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Abbreviation : Arg1
Long Form : arginase 1
No. Year Title Co-occurring Abbreviation
2023 Arginase 1 is a key driver of immune suppression in pancreatic cancer. ---
2023 Arginase-1 inhibition reduces migration ability and metastatic colonization of colon cancer cells. ---
2023 Notch signaling regulates immunosuppressive tumor-associated macrophage function in pancreatic cancer. PDA, TAMs
2023 Sodium selenite modulates global activation of proinflammatory M1-like macrophages, necroinflammation and M1-like/M2-like dichotomy at the onset of human type 1 diabetes. MDMs, NO, SS, T1D
2022 A Delayed Presentation of Arginase Deficiency Presenting with Status Epilepticus. ---
2022 Activating toll-like receptor 4 after traumatic brain injury inhibits neuroinflammation and the accelerated development of seizures in rats. MPL, TBI, TLR4
2022 Annexin A2/TLR2/MYD88 pathway induces arginase 1 expression in tumor-associated neutrophils. NSCLC, TANs
2022 Arginase-1 Deletion in Erythrocytes Promotes Vascular Calcification via Enhanced GSNOR (S-Nitrosoglutathione Reductase) Expression and NO Signaling in Smooth Muscle Cells. HSP
2022 Arginase-1 Is Required for Macrophage-Mediated Renal Tubule Regeneration. MRC1, MSR1
10  2022 Arginase: An emerging and promising therapeutic target for cancer treatment. ARG2
11  2022 Arginase: Biological and Therapeutic Implications in Diabetes Mellitus and Its Complications. ARG2, DM, IR, NO, UC
12  2022 Association analysis of single nucleotide polymorphisms in autophagy related 7 (ATG7) gene in patients with coronary artery disease. ATG7, CAD, OR
13  2022 Brain-associated innate leukocytes display diverse inflammatory states following experimental stroke. CL, IL, IL, pMCAO, TNF-alpha
14  2022 CD15+ Bone Marrow-derived Cells Are Regulators of Immune Response in ARG1-producing Colorectal Cancer Cells. TILs
15  2022 Characterization of exosomes derived from IPEC-J2 treated with probiotic Bacillus amyloliquefaciens SC06 and its regulation of macrophage functions. iNOS
16  2022 Decreased ARG1 expression as an adverse prognostic phenotype in non-alcoholic non-virus-related hepatocellular carcinoma. NANV-HCC
17  2022 Depletion of Arg1-Positive Microglia/Macrophages Exacerbates Cerebral Ischemic Damage by Facilitating the Inflammatory Response. MCLs
18  2022 Diverse facets of MDSC in different phases of chronic HBV infection: Impact on HBV-specific T-cell response and homing. CHB, CHI, CTLA-4, EN-CHB, HC, IFN-gamma, iNOS, IT, MDSCs, PD-L1
19  2022 Downregulation of eNOS and preserved endothelial function in endothelial-specific arginase 1-deficient mice. ECs, eNOS, NO
20  2022 Early expression of IL-10, IL-12, ARG1, and NOS2 genes in peripheral blood mononuclear cells synergistically correlate with patient outcome after burn injury. IL, NOS2, NOS2-IL-12
21  2022 Elafibranor modulates ileal macrophage polarization to restore intestinal integrity in NASH: Potential crosstalk between ileal IL-10/STAT3 and hepatic TLR4/NF-κB axes. ELA, IL-10, iNOS, MP, NASH, NF-kappaB, PPARs, STAT3, TLR4
22  2022 Elevated serum extracellular vesicle arginase 1 in type 2 diabetes mellitus: a cross-sectional study in middle-aged and elderly population. EV, FPG
23  2022 Establishment of a Novel Mouse Hepatocellular Carcinoma Model for Dynamic Monitoring of Tumor Development by Bioluminescence Imaging. BLI, HCC, HDI
24  2022 Expression of Inhibitory Molecules (Arginase-1, IDO, and PD-L1) by Myeloid-Derived Suppressor Cells in Multiple Myeloma Patients in Remission. HSC, IDO, MDSC
25  2022 Flow Cytometric Characterization of Macrophages Infected in vitro with Salmonella enterica Serovar Typhimurium Expressing Red Fluorescent Protein. iNOS, RFP, STm
26  2022 Glial cell reactivity and oxidative stress prevention in Alzheimer's disease mice model by an optimized NMDA receptor antagonist. CaN, GFAP, Iba1, OS
27  2022 Gut microbiota-derived butyrate regulates gut mucus barrier repair by activating the macrophage/WNT/ERK signaling pathway. DSS, MUC2, UC
28  2022 Helminth resistance is mediated by differential activation of recruited monocyte-derived alveolar macrophages and arginine depletion. AM, Mo-AMs, TD-AMs
29  2022 High Hydrostatic Pressure Extract of Mulberry Leaf Attenuated Obesity-Induced Inflammation in Rats. ACC, CD36, FAS, HF, IL-6, iNOS, PPARgamma, SREBP-1c, TNF-alpha
30  2022 Immunometabolic attributes and mitochondria-associated signaling of Tumor-Associated Macrophages in tumor microenvironment modulate cancer progression. FAO, TAMs, TME
31  2022 Irisin Activates M1 Macrophage and Suppresses Th2-Type Immune Response in Rats with Pelvic Inflammatory Disease. APID, ELISA, IFN-gamma, iNOS
32  2022 Lactylated Histone H3K18 as a Potential Biomarker for the Diagnosis and Predicting the Severity of Septic Shock. KLF4, PBMC, qRT-PCR
33  2022 Modulation of Arginase-2 mRNA Levels by omega-3 PUFAs and Aspirin in Asthmatic Human Lung Fibroblasts. AR, ARG2, ASA, DEX, DHA, EPA, HLF, OAT, ODC, omega-3 PUFAs, RT-qPCR, RvD1
34  2022 Mouse pulmonary interstitial macrophages mediate the pro-tumorigenic effects of IL-9. ---
35  2022 Myeloid Diagnostic and Prognostic Markers of Immune Suppression in the Blood of Glioma Patients. MDSC
36  2022 Nigella sativa Oil Reduces LPS-Induced Microglial Inflammation: An Evaluation on M 1/M 2 Balance. COX-2, IL-1beta, iNOS, NO, NSO, PGE2, TNF-alpha
37  2022 Oral Administration of Cryptotanshinone-Encapsulated Nanoparticles for the Amelioration of Ulcerative Colitis. BMDMs, CTS, DSS, IL, NPCTS, TNF
38  2022 Physical Interaction between Embryonic Stem Cell-Expressed Ras (ERas) and Arginase-1 in Quiescent Hepatic Stellate Cells. ERas, HSCs, Nex
39  2022 PINK1/Parkin-Mediated Mitophagy Partially Protects against Inorganic Arsenic-Induced Hepatic Macrophage Polarization in Acute Arsenic-Exposed Mice. IL, iNOS, Mcp-1, MIP-2, PINK1, TNF
40  2022 Plasma arginase-1 as a predictive marker for early transarterial chemoembolization refractoriness in unresectable hepatocellular carcinoma. HCC, TACE
41  2022 Possible role of arginase 1 positive microglia on depressive/anxiety-like behaviors in atopic dermatitis mouse model. AD, BDNF, Dfb, DG, IL-4, OFT, pCREB, SPT, TST
42  2022 Succinate aggravates intestinal injury in mice with necrotizing enterocolitis. HIF-1a, IL-1beta, iNOS, NEC, SUCNR1, TGF, TNF
43  2022 Systemic Administration of Pegylated Arginase-1 Attenuates the Progression of Diabetic Retinopathy. BRB, DR, iNOS, PEG-Arg1, ROS
44  2022 Targeting arginase-1 exerts antitumor effects in multiple myeloma and mitigates bortezomib-induced cardiotoxicity. MM
45  2022 TERT silencing alters the expression of ARG1, GLUL, VIM, NES genes and hsa-miR-29b-3p in the T98G cell line. GLUL
46  2022 The Anti-hyperuricemia and Anti-inflammatory Effects of Atractylodes Macrocephala in Hyperuricemia and Gouty Arthritis Rat Models. ADA, AMPK, ELISA, GA, IL, iNOS, MSU, NF-kappaB, SIRT, TNF, UA, XOD
47  2022 Vagus nerve stimulation promotes the M1-to-M2 transition via inhibition of TLR4/NF-kappaB in microglial to rescue the reperfusion injury. IR, TLR4, VNS
48  2022 [Effects of exosomes from human adipose-derived mesenchymal stem cells on inflammatory response of mouse RAW264.7 cells and wound healing of full-thickness skin defects in mice]. ADSCs, ADSCs-Exos, CVF, IL-1beta, iNOS, LPS, PBS, PID, RT-PCR, TNF-alpha, TSG101, VEGF
49  2022 [Melanoma-associated macrophages-from molecular signals to therapeutic application]. CAR, CSF-1R, HDAC, IDO, IFN, M-CSF, PI3Kgamma, STAT3, T-VEC, TAMs, TME
50  2022 [Voluntary wheel running exercise regulates microglia polarization in hippocampus through STAT3 signal pathway to inhibit depression-like behavior induced by chronic stress in rats]. CWIRS, Iba1, IL-1beta, iNOS, LPS, p-STAT3, SD, t-STAT3
51  2021 Acute exposure to paraquat affects the phenotypic differentiation of substantia nigra microglia in rats. iNOS, PQ
52  2021 An Epidermal-Specific Role for Arginase1 during Cutaneous Wound Repair. ---
53  2021 An injectable hydrogel using an immunomodulating gelator for amplified tumor immunotherapy by blocking the arginase pathway. ---
54  2021 Anti-neuroinflammatory activity of Shenqi Fuzheng Injection and its main active constituents. SFI, Tgfb1
55  2021 ARG1 mRNA Level Is a Promising Prognostic Marker in Head and Neck Squamous Cell Carcinomas. CD163, FFPE, HNSCC, HPV, NOS2, PTGS2, TAMs
56  2021 Arginase 1 (Arg1) as an Up-Regulated Gene in COVID-19 Patients: A Promising Marker in COVID-19 Immunopathy. cDNA, COVID-19, ROC, SARS-CoV-2
57  2021 Arginase 1 Insufficiency Precipitates Amyloid-beta Deposition and Hastens Behavioral Impairment in a Mouse Model of Amyloidosis. AD, mTORC1
58  2021 Arginase-1 deficiency in neural cells does not contribute to neurodevelopment or functional outcomes after sciatic nerve injury. KO
59  2021 Blocking the CCL5-CCR5 Axis Using Maraviroc Promotes M1 Polarization of Macrophages Cocultured with Irradiated Hepatoma Cells. CCL5, IL, MVC, SOCS3, STAT3, TGF-beta1, TNF-alpha
60  2021 Breast cancer-derived GM-CSF regulates arginase 1 in myeloid cells to promote an immunosuppressive microenvironment. ---
61  2021 Current status of surviving patients with arginase 1 deficiency in Japan. UCD
62  2021 Cytokine-Mediated Regulation of ARG1 in Macrophages and Its Impact on the Control of Salmonella enterica Serovar Typhimurium Infection. BMDM, IL, iNOS, NRAMP1, STm, TNF
63  2021 Effect of Hyperbaric Oxygen Therapy on Polarization Phenotype of Rat Microglia After Traumatic Brain Injury. HBOT, iNOS, MG, SH, TBI, TGF-beta1, TNF-alpha
64  2021 Effects of Des-acyl Ghrelin on Insulin Sensitivity and Macrophage Polarization in Adipose Tissue. DAG, HFD, iNOS, MGL-1, MRC1, TNF-alpha
65  2021 Effects of Ultrashort Wave Therapy on Inflammation and Macrophage Polarization after Acute Lung Injury in Rats. ALI, IL-1beta, LPS, mRNA, TNF-alpha, USWs
66  2021 Efferocytosis Modulates Arginase-1 and Tyrosine Kinase Mer Expression in GM-CSF-Differentiated Human Macrophages. ---
67  2021 Electroacupuncture Improves M2 Microglia Polarization and Glia Anti-inflammation of Hippocampus in Alzheimer's Disease. AD, AD, CNS, iNOS, MWM, NS, PCR, SD, Stat6
68  2021 Folic acid oversupplementation during pregnancy disorders lipid metabolism in male offspring via regulating arginase 1-associated NOS3-AMPKalpha pathway. FASDP, NOS3
69  2021 Genetic ablation of Nrf2 exacerbates neurotoxic effects of acrylamide in mice. ACR, CD206, Chi3l3, HO-1, IL-1beta, IL-4Ralpha, iNOS, NA, NQO1, Nrf2, qRT-PCR, SOD1, TGF-beta1, WT
70  2021 High Inflammatory Tendency Induced by Malignant Stimulation Through Imbalance of CD28 and CTLA-4/PD-1 Contributes to Dopamine Neuron Injury. CTLA-4, Iba1, IL-1beta, iNOS, MHC-II, PD-1, TNF-alpha, TUNEL
71  2021 High-Expressed Macrophage Scavenger Receptor 1 Predicts Severity Clinical Outcome in Transplant Patient in Idiopathic Pulmonary Fibrosis Disease. AUC, IHC, IPF, PAH
72  2021 IL-23 reshapes kidney resident cell metabolism and promotes local kidney inflammation. IL-23, IL-23R, TECs
73  2021 Immunosuppressive network promotes immunosenescence associated with aging and chronic inflammatory conditions. IDO, MDSC, NK
74  2021 Inhibition of arginase modulates T-cell response in the tumor microenvironment of lung carcinoma. ---
75  2021 Lactate and IL6 define separable paths of inflammatory metabolic adaptation. IL-6, LPS
76  2021 Metabolomic Analysis of Diverse Mice Reveals Hepatic Arginase-1 as Source of Plasma Arginase in Plasmodium chabaudi Infection. ---
77  2021 Metformin Inhibits the Urea Cycle and Reduces Putrescine Generation in Colorectal Cancer Cell Lines. AMP, CPS1, CRC, MET, OTC, T2D, UC
78  2021 miR-21-regulated M2 polarization of macrophage is involved in arsenicosis-induced hepatic fibrosis through the activation of hepatic stellate cells. miR-21, p-mTOR, PTEN, THP-M
79  2021 Myeloid Arginase 1 Insufficiency Exacerbates Amyloid-beta Associated Neurodegenerative Pathways and Glial Signatures in a Mouse Model of Alzheimer's Disease: A Targeted Transcriptome Analysis. AD, GWAS, LysM
80  2021 Neutrophils recognize and amplify IFNT signals derived from day 7 bovine embryo for stimulation of ISGs expression invitro: A possible implication for the early maternal recognition of pregnancy. CM, ECM, IFNT, PMNs
81  2021 Possible impact of neutrophils on immune responses during early pregnancy in ruminants. IFNT, IL-10, ISGs, PMNs, TGFB
82  2021 Progesterone alters the activation and typing of the microglia in the optic nerve crush model. CNS, GCL, IL-4, IL-6, iNOS, IPL, ONC, TNF-alpha
83  2021 S-1-Propenylcysteine promotes IL-10-induced M2c macrophage polarization through prolonged activation of IL-10R/STAT3 signaling. AGE, HIF2alpha, IL-10, IL-10Ralpha, S1PC, SHIP1, STAT3
84  2021 Screening of differentially expressed proteins in placentas from patients with late-onset preeclampsia. DEPs, FTL, PE
85  2021 The glycolysis inhibitor 2-deoxyglucose ameliorates adjuvant-induced arthritis by regulating macrophage polarization in an AMPK-dependent manner. 2-DG, AA, AMPK, ECAR, iNOS, NF-kappaB, OCR, OXPHOS, RA
86  2021 The roles of exosomal immune checkpoint proteins in tumors. CTLA-4, EBAG9, PD-L1, TIM-3
87  2021 The roles of polymorphonuclear myeloid-derived suppressor cells in endometriosis. LOX1, MMP-9, PMN-MDSCs
88  2021 Tianlongkechuanling Inhibits Pulmonary Fibrosis Through Down-Regulation of Arginase-Ornithine Pathway. alpha-SMA, ASL, BLM, GO, iNOS, KEGG, Nib, OAT, PF, PPI, TL, TMT
89  2021 Two Japanese siblings with arginase-1 deficiency identified using a novel frameshift mutation of ARG1 (p.Lys41Thrfs∗2). ---
90  2021 Vagal-α7nAChR signaling is required for lung anti-inflammatory responses and arginase 1 expression during an influenza infection. BAL, BMDM
91  2021 [Hepatitis A virus cell membrane protein receptor 2 promotes endotoxin tolerance in mouse macrophages]. DEG, ET, GEO, GO, HAVCR2, HIF-1, IL-1beta, JAK/STAT, LPS, NOS2, PBS, PPI, RT-qPCR, shRNA, STRING, TLR, TNF-alpha
92  2021 [Lycium barbarum polysaccharide promotes M2 polarization of BV2 microglia induced by LPS via inhibiting the TLR4/NF-kappaB signaling pathway]. Iba1, IL-1beta, iNOS, LBP, LPS, NF-kappaB, TLR4, TNF-alpha
93  2020 A novel compound heterozygous mutation in the arginase-1 gene identified in a Chinese patient with argininemia: A case report. ---
94  2020 Accumulation of 8-hydroxydeoxyguanosine, L-arginine and Glucose Metabolites by Liver Tumor Cells Are the Important Characteristic Features of Metabolic Syndrome and Non-Alcoholic Steatohepatitis-Associated Hepatocarcinogenesis. 8-OHdG, HCCs, mTOR, NASH, PI3K, TSOD
95  2020 Alternative Activation of Macrophages in Mice Peritoneal Cavities and Diaphragms by Newborn Larvae of Trichinella spiralis. dpi, NBL
96  2020 Amino Acid Metabolism in Rheumatoid Arthritis: Friend or Foe? Arg, IDO1, RA, Trp
97  2020 Analysis of Cyclooxygenase 2, Programmed Cell Death Ligand 1, and Arginase 1 Expression in Human Pituitary Adenoma. COX-2, fPA, NFPA, PA, PD-L1
98  2020 Antileishmanial Effects of Synthetic EhPIb Analogs Derived from the Entamoeba histolytica Lipopeptidephosphoglycan. IL-4
99  2020 Arginase impedes the resolution of colitis by altering the microbiome and metabolome. IBD
100  2020 CD200R Is Involved in the Anti-inflammatory Effect of Dexmedetomidine in Lipopolysaccharide-Stimulated Microglia. IL-10, IL-6, LPS, TNF-alpha