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Abbreviation : 3alpha-diol
Long Form : 5alpha-androstane-3alpha,17beta-diol
No. Year Title Co-occurring Abbreviation
2021 Exploring the Impact of the Microbiome on Neuroactive Steroid Levels in Germ-Free Animals. GF
2020 Consequences of steroid-5alpha-reductase deficiency and inhibition in vertebrates. 5 alpha-DHT, 5ARIs, ALLO, DUT, FIN, SRD5alpha2
2019 Allopregnanolone is required for prepulse inhibition deficits induced by D1 dopamine receptor activation. 5alpha-R, AP, DHP, DHT, KO, PPI
2019 Formation of 5alpha-dihydrotestosterone from 5alpha-androstane-3alpha,17beta-diol in prostate cancer LAPC-4 cells - Identifying inhibitors of non-classical pathways producing the most potent androgen. 5 alpha-DHT, AR, PC
2019 Simultaneous measurement of 18 steroids in human and mouse serum by liquid chromatography-mass spectrometry without derivatization to profile the classical and alternate pathways of androgen synthesis and metabolism. AD, DHEA, DHP, DHT, LLE, LOQ
2018 Neurosteroid metabolites of testosterone and progesterone differentially inhibit ERK phosphorylation induced by amyloid beta in SH-SY5Y cells and primary cortical neurons. Abeta42, ERK, GABA
2018 The testosterone metabolite 3alpha-androstanediol inhibits oxidative stress-induced ERK phosphorylation and neurotoxicity in SH-SY5Y cells through an MKP3/DUSP6-dependent mechanism. ERK
2017 Expression of aldo-keto reductase family 1, member C14 during ovulation in the rat. Akr1c14, hCG
2017 Regulation of uridine diphosphate-glucuronosyltransferase 2B15 expression during ovulation in the rat. 3alpha-diol G, LH, UGT2B15
10  2017 Transition from androgenic to neurosteroidal action of 5alpha-androstane-3alpha, 17beta-diol through the type A gamma-aminobutyric acid receptor in prostate cancer progression. AKR1C3, AR, CAM, CNS, CRPC, DHT, EGF, EGFR, GABAAR, PCa
11  2016 5alpha-Androstane-3alpha,17beta-Diol Inhibits Neurotoxicity in SH-SY5Y Human Neuroblastoma Cells and Mouse Primary Cortical Neurons. Abeta42
12  2015 Testicular function in a birth cohort of young men. 3beta-diol, DHEA, DHT, FSH, LH, SCSA
13  2014 Neuroactive steroid treatment modulates myelin lipid profile in diabetic peripheral neuropathy. ---
14  2013 Expression of aldo-keto reductase family 1 member C3 (AKR1C3) in neuroendocrine tumors & adenocarcinomas of pancreas, gastrointestinal tract, and lung. 5 alpha-DHT, AKR1C3, DDx, NE
15  2012 Aldo-keto reductase family 1 member C3 (AKR1C3) is expressed in adenocarcinoma and squamous cell carcinoma but not small cell carcinoma. 5 alpha-DHT, AKR1C3, DDx, HSD, NSCLC
16  2012 Cloning, characterization, and expression analysis of a putative 17 beta-hydroxysteroid dehydrogenase 11 in the abalone, Haliotis diversicolor supertexta. 17beta-HSDs, HEK293, ORF, SDR
17  2012 New insights into melatonin/CRH signaling in hamster Leydig cells. CRH, Erk, JNK, MEK, mel1a, RT-qPCR, StAR
18  2012 Validation of a sequential extraction and liquid chromatography-tandem mass spectrometric method for determination of dihydrotestosterone, androstanediol and androstanediol-glucuronide in prostate tissues. BPH, DHT, LLOQ
19  2011 Simultaneous quantification of steroids in rat intratesticular fluid by HPLC-isotope dilution tandem mass spectrometry. DHT
20  2010 The androgen derivative 5alpha-androstane-3beta,17beta-diol inhibits tumor necrosis factor alpha and lipopolysaccharide induced inflammatory response in human endothelial cells and in mice aorta. ERs
21  2009 17beta-hydroxysteroid dehydrogenase type 11 (Pan1b) expression in human prostate cancer. ---
22  2008 3alpha-Hydroxysteroid dehydrogenase type III deficiency: a novel mechanism for hirsutism. 3alpha-HSD, DHT
23  2008 5alpha-androstane-3alpha,17beta-diol selectively activates the canonical PI3K/AKT pathway: a bioinformatics-based evidence for androgen-activated cytoplasmic signaling. 3alpha-HSDs, 5 alpha-DHT, AR
24  2008 5alpha-androstane-3alpha,17beta-diol supports human prostate cancer cell survival and proliferation through androgen receptor-independent signaling pathways: implication of androgen-independent prostate cancer progression. 3alpha-HSDs, 5 alpha-DHT, AR
25  2008 Androgen biosynthetic pathways in the human prostate. 3alpha-HSD, DHEA, DHEAS, DHT
26  2008 Androgens with activity at estrogen receptor beta have anxiolytic and cognitive-enhancing effects in male rats and mice. DHT, s.c
27  2008 Inactivation by UDP-glucuronosyltransferase enzymes: the end of androgen signaling. ADT, UGT
28  2008 Neuroactive Steroid Levels in a transgenic rat model of CMT1A Neuropathy. CMT1A, THP
29  2008 The impact of unabated stimulation by human chorionic gonadotropin on the steroid hormone environment of pregnant rats and the spontaneous expression of ovarian cysts in female progeny. hCG
30  2007 Differential androgen and estrogen substrates specificity in the mouse and primates type 12 17beta-hydroxysteroid dehydrogenase. 5-diol, DHEA, HEK
31  2007 Effect of testosterone metabolites on ABC half-transporter relative gene expression in X-linked adrenoleukodystrophy. DHT, X-ALD
32  2007 Evaluation of neuroactive steroid levels by liquid chromatography-tandem mass spectrometry in central and peripheral nervous system: effect of diabetes. DHP, DHT, PREG, PROG, THP
33  2006 A neuroactive steroid 5alpha-androstane-3alpha,17beta-diol regulates androgen receptor level in astrocytes. 5 alpha-DHT, AR, ERK, GFAP, MAPK, ONH, PI3K
34  2006 Increased expression of type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) and its relationship with androgen receptor in prostate carcinoma. 3alpha-HSD, AKR, PG
35  2005 Androgen receptor and NFkB expression in human normal and glaucomatous optic nerve head astrocytes in vitro and in experimental glaucoma. AR, ExpG, ONH, RGC
36  2005 Identification of the major oxidative 3alpha-hydroxysteroid dehydrogenase in human prostate that converts 5alpha-androstane-3alpha,17beta-diol to 5alpha-dihydrotestosterone: a potential therapeutic target for androgen-dependent disease. AR, DHT, HSD, RODH 4
37  2005 Isolation and characterization of a cDNA encoding mouse 3alpha-hydroxysteroid dehydrogenase: an androgen-inactivating enzyme selectively expressed in female tissues. 5alpha-dione, ADT, DHP, DHT
38  2004 5alpha-Androstane-3alpha,17beta-diol activates pathway that resembles the epidermal growth factor responsive pathways in stimulating human prostate cancer LNCaP cell proliferation. 5 alpha-DHT, EGF
39  2004 Androgens in the hippocampus can alter, and be altered by, ictal activity. ---
40  2004 HPLC-RIA analysis of steroid hormone profile in a virilizing stromal tumor of the ovary. 17alpha-H, 4-en-dione, DHT, HPLC-RIA, PROG, TEST
41  2004 Partitioning of 5alpha-dihydrotestosterone and 5alpha-androstane-3alpha, 17beta-diol activated pathways for stimulating human prostate cancer LNCaP cell proliferation. 3alpha-HSDs, 5 alpha-DHT, AR, ARGs
42  2004 The synthesis of glycoprotein Po and peripheral myelin protein 22 in sciatic nerve of male rats is modulated by testosterone metabolites. AR, PMP22
43  2003 Immunization against 5alpha-androstane-3alpha,17beta-diol affects ovarian folliculogenesis in Merino ewes. DHT
44  2003 Progesterone and its derivatives dihydroprogesterone and tetrahydroprogesterone reduce myelin fiber morphological abnormalities and myelin fiber loss in the sciatic nerve of aged rats. DHP, DHT, THP
45  2002 Androgens and fatty acid metabolism in X-linked Adrenoleukodystrophy. DHT, X-ALD
46  2002 Testosterone enhances aggression of wild-type mice but not those deficient in type I 5alpha-reductase. ---
47  2001 Modulation of the androgenic response by recombinant human 11-cis retinol dehydrogenase. 11-cis-RoDH, 3alpha-HSD, DHT, HEK293, pCMV-11-cisRoDH, PSA
48  2001 Neuroactive steroids and peripheral myelin proteins. DHT, PMP22, PROG
49  2001 Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution. ---
50  2001 The action of steroid hormones on peripheral myelin proteins: a possible new tool for the rebuilding of myelin? DHP, DHTT, PMP22, THP
51  2000 Differential androgen sensitivity is associated with clonal heterogeneity in steroid metabolism, ornithine decarboxylase regulation and IL-1alpha action in mouse mammary tumor cells. DHT, e.g. ODC, IL-1alpha, ODC
52  1999 Characterization and substrate specificity of UGT2B4 (E458): a UDP-glucuronosyltransferase encoded by a polymorphic gene. ADT, HDCA
53  1999 Metabolism of dihydrotestosterone in human liver: importance of 3alpha- and 3beta-hydroxysteroid dehydrogenase. 3alpha-HSD, 3beta-HSD, DHT
54  1998 Isolation and characterization of a simian UDP-glucuronosyltransferase UGT2B18 active on 3-hydroxyandrogens. ADT, UGT
55  1998 Sex hormone-binding globulin mediates prostate androgen receptor action via a novel signaling pathway. AE, ARs, SHBG
56  1997 Chromosomal localization, structure, and regulation of the UGT2B17 gene, encoding a C19 steroid metabolizing enzyme. ADT, DHT, EGF, PAC
57  1996 Isolation and characterization of a novel cDNA encoding a human UDP-glucuronosyltransferase active on C19 steroids. ADT
58  1979 Hormone blood levels and their inter-relationships in normal men and men with benign prostatic hyperplasia (BPH). BPH, DHT, FSH, LH, PRL, SHBG
59  1978 The effects of 5alpha-reduced androgens on maintenance and regeneration of prostate glands and seminal vesicles in castrated and hypophysectomized rats. CR
60  1977 Altered metabolism of androgens in elderly men with benign prostatic hyperplasia. BPH, CR, DHT, MCR
61  1977 Androgen metabolism by rat epididymis. Metabolic conversion of 3H 5alpha-androstane-3alpha,17beta-diol, in vitro. ---
62  1977 Synthesis of new steroid haptens for radioimmunoassay. Part III. 15beta-Carboxyethylmercaptosteroid-bovine serum albumin conjugates. Specific antisera for radioimmunoassay of 5alpha-dihydrotestosterone, 5alpha-androstane-3beta, 17beta-diol and 5alpha-androstane-3alpha, 17beta-diol. 5 alpha-DHT, BSA, RIA
63  1976 Role of testosterone and its metabolites in the differentiation of the mammary gland in rats. DHT
64  1975 Binding and metabolism of 5alpha-androstane-3alpha, 17 beta-diol and of 5alpha-androstane-3beta, 17 beta-diol in the prostate, seminal vesicles and plasma of male rats: studies in vivo and in vitro. 5 alpha-DHT
65  1975 In vivo uptake and metabolism of 3-h-5alpha-androstane-3alpha,17beta-diol and of 3-h-5alpha-androstane-3beta,17beta-diol by human prostatic hypertrophy. bph
66  1974 3Alpha-androstanediol kinetics in man. ---
67  1971 The metabolic clearance rate and origin of plasma dihydrotestosterone in man and its conversion to the 5-alpha-androstanediols. ---