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Abbreviation : ACC1
Long Form : acetyl-CoA carboxylase 1
No. Year Title Co-occurring Abbreviation
2022 A MIR17HG-derived Long Noncoding RNA Provides an Essential Chromatin Scaffold for Protein Interaction and Myeloma Growth. lncRNA, MIR17HG, MM
2022 A polysaccharide from Sargassum pallidum reduces obesity in high-fat diet-induced obese mice by modulating glycolipid metabolism. D-SPP, FAS, HFD, PPARgamma, RT-qPCR, SPP
2022 Acetyl-CoA carboxylase 1 depletion suppresses de novo fatty acid synthesis and mitochondrial β-oxidation in castration-resistant prostate cancer cells. ACACA, CRPC, PCa, ROS
2022 Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion. GLP-1
2022 Beshanzoides A-D, unprecedented cycloheptanone-containing polyketides from Penicillium commune P-4-1, an endophytic fungus of the endangered conifer Abies beshanzuensis. ACL
2022 Chronic exposure to low concentration of MC-LR caused hepatic lipid metabolism disorder. ACOX1, CD36, FASN, IL-6, MC-LR, nSREBP-1c, SCD1, TC, TG, TNF-alpha
2022 circCAPRIN1 interacts with STAT2 to promote tumor progression and lipid synthesis via upregulating ACC1 expression in colorectal cancer. circRNAs, CRC, FISH, ISH, pre-mRNAs, qPCR, STAT2
2022 Combined exposure to PM2.5 and high-fat diet facilitates the hepatic lipid metabolism disorders via ROS/miR-155/PPARγ pathway. FAS, HFD, LXRalpha, MAFLD, PA, PPARgamma, SCD1, SREBP-1, STD
2022 Comprehensive Analysis of Metabolic Isozyme Targets in Cancer. LID
10  2022 CRISPR/Cas9 Screens Reveal that Hexokinase 2 Enhances Cancer Stemness and Tumorigenicity by Activating the ACSL4-Fatty Acid β-Oxidation Pathway. ACSL4, ALDOA, FABP5, HK2
11  2022 Effects of Oat Complex High-Fiber Formula Powder on the Composition of Intestinal Microbiota and Enzyme Activities in Mice Induced by a High-Fat Diet. AMPK, FAS, LPL, SREBPs
12  2022 Fine-tuning acetyl-CoA carboxylase 1 activity through localization: functional genomics reveals a role for the lysine acetyltransferase NuA4 and sphingolipid metabolism in regulating Acc1 activity and localization. ---
13  2022 Follistatin Alleviates Hepatic Steatosis in NAFLD via the mTOR Dependent Pathway. AAV, ChREBP, DNL, FASN, FFA, FST, HFD, SREBP1
14  2022 Gestational bisphenol A exposure impairs hepatic lipid metabolism by altering mTOR/CRTC2/SREBP1 in male rat offspring. BPA, CPT1alpha, CRTC2, FAS, PPARalpha, SCD-1, SREBP-1, TC, TG
15  2022 Increased mitochondrial fission drives the reprogramming of fatty acid metabolism in hepatocellular carcinoma cells through suppression of Sirtuin 1. ACOX1, CPT1A, ELOVL6, FASN, HCC, SIRT1, SREBP1
16  2022 L-Theanine Mitigates the Harmful Effects of Excess High-Protein Diet in Rats by Regulating Protein Metabolism. aa, FA, Fabp5, HPDs, LTA, mTOR, SD
17  2022 Liquiritigenin Inhibits Lipid Accumulation in 3T3-L1 Cells via mTOR-Mediated Regulation of the Autophagy Mechanism. ATG7, FASN, LC3B, LQG, mTOR, PPARgamma, SREBP-1c
18  2022 MicroRNA-206 inhibits HCV proliferation through depressing ACC1 lipid synthesis signalling pathway. miR-206
19  2022 Mitigation of MAFLD in High Fat-High Sucrose-Fructose Fed Mice by a Combination of Genistein Consumption and Exercise Training. FBP1, GLUT2, GR, MAFLD
20  2022 No Back-up Plan: Loss of Isozyme Diversity as a Promising Therapeutic Strategy for Cancer. LID
21  2022 Organic chromium derived from the chelation of Ganoderma lucidum polysaccharide and chromium (III) alleviates metabolic syndromes and intestinal microbiota dysbiosis induced by high-fat and high-fructose diet. CD36, G6Pase, GLUT4, HFHFD, MetS, SREBP-1c, TC, TG
22  2022 Paired related homeobox 1 attenuates autophagy via acetyl-CoA carboxylase 1-regulated fatty acid metabolism in salivary adenoid cystic carcinoma. FFAs, PRRX1, SACC
23  2022 Structurally diverse glycosides of secoiridoid, bisiridoid, and triterpene-bisiridoid conjugates from the flower buds of two Caprifoliaceae plants and their ATP-citrate lyase inhibitory activities. ATP, ECD
24  2022 The Role of AMP-activated Protein Kinase in Oxytosis/Ferroptosis: Protector or Potentiator? AMPK
25  2022 Vine Tea (Ampelopsis grossedentata) Extract Attenuates CCl4 -Induced Liver Injury by Restoring Gut Microbiota Dysbiosis in Mice. ALI, HMG-CoAR, IL, iNOS, PPARgamma, qRT, TLR4, ZO-1
26  2022 Withaferin A Inhibits Fatty Acid Synthesis in Rat Mammary Tumors. ACLY, CPT1A, FASN, SREBP1
27  2022 [Cordycepin inhibits the proliferation and migration of human gastric cancer cells by suppressing lipid metabolism via AMPK and MAPK activation]. c-caspase-9, EMT, FASN, MMP-2, p-AMPK, p-JNK, SREBF1
28  2022 [Effects of Xiangqin Jiere Granules on lipid metabolism and chronic inflammation in different obesity model mice]. DGAT1, FAS, HFD, IL-6, LDL-C, MSG, qPCR, TC, TG, TNF-alpha, XQ
29  2022 [Research on the mechanism of hypoxia promoting the migration of lung adenocarcinoma A549 cells]. EMT, HIF-1alpha, LA, RT-qPCR, SREBP-1
30  2021 A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth. 6PGD, AMPK, AR, mTORC1, PPP, SREBP1
31  2021 ACC1-expressing pathogenic T helper 2 cell populations facilitate lung and skin inflammation in mice. ---
32  2021 Bioactive flavonoids and stilbenes from the leaf of Morus alba var. multicaulis. AMPKalpha, CPT1A, FAS, SCD1, TG
33  2021 Blueberry-derived exosomes-like nanoparticles ameliorate nonalcoholic fatty liver disease by attenuating mitochondrial oxidative stress. BELNs, FAS, HFD, HO-1, NAFLD, ROS
34  2021 Carnosic Acid and Carnosol Activate AMPK, Suppress Expressions of Gluconeogenic and Lipogenic Genes, and Inhibit Proliferation of HepG2 Cells. AMPK, CA, CL, FAS, G6PC, PCK1, RA, SREBP-1c
35  2021 Cuticle permeability is an important parameter for the trade-off strategy between drought tolerance and CO2 uptake in land plants. extra1, slac1
36  2021 Dapagliflozin Alleviates Hepatic Steatosis by Restoring Autophagy via the AMPK-mTOR Pathway. ACOX1, NAFLD, PA, SGLT2, ZDF
37  2021 Effect of conditioned medium from adipose derived mesenchymal stem cells on endoplasmic reticulum stress and lipid metabolism after hepatic ischemia reperfusion injury and hepatectomy in swine. ERS, HDL, HIRI, TC, TG, VLDL
38  2021 Fatty Acid Metabolism-Related lncRNAs Are Potential Biomarkers for Predicting the Overall Survival of Patients With Colorectal Cancer. ceRNA, CRC, DCA, FASN, GSVA, LASSO, lncRNAs, qRT-PCR, ROC, TG
39  2021 Inhibition of lipogenesis and induction of apoptosis by valproic acid in prostate cancer cells via the C/EBPalpha/SREBP-1 pathway. Bcl-2, FASN, SREBP-1, VPA
40  2021 Multiple omics study identifies an interspecies conserved driver for nonalcoholic steatohepatitis. ALOX12, NASH
41  2021 Quinizarin suppresses the differentiation of adipocytes and lipogenesis in vitro and in vivo via downregulation of C/EBP-beta/SREBP pathway. CPT1, FAS, HD, TG
42  2021 Rubus chingii var. suavissimus alleviates high-fat diet-induced lipid metabolism disorder via modulation of the PPARs/SREBP pathway in Syrian golden hamsters. FAS, GLUT4, LPL, PPARalpha, SCD1, SREBP1
43  2021 SREBP1-Induced Glutamine Synthetase Triggers a Feedforward Loop to Upregulate SREBP1 through Sp1 O-GlcNAcylation and Augments Lipid Droplet Formation in Cancer Cells. GS, LD, O-GlcNAcylation, Sp1, SREBP1
44  2021 Stabilization of fatty acid synthesis enzyme acetyl-CoA carboxylase 1 suppresses acute myeloid leukemia development. AML
45  2021 Surface-Displayed Amuc_1100 From Akkermansia muciniphila on Lactococcus lactis ZHY1 Improves Hepatic Steatosis and Intestinal Health in High-Fat-Fed Zebrafish. AST, FAS, IL, qPCR, SREBP-1c, TJ, TNF
46  2020 Chrysanthemum morifolium Flower Extract Inhibits Adipogenesis of 3T3-L1 Cells via AMPK/SIRT1 Pathway Activation. AMPK, C-EBPalpha, FABP4, FAS, GPDH, HCF, PPARgamma, SIRT1, SREBP-1c
47  2020 Genistin: A Novel Potent Anti-Adipogenic and Anti-Lipogenic Agent. ACL, AMPKalpha, aP2, FABP4, FAS, PPARgamma, SREBP-1c
48  2020 High-altitude chronic hypoxia ameliorates obesity-induced non-alcoholic fatty liver disease in mice by regulating mitochondrial and AMPK signaling. AMPK, CPT1, FAS, NAFLD, p-AMPK, SREBP-1c
49  2020 Impact of post-ruminally infused macronutrients on bovine mammary gland expression of genes involved in fatty acid synthesis, energy metabolism, and protein synthesis measured in RNA isolated from milk fat. aa, EIF2B5, ER, FA, FASN, ISR, mTORC1, XBP1
50  2020 Liver X receptor alpha participates in LPS-induced reduction of triglyceride synthesis in bovine mammary epithelial cells. DCMECs, FAS, LPS, LXRalpha, SREBP1
51  2020 Loss of LAMTOR1 in pancreatic beta‑cells increases glucose‑stimulated insulin secretion in mice. LAMTOR1
52  2020 Photobiomodulation (450 nm) alters the infection of periodontitis bacteria via the ROS/MAPK/mTOR signaling pathway. AMPK, CAT, IL, IL-1ra, JNK, MDA, mTOR, PBM, RNS, ROS, TAC, TNF
53  2020 Selenoneine Ameliorates Hepatocellular Injury and Hepatic Steatosis in a Mouse Model of NAFLD. FXR, GPX1, Gsta1, HMOX1, NAFLD, SCD1
54  2020 Sirtuin 3 improves fatty acid metabolism in response to high nonesterified fatty acids in calf hepatocytes by modulating gene expression. ACO, FAS, NEFA, si, SIRT3, TG
55  2020 Slow-Release H2S Donor Anethole Dithiolethione Protects Liver From Lipotoxicity by Improving Fatty Acid Metabolism. CPT1alpha, FADS, FAs, FAS, FATPs, HFD, L-FABP, SCD1
56  2020 Targeting cellular fatty acid synthesis limits T helper and innate lymphoid cell function during intestinal inflammation and infection. FA, ILC, Th
57  2020 The Dietary Replacement of Soybean Oil by Canola Oil Does Not Prevent Liver Fatty Acid Accumulation and Liver Inflammation in Mice. FA, HCD, IL, MUFAs, n-6 PUFAs, TNF-alpha
58  2020 Withania somnifera root extract inhibits fatty acid synthesis in prostate cancer cells. ACLY, CPT1A, FASN
59  2019 Absence of the beta1 subunit of AMP-activated protein kinase reduces myofibroblast infiltration of the kidneys in early diabetes. alpha-SMA, AMPK, STZ, WT
60  2019 Acetyl-CoA carboxylase 1-dependent lipogenesis promotes autophagy downstream of AMPK. ---
61  2019 Adolescent exposure to environmental level of PCBs (Aroclor 1254) induces non-alcoholic fatty liver disease in male mice. ACC2, COX-2, ER, FASN, IRE1alpha-XBP1, NAFLD, NF-kappaB, PCBs, PPARalpha
62  2019 ALOX12 inhibition sensitizes breast cancer to chemotherapy via AMPK activation and inhibition of lipid synthesis. 12S-HETE, Alox12, AMPK
63  2019 Amelioration of nonalcoholic fatty liver disease by swertiamarin in fructose-fed mice. FAS, NAFLD, Nrf2, SREBP-1, XO
64  2019 Arazyme Suppresses Hepatic Steatosis and Steatohepatitis in Diet-Induced Non-Alcoholic Fatty Liver Disease-Like Mouse Model. DGAT1, FAS, HFD, IL1B, MT, PA, SCD1, TC, TG, TNFA
65  2019 Combined Exposure to Fructose and Bisphenol A Exacerbates Abnormal Lipid Metabolism in Liver of Developmental Male Rats. ATGL, BPA, ERalpha, FAS, HSL, SREBP1, TCHO, TG
66  2019 Dietary beta-Cryptoxanthin Inhibits High-Refined Carbohydrate Diet-Induced Fatty Liver via Differential Protective Mechanisms Depending on Carotenoid Cleavage Enzymes in Male Mice. BCO1, BCX, DKO, HRCD, MATs, NAFLD, WT
67  2019 Elevated O-GlcNAcylation enhances pro-inflammatory Th17 function by altering the intracellular lipid microenvironment. IL-17A, RORgammat, Th17
68  2019 Elevating acetyl-CoA levels reduces aspects of brain aging. acetyl-CoA, AD
69  2019 Fatty Acids Regulate Porcine Reproductive and Respiratory Syndrome Virus Infection via the AMPK-ACC1 Signaling Pathway. AMP, FAs, PRRSV
70  2019 Non-alcoholic Fatty Liver Disease Induced by Perinatal Exposure to Bisphenol a Is Associated With Activated mTOR and TLR4/NF-kappaB Signaling Pathways in Offspring Rats. BPA, FAS, NAFLD, SREBP1
71  2019 Novel anti-obesity peptide (RLLPH) derived from hazelnut (Corylus heterophylla Fisch) protein hydrolysates inhibits adipogenesis in 3T3-L1 adipocytes by regulating adipogenic transcription factors and adenosine monophosphate-activated protein kinase (AMPK) activation. ACC, AMPK, aP2, C.heterophylla Fisch, FAS, HMGCR, PPARgamma, RLLPH, RT-PCR, SREBP-1c
72  2019 Pin1 Plays Essential Roles in NASH Development by Modulating Multiple Target Proteins. AMPK, IRS-1, NASH, TGF-beta
73  2019 Prolyl isomerase Pin1 binds to and stabilizes acetyl CoA carboxylase 1 protein, thereby supporting cancer cell proliferation. ACC2, FAs
74  2019 Quercetin inhibition of SREBPs and ChREBP expression results in reduced cholesterol and fatty acid synthesis in C6 glioma cells. FAS, HMGCR, QUE
75  2019 Synthesis and anti-cancer activity of ND-646 and its derivatives as acetyl-CoA carboxylase 1 inhibitors. FASyn, NSCLC
76  2019 The potential efficacy of dietary fatty acids and fructose induced inflammation and oxidative stress on the insulin signaling and fat accumulation in mice. AMPK, CRP, HOMA-IR, IL 10, IRS-1, MCP-1, MUFA, NEFA, SFA, TBARS, TG, TLR4
77  2019 Tomatidine Reduces Palmitate-Induced Lipid Accumulation by Activating AMPK via Vitamin D Receptor-Mediated Signaling in Human HepG2 Hepatocytes. AMPK, ATGL, FAS, FOXO1, NAFLD, SREBP-1c
78  2019 TSC1/mTOR-controlled metabolic-epigenetic cross talk underpins DC control of CD8+ T-cell homeostasis. acetyl-CoA, CD, DCs, IL, MHC, TSC1
79  2019 Whole-Genome Re-Sequencing of Corylus heterophylla Blank-Nut Mutants Reveals Sequence Variations in Genes Associated With Embryo Abortion. DMS3, SNP, SS4, UGT74E2
80  2019 Yangonin protects against non-alcoholic fatty liver disease through farnesoid X receptor. FAS, FXR, G6Pase, GSK-3beta, HFD, NAFLD, PDase, PEPCK, SCD1, SREBP-1c
81  2018 Adaptations of hepatic lipid metabolism and mitochondria in dairy cows with mild fatty liver. ACO, ATP, COXIV, CPT1A, FAS, NRF1, PA, PGC-1alpha, PPARalpha, SREBP-1c, VDAC1
82  2018 Buffering agent via insulin-mediated activation of PI3K/AKT signaling pathway to regulate lipid metabolism in lactating goats. FAS, HC, NEFA, PI3K, SARA, SREBP-1c
83  2018 Cholic Acid Supplementation of a High-Fat Obesogenic Diet Suppresses Hepatic Triacylglycerol Accumulation in Mice via a Fibroblast Growth Factor 21-Dependent Mechanism. CA, FGF21, FGF21KO, HFD, HOMA-IR, HSL, TG, WT
84  2018 Disrupted sphingolipid metabolism following acute clozapine and olanzapine administration. CerS2, ELOVL1, ER, ESI, FAS, IRE1, SGAs
85  2018 Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass. mTOR
86  2018 Expression patterns of hepatic genes involved in lipid metabolism in cows with subclinical or clinical ketosis. ACSL1, BHB, CK, CPT1A, CPT2, DGAT1, DGAT2, FAS, PPARA, SCD1, SCK, SREBP1, TG
87  2018 Genome-wide association analysis of the lipid and fatty acid metabolism regulatory network in the mesocarp of oil palm (Elaeis guineensis Jacq.) based on small noncoding RNA sequencing. ECR, ENR, FA, GPAT, KCS12, kn-miRNAs, LACS9, miRNAs, ncRNA, PAP1, SPL
88  2018 Heat stress decreases metabolic flexibility in skeletal muscle of growing pigs. beta-HAD, FI, HS, PDH, PF, Tb, TN
89  2018 Identification of a highly neurotoxic alpha-synuclein species inducing mitochondrial damage and mitophagy in Parkinson's disease. PD, PFFs
90  2018 Impact of systemic and tumor lipid metabolism on everolimus efficacy in advanced pancreatic neuroendocrine tumors (pNETs). FASN, FFPE, PFS, PNETs
91  2018 Prostate cancer chemoprevention by sulforaphane in a preclinical mouse model is associated with inhibition of fatty acid metabolism. CPT1A, FASN, SFN, TRAMP
92  2018 Protection by the Total Flavonoids from Rosa laevigata Michx Fruit against Lipopolysaccharide-Induced Liver Injury in Mice via Modulation of FXR Signaling. ALT, AST, COX-2, CPT1, FASN, FXR, GCLC, GCLM, HMGB1, HO-1, LPS, nuclear factor-kappa B, SCD1, TC, TFs
93  2018 Short-term propamocarb exposure induces hepatic metabolism disorder associated with gut microbiota dysbiosis in adult male zebrafish. ACO, Apo, Dgat, FAS, HK1, PK, PM, PPAR-alpha, TG
94  2018 Sulforaphane Improves Abnormal Lipid Metabolism via Both ERS-Dependent XBP1/ACC &SCD1 and ERS-Independent SREBP/FAS Pathways. PERK, SCD1, SFN, SREBP-1c, XBP1
95  2018 Taxifolin binds with LXR (alpha & beta) to attenuate DMBA-induced mammary carcinogenesis through mTOR/Maf-1/PTEN pathway. DMBA, FASN, HMG-CoAR, LXR, MC, PI3K, TAX
96  2018 Translational control of human acetyl-CoA carboxylase 1 mRNA is mediated by an internal ribosome entry site in response to ER stress, serum deprivation or hypoxia mimetic CoCl2. 5'UTR, ER, IRES, UPR
97  2017 Cytosolic acetyl-CoA promotes histone acetylation predominantly at H3K27 in Arabidopsis. acetyl-CoA, ATP, H3K27ac
98  2017 Dietary alpha-lactalbumin induced fatty liver by enhancing nuclear liver X receptor alphabeta/sterol regulatory element-binding protein-1c/PPARgamma expression and minimising PPARalpha/carnitine palmitoyltransferase-1 expression and AMP-activated protein kinase alpha phosphorylation associated with atherogenic dyslipidaemia, insulin resistance and oxidative stress in Balb/c mice. alpha-Lac, AMPKalpha, CPT-1, FAO, IR, LXRalphabeta, SREBP-1c
99  2017 ERK1 and ERK2 activation modulates diet-induced obesity in mice. FAS, HFD, HOMA-IR, MAP, WT
100  2017 Fatty Acid Synthesis Intermediates Represent Novel Noninvasive Biomarkers of Prostate Cancer Chemoprevention by Phenethyl Isothiocyanate. CPT1A, FASN, PEITC, TRAMP