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Abbreviation : 5-HETE
Long Form : 5-hydroxyeicosatetraenoic acid
No. Year Title Co-occurring Abbreviation
2022 Associations of Gut Microbiota and Fatty Metabolism With Immune Thrombocytopenia. IL-6, ITP, LC-MS, RvD2, TNF-alpha
2022 Baseline Elevations of Leukotriene Metabolites and Altered Plasmalogens Are Prognostic Biomarkers of Plaque Progression in Systemic Lupus Erythematosus. BCAA, HODE, LTB4, SLE, SLEPP
2022 Capsaicin induces redox imbalance and ferroptosis through ACSL4/GPx4 signaling pathways in U87-MG and U251 glioblastoma cells. ACSL4, BrdU, GPX4, LDH, MDA, TAS, TOS
2021 A Protective Role for Arachidonic Acid Metabolites against Advanced Colorectal Adenoma in a Phase III Trial of Selenium. ARA, PGE2, Sel
2021 ALOX5-5-HETE promotes gastric cancer growth and alleviates chemotherapy toxicity via MEK/ERK activation. ALOX5
2021 Mitochondrial aldehyde dehydrogenase (ALDH2) rescues cardiac contractile dysfunction in an APP/PS1 murine model of Alzheimer's disease via inhibition of ACSL4-dependent ferroptosis. ACSL4, AD, Sp1, TA, TC
2020 16HBE Cell Lipid Mediator Responses to Mono and Co-Infections with Respiratory Pathogens. IAV, S. aureus, S. pneumoniae
2020 Alterations in the Human Plasma Lipidome in Response to Tularemia Vaccination. DHET
2020 Ferroptosis mediated by the interaction between Mfn2 and IREα promotes arsenic-induced nonalcoholic steatohepatitis. IRE1alpha, Mfn2, NASH
10  2019 Oxylipin profiling of human plasma reflects the renal dysfunction in uremic patients. 5,6-DHET, eGFR, OPLS-DA, PCA, PUFAs, ROC
11  2018 Integrated eicosanoid lipidomics and gene expression reveal decreased prostaglandin catabolism and increased 5-lipoxygenase expression in aggressive subtypes of endometrial cancer. EC, HPGD
12  2018 Lipid Mediator Quantification in Isolated Human and Guinea Pig Airways: An Expanded Approach for Respiratory Research. ee
13  2018 The effect of n-3 fatty acids and coenzyme Q10 supplementation on neutrophil leukotrienes, mediators of inflammation resolution and myeloperoxidase in chronic kidney disease. 17-HDHA, 18-HEPE, CKD, DHA, EPA, LT, MPO, n-3 FA, RvD5, RvE1, RvE2, RvE3, SPM
14  2017 Cross-Talk between Cancer Cells and the Tumour Microenvironment: The Role of the 5-Lipoxygenase Pathway. ---
15  2017 Design and synthesis of affinity chromatography ligands for the purification of 5-hydroxyeicosanoid dehydrogenase. 5-HEDH, 5-LO, 5-oxo-ETE, AA
16  2017 Lipoxygenase Activity Accelerates Programmed Spore Germination in Aspergillus fumigatus. AA, GL, OE, SS
17  2017 Nrf2 Activation by 5-lipoxygenase Metabolites in Human Umbilical Vascular Endothelial Cells. 5-HEPE, 5-LOX, 5-oxo-ETE, AA, EPA, HUVECs, Nrf2, ROS
18  2016 Ferromagnetic particles as a rapid and robust sample preparation for the absolute quantification of seven eicosanoids in human plasma by UHPLC-MS/MS. AA, LPS, on-line SPE, PGE2, TXB2
19  2016 Identification of ACSL4 as a biomarker and contributor of ferroptosis. ACSL4
20  2016 Molecular cloning and functional characterization of arachidonate 5-lipoxygenase (Alox5), and its expression in response to the ratio of linolenic acid to linoleic acid in diets of large yellow croaker (Larmichthys crocea). AA, ALOX5, LNA, NF-kappaB
21  2015 Inhibition of long-chain acyl-CoA synthetase 4 facilitates production of 5, 11-dihydroxyeicosatetraenoic acid via the cyclooxygenase-2 pathway. 5,11-diHETE, AA, ACSLs, COX, IL-1beta, PG
22  2015 Melatonin promotes Bax sequestration to mitochondria reducing cell susceptibility to apoptosis via the lipoxygenase metabolite 5-hydroxyeicosatetraenoic acid. 5-LOX
23  2015 The Intracellular Localisation and Phosphorylation Profile of the Human 5-Lipoxygenase Delta13 Isoform Differs from That of Its Full Length Counterpart. 5-LO, CLP, LT
24  2014 Comparative analysis and modeling of the severity of steatohepatitis in DDC-treated mouse strains. 15-HETE, AA, DDC, NAFLD, PGD2, SAMe
25  2014 Effects of perioperative supplementation with omega-3 fatty acids on leukotriene B₄ and leukotriene B₅ production by stimulated neutrophils in patients with colorectal cancer: a randomized, placebo-controlled intervention trial. 5-HEPE, DHA, EPA, LTB4, LTB5, ONS
26  2014 Human cytomegalovirus infection induces leukotriene B4 and 5-lipoxygenase expression in human placentae and umbilical vein endothelial cells. 5-LO, HCMV, HCMV-IEA, HUVEC, LTB4, LTs
27  2014 [Isomeric specific analysis of hydroxyeicosatetraenoic acid in blood samples from obese patients with non-alcoholic and alcoholic steatohepatitis]. HETE, REE
28  2013 Ascorbic acid 6-palmitate: a potent inhibitor of human and soybean lipoxygenase-dependent lipid peroxidation. LOX, sLOX
29  2013 Diversity of lipid mediators in human adipose tissue depots. BMI, LT, LX, PG, PVD, Rv, s.c, SPM
30  2013 Electrophilic fatty acid species inhibit 5-lipoxygenase and attenuate sepsis-induced pulmonary inflammation. LPS, PMNL
31  2013 Inhibitor of 5-lipoxygenase, zileuton, suppresses prostate cancer metastasis by upregulating E-cadherin and paxillin. 5-LOX
32  2012 Overexpression of 5-lipoxygenase and its relation with cell proliferation and angiogenesis in 7,12-dimethylbenz(alpha)anthracene-induced rat mammary carcinogenesis. 5-LOX, BrdU LI, DMBA, LTB4
33  2012 The effect of low-dose marine n-3 fatty acids on the biosynthesis of pro-inflammatory 5-lipoxygenase pathway metabolites in overweight subjects: a randomized controlled trial. 5-HEPE, PUFA
34  2011 ALOX5 gene variants affect eicosanoid production and response to fish oil supplementation. DHA, EPA
35  2011 Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia. ACF
36  2011 The anti-inflammatory activities of an extract and compounds isolated from Platycladus orientalis (Linnaeus) Franco in vitro and ex vivo. 5-LOX, CHL, LPS, LTB4, TNF-alpha
37  2011 The effect of n-3 polyunsaturated fatty acids on leukotriene B₄ and leukotriene B₅ production from stimulated neutrophil granulocytes in patients with chronic kidney disease. 5-HEPE, CKD, PUFA
38  2011 The inhibitory activities of the components of Huang-Lian-Jie-Du-Tang (HLJDT) on eicosanoid generation via lipoxygenase pathway. 12-HHT, 5-, 15-LO, AA, HLJDT
39  2009 HPLC quantification of 5-hydroxyeicosatetraenoic acid in human lung cancer tissues. ---
40  2009 The plasma lipidomic signature of nonalcoholic steatohepatitis. LOX, NAFL, NAFLD, NASH, PC, PE, PUFA
41  2008 Formation of eicosanoids, E2/D2 isoprostanes, and docosanoids following decapitation-induced ischemia, measured in high-energy-microwaved rat brain. AA, DHA
42  2008 Measurement of prostaglandins and other eicosanoids. LT, PG, RIA, TX
43  2008 The development of methodology for clinical measurement of 5-lipoxygenase pathway intermediates from human peripheral blood mononuclear cells. 5-LO, EIA, PBMCs
44  2007 Capturing proteins that bind polyunsaturated fatty acids: demonstration using arachidonic acid and eicosanoids. LT, PUFA
45  2006 Evaluation of targeted arterial delivery of the branched chain fatty acid 12-methyltetradecanoic acid as a novel therapy for solid tumors. 12-MTA, COX-2, LOX, PGE2
46  2006 Insulin and glucose play a role in foam cell formation and function. LDL, MM-LDL, oxLDL
47  2006 Monitoring eicosanoid biosynthesis via lipoxygenase and cyclooxygenase pathways in human whole blood by single HPLC run. 12-HETE, 12-HHT, 15-HETE, LTB4
48  2006 Platelet-induced growth of human fibroblasts is associated with an increased expression of 5-lipoxygenase. 5,6-dAA, CDC, COX, DMDA, ETI, ETYA, LOX, RT-PCR
49  2005 Attenuation of breast tumor cell growth by conjugated linoleic acid via inhibition of 5-lipoxygenase activating protein. AA, CLA, FLAP
50  2005 Conjugated linoleic acid reduction of murine mammary tumor cell growth through 5-hydroxyeicosatetraenoic acid. CLA, LA
51  2005 Inhibition of 5-lipoxygenase and leukotriene C4 synthase in human blood cells by thymoquinone. LTs, TQ
52  2003 Increased neutrophil mediator release in patients with pulmonary hypertension--suppression by inhaled iloprost. fMLP, LT, PAF, PMN, PPH
53  2003 Inhibition of proliferation of PC3 cells by the branched-chain fatty acid, 12-methyltetradecanoic acid, is associated with inhibition of 5-lipoxygenase. 12-MTA, COX, LOX, PI
54  2003 Involvement of 5-lipoxygenase metabolites of arachidonic acid in cyclic AMP-stimulated steroidogenesis and steroidogenic acute regulatory protein gene expression. 5-HPETE, AA, cAMP, DBcAMP, StAR
55  2003 Platelets may inhibit leucotriene biosynthesis by human neutrophils at the integrin level. AA, LT
56  2003 Prolonged lipopolysaccharide inhibits leukotriene synthesis in peritoneal macrophages: mediation by nitric oxide and prostaglandins. COX-2, LPS, NOS
57  2002 Expression of 5-lipoxygenase in pulmonary artery endothelial cells. 5-LO, PAECs, RT-PCR
58  2002 Nigella sativa oil, nigellone and derived thymoquinone inhibit synthesis of 5-lipoxygenase products in polymorphonuclear leukocytes from rats. 5-LO, NSO, PMNL
59  2002 Staphylococcal alpha-toxin provokes neutrophil-dependent cardiac dysfunction: role of ICAM-1 and cys-leukotrienes. CPP, Cys, ICAM, LT, PMN
60  2001 Lipoxygenase-5 is overexpressed in prostate adenocarcinoma. 5-LO
61  2001 Subthreshold concentrations of anti-proteinase 3 antibodies (c-ANCA) specifically prime human neutrophils for fMLP-induced leukotriene synthesis and chemotaxis. ab, ANCA, fMLP, LT, PAF, PR3
62  2001 Synthesis of 5-oxo-6,8,11,14-eicosatetraenoic acid and identification of novel omega-oxidized metabolites in the mouse macrophage. 5-oxo-ETE
63  2001 [Differential action of non-steroidal antiinflammatory drugs on human gallbladder cyclooxygenase and lipoxygenase]. 6-keto PGF1 alpha, COX-I, INDO, LC, NSAID, PGE2, PGF2 alpha, PGs
64  2001 [Effect of nonsteroidal antiinflammatory drugs on colonic lipoxygenase and cyclooxygenase activities from patients with colonic neoplasia]. COX-1, COX-2, INDO, LC, NSAID, PG
65  2000 Human dendritic cells are a physiological source of the chemotactic arachidonic acid metabolite 5-oxo-eicosatetraenoic acid. 5-oxo-ETE, PMA
66  2000 Involvement of lipoxygenase in lysophosphatidic acid-stimulated hydrogen peroxide release in human HaCaT keratinocytes. 5-HPETE, EGF, LPA, MAP, ROS
67  1999 Biological inactivation of 5-oxo-6,8,11,14-eicosatetraenoic acid by human platelets. 5-oxo-ETE
68  1999 Cellular glutathione peroxidase as a predominant scavenger of hydroperoxyeicosatetraenoic acids in rabbit alveolar macrophages. 5-HPETE, cGPx, SDS-PAGE
69  1999 Electrospray mass spectrometric analysis of 5-hydroperoxy and 5-hydroxyeicosatetraenoic acids generated by lipid peroxidation of red blood cell ghost phospholipids. 5-HPETE, 5-oxo-ETE, tBuOOH
70  1998 5-Lipoxygenase reaction products modulate alveolar macrophage phagocytosis of Klebsiella pneumoniae. LTB4
71  1998 Action of immunoregulatory agents on 5-HETE production by cultured human amnion cells. CsA, IL-10, PG, PGE2
72  1998 Activation of human polymorphonuclear leukocytes by products derived from the peroxidation of human red blood cell membranes. 5-HPETE, PMN, RBC, t-BuOOH, TBARS
73  1998 Inhibition of icosanoid production in MC/9 mouse mast cells by n-3 polyunsaturated fatty acids isolated from edible marine algae. LTB4, LTC4
74  1998 Integrin-dependent homotypic adhesion of neutrophils. Arachidonic acid activates Raf-1/Mek/Erk via a 5-lipoxygenase- dependent pathway. ---
75  1998 Suppression of leukotriene formation in RBL-2H3 cells that overexpressed phospholipid hydroperoxide glutathione peroxidase. 5-HPETE, LTB4, LTC4, PHGPx
76  1998 Synthesis, biological effects and pathophysiological implications of the novel arachidonic acid metabolite 5-oxo-eicosatetraenoic acid (Review). 5-oxo-ETE
77  1997 Azelastine suppresses the release of arachidonic acid metabolites from cultured human umbilical vein endothelial cells. HPLC, HUVEC, LTB4, PGF2 alpha
78  1997 Discovery of 5R-lipoxygenase activity in oocytes of the surf clam, Spisula solidissima. ---
79  1997 Inhibitory effect of leukotrienes on luteinizing hormone release. 5-HPETE, GnRH, LH, LT
80  1997 Preferential esterification of endogenously formed 5-hydroxyeicosatetraenoic acid to phospholipids in activated polymorphonuclear leukocytes. PMNL
81  1997 Quantitation of 5-lipoxygenase products by electrospray mass spectrometry: effect of ethanol on zymosan-stimulated production of 5-lipoxygenase products by human neutrophils. LTB4
82  1997 Tenidap inhibits 5-lipoxygenase product formation in vitro, but this activity is not observed in three animal models. 5-LO, AA, RBL, TLC
83  1996 5-Hydroxyeicosatetraenoic acid and human parturition. AA, ASA
84  1996 Age-related enhancement of 5-lipoxygenase metabolic capacity in cattle alveolar macrophages. 5-LO, AA, AM, LT
85  1996 Arachidonic acid and lipoxygenase products stimulate protein kinase C beta mRNA levels in pituitary alpha T3-1 cell line: role in gonadotropin-releasing hormone action. AA, GnRH, LTC4, PKCbeta
86  1996 Arachidonic acid metabolism in murine lymphoma cell sublines differing in radiation sensitivity. PG
87  1996 Dietary linoleic acid-stimulated human breast cancer cell growth and metastasis in nude mice and their suppression by indomethacin, a cyclooxygenase inhibitor. LA, PG, TXB2
88  1996 Leukotriene B4 stimulates osteoclastic bone resorption both in vitro and in vivo. 5-LO
89  1996 Lung cancer cell lines inhibit leukotriene B4 production by human polymorphonuclear leukocytes at the level of phospholipase A2. 12-HETE, AA, LTB4, PLA2, PMN
90  1995 5-Lipoxygenase products modulate the activity of the 85-kDa phospholipase A2 in human neutrophils. AA, LTB4, PLA2
91  1995 Arachidonic acid metabolism in the human mast cell line HMC-1: 5-lipoxygenase gene expression and biosynthesis of thromboxane. GC-MS, LT, PG, TX
92  1995 Croconazole: an inhibitor of eicosanoid synthesis in A23187-stimulated human polymorphonuclear leukocytes and human whole blood. 12-HETE, 5-LOX, COX, HHT, LTB4, PMN
93  1995 Cyclosporin A inhibits leukotriene production in intact RBL-1 cells without inhibiting leukotriene biosynthetic enzymes. AA, CsA, HPLC, RBL-1
94  1995 Dapsone inhibits the generation of 5-lipoxygenase products in human polymorphonuclear leukocytes. 5-LOX, LTB4, PMN, RP-HPLC
95  1995 Inhibition of leukotriene production by FK506 in rat basophilic leukemia-1 cells. AA, LTB4, LTs
96  1995 Mouse spermatozoa can synthesize PGE2 and 5-HETE in vitro: stimulatory action of nitric oxide. AA, Hb, NO, NP, PGs
97  1995 Role of interferon-alpha in arachidonic acid metabolism by the rat uteri from spayed animals: effect of 17 beta-estradiol. AA, IFN, PG, TXB2
98  1995 Studies on the regulation and localization of 5-lipoxygenase in human B-lymphocytes. LT, RT
99  1995 The regulation of arachidonate lipoxygenase metabolite formation in cells derived from intrauterine tissues. AA, LTB4
100  1994 Arachidonate lipoxygenase metabolite formation in gestational tissues. LTB4, PMA