip hypertension. Ang II, eNOS
68  2005 AT(2) receptors mediate tonic renal medullary vasoconstriction in renovascular hypertension. Ang II, i.v
69  2005 Effects of angiotensin-(1-7) blockade on renal function in rats with enhanced intrarenal Ang II activity. GFR, HanSD, i.r, RAS, RPF, TGR
70  2005 Evaluation of vascular function in apolipoprotein E knockout mice with angiotensin-dependent renovascular hypertension. ACh, NE, SNP
71  2005 Homocysteine-dependent cardiac remodeling and endothelial-myocyte coupling in a 2 kidney, 1 clip Goldblatt hypertension mouse model. CZ, Hcy, PPARgamma, RVH
72  2005 Losartan reduces monocyte chemoattractant protein-1 expression in aortic tissues of 2K1C hypertensive rats. Ang II, MCP-1, RT-PCR, WKY
73  2004 Renovascular hypertension in mice with brain-selective overexpression of AT1a receptors is buffered by increased nitric oxide production in the periphery. Ang II, BP, HR, NOS, NT
74  2003 Expression of the translational repressor NAT1 in experimental models of cardiac hypertrophy. NAT1
75  2003 Roles of oxidative stress and AT1 receptors in renal hemodynamics and oxygenation in the postclipped 2K,1C kidney. Ang II, CAND, MAP, MDA, sham, SHR, Temp, TNa
76  2002 Cyclooxygenase-2 inhibitors attenuate increased blood pressure in renovascular hypertensive models, but not in deoxycorticosterone-salt hypertension. 1K1C, COX, DOCA, MBP
77  2001 Angiotensin II AT(1A) receptor antisense lowers blood pressure in acute 2-kidney, 1-clip hypertension. ---
78  2001 Antisense inhibition of brain renin-angiotensin system decreased blood pressure in chronic 2-kidney, 1 clip hypertensive rats. AGT, Ang II, AS-ODNs, BP, RAS, SBP
79  2001 Ca(2+) influx is increased in 2-kidney, 1-clip hypertensive rat aorta. ---
80  2000 Intrarenal angiotensin II augmentation in angiotensin II dependent hypertension. Ang II
81  1999 Endothelin system-dependent cardiac remodeling in renovascular hypertension. ET
82  1999 L-arginine restores the effect of ouabain on baroreceptor activity and prevents hypertension. BNA, DOCA, L-NAME
83  1998 Effect of chronic therapy with proteolytic enzymes on hypertension-induced renal injury in the rat model of Goldblatt hypertension. SBP
84  1998 Increase in functional Ca2+ channels in cerebral smooth muscle with renal hypertension. Erev
85  1997 Changes of the plasma endothelin in adaptation to increased salt intake in rats. L-NAME, NO, VE
86  1995 Impairment of endothelium-dependent vasorelaxation in chronic two-kidney, one clip hypertensive rats. EDNO
87  1994 Cardiovascular responses to intracerebroventricular injection of GABA in renovascular hypertensive rats. BP, i.c.v, RVHR
88  1994 Regional haemodynamic effects of the novel AT1 receptor antagonist, CV-11974, in conscious rats. AII, MAP, SHR
89  1994 Telemetric blood pressure monitoring in benign 2-kidney, 1-clip renovascular hypertension: effect of chronic caffeine ingestion. MABP, SHAM
90  1993 Effect of caffeine treatment on plasma renin activity and angiotensin I concentrations in rats on a low sodium diet. ---
91  1992 Dietary sodium restriction and the development of two-kidney, one-clip hypertension in young versus adult rats. BP, PRA
92  1992 Kinin contribution to chronic antihypertensive actions of ACE-inhibitors in hypertensive rats. BN-K, SHR, WI
93  1986 Pressor sensitivity to angiotensin I and angiotensin II during the development of experimental renal hypertension in the rat. AII