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Abbreviation : ACL
Long Form : ATP citrate lyase
No. Year Title Co-occurring Abbreviation
2022 Bempedoic acid in patients with type 2 diabetes mellitus, prediabetes, and normoglycaemia: A post hoc analysis of efficacy and glycaemic control using pooled data from phase 3 clinical trials. ---
2022 Beshanzoides A-D, unprecedented cycloheptanone-containing polyketides from Penicillium commune P-4-1, an endophytic fungus of the endangered conifer Abies beshanzuensis. ACC1
2022 Disruption of the Snf1 Gene Enhances Cell Growth and Reduces the Metabolic Burden in Cellulase-Expressing and Lipid-Accumulating Yarrowia lipolytica. CBP, DGA1, FAME, Snf1
2022 Ellagic acid ameliorates high fructose-induced hyperuricemia and non-alcoholic fatty liver in Wistar rats: Focusing on the role of C1q/tumor necrosis factor-related protein-3 and ATP citrate lyase. CTRP3, FAS, HF, HFD, IR, MDA, NAFLD, p-AMPK, XO
2022 Pyruvate Dehydrogenase A1 Phosphorylated by Insulin Associates with Pyruvate Kinase M2 and Induces LINC00273 through Histone Acetylation. EMT, HAT, LINC, p-PDHA1, PDC, PDH, PKM2
2021 Bempedoic Acid in the Treatment of Patients with Dyslipidemias and Statin Intolerance. ACSVD, i-PSCK9, LDL-C
2021 Forrestiacids A and B, Pentaterpene Inhibitors of ACL and Lipogenesis: Extending the Limits of Computational NMR Methods in the Structure Assignment of Complex Natural Products. MoIN
2021 Global Transcriptome Profile of the Oleaginous Yeast Saitozyma podzolica DSM 27192 Cultivated in Glucose and Xylose. ---
2021 Novel Strategy of Proxalutamide for the Treatment of Prostate Cancer through Coordinated Blockade of Lipogenesis and Androgen Receptor Axis. ACC, AR, FASN, PCa, SREBP-1
10  2020 Comparative Metabolites and Citrate-Degrading Enzymes Activities in Citrus Fruits Reveal the Role of Balance between ACL and Cyt-ACO in Metabolite Conversions. cyt-ACO
11  2020 Distinct dual roles of p-Tyr42 RhoA GTPase in tau phosphorylation and ATP citrate lyase activation upon different Abeta concentrations. AD, NADK, p-Ser422 Tau, p-Tau, SREBP1
12  2020 Effects of PKB/Akt inhibitors on insulin-stimulated lipogenesis and phosphorylation state of lipogenic enzymes in white adipose tissue. ACC, PDH, PKB
13  2020 Enhancement of docosahexaenoic acid production by overexpression of ATP-citrate lyase and acetyl-CoA carboxylase in Schizochytrium sp. ACC, DHA
14  2020 Genistin: A Novel Potent Anti-Adipogenic and Anti-Lipogenic Agent. ACC1, AMPKalpha, aP2, FABP4, FAS, PPARgamma, SREBP-1c
15  2020 Identification and importance of mitochondrial citrate carriers and ATP citrate lyase for glycolipid production in Starmerella bombicola. FAS
16  2020 Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii. ACS, BCKDH, PDH
17  2020 PaACL silencing accelerates flower senescence and changes the proteome to maintain metabolic homeostasis in Petunia hybrida. ---
18  2020 Stewartiacids A-N, C-23 carboxylated triterpenoids from Chinese Stewartia and their inhibitory effects against ATP-citrate lyase and NF-κB. ECD
19  2020 The Drosophila Citrate Lyase Is Required for Cell Division during Spermatogenesis. ---
20  2019 A role for ATP Citrate Lyase in cell cycle regulation during myeloid differentiation. FASN
21  2019 Allopurinol Prevents the Lipogenic Response Induced by an Acute Oral Fructose Challenge in Short-Term Fructose Fed Rats. ACC, AMPK, CIDEC, eNOS, FAS, NAFLD
22  2019 ATP-citrate lyase is an epigenetic regulator to promote obesity-related kidney injury. CKD, ELA
23  2019 Cytosolic Acetyl-CoA Generated by ATP-Citrate Lyase Is Essential for Acetylation of Cell Wall Polysaccharides. RWA
24  2019 Earlier Degraded Tapetum1 (EDT1) Encodes an ATP-Citrate Lyase Required for Tapetum Programmed Cell Death. edt1, EDT1, PCD
25  2019 GSK-3beta at the Crossroads in Regulating Protein Synthesis and Lipid Deposition in Zebrafish. ACC, FAS, HMGCR, mTOR, NEFA, PPARgamma, S6K1, TC, TG, TSC2
26  2019 Lack of adipose-specific hexose-6-phosphate dehydrogenase causes inactivation of adipose glucocorticoids and improves metabolic phenotype in mice. ACC, ATGL, FFA, GC, H6PDH, H6PDH, HSL, MS
27  2019 Metabolic engineering with ATP-citrate lyase and nitrogen source supplementation improves itaconic acid production in Aspergillus niger. ---
28  2019 Phytochemical and biological studies on rare and endangered plants endemic to China. Part XV. Structurally diverse diterpenoids and sesquiterpenoids from the vulnerable conifer Pseudotsuga sinensis. ECD
29  2019 Transcriptome analysis of the dimorphic transition induced by pH change and lipid biosynthesis in Trichosporon cutaneum. DCW, ICL, IDH, Mae
30  2019 Wnt10b Participates in Regulating Fatty Acid Synthesis in the Muscle of Zebrafish. ACC, FAS, GSK-3beta, NEFA, PPARgamma, TC, TG
31  2018 ATP Citrate Lyase: A New Player Linking Skeletal Muscle Metabolism and Epigenetics. acetyl-CoA
32  2018 Effects of hot air treatment and chitosan coating on citric acid metabolism in ponkan fruit during cold storage. GABA, TA
33  2018 First evidence for a multienzyme complex of lipid biosynthesis pathway enzymes in Cunninghamella bainieri. ACC, BN, FAS, MDH, ME, PC
34  2018 OsACL-A2 negatively regulates cell death and disease resistance in rice. EMS, spl30-1, UPS
35  2018 RIPK3 promotes kidney fibrosis via AKT-dependent ATP citrate lyase. AD-induced, CKD, MLKL, RIPK3, UUO-induced
36  2018 The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase. BCAA, BCKDH
37  2017 ATP Citrate Lyase Regulates Myofiber Differentiation and Increases Regeneration by Altering Histone Acetylation. SC
38  2017 ATP-citrate lyase is essential for high glucose-induced histone hyperacetylation and fibrogenic gene upregulation in mesangial cells. CTGF, ECM, GFP, HG, MCs
39  2017 Discovery of furan carboxylate derivatives as novel inhibitors of ATP-citrate lyase via virtual high-throughput screening. ---
40  2017 Growth kinetics, fatty acid composition and metabolic activity changes of Crypthecodinium cohnii under different nitrogen source and concentration. FAS, G6PDH, ME
41  2017 Isoprenoid biosynthesis in dandelion latex is enhanced by the overexpression of three key enzymes involved in the mevalonate pathway. AACT, HMGR, MVA
42  2017 Targeting ATP-Citrate Lyase in Hyperlipidemia and Metabolic Disorders. ASCVD, CoA, NAFLD
43  2016 ATP citrate lyase mediated cytosolic acetyl-CoA biosynthesis increases mevalonate production in Saccharomyces cerevisiae. ---
44  2016 Bempedoic Acid (ETC-1002): an Investigational Inhibitor of ATP Citrate Lyase. LDL-C
45  2016 Design and synthesis of emodin derivatives as novel inhibitors of ATP-citrate lyase. SAR
46  2016 Fatty acid biosynthesis during the life cycle of Debaryomyces etchellsii. ME, NL, NLM, NRM
47  2016 Global iTRAQ-based proteomic profiling of Toxoplasma gondii oocysts during sporulation. DEPs, DHFR-TS, IMPDH
48  2016 Lipogenesis in a wing-polymorphic cricket: Canalization versus morph-specific plasticity as a function of nutritional heterogeneity. ---
49  2016 Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis. AMPK, LDL-C
50  2016 Metabolic Flux Analysis of Lipid Biosynthesis in the Yeast Yarrowia lipolytica Using 13C-Labled Glucose and Gas Chromatography-Mass Spectrometry. ---
51  2016 mTOR complex-2 stimulates acetyl-CoA and de novo lipogenesis through ATP citrate lyase in HER2/PIK3CA-hyperactive breast cancer. mTOR, mTORC1, mTORC2
52  2016 Oncometabolite d-2-hydroxyglutarate impairs alpha-ketoglutarate dehydrogenase and contractile function in rodent heart. d-2HG
53  2015 Acetyl-CoA synthetase is activated as part of the PDH-bypass in the oleaginous green alga Chlorella desiccata. AcCoA, ptACS, ptPDH, TAG
54  2015 Analysis of ATP-citrate lyase and malic enzyme mutants of Yarrowia lipolytica points out the importance of mannitol metabolism in fatty acid synthesis. FA, Mae
55  2015 ATP citrate lyase improves mitochondrial function in skeletal muscle. ---
56  2015 BNIP-H Recruits the Cholinergic Machinery to Neurite Terminals to Promote Acetylcholine Signaling and Neuritogenesis. ACh, ChAT
57  2015 Comparison of Biochemical Activities between High and Low Lipid-Producing Strains of Mucor circinelloides: An Explanation for the High Oleaginicity of Strain WJ11. CDW, GLA
58  2015 Gene fusion, fission, lateral transfer, and loss: Not-so-rare events in the evolution of eukaryotic ATP citrate lyase. ssACL
59  2015 Molecular cloning and characterization of the ATP citrate lyase from carotenogenic yeast Phaffia rhodozyma. ---
60  2015 White Adipose Tissue Depot-Specific Activity of Lipogenic Enzymes in Response to Fasting and Refeeding in Young and Old Rats. FAS, G6PD, WAT
61  2015 [BAY11-7082 inhibits proliferation and promotes apoptosis in breast carcinoma MCF-7 cells by inhibiting phosphorylation of ATP citrate lyase]. p-ACL, p-Akt, p-NF-kappaB
62  2014 ATP citrate lyase activity is post-translationally regulated by sink strength and impacts the wax, cutin and rubber biosynthetic pathways. PHB
63  2014 Docking study of novel antihyperlipidemic thieno[2,3-d]pyrimidine; LM-1554, with some molecular targets related to hyperlipidemia - an investigation into its mechanism of action. CRP, FXR, NPC1L1, SqS
64  2014 Enhanced lipid accumulation in the yeast Yarrowia lipolytica by over-expression of ATP:citrate lyase from Mus musculus. ---
65  2014 Genome and transcriptome analysis of the basidiomycetous yeast Pseudozyma antarctica producing extracellular glycolipids, mannosylerythritol lipids. MELs
66  2014 Glycogen Synthase Kinase 3 Inactivation Induces Cell Senescence through Sterol Regulatory Element Binding Protein 1-Mediated Lipogenesis in Chang Cells. DFO, GSK-3alpha, SREBP1
67  2014 Hepatic carboxylesterase 1 is induced by glucose and regulates postprandial glucose levels. CES1
68  2014 Investigation of fatty acid accumulation in the engineered Saccharomyces cerevisiae under nitrogen limited culture condition. ---
69  2014 Short-term calorie restriction and refeeding differently affect lipogenic enzymes in major white adipose tissue depots of young and old rats. FAS, G6PD, SCR, WAT
70  2014 Strategic feeding of ammonium and metal ions for enhanced GLA-rich lipid accumulation in Cunninghamella bainieri 2A1. FAS, ME
71  2014 Transcriptome and metabolome analyses of sugar and organic acid metabolism in Ponkan (Citrus reticulata) fruit during fruit maturation. AST, GABA, GAD, SPS
72  2013 ATP citrate lyase knockdown impacts cancer stem cells in vitro. EMT, KD, MAPK, PI3K
73  2013 Batten disease is linked to altered expression of mitochondria-related metabolic molecules. BD, PDH, PEPCK
74  2013 Correlation of ATP citrate lyase and acetyl CoA levels with trichothecene production in Fusarium graminearum. ---
75  2013 DNMT1 is regulated by ATP-citrate lyase and maintains methylation patterns during adipocyte differentiation. acetyl-CoA, DNMT1, miR-148a
76  2013 Fatty acid shifts and metabolic activity changes of Schizochytrium sp. S31 cultured on glycerol. FA, GK, ME
77  2013 Metabolic engineering for enhanced fatty acids synthesis in Saccharomyces cerevisiae. TCA cycle
78  2013 Metagenome sequence analysis of filamentous microbial communities obtained from geochemically distinct geothermal channels reveals specialization of three aquificales lineages. CCL, CCS, YNP
79  2013 Strain design of Ashbya gossypii for single-cell oil production. CoA, FAs, SCO
80  2012 Acetylcholine content and viability of cholinergic neurons are influenced by the activity of protein histidine phosphatase. PHP
81  2012 Comparative proteomic analysis of pistil abortion in Japanese apricot (Prunus mume Sieb. et Zucc). CCoAOMT, GO, SAM, SHT, XTHs
82  2012 De novo lipogenesis in adipose tissue is associated with course of morbid obesity after bariatric surgery. ACC1, ACSS2, SAT, VAT
83  2012 On the catalytic mechanism of human ATP citrate lyase. CoA
84  2012 Potential predictive biomarkers of obesity in Burmese cats. DSHs, FAS, PBLs, SREBP-1c
85  2012 Prognostic and therapeutic implications of increased ATP citrate lyase expression in human epithelial ovarian cancer. ---
86  2011 Exercise training enhances rat pancreatic islets anaplerotic enzymes content despite reduced insulin secretion. CTL, GDH, GSIS, PDH, PDK4, PYC, TRE1, TRE3
87  2011 Functional analyses of two acetyl coenzyme A synthetases in the ascomycete Gibberella zeae. acetyl-CoA
88  2011 Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K)/AKT pathways. HMG-CoA, MAPK, NSCLC, PI3K
89  2011 Ionising radiation triggers fat accumulation in white adipose tissue. ACC, DGAT1, DGAT2, FAS, G6PD2, Gy, LEP, ME1, mRNA, RT-PCR, SREBP-1c
90  2011 Lipogenic gene expression in abdominal adipose and liver tissues of diet-induced overweight cats. FAS
91  2010 Carbon metabolism-mediated myogenic differentiation. H6PD
92  2010 Deficiency in hepatic ATP-citrate lyase affects VLDL-triglyceride mobilization and liver fatty acid composition in mice. ---
93  2010 Effects of early neonatal development and delayed feeding immediately post-hatch on the hepatic lipogenic program in broiler chicks. ACCalpha, ChREB, FAS, LXR, ME, PH, PPARgamma, SCD-1, SREBP-2
94  2010 Human cytomegalovirus activates glucose transporter 4 expression to increase glucose uptake during infection. GLUTs, HCMV, HFs
95  2010 Regulation of glucose- and mitochondrial fuel-induced insulin secretion by a cytosolic protein histidine phosphatase in pancreatic beta-cells. PHP
96  2010 Reversible acetylation of PGC-1: connecting energy sensors and effectors to guarantee metabolic flexibility. AMPK, NAD, PGC
97  2009 A novel direct homogeneous assay for ATP citrate lyase. ---
98  2009 Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice. CoA, NAFLD
99  2009 AMP-activated protein kinase and carbohydrate response element binding protein: a study of two potential regulatory factors in the hepatic lipogenic program of broiler chickens. ACCalpha, AMPK, ChREBP, FAS, ME, SCD-1, SREBP-1
100  2009 ATP-citrate lyase activity and carotenoid production in batch cultures of Phaffia rhodozyma under nitrogen-limited and nonlimited conditions. DO