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Abbreviation : 3-AB
Long Form : 3-aminobenzamide
No. Year Title Co-occurring Abbreviation
2022 Sevoflurane exposure during the second trimester induces neurotoxicity in offspring rats by hyperactivation of PARP-1. AIF, DHE, MWM, Nogo-A, PARP-1, PND 28-33, Pyk2, ROS, STEP61
2020 3-Aminobenzamide alleviates elevated DNA damage and DNA methylation in a BTBR T+Itpr3tf/J mouse model of autism by enhancing repair gene expression. ---
2020 Effect of 3-Aminobenzamide on the Ultrastructure of Astrocytes and Microvessels After Focal Cerebral Ischemia in Rats. BBB, EB, i.p, PARP
2020 Effects of the DNA repair inhibitors, cytosine arabinoside and 3-aminobenzamide, on the frequency of radiation-induced micronuclei, nuclear buds, and nucleoplasmic bridges. CBMN, MN, NBUD, NPB
2020 Function and mechanism of combined PARP-1 and BRCA genes in regulating the radiosensitivity of breast cancer cells. CTRL, IR, PARP-1
2020 mTOR may interact with PARP-1 to regulate visible light-induced parthanatos in photoreceptors. AIF, ERG, mTOR, PI, shRNA, SIRT1
2020 Synthesis, chemical characterization, PARP inhibition, DNA binding and cellular uptake of novel ruthenium(II)-arene complexes bearing benzamide derivatives in human breast cancer cells. PARP-1
2019 3-Aminobenzamide Blocks MAMP-Induced Callose Deposition Independently of Its Poly(ADPribosyl)ation Inhibiting Activity. MAMPs, PARPs, PMR4
2019 3-Aminobenzamide protects against cerebral artery injury and inflammation in rats with intracranial aneurysms. HE, IA, SD
10  2019 Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular PARylation. CHR, DOX
11  2019 Combined Administration of Poly-ADP-Ribose Polymerase-1 and Caspase-3 Inhibitors Alleviates Neuronal Apoptosis After Spinal Cord Injury in Rats. AIF, PARP-1, SCI
12  2019 Potential role of poly (ADP-ribose) polymerase in delayed cerebral vasospasm following subarachnoid hemorrhage in rats. CRP, DCVS, MCP-1, NF, SAH
13  2019 Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide. CEES, MESNA, NAC
14  2019 Treatment with 3-aminobenzamide during ex vivo lung perfusion of damaged rat lungs reduces graft injury and dysfunction after transplantation. BAL, CI, CTRL, EVLP, PARP, WI
15  2018 3-Aminobenzamide Prevents Concanavalin A-Induced Acute Hepatitis by an Anti-inflammatory and Anti-oxidative Mechanism. DPI, LPS, NAC, PARP-1
16  2018 Modulation of hypersensitivity to oxidative DNA damage in ATM defective cells induced by potassium bromate by inhibition of the Poly (ADP-ribose) polymerase (PARP). ATM, LCLs
17  2017 A transcriptomics approach uncovers novel roles for poly(ADP-ribosyl)ation in the basal defense response in Arabidopsis thaliana. 3-MB, MAMPs, PARP
18  2017 Anti-apoptotic effect of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) polymerase, against multiple organ damage induced by gamma irradiation in rats. ATP, COX-2, Gy, IR, LDH, MPO, TBARS
19  2017 Inhibitors of telomerase and poly(ADP-ribose) polymerases synergize to limit the lifespan of pancreatic cancer cells. ---
20  2017 Poly(ADP-ribose) polymerase 1 induces cardiac fibrosis by mediating mammalian target of rapamycin activity. AAC, CFs, mTOR, NAD, PARP-1
21  2017 Simultaneous blockade of NMDA receptors and PARP-1 activity synergistically alleviate immunoexcitotoxicity and bioenergetics in 3-nitropropionic acid intoxicated mice: Evidences from memantine and 3-aminobenzamide interventions. 3-NP, COM, HD, MN, SDH
22  2016 3-aminobenzamide, one of poly(ADP-ribose)polymerase-1 inhibitors, rescuesapoptosisin rat models of spinal cord injury. AIF, Bcl-2, CNS, PARP-1, SCI, SD
23  2016 Mechanisms underlying lung resistance-related protein (LRP)-mediated doxorubicin resistance of non-small cell lung cancer cells. DOX, LRP, MVP, NSCLC, siLRP
24  2016 PARP inhibition attenuates neuroinflammation and oxidative stress in chronic constriction injury induced peripheral neuropathy. CCI, COX-2, ISO, NF-kappaB, SFI
25  2016 Pharmacological Reconditioning of Marginal Donor Rat Lungs Using Inhibitors of Peroxynitrite and Poly (ADP-ribose) Polymerase During Ex Vivo Lung Perfusion. EVLP, PARP, ROS, WI
26  2016 Poly(ADP-ribose) polymerase regulates glycolytic activity in kidney proximal tubule epithelial cells. PARP
27  2016 Poly(ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors Reduce Reactive Gliosis and Improve Angiostatin Levels in Retina of Diabetic Rats. DR, GFAP, NAM, PARP-1, PARs, STZ
28  2016 The effect of poly (ADP-ribose) polymerase inhibition on aminoglycoside-induced acute tubular necrosis in rats. AG, PARP, PCNA, ROS, TIA
29  2016 The poly(ADP-ribosyl)ation of FoxO3 mediated by PARP1 participates in isoproterenol-induced cardiac hypertrophy. Ad-PARP1, FoxO3, ISO, PAR, PARP-1, PARylation, SD
30  2015 3-aminobenzamide, a poly (ADP ribose) polymerase inhibitor, enhances wound healing in whole body gamma irradiated model. ACOX-2, ROS
31  2015 Effect of 3-aminobenzamide on perforation an experimental colitis model. MDA, TNF-alpha
32  2015 Inhibition of Poly-(ADP-Ribose) Polymerase Protects the Kidney in a Canine Model of Endotoxic Shock. AKI, ES, PARPs
33  2015 PARP inhibition prevents acetaminophen-induced liver injury and increases survival rate in rats. PARP
34  2014 3-Aminobenzamide--a PARP inhibitor enhances the sensitivity of peripheral blood micronucleus and comet assays in mice. PARP, PBMN
35  2014 A new combination therapy in severe acute pancreatitis--hyperbaric oxygen plus 3-aminobenzamide: an experimental study. AP, Bact-Trans, HBO, THSc, TOSp
36  2014 Attenuation of the progression of adjuvant-induced arthritis by 3-aminobenzamide treatment. AIA, i.p, PARP, RA
37  2014 Effects of 3-aminobenzamide on ventricular function in infarct heart assessed by quantitative tissue velocity imaging. MI, PARP
38  2014 Efficacy of poly(adenosine diphosphate-ribose) polymerase inhibition in extracorporeal shock wave-induced renal injury. ESW, PARP
39  2014 Ex vivo protective effects of nicotinamide and 3-aminobenzamide on rat synaptosomes treated with Abeta(1-42). AD, NA, PARP-1
40  2014 Necroptosis and parthanatos are involved in remote lung injury after receiving ischemic renal allografts in rats. Nec-1, Rip1
41  2014 Poly(ADP-ribose) polymerase activation mediates synchrotron radiation X-ray-induced damage of rodent testes by exacerbating DNA damage and apoptotic changes. DSB, NAC, PAR, PARP, SR, TUNEL
42  2014 Protective effect of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) polymerase in distant liver injury induced by renal ischemia-reperfusion in rats. IR, MDA, NO, OSI, TAS, TOS
43  2014 Salvianolic acid B protects cardiomyocytes from angiotensin II-induced hypertrophy via inhibition of PARP-1. Ang II, Sal B
44  2013 Continuous inhibition of poly(ADP-ribose) polymerase does not reduce reperfusion injury in isolated rat heart. PARP
45  2013 Docosahexaenoic acid and tetracyclines as promising neuroprotective compounds with poly(ADP-ribose) polymerase inhibitory activities for oxidative/genotoxic stress treatment. AIF, DHA, MNNG, PAR, PARP-1
46  2013 Effects of poly (ADP-ribosyl) polymerase (PARP) inhibitor on cisplatin resistance & proliferation of the ovarian cancer C13* cells. Pt, RT-PCR
47  2013 Expression and activity of PARP family members in the hippocampus during systemic inflammation: their role in the regulation of prooxidative genes. COX-2, iNOS, LPS, PAR, PARP-1, SIR
48  2013 Inhibition of poly (adenosine diphosphate-ribose) polymerase attenuates lung-kidney crosstalk induced by intratracheal lipopolysaccharide instillation in rats. ARDS, IL, LPS, NF, PARP, TNF
49  2013 Involvement of homologous recombination in the synergism between cisplatin and poly (ADP-ribose) polymerase inhibition. 5-FU, ESCC
50  2013 Poly(ADP-ribose) polymerase-1 regulates the mechanism of irradiation-induced CNE-2 human nasopharyngeal carcinoma cell autophagy and inhibition of autophagy contributes to the radiation sensitization of CNE-2 cells. IR, LC3, PAR, PARP-1, RAPA, TEM
51  2012 3-Aminobenzamide protects primary human keratinocytes from UV-induced cell death by a poly(ADP-ribosyl)ation independent mechanism. PARylation
52  2012 NGF promotes long-term memory formation by activating poly(ADP-ribose)polymerase-1. NGF
53  2012 Poly(ADP-ribosylation) and neoplastic transformation: effect of PARP inhibitors. PARPs
54  2012 Suppressive effect of PARP-1 inhibitor on JC virus replication in vitro. JCV, PML
55  2011 Novel pathway of centrosome amplification that does not require DNA lesions. MNNG, PARPs
56  2011 PARP inhibition restores erectile function by suppressing corporal smooth muscle apoptosis in diabetic rats. AIF, ATP, Bad, Bax, Bcl-2, ED, i.p, MDA, PARP
57  2011 Poly(ADP-ribose) polymerase 1 is indispensable for transforming growth factor-beta Induced Smad3 activation in vascular smooth muscle cell. PARP-1, ROS, SBE, TGF-beta, VSMCs
58  2011 The poly(ADP-ribose) polymerase-1 inhibitor 3-aminobenzamide suppresses cell growth and migration, enhancing suppressive effects of cisplatin in osteosarcoma cells. PARP
59  2011 [Suppressing poly(ADP-ribose)polymerase-1 inhibits tau phosphorylation in HEK293/tau441 cells]. GSK-3, PARP-1
60  2010 Effect of acute poly(ADP-ribose) polymerase inhibition by 3-AB on blood-brain barrier permeability and edema formation after focal traumatic brain injury in rats. BBB, MMP-9, MRI, PARP, TBI
61  2010 Effects of 3-aminobenzamide on unilateral testicular ischemia-reperfusion injury: what is the role of PARP inhibition? CAT, GSH-Px, I/R, SOD
62  2010 Fertilization capacity with rainbow trout DNA-damaged sperm and embryo developmental success. ---
63  2009 3-aminobenzamide, a poly ADP ribose polymerase inhibitor, attenuates renal ischemia/reperfusion injury. AST, BUN, I/R
64  2009 Identification and expansion of human osteosarcoma-cancer-stem cells by long-term 3-aminobenzamide treatment. ---
65  2008 Combinatorial-approached neuroprotection using pan-caspase inhibitor and poly (ADP-ribose) polymerase (PARP) inhibitor following experimental stroke in rats; is there additional benefit? MCAO
66  2008 Effect of 3-amino benzamide, a poly(adenosine diphosphate-ribose) polymerase inhibitor, in experimental caustic esophageal burn. GPx, MDA, PCC, SOD
67  2008 GSK-3beta and oxidative stress in aged brain. Role of poly(ADP- -ribose) polymerase-1. GSK-3
68  2008 Induction of cytogenetic adaptive response in spermatogonia and spermatocytes by pre-exposure of mouse testis to low-dose (12)C(6+) ions. PARPs
69  2008 Ischemic and peroxynitrite preconditioning effects in chronic hypoxic rat lung. NO
70  2008 Meta-iodobenzylguanidine, an inhibitor of arginine-dependent mono(ADP-ribosyl)ation, prevents neointimal hyperplasia. MIBG, PARP
71  2008 Non-enzymatic fast repair of DNA oxidative damage might also exist in cells. CHO, MMP, MX, NIC, RA, ROS, VER
72  2008 Poly (ADP-ribose) polymerase inhibition improves endothelial dysfunction induced by hyperhomocysteinemia in rats. ET, Hhcy
73  2008 [Effect of poly-adenosine diphosphate ribosyl-polymerase on vascular hyporeactivity in rats with hemorrhagic shock]. NE, NO, PARP, SD, SMA
74  2007 Inhibition of poly(ADP-ribose) polymerase (PARP) influences the mode of sulfur mustard (SM)-induced cell death in HaCaT cells. PARP, SM
75  2007 Lactate down-regulates cellular poly(ADP-ribose) formation in cultured human skin fibroblasts. NHDF, pADPR, PARP-1
76  2007 Oxidative stress-induced poly(ADP-ribosyl)ation in chick limb bud-derived chondrocytes. HDC, PARP-1
77  2007 Poly(ADP-ribose) polymerase inhibitor is neuroprotective in epileptic rat via apoptosis-inducing factor and Akt signaling. PARP
78  2006 Effect of 3-aminobenzamide on Bcl-2, Bax and AIF localization in hippocampal neurons altered by ischemia-reperfusion injury. the immunocytochemical study. AIF
79  2006 Effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) polymerase, in a mouse model of acute pancreatitis induced by cerulein. ICAM-1, TGF-beta, VEGF
80  2006 Effects of poly(ADP-ribose) polymerase inhibition on dysfunction of non-adrenergic non-cholinergic neurotransmission in gastric fundus in diabetic rats. eNOS, NO, PARP
81  2006 In vivo exposure of swiss albino mice to chronic low dose of dimethylnitrosamine (DMN) lowers poly-ADP-ribosylation (PAR) of bone marrow cell and blood lymphocyte proteins. BL, BMC, DMN, PAR
82  2006 Inhibition of poly(ADP-ribose)polymerase does not affect the recombination events in CHO xrs6 and wild type cells. HR, NHEJ
83  2006 Poly (ADP-ribose) polymerase inhibitor 3-aminobenzamide rescues N-methyl-N-nitrosourea-induced photoreceptor cell apoptosis in Sprague-Dawley rats through preservation of nuclear factor-kappaB activity. MNU, NF
84  2006 Poly(ADP-ribose) polymerase-1 inhibitor 3-aminobenzamide enhances apoptosis induction by platinum complexes in cisplatin-resistant tumor cells. ---
85  2005 3-aminobenzamide prevents restraint-evoked immunocompromise. KLH, PARP
86  2005 Effect of 3-aminobenzamide, PARP inhibitor, on matrix metalloproteinase-9 level in plasma and brain of ischemic stroke model. MMP-9, NF-kappaB, PARP
87  2005 Effect of poly(ADP-ribosyl)ation inhibitors on the genotoxic effects of the boron neutron capture reaction. 5-AIQ, BNC, DNA-PK, PARP-1
88  2005 Inhibition of poly(ADP-ribose) polymerase activity protects hippocampal cells against morphological and ultrastructural alteration evoked by ischemia-reperfusion injury. GFAP
89  2005 Inhibition of poly(ADP-ribose) polymerase attenuates lung tissue damage after hind limb ischemia-reperfusion in rats. BAL, I/R, MDA, PARP
90  2005 Inhibitors of poly (ADP-ribose) polymerase ameliorate myocardial reperfusion injury by modulation of activator protein-1 and neutrophil infiltration. AP-1, PARP-1
91  2005 Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and the development of bleomycin-induced lung injury. 5-AIQ, PARP
92  2005 Poly (adp-ribose) synthetase inhibition reduces oxidative and nitrosative organ damage after thermal injury. NAD
93  2004 3-Aminobenzamide reduces brain infarction and neutrophil infiltration after transient focal cerebral ischemia in mice. MPO, PARP
94  2004 5-Aminoisoquinolinone reduces colon injury by experimental colitis. 5-AIQ, DNBS, ICAM-1, MPO
95  2004 Apoptosis inhibition plays a greater role than necrosis inhibition in decreasing bacterial translocation in experimental intestinal transplantation. BT
96  2004 Caspase inhibition switches the mode of cell death induced by cyanide by enhancing reactive oxygen species generation and PARP-1 activation. ROS
97  2004 Caspase-1 and poly (ADP-ribose) polymerase inhibitors may protect against peroxynitrite-induced neurotoxicity independent of their enzyme inhibitor activity. DHQ
98  2004 Effect of DNA repair inhibitor (3-aminobenzamide) on genetic stability of loach (Misgurnus fossilis) embryos derived from cryopreserved sperm. PARP
99  2004 Effect of poly(ADP-ribose) polymerase inhibitors on oxidative stress evoked hydroxyl radical level and macromolecules oxidation in cell free system of rat brain cortex. DHIQ, DPQ, PARP-1
100  2004 Effects 3-aminobenzamide on ultrastructure of hippocampal CA1 layer after global ischemia in gerbils. ---