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Abbreviation : APOE
Long Form : apolipoprotein E
No. Year Title Co-occurring Abbreviation
2021 A combination of single nucleotide polymorphisms is associated with the interindividual variability in the blood lipid response to dietary fatty acid consumption in a randomized clinical trial. CHO, MUFAs, PUFAs, SFAs, SNPs, TG
2021 A cross-sectional examination of a family history of Alzheimer's disease and ApoE epsilon 4 on physical fitness, molecular biomarkers, and neurocognitive performance. AD, ERP
2021 A longitudinal 18F-fluorodeoxyglucose (18F-FDG) and 18F-sodium fluoride (18F-NaF) positron emission tomography/computed tomography (PET/CT) study in apolipoprotein E (ApoE) knockout rats fed with a Western diet. 18F-FDG, HIF-1alpha, MRI, PET/CT, VOIs
2021 A quadratic function of activation in individuals at risk of Alzheimer's disease. AD, fMRI, MCI
2021 Accelerated Brain Aging in Mild Traumatic Brain Injury: Longitudinal Pattern Recognition with White Matter Integrity. brain-PAD, mTBI
2021 Alzheimer's disease: from basic science to precision medicine approach. AD, CSF
2021 ApoE and ApoE Nascent-Like HDL Particles at Model Cellular Membranes: Effect of Protein Isoform and Membrane Composition. ApoA1, POPC, rHDL
2021 APOE and MAPT Are Associated With Dementia in Neuropathologically Confirmed Parkinson's Disease. MAPT
2021 APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function. AD, ARIA, CAA
10  2021 APOE signaling in neurodegenerative diseases: an integrative approach targeting APOE coding and noncoding variants for disease intervention. ---
11  2021 ApoE-Targeting Increases the Transfer of Solid Lipid Nanoparticles with Donepezil Cargo across a Culture Model of the Blood-Brain Barrier. BBB, CNS, NPs
12  2021 APOE2 mitigates disease-related phenotypes in an isogenic hiPSC-based model of Alzheimer's disease. AD, APP, GWAS, hiPSC
13  2021 APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia. AD, iPSC
14  2021 APOE: The New Frontier in the Development of a Therapeutic Target towards Precision Medicine in Late-Onset Alzheimer's. AD, LOAD
15  2021 Apolipoprotein E (APOE) ε4 moderates the relationship between c-reactive protein, cognitive functioning, and white matter integrity. CRP, DTI
16  2021 Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanoparticles. DSPC, LNPs, mRNA-LNPs
17  2021 Apolipoprotein E deficiency induces a progressive increase in tissue iron contents with age in mice. AD, KO, Nrf2, p-ERK, TfR1
18  2021 Apolipoprotein E genotype predicts subarachnoid extension in spontaneous intracerebral haemorrhage. CI, ICH, OR, SAHE
19  2021 Apolipoprotein E genotype-dependent nutrigenetic effects to prebiotic inulin for modulating systemic metabolism and neuroprotection in mice via gut-brain axis. BBB, E4FAD mice
20  2021 Apolipoprotein E homozygous ε4 allele status: Effects on cortical structure and white matter integrity in a young to mid-age sample. AD
21  2021 Apolipoprotein E isoform-dependent effects on the processing of Alzheimer's amyloid-β. ---
22  2021 Apolipoprotein E Polymorphism and Frailty: Apolipoprotein ε4 Allele Is Associated with Fatigue but Not Frailty Syndrome in a Community-Dwelling Older Population Cohort. FI
23  2021 Apolipoprotein E Polymorphism and Oxidative Stress in Human Peripheral Blood Cells: Can Physical Activity Reactivate the Proteasome System through Epigenetic Mechanisms? AD, AOC, Nrf2
24  2021 Apolipoprotein E promotes immune suppression in pancreatic cancer through NF-kB-mediated production of CXCL1. PDA, TAM
25  2021 Apolipoprotein E variants correlate with the clinical presentation of paediatric inflammatory bowel disease: A cross-sectional study. IBD
26  2021 Apolipoprotein E ε4 Allele-Based Differences in Brain Volumes Are Largely Uniform Across Late Middle Aged and Older Hispanic/Latino- and Non-Hispanic/Latino Whites Without Dementia. AD
27  2021 Apolipoprotein E ϵ4 allele and neuropsychiatric symptoms among older adults in Central Africa (EPIDEMCA study). CAR, MCI, PCR, RoC, SSA
28  2021 Apolipoprotein E4 Reduction with Antisense Oligonucleotides Decreases Neurodegeneration in a Tauopathy Model. ASOs, NfL
29  2021 Apolipoprotein ɛ4 Status and Brain Structure 12 Months after Mild Traumatic Injury: Brain Age Prediction Using Brain Morphometry and Diffusion Tensor Imaging. DTI, FA, FDR, mTBI, TBI
30  2021 Application of the ATN classification scheme in a population without dementia: Findings from the EPAD cohort. AD, ATN, EPAD
31  2021 Arterial Blood Pressure Variability and Other Vascular Factors Contribution to the Cognitive Decline in Parkinson's Disease. BP, COMT, HHcy, PD, VEGF, WMH
32  2021 Association Analysis of Polymorphisms in BIN1, MC1R, STARD6 and PVRL2 with Mild Cognitive Impairment in Elderly Carrying APOE ε4 Allele. MCI
33  2021 Association between methylation of BIN1 promoter in peripheral blood and preclinical Alzheimer's disease. BIN1, CABLE, CN, CSF, LOAD, SCD, SNPs
34  2021 Association Between Serum Lipid Levels and Patients With Primary Angle-Closure Glaucoma in China: A Cross Sectional, Case-Control Study. ApoA, apoB, Chol, CI, HDL-C, LDL-C, Lpa, OR, PACG, sdLDL-C, TRIG
35  2021 Association of Aortic Stiffness With Biomarkers of Neuroinflammation, Synaptic Dysfunction, and Neurodegeneration. CSF, NfL, p-tau, PWV, t-tau
36  2021 Association of apoE gene polymorphisms with lipid metabolism in renal diseases. HDL, LDL, TC, TG
37  2021 Association of Apolipoprotein E Gene Polymorphism with Lipid Profile and Ischemic Stroke Risk in Type 2 Diabetes Mellitus Patients. HDL-C, IS, LDL-C, T2DM, TC
38  2021 Association of Apolipoprotein E Polymorphisms and Risks of Ischemic Stroke in Chinese Patients with Type 2 Diabetes Mellitus. DBP, IS, SBP, T2DM
39  2021 Association of apolipoprotein E variation with cognitive impairment across multiple neurodegenerative diagnoses. FTD
40  2021 Association of dietary fat composition with cognitive performance and brain morphology in cognitively healthy individuals. CVLT, GMV, MRI, SFA
41  2021 Association of laboratory parameters and genetic polymorphisms with ischemic stroke in Chinese Han population. ACE, beta-Fg, IS, LDL-C, MTHFR, PAI
42  2021 Association of Midlife Depressive Symptoms with Regional Amyloid-β and Tau in the Framingham Heart Study. CES-D, PET
43  2021 Associations between APOE-, COMT Val108/158Met- and BDNF Val66Met polymorphisms and variations in depressive and anxiety symptoms, sense of coherence and vital exhaustion in the real-life setting of mandatory basic military training. BDNF, COMT, SNPs, SOC, VE
44  2021 Associations between neighborhood greenspace and brain imaging measures in non-demented older adults: the Cardiovascular Health Study. CHS, MRI, SD
45  2021 Associations of Vascular Risk Factors, APOE and TOMM40 Polymorphisms With Cognitive Function in Dementia-Free Chinese Older Adults: A Community-Based Study. HDL-C, LDL-C, MMSE, TC, TG, TOMM40, VRFs
46  2021 Astrocyte-derived extracellular vesicles enhance the survival and electrophysiological function of human cortical neurons in vitro. EVs, G6PD, hiPSCs, KIF5B, LRP1, SPTAN1
47  2021 Based on biomedical index data: Risk prediction model for prostate cancer. OR, ROC, TG, tPSA
48  2021 Baseline cognition is the best predictor of 4-year cognitive change in cognitively intact older adults. BDNF, F-PACK
49  2021 BIN1 rs744373 SNP and COVID-19 mortality. AD, BIN1, CHD, PDB, SNPs, UKB
50  2021 Brain health registry GenePool study: A novel approach to online genetics research. AD, BHR, BHR-GPS, HM, HT, NC
51  2021 Cholesterol, Atherosclerosis, and APOE in Vascular Contributions to Cognitive Impairment and Dementia (VCID): Potential Mechanisms and Therapy. AD, BBB, CAS, VCID
52  2021 Cognitively normal APOE ε4 carriers have specific elevation of CSF SNAP-25. AD, CSF, NfL, Ng, p-tau181, SNAP-25, t-tau
53  2021 Coix lacryma-jobi Seed Oil Reduces Fat Accumulation in Nonalcoholic Fatty Liver Disease by Inhibiting the Activation of the p-AMPK/SePP1/apoER2 Pathway. AMP, apoER, CLS, CLSO, ER, HDL, MDA, NAFLD, OP, SEPP1, SOD, TC, TG, TM
54  2021 Conformational Reorganization of Apolipoprotein E Triggered by Phospholipid Assembly. LDLR, SAXS
55  2021 COVID-19 enters the expanding network of apolipoprotein E4-related pathologies. CFR
56  2021 Critical Molecular and Cellular Contributors to Tau Pathology. AD, MAPT
57  2021 Culture Variabilities of Human iPSC-Derived Cerebral Organoids Are a Major Issue for the Modelling of Phenotypes Observed in Alzheimer's Disease. AD, iPSCs
58  2021 Diagnostic Accuracy of Serum Calcitonin Gene-Related Peptide and Apolipoprotein E in Migraine: A Preliminary Study. CGRP, ROC
59  2021 Dissecting the role of Amerindian genetic ancestry and the ApoE ε4 allele on Alzheimer disease in an admixed Peruvian population. AD, AI
60  2021 Dual Effect of PER2 C111G Polymorphism on Cognitive Functions across Progression from Subjective Cognitive Decline to Mild Cognitive Impairment. MCI, PER2, SCD
61  2021 Effects of APOE ε2 on the Fractional Amplitude of Low-Frequency Fluctuation in Mild Cognitive Impairment: A Study Based on the Resting-State Functional MRI. AD, fALFF, FDG-PET, HC, IPL, MCI
62  2021 Elevated Inflammatory Markers and Arterial Stiffening Exacerbate Tau but Not Amyloid Pathology in Older Adults with Mild Cognitive Impairment. Abeta42, AD, CN, MCI, p-tau, PP, t-tau
63  2021 Event-Related Potentials, Inhibition, and Risk for Alzheimer's Disease Among Cognitively Intact Elders. AD, ERP
64  2021 Exercise as Potential Therapeutic Target to Modulate Alzheimer's Disease Pathology in APOE ε4 Carriers: A Systematic Review. AD
65  2021 Expression and secretion of apoE isoforms in astrocytes and microglia during inflammation. ---
66  2021 From adsorption to covalent bonding: Apolipoprotein E functionalization of polymeric nanoparticles for drug delivery across the blood-brain barrier. BBB, LDL, NPs
67  2021 Generation of APOE knock-down SK-N-SH human neuroblastoma cells using CRISPR/Cas9: a novel cellular model relevant to Alzheimer's disease research. AD, HtrA1, KD
68  2021 Glaucoma as Neurodegeneration in the Brain. AD, CTE, POAG
69  2021 Glycolytic Metabolism, Brain Resilience, and Alzheimer's Disease. AD
70  2021 Harnessing the paradoxical phenotypes of APOE ɛ2 and APOE ɛ4 to identify genetic modifiers in Alzheimer's disease. AD, LOAD
71  2021 Helper lipid structure influences protein adsorption and delivery of lipid nanoparticles to spleen and liver. DOPE, DSPC, LNPs, QCM-D
72  2021 Hyperlipidemic myeloma, a rare form of acquired dysbetalipoproteinemia, in an HIV seropositive African female. DBL, HLM
73  2021 Hyperphosphatemia in chronic kidney disease exacerbates atherosclerosis via a mannosidases-mediated complex-type conversion of SCAP N-glycans. CKD, SREBP
74  2021 Identification of epigenome-wide DNA methylation differences between carriers of APOE ε4 and APOE ε2 alleles. DMR, meQTL
75  2021 Impact of IL10, MTP, SOD2, and APOE Gene Polymorphisms on the Severity of Liver Fibrosis Induced by HCV Genotype 4. HCV, HCV-gt4, IL-10, MTP, SOD2
76  2021 Impact of the apolipoprotein E ε4 allele on early Parkinson's disease progression. DAT, PD
77  2021 Increased APOE ε4 expression is associated with the difference in Alzheimer's disease risk from diverse ancestral backgrounds. AD, ALA, ELA, LAs
78  2021 Influence of regional white matter hyperintensity volume and apolipoprotein E ε4 status on hippocampal volume in healthy older adults. MRI, WMH
79  2021 Insights into early ontogenesis: characterization of stress and development key genes of pikeperch (Sander lucioperca) in vivo and in vitro. CKM, dph, SOX9
80  2021 Interplay Between Microglia and Alzheimer's Disease-Focus on the Most Relevant Risks: APOE Genotype, Sex and Age. CNS
81  2021 Learning deficit in cognitively normal APOE ε4 carriers with LOW β-amyloid. AD, CN, ORCA-LLT
82  2021 Lower cerebral perfusion is associated with tau-PET in the entorhinal cortex across the Alzheimer's continuum. AD, CBF, SVD
83  2021 Lower complexity and higher variability in beat-to-beat systolic blood pressure are associated with elevated long-term risk of dementia: The Rotterdam Study. BP, CI, HR, SBP
84  2021 Lung Function Impairment and the Risk of Incident Dementia: The Rotterdam Study. AD, COPD, HRs
85  2021 Mast Cell and Astrocyte Hemichannels and Their Role in Alzheimer's Disease, ALS, and Harmful Stress Conditions. AD, ALS, ATP, Cxs, HCs, MCs
86  2021 Matching Clinical Diagnosis and Amyloid Biomarkers in Alzheimer's Disease and Frontotemporal Dementia. AD, CSF, FTD, PET
87  2021 Maternal hypercholesterolemia exacerbates atherosclerosis lesions in female offspring through potentiating macrophage polarization toward an inflammatory M1 phenotype. CD, WD
88  2021 Meat consumption and risk of incident dementia: cohort study of 493,888 UK Biobank participants. AD, VD
89  2021 Mechanistic investigation of thermosensitive liposome immunogenicity and understanding the drivers for circulation half-life: A polyethylene glycol versus 1,2-dipalmitoyl-sn-glycero-3-phosphodiglycerol study. ABC, DPPG2, PEG, TSL
90  2021 Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis. LDL, LDLR, MT1-MMP
91  2021 Modeling semi-competing risks data as a longitudinal bivariate process. AD
92  2021 Modulation of motor cortical excitability by continuous theta-burst stimulation in adults with autism spectrum disorder. ASD, BDNF, cTBS, NT
93  2021 Multimorbidity burden and dementia risk in older adults: The role of inflammation and genetics. CI, CRP, HR, SNAC-K
94  2021 Multiomics integrative analysis identifies APOE allele-specific blood biomarkers associated to Alzheimer's disease etiopathogenesis. AD, GWAS, LOAD
95  2021 Multiple Reaction Monitoring-Based Targeted Assays for the Validation of Protein Biomarkers in Brain Tumors. ANXA1, ApoA1, CLU, CSF, MAP-2, MRM, SF3B2, VIM, VTN
96  2021 Network dysfunction in cognitively normal APOE ε4 carriers is related to subclinical tau. AD, CSF
97  2021 Neuroprotective Pentapeptide, CN-105, Improves Outcomes in Translational Models of Intracerebral Hemorrhage. ICH
98  2021 Photobiomodulation therapy promotes the ATP-binding cassette transporter A1-dependent cholesterol efflux in macrophage to ameliorate atherosclerosis. PBMT, WD
99  2021 Pilot study of an Alzheimer's disease risk assessment program in a primary care setting. AD
100  2021 Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants. AD