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Abbreviation : ABHD6
Long Form : alpha/beta-hydrolase domain 6
No. Year Title Co-occurring Abbreviation
2022 1-, 2- and 3-AG as substrates of the endocannabinoid enzymes and endogenous ligands of the cannabinoid receptor 1. 2-AG, CB1, FAAH, MGL
2022 Semaglutide May Alleviate Hepatic Steatosis in T2DM Combined with NFALD Mice via miR-5120/ABHD6. NAFLD, T2DM
2021 Phenotypic Characterization of the Endocannabinoid-Degrading Enzyme Alpha/Beta-Hydrolase Domain 6 Knockout Rat. CRISPR, PGE2, WT
2021 Untapped endocannabinoid pharmacological targets: Pipe dream or pipeline? 2-AG, DAGL-beta, DAGLalpha, FAAH, MAGL
2020 Adipose ABHD6 regulates tolerance to cold and thermogenic programs. GL/FFA, MAG, WAT
2020 Impact of tetrahydrocannabinol on the endocannabinoid 2-arachidonoylglycerol metabolism: ABHD6 and ABHD12 as novel players in human placenta. 2-AG, AEA, DAGLalpha, MAGL
2020 Therapeutic potential of targeting alpha/beta-Hydrolase domain-containing 6 (ABHD6). 2-AG, MAG
2019 Pseudomonas aeruginosa esterase PA2949, a bacterial homolog of the human membrane esterase ABHD6: expression, purification and crystallization. 2-AG
2019 The alpha/beta-hydrolase domain 6 inhibitor WWL70 decreases endotoxin-induced lung inflammation in mice, potential contribution of 2-arachidonoylglycerol, and lysoglycerophospholipids. 2-AG, ALI
10  2018 Lysophosphatidylinositols in inflammation and macrophage activation: Altered levels and anti-inflammatory effects. cPLA2alpha, DSS, LPI, TNBS
11  2018 WWL70 protects against chronic constriction injury-induced neuropathic pain in mice by cannabinoid receptor-independent mechanisms. 2-AG, AA, CCI, COX-2, cPLA2, DRG, ELISA, MAGL, PGE2, PGES2
12  2017 Endocannabinoid hydrolases in avian HD11 macrophages identified by chemoproteomics: inactivation by small-molecule inhibitors and pathogen-induced downregulation of their activity. 2-AG, ABPP, eCBs, FAAH, MudPIT, SH
13  2017 Monoacylglycerol signalling and ABHD6 in health and disease. MAG, Munc13-1
14  2017 WWL70 attenuates PGE2 production derived from 2-arachidonoylglycerol in microglia by ABHD6-independent mechanism. 2-AG, COX-2, EAE, EIA, LPS, PGE2, PGE2-G, siRNA
15  2016 alpha/beta-Hydrolase Domain 6 in the Ventromedial Hypothalamus Controls Energy Metabolism Flexibility. 2-AG
16  2016 alpha/beta-Hydrolase domain-6 and saturated long chain monoacylglycerol regulate insulin secretion promoted by both fuel and non-fuel stimuli. GSIS, MAG
17  2016 Beyond the Direct Activation of Cannabinoid Receptors: New Strategies to Modulate the Endocannabinoid System in CNS-Related Diseases. 2-AG, AEA, CB1, CNS, ECS, ECs, FAAH, MAGL
18  2015 Activation of CB2 receptor is required for the therapeutic effect of ABHD6 inhibition in experimental autoimmune encephalomyelitis. 2-AG, EAE, MS
19  2014 ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice. 2-AG, eCB, NPY, PTZ
20  2014 alpha/beta-Hydrolase domain-6-accessible monoacylglycerol controls glucose-stimulated insulin secretion. GSIS
21  2014 Discovery of glycine sulfonamides as dual inhibitors of sn-1-diacylglycerol lipase alpha and alpha/beta-hydrolase domain 6. ABPP, DAGLalpha
22  2014 Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors. FAAH, hABHD6, LAL
23  2013 Endocannabinoid metabolism in the prefrontal cortex in schizophrenia. 2-AG
24  2013 Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6. 2-AG, PGD2-G
25  2013 The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome. 2-AG, ASOs
26  2012 Inhibitors of the endocannabinoid-degrading enzymes, or how to increase endocannabinoid's activity by preventing their hydrolysis. FAAH, MAGL, NAAA
27  2012 Selective inhibition of alpha/beta-hydrolase domain 6 attenuates neurodegeneration, alleviates blood brain barrier breakdown, and improves functional recovery in a mouse model of traumatic brain injury. 2-AG, TBI
28  2011 COX-2 and fatty acid amide hydrolase can regulate the time course of depolarization-induced suppression of excitation. ABHD12, DSI, eCB, FAAH, MGL
29  2010 Architecture of cannabinoid signaling in mouse retina. 2-AG, CRIP1a, eCBs, FAAH, MGL, NAAA
30  2010 The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors. 2-AG