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Abbreviation : 2OG
Long Form : 2-oxoglutarate
No. Year Title Co-occurring Abbreviation
2022 A Unique Set of Auxiliary Metabolic Genes Found in an Isolated Cyanophage Sheds New Light on Marine Phage-Host Interactions. MPI
2022 An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma. ccRCC, DGAT1, JMJD6
2022 BSA‑seq and genetic mapping identified candidate genes for branching habit in peanut. BSA-seq, CK, LBA, MAS
2022 De novo generation of a bright blue fluorophore from 2-oxoglutarate in biological samples. ---
2022 Discovery of two novel ALKBH5 selective inhibitors that exhibit uncompetitive or competitive type and suppress the growth activity of glioblastoma multiforme. AlkB, FTO
2022 Functions and Interactions of Mammalian KDM5 Demethylases. HDAC, Rb
2022 How Human TET2 Enzyme Catalyzes the Oxidation of Unnatural Cytosine Modifications in Double-Stranded DNA. 4dmC, 5eyC, 5fmC, 5vC, ds, HAT, MD, QM/MM, TET
2022 IOX1 Fails to Reduce α-Globin and Mediates γ-Globin Silencing in Adult β0-Thalassemia/Hemoglobin E Erythroid Progenitor Cells. HbE
2022 Prolyl Hydroxylase Domain Protein Inhibitor Not Harboring a 2-Oxoglutarate Scaffold Protects against Hypoxic Stress. HIF-alpha, PHDs, PyrzA
10  2022 QTLs Identification for Iron Chlorosis in a Segregating Peach-Almond Progeny Through Double-Digest Sequence-Based Genotyping (SBG). NIFU2, SBG
11  2022 Regulatory role of JMJD6 in placental development. JMJD6
12  2022 SDHB knockout and succinate accumulation are insufficient for tumorigenesis but dual SDHB/NF1 loss yields SDHx-like pheochromocytomas. ---
13  2022 Whole-Cell Biotransformation of Penicillin G by a Three-Enzyme Co-expression System with Engineered Deacetoxycephalosporin C Synthase. DAOCS, G-7-ADCA
14  2021 2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases. AspH, FIH
15  2021 Catalysis by the JmjC histone demethylase KDM4A integrates substrate dynamics, correlated motions and molecular orbital control. MD, QM/MM
16  2021 Catalytic promiscuity of rice 2-oxoglutarate/Fe(II)-dependent dioxygenases supports xenobiotic metabolism. bTHs, HSL, TE
17  2021 Crystal structures of adenylylated and unadenylylated PII protein GlnK from Corynebacterium glutamicum. adGlnK, unGlnK
18  2021 Discovery of JMJD7 inhibitors with the aid of virtual screening and bioactivity evaluation. JmjC
19  2021 Effect of Posttranslational Modifications on the Structure and Activity of FTO Demethylase. N6-meA
20  2021 Endomembrane-Targeting Plasmodiophora brassicae Effectors Modulate PAMP Triggered Immune Responses in Plants. dpi, ER, PbPEs, PCD, PM, SP
21  2021 Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases. 2,4-PDCA, AspH
22  2021 High complexity of Glutamine synthetase regulation in Methanosarcina mazei: Small protein 26 interacts and enhances glutamine synthetase activity. NMR, sORF
23  2021 High-Level Production of Lysine in the Yeast Saccharomyces cerevisiae by Rational Design of Homocitrate Synthase. AcCoA, HCS
24  2021 Human Oxygenase Variants Employing a Single Protein FeII Ligand Are Catalytically Active. AspH, EGFDs
25  2021 Hybrid radical-polar pathway for excision of ethylene from 2-oxoglutarate by an iron oxygenase. EFE
26  2021 Integrated transcript and metabolite profiling reveals coordination between biomass size and nitrogen metabolism in Arabidopsis F1 hybrids. GO
27  2021 JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells. HSCs, OXPHOS, ROS
28  2021 Measurement of the nuclear concentration of α-ketoglutarate during adipocyte differentiation by using a fluorescence resonance energy transfer-based biosensor with nuclear localization signals. alpha-KG, dimethyl-2-OG, FRET, JMJDs, NLSs, TCA, TETs
29  2021 Roles of HIF and 2-Oxoglutarate-Dependent Dioxygenases in Controlling Gene Expression in Hypoxia. HIF
30  2021 Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat. PHDs
31  2021 Structural Insight into the Catalytic Mechanism of the Endoperoxide Synthase FtmOx1. ---
32  2021 Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors. FTO, m6A
33  2021 Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-β-hydroxylase. AspH, EGFDs
34  2021 The novel PII-interactor PirC identifies phosphoglycerate mutase as key control point of carbon storage metabolism in cyanobacteria. PGAM
35  2021 The Role of Sugar Signaling in Regulating Plant Fatty Acid Synthesis. ACCase, DGAT1, FA, SnRK1, T6P
36  2020 Catalysis by the Non-Heme Iron(II) Histone Demethylase PHF8 Involves Iron Center Rearrangement and Conformational Modulation of Substrate Orientation. MD, QM/MM
37  2020 Crystal structure and interaction studies of human DHTKD1 provide insight into a mitochondrial megacomplex in lysine catabolism. 2OA
38  2020 Human 2-oxoglutarate-dependent oxygenases: nutrient sensors, stress responders, and disease mediators. ---
39  2020 Human and Arabidopsis alpha-ketoglutarate-dependent dioxygenase homolog proteins-New players in important regulatory processes. ALKBH, FTO, N6 meA
40  2020 Hypoxia and Oxygen-Sensing Signaling in Gene Regulation and Cancer Progression. HIF
41  2020 Hypoxia-driven epigenetic regulation in cancer progression: A focus on histone methylation and its modifying enzymes. HIF
42  2020 Identification and characterization of isocitrate dehydrogenase 1 (IDH1) as a functional target of marine natural product grincamycin B. APL, GCNB, GCNs, IDH1, ROS
43  2020 Identification of Specific N6-Methyladenosine RNA Demethylase FTO Inhibitors by Single-Quantum-Dot-Based FRET Nanosensors. FRET, FTO, m6A, QD
44  2020 JMJD6 Regulates Splicing of Its Own Gene Resulting in Alternatively Spliced Isoforms with Different Nuclear Targets. hnRNPs, JMJD6, RS, SMN, UBF
45  2020 Jumonji domain-containing protein 6 protein and its role in cancer. JMJD6
46  2020 Kinetic parameters of human aspartate/asparagine-beta-hydroxylase suggest that it has a possible function in oxygen sensing. AspH, EGFDs
47  2020 NAD+ biosynthesis in bacteria is controlled by global carbon/nitrogen levels via PII signaling. NAAD
48  2020 Priming of tomato seedlings with 2-oxoglutarate induces arsenic toxicity alleviatory responses by involving endogenous nitric oxide. NO
49  2020 Reducing Agent-Mediated Nonenzymatic Conversion of 2-Oxoglutarate to Succinate: Implications for Oxygenase Assays. l-Asc
50  2020 Role of Structural Dynamics in Selectivity and Mechanism of Non-heme Fe(II) and 2-Oxoglutarate-Dependent Oxygenases Involved in DNA Repair. m3C, MD, QM/MM
51  2020 Small-molecule active pharmaceutical ingredients of approved cancer therapeutics inhibit human aspartate/asparagine-β-hydroxylase. APIs, AspH, Bcl-2, EGFDs, MS
52  2020 Structural Studies of Glutamate Dehydrogenase (Isoform 1) From Arabidopsis thaliana, an Important Enzyme at the Branch-Point Between Carbon and Nitrogen Metabolism. GDH, MPP
53  2020 Synthesis of Novel Pyridine-Carboxylates as Small-Molecule Inhibitors of Human Aspartate/Asparagine-β-Hydroxylase. 2,4-PDCA, AspH, EGFD
54  2020 [Hypoxic response as a therapeutic target of human diseases]. HIFalpha
55  2019 2-oxoglutarate modulates the affinity of FurA for the ntcA promoter in Anabaena sp. PCC 7120. ---
56  2019 ALKBH overexpression in head and neck cancer: potential target for novel anticancer therapy. HNSCC
57  2019 Association between admission plasma 2-oxoglutarate levels and short-term outcomes in patients with acute heart failure: a prospective cohort study. AHF, CI, EF, eGFR, HF, NT-proBNP, OR
58  2019 Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6. HSP70, JMJD6, U2AF65
59  2019 Carbon/nitrogen homeostasis control in cyanobacteria. C/N
60  2019 Comparative transcriptome analysis reveals differentially expressed genes related to the tissue-specific accumulation of anthocyanins in pericarp and aleurone layer for maize. ---
61  2019 Exogenous 2-(3,4-Dichlorophenoxy) triethylamine ameliorates the soil drought effect on nitrogen metabolism in maize during the pre-female inflorescence emergence stage. AlaAT, AspAT, Ci, DCPTA, GDH, ICDH, NiR, NR, Pn, RGR, RWC, Tr
62  2019 Glutarate L-2-hydroxylase (CsiD/GlaH) is an archetype Fe(II)/2-oxoglutarate-dependent dioxygenase. GABA
63  2019 Heteroexpression of Mycobacterium leprae hypothetical protein ML0190 provides protection against DNA-alkylating agent methyl methanesulfonate. AlkB, MMS
64  2019 In Silico Discovery of JMJD6 Inhibitors for Cancer Treatment. ---
65  2019 Investigating the active site of human trimethyllysine hydroxylase. TMLH
66  2019 Redox interference in nitrogen status via oxidative stress is mediated by 2-oxoglutarate in cyanobacteria. GS, ROS
67  2019 Regulation of Herbaspirillum seropedicae NifA by the GlnK PII signal transduction protein is mediated by effectors binding to allosteric sites. ---
68  2019 Selective Inhibitors of AlkB Family of Nucleic Acid Demethylases. ---
69  2019 Strongly Coupled Redox-Linked Conformational Switching at the Active Site of the Non-Heme Iron-Dependent Dioxygenase, TauD. ---
70  2019 Structural Origin of the Large Redox-Linked Reorganization in the 2-Oxoglutarate Dependent Oxygenase, TauD. TauD
71  2019 Structure-function relationships in KDM7 histone demethylases. JmjC, KDM7B
72  2019 Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors. HIF, PHDs
73  2019 Sufficiency of hypoxia-inducible 2-oxoglutarate dioxygenases to block chemical oxidative stress-induced differentiation of human embryonic stem cells. 5hmC, hESC
74  2019 The Arabidopsis E1 subunit of the 2-oxoglutarate dehydrogenase complex modulates plant growth and seed production. 2-OGDH
75  2019 The Clinically Used Iron Chelator Deferasirox Is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases. ---
76  2018 2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2. HIF, PHD
77  2018 2-Oxoglutarate-Dependent Oxygenases. ---
78  2018 Adventures in Defining Roles of Oxygenases in the Regulation of Protein Biosynthesis. ---
79  2018 Aglycemic HepG2 Cells Switch From Aminotransferase Glutaminolytic Pathway of Pyruvate Utilization to Complete Krebs Cycle at Hypoxia. ACO-IDH3, AOA, dm2OG, HIF, OXPHOS
80  2018 Aspartate beta-hydroxylase promotes cholangiocarcinoma progression by modulating RB1 phosphorylation. ASPH, CCA
81  2018 Cancer-associated 2-oxoglutarate analogues modify histone methylation by inhibiting histone lysine demethylases. 2-OGDDs, R-2HG
82  2018 Efficient production of trans-4-Hydroxy-l-proline from glucose by metabolic engineering of recombinant Escherichia coli. AceA, P4H, PutA, SucAB, trans-Hyp
83  2018 FTO is a transcriptional repressor to auto-regulate its own gene and potentially associated with homeostasis of body weight. BHB, FTO
84  2018 Identification of candidate resistance genes of cotton against Aspergillus flavus infection using a comparative transcriptomics approach. ---
85  2018 Inhibitors of both the N-methyl lysyl- and arginyl-demethylase activities of the JmjC oxygenases. JmjC
86  2018 Lactate dehydrogenase C is required for the protein expression of a sperm-specific isoform of lactate dehydrogenase A. 2-HG, IDH, LDHC
87  2018 Metabolic Regulation of Hypoxia-Inducible Transcription Factors: The Role of Small Molecule Metabolites and Iron. 2-HG, HIFs, PHDs, TCA
88  2018 Mitochondria and Hypoxia: Metabolic Crosstalk in Cell-Fate Decisions. SCs
89  2018 Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials. HIF, ODDs
90  2018 Nitrogen metabolism in cyanobacteria: metabolic and molecular control, growth consequences and biotechnological applications. ---
91  2018 Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding. ---
92  2018 Quality markers of animal medicinal materials: Correlative analysis of musk reveals distinct metabolic changes induced by multiple factors. PLS, Q-marker
93  2018 Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in β-lactam biosynthesis. IPNS
94  2018 The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases. JmjC, TRAFAC
95  2018 The PII-NAGK-PipX-NtcA Regulatory Axis of Cyanobacteria: A Tale of Changing Partners, Allosteric Effectors and Non-covalent Interactions. ADP, PLP
96  2018 Thermodynamics of Iron(II) and Substrate Binding to the Ethylene-Forming Enzyme. Arg, EFE
97  2018 Thioether Macrocyclic Peptides Selected against TET1 Compact Catalytic Domain Inhibit TET1 Catalytic Activity. RaPID, TET, TET1-CD, TET1CCD
98  2017 Bifunctional Enzyme JMJD6 Contributes to Multiple Disease Pathogenesis: New Twist on the Old Story. FMDV, JMJD6, PSR
99  2017 Coordinating carbon and nitrogen metabolic signaling through the cyanobacterial global repressor NdhR. 2PG, NdhR, RD
100  2017 Effects of global transcription factor NtcA on photosynthetic production of ethylene in recombinant Synechocystis sp. PCC 6803. EFE, NtcA, TCA