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Abbreviation : 7-DHC
Long Form : 7-dehydrocholesterol
No. Year Title Co-occurring Abbreviation
2022 7-Dehydrocholesterol Encapsulated Polymeric Nanoparticles As a Radiation-Responsive Sensitizer for Enhancing Radiation Therapy. ---
2022 Desmosterol and 7-dehydrocholesterol concentrations in post mortem brains of depressed people: The role of trazodone. HDI, MDD
2022 Engineered yeast for efficient de novo synthesis of 7-dehydrocholesterol. CRISPRi
2022 Vitamin D esters are the major form of vitamin D produced by UV irradiation in mice. UV
2021 Altered Cholesterol Biosynthesis Affects Drug Metabolism. ARI, CAR, DHCR7
2021 Biochemical and Clinical Effects of Vitamin E Supplementation in Hungarian Smith-Lemli-Opitz Syndrome Patients. 8-DHC, HPLC, SLOS
2021 Compartmentalized Reconstitution of Post-squalene Pathway for 7-Dehydrocholesterol Overproduction in Saccharomyces cerevisiae. ER, LD
2021 Cutaneous concentrations of 7-dehydrocholesterol in Hoffmann's two-toed sloths (Choloepus hoffmanni) in managed care. ---
2021 Generation and validation of a conditional knockout mouse model for the study of the Smith-Lemli-Opitz syndrome. SLOS
10  2021 Isolated autism is not an indication for Smith-Lemli-Opitz syndrome biochemical testing. ASD, SLOS
11  2021 Medication effects on developmental sterol biosynthesis. DHCR7
12  2021 Metabolic Control of Sensory Neuron Survival by the p75 Neurotrophin Receptor in Schwann Cells. DRG, SREBP2
13  2021 Selective ability of rat 7-Dehydrocholesterol reductase (DHCR7) to act on some 7-Dehydrocholesterol metabolites but not on lumisterol metabolites. 7DHP, DHCR7
14  2021 Sterol Biosynthesis Inhibition in Pregnant Women Taking Prescription Medications. DHCR7
15  2021 Sun-induced production of vitamin D3 throughout 1 year in tropical and subtropical regions: relationship with latitude, cloudiness, UV-B exposure and solar zenith angle. HPLC, SZA
16  2021 Transcriptomic Changes Associated with Loss of Cell Viability Induced by Oxysterol Treatment of a Retinal Photoreceptor-Derived Cell Line: An In Vitro Model of Smith-Lemli-Opitz Syndrome. Chol, DEGs, SLOS
17  2021 Trazodone effects on developing brain. TRZ
18  2020 (Sterol)ized Immunity: Could PI3K/AKT3 Be the Answer? IFNs
19  2020 7-dehydrocholesterol suppresses melanoma cell proliferation and invasion via Akt1/NF-kappaB signaling. BRAF
20  2020 Associations of cholesterol and vitamin D metabolites with the risk for development of high grade colorectal cancer. CRC, TC, VDMR
21  2020 Bile acid biosynthesis in Smith-Lemli-Opitz syndrome bypassing cholesterol: Potential importance of pathway intermediates. Hh, LC-MS, SLOS, Smo
22  2020 Detection of 7-Dehydrocholesterol and Vitamin D3 Derivatives in Honey. UVB
23  2020 Familial DHCR7 genotype presenting as a very mild form of Smith-Lemli-Opitz syndrome and lethal holoprosencephaly. SLOS
24  2020 Photoprotective Properties of Vitamin D and Lumisterol Hydroxyderivatives. 7DHP
25  2020 Reactive Sterol Electrophiles: Mechanisms of Formation and Reactions with Proteins and Amino Acid Nucleophiles. ---
26  2020 Role of Cholesterol and Its Immediate Biosynthetic Precursors in Membrane Dynamics and Heterogeneity: Implications for Health and Disease. MEM
27  2020 Structural Stringency and Optimal Nature of Cholesterol Requirement in the Function of the Serotonin1A Receptor. GPCR
28  2019 Desmosterolosis and desmosterol homeostasis in the developing mouse brain. ---
29  2019 Effect of sterol structure on ordered membrane domain (raft) stability in symmetric and asymmetric vesicles. DOPC
30  2019 Effects of B-Wave Ultraviolet Supplementation Using Light-Emitting Diodes on Caged Laying Hens during the Later Phase of the Laying Cycle. BMD, Ca, LEDs, UV
31  2019 Incorporation of 7-dehydrocholesterol into liposomes as a simple, universal and efficient way to enhance anticancer activity by combining PDT and photoactivated chemotherapy. Chol, PDT
32  2019 Maternal aripiprazole exposure interacts with 7-dehydrocholesterol reductase mutations and alters embryonic neurodevelopment. ARI, DHCR7, SLOS, VEH
33  2019 Small Molecule Antipsychotic Aripiprazole Potentiates Ozone-Induced Inflammation in Airway Epithelium. APZ, DHCR7
34  2019 Soluble expression, purification and biochemical characterization of a C-7 cholesterol dehydrogenase from Drosophila melanogaster. GST, MBP
35  2019 Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection. DHCR7
36  2019 The Smith-Lemli-Opitz syndrome and dentofacial anomalies diagnostic: Case reports and literature review. DHCR7, SLOS
37  2019 UV increases skin-derived 1alpha,25-dihydroxyvitamin D3 production, leading to MMP-1 expression by altering the balance of vitamin D and cholesterol synthesis from 7-dehydrocholesterol. ---
38  2019 UV light suppression of EAE (a mouse model of multiple sclerosis) is independent of vitamin D and its receptor. EAE, MS, UV, VDR
39  2018 A simple and precise method to detect sterol esterification activity of lecithin/cholesterol acyltransferase by high-performance liquid chromatography. apoAI, CV, CVD, FERHDL, HDL, HDL-C, HPLC
40  2018 Compromised phagosome maturation underlies RPE pathology in cell culture and whole animal models of Smith-Lemli-Opitz Syndrome. iPSC, RPE, SLOS
41  2018 Determining the target of membrane sterols on voltage-gated potassium channels. PD, VSD
42  2018 Dichlorophenyl piperazines, including a recently-approved atypical antipsychotic, are potent inhibitors of DHCR7, the last enzyme in cholesterol biosynthesis. ---
43  2018 Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri. PAM
44  2018 Identification and characterization of prescription drugs that change levels of 7-dehydrocholesterol and desmosterol. Chol, DES
45  2018 Metabolic engineering of Saccharomyces cerevisiae for 7-dehydrocholesterol overproduction. DHCR24, MVA
46  2018 Oxysterols and Retinal Degeneration in a Rat Model of Smith-Lemli-Opitz Syndrome: Implications for an Improved Therapeutic Intervention. SLOS
47  2018 Prevention of Retinal Degeneration in a Rat Model of Smith-Lemli-Opitz Syndrome. Chol, DHCR7, SLOS
48  2018 Temperature-dependent vitamin D signaling regulates developmental trajectory associated with diapause in an annual killifish. NRs, VDR
49  2018 Vitamin D in Nature: A Product of Synthesis and/or Degradation of Cell Membrane Components. ---
50  2017 1α-Hydroxy derivatives of 7-dehydrocholesterol are selective liver X receptor modulators. LXR
51  2017 Attenuation of UVR-induced vitamin D3 synthesis in a mouse model deleted for keratinocyte lathosterol 5-desaturase. Sc5d, UVR
52  2017 Effect of psychotropic drug treatment on sterol metabolism. 8-DHC, DHCR7
53  2017 Oxidative stress, serotonergic changes and decreased ultrasonic vocalizations in a mouse model of Smith-Lemli-Opitz syndrome. ---
54  2017 Photosensitization of TRPA1 and TRPV1 by 7-dehydrocholesterol: implications for the Smith-Lemli-Opitz syndrome. ---
55  2017 Prenatal diagnosis of holoprosencephaly associated with Smith-Lemli-Opitz syndrome (SLOS) in a 46,XX fetus. 8-DHC, SLOS
56  2017 Probes for protein adduction in cholesterol biosynthesis disorders: Alkynyl lanosterol as a viable sterol precursor. a-7-DHC, a-Chol, a-Lan, SLOS
57  2017 Propagation rate constants for the peroxidation of sterols on the biosynthetic pathway to cholesterol. SLOS
58  2017 Vitamin D levels in Smith-Lemli-Opitz syndrome. NIHCC, SLOS
59  2016 7-Dehydrocholesterol (7-DHC), But Not Cholesterol, Causes Suppression of Canonical TGF-beta Signaling and Is Likely Involved in the Development of Atherosclerotic Cardiovascular Disease (ASCVD). ASCVD, MbetaCD
60  2016 7DHC-induced changes of Kv1.3 operation contributes to modified T cell function in Smith-Lemli-Opitz syndrome. SLOS
61  2016 Cholesterol-mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis. DHCR7
62  2016 Development, behavior, and biomarker characterization of Smith-Lemli-Opitz syndrome: an update. SLOS
63  2016 Differential cytotoxic effects of 7-dehydrocholesterol-derived oxysterols on cultured retina-derived cells: Dependence on sterol structure, cell type, and density. 4HDHC, 7-Kchol, Chol, DHCEO, EPCD, mRPE, RPE, SLOS, STSP
64  2016 Effect of Sterol Structure on the Physical Properties of 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine Membranes Determined Using (2)H Nuclear Magnetic Resonance. ---
65  2016 Endogenous B-ring oxysterols inhibit the Hedgehog component Smoothened in a manner distinct from cyclopamine or side-chain oxysterols. ---
66  2016 Identification of Environmental Quaternary Ammonium Compounds as Direct Inhibitors of Cholesterol Biosynthesis. BACs, DHCR7, DSSTox
67  2016 Inhibitors of 7-Dehydrocholesterol Reductase: Screening of a Collection of Pharmacologically Active Compounds in Neuro2a Cells. SLOS
68  2016 Modeling Smith-Lemli-Opitz syndrome with induced pluripotent stem cells reveals a causal role for Wnt/beta-catenin defects in neuronal cholesterol synthesis phenotypes. iPSCs, SLOS
69  2016 New Approach to Develop Optimized Sunscreens that Enable Cutaneous Vitamin D Formation with Minimal Erythema Risk. Eer, EVD
70  2016 Plant Oils as Potential Sources of Vitamin D. ---
71  2016 Sterols and oxysterols in plasma from Smith-Lemli-Opitz syndrome patients. SLOS
72  2016 Titanium implants coated with UV-irradiated vitamin D precursor and vitamin E: invivo performance and coating stability. Vit E
73  2015 A calorimetric and spectroscopic comparison of the effects of cholesterol and its immediate biosynthetic precursors 7-dehydrocholesterol and desmosterol on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes. Chol, DES, DPPC, DSC, FTIR
74  2015 Altered lipid subfraction profile and impaired antioxidant defense of high-density lipoprotein in Smith-Lemli-Opitz syndrome. HDL, LDL, PON1, SLOS
75  2015 Androgens Attenuate Vitamin D Production Induced by UVB Irradiation of the Skin of Male Mice by an Enzymatic Mechanism. ---
76  2015 Detection of novel CYP11A1-derived secosteroids in the human epidermis and serum and pig adrenal gland. ---
77  2015 Expression of human CYP27A1 in B. megaterium for the efficient hydroxylation of cholesterol, vitamin D3 and 7-dehydrocholesterol. 27HC, AdR, Adx, PHB
78  2015 Improved human gingival fibroblast response to titanium implants coated with ultraviolet-irradiated vitamin D precursor and vitamin E. HGFs, Ti, UV, Vit E
79  2015 Influence of UVB exposure on the vitamin D status and calcium homoeostasis of growing sheep and goats. ---
80  2015 Oral intake of 7-dehydrocholesterol increases vitamin D3 concentrations in the liver and kidney. ---
81  2015 Profiling and Imaging Ion Mobility-Mass Spectrometry Analysis of Cholesterol and 7-Dehydrocholesterol in Cells Via Sputtered Silver MALDI. AgNP, MALDI, MS, SLOS
82  2015 Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome. DHCR7, SHH, SLOS, Smo
83  2015 Trends in prenatal diagnosis of non-specific multiple malformations disorders with reference to the own experience and research study on Smith-Lemli-Opitz syndrome. 8-DHC, GC/MS
84  2014 Characterization of large deletions in the DHCR7 gene. MLPA, SLOS
85  2014 Characterization of vitamin D production by human ocular barrier cells. EIA, HSF, UV, VDR
86  2014 Cholecalciferol synthesized after UV-activation of 7-dehydrocholesterol onto titanium implants inhibits osteoclastogenesis in vitro. Ti
87  2014 Elevated Autophagy and Mitochondrial Dysfunction in the Smith-Lemli-Opitz Syndrome. SLOS
88  2014 Evaluation of cytotoxic effects of 7-dehydrocholesterol on melanoma cells. ---
89  2014 Lumisterol is metabolized by CYP11A1: discovery of a new pathway. pL
90  2014 Novel activities of CYP11A1 and their potential physiological significance. ---
91  2014 Novel vitamin D photoproducts and their precursors in the skin. ---
92  2014 Rapid suppression of 7-dehydrocholesterol reductase activity in keratinocytes by vitamin D. DHCR7, HEKa, Hh
93  2014 Reactivities and products of free radical oxidation of cholestadienols. 8-DHC
94  2014 Tunneling in tocopherol-mediated peroxidation of 7-dehydrocholesterol. KIE, SLOS
95  2014 [Match of functional module with chassis in 7-dehydrocholesterol synthesis]. ---
96  2013 7-Dehydrocholesterol metabolites produced by sterol 27-hydroxylase (CYP27A1) modulate liver X receptor activity. LXR
97  2013 A highly sensitive method for analysis of 7-dehydrocholesterol for the study of Smith-Lemli-Opitz syndrome. Dhcr7, PTAD
98  2013 Aripiprazole and trazodone cause elevations of 7-dehydrocholesterol in the absence of Smith-Lemli-Opitz Syndrome. SLOS
99  2013 Cytochromes p450 and skin cancer: role of local endocrine pathways. UVB
100  2013 Hepatic isoprenoid metabolism in a rat model of Smith-Lemli-Opitz Syndrome. Chol, SLOS