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Abbreviation : BCECs
Long Form : brain capillary endothelial cells
No. Year Title Co-occurring Abbreviation
2022 Enhanced BBB and BBTB penetration and improved anti-glioma behavior of Bortezomib through dual-targeting nanostructured lipid carriers. BBB, BBTB, BTZ, csGRP78, nAChRs, NLCs
2022 Hypoxia increases expression of selected blood-brain barrier transporters GLUT-1, P-gp, SLC7A5 and TFRC, while maintaining barrier integrity, in brain capillary endothelial monolayers. DFO, TEER
2022 Serial ultrathin sections to identify ultrastructural localization of GLUT1 molecules in vesicles in brain endothelial cells-correlative light and electron microscopy in depth. EM, GLUT1
2022 The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2. ACE2, BBB, hiPSC, NRP1, TMPRSS2
2021 Age influences susceptibility of brain capillary endothelial cells to La Crosse virus infection and cell death. BBB, CLEM, CPE, LACV, OB/OT
2021 Brain pharmacokinetics of anti-transferrin receptor antibody affinity variants in rats determined using microdialysis. bISF, CNS, mAb, PK, RMT, TfR
2021 Concentration-dependent duality of bFGF in regulation of barrier properties of human brain endothelial cells. bFGF, PI-3K, TEER, ZO
2021 Hypoxia increases the proliferation of brain capillary endothelial cells via upregulation of TMEM16A Ca2+-activated Cl- channels. BBB
2021 Similarities and differences in the localization, trafficking, and function of P-glycoprotein in MDR1-EGFP-transduced rat versus human brain capillary endothelial cell lines. P-gp, WT
10  2020 A face-to-face comparison of claudin-5 transduced human brain endothelial (hCMEC/D3) cells with porcine brain endothelial cells as blood-brain barrier models for drug transport studies. BBB
11  2020 Angiopep-2 conjugated nanoparticles loaded with doxorubicin for the treatment of primary central nervous system lymphoma. ANG, BBB, DOX, LRP, PCNSL, PEG-b-PCL
12  2020 Epigenetic Regulation of Ferroportin in Primary Cultures of the Rat Blood-Brain Barrier. BBB, Fpn, NVU, SB, VPA
13  2020 Gene therapy to the blood-brain barrier with resulting protein secretion as a strategy for treatment of Niemann Picks type C2 disease. BBB, CNS, LSD, rBCECs
14  2020 Human iPSC-Derived Blood-Brain Barrier Models: Valuable Tools for Preclinical Drug Discovery and Development? BBB, hiPSCs, PAMPA
15  2020 TMEM16A Ca2+-Activated Cl- Channel Regulates the Proliferation and Migration of Brain Capillary Endothelial Cells. BBB, mBCECs, siRNA
16  2019 Dual-targeting and microenvironment-responsive micelles as a gene delivery system to improve the sensitivity of glioma to radiotherapy. BBB, CMC, LRP1, MMP-2, RT
17  2019 Evaluation of Targeted Delivery to the Brain Using Magnetic Immunoliposomes and Magnetic Force. BBB
18  2019 Modulating the antibody density changes the uptake and transport at the blood-brain barrier of both transferrin receptor-targeted gold nanoparticles and liposomal cargo. AuNPs, BBB, TfR
19  2019 Oxidative stress facilitates cell death by inhibiting Orai1-mediated Ca2+ entry in brain capillary endothelial cells. 2-APB, BBB, NAC, ROS
20  2019 Transferrin Receptor-Mediated Uptake at the Blood-Brain Barrier Is Not Impaired by Alzheimer's Disease Neuropathology. AD, BBB, TfR
21  2018 Brain-targeted delivery of PEGylated nano-bacitracin A against Penicillin-sensitive and -resistant Pneumococcal meningitis: formulated with RVG29 and Pluronic P85 unimers. BBB, PM
22  2018 Hypoxic stress upregulates Kir2.1 expression by a pathway including hypoxic-inducible factor-1alpha and dynamin2 in brain capillary endothelial cells. BBB, HIF-1alpha
23  2018 Substance P-modified human serum albumin nanoparticles loaded with paclitaxel for targeted therapy of glioma. BBB, GBM, HSA, NPs, PTX, SP
24  2017 Large Amino Acid Transporter 1 Selective Liposomes of l-DOPA Functionalized Amphiphile for Combating Glioblastoma. BBB, l-DOPA, LAT1, OS
25  2017 Pluronic F127 and D-alpha-Tocopheryl Polyethylene Glycol Succinate (TPGS) Mixed Micelles for Targeting Drug Delivery across The Blood Brain Barrier. BBB, beta-Gal, Rho123, TPGS
26  2017 Serial block-face scanning electron microscopy applied to study the trafficking of 8D3-coated gold nanoparticles at the blood-brain barrier. BBB, mAb, SBF-SEM
27  2017 The vascular basement membrane in the healthy and pathological brain. BBB
28  2017 Transfection of primary brain capillary endothelial cells for protein synthesis and secretion of recombinant erythropoietin: a strategy to enable protein delivery to the brain. BBB, BDNF, CNS, EPO, PEI, RBECs
29  2016 Asn-Gly-Arg-modified polydopamine-coated nanoparticles for dual-targeting therapy of brain glioma in rats. BBB, CD13, DOX, PDA
30  2016 Blood-brain barrier transport machineries and targeted therapy of brain diseases. BBB, CNS, NSs
31  2016 Hypoxic stress up-regulates Kir2.1 expression and facilitates cell proliferation in brain capillary endothelial cells. BBB
32  2016 Synthesis and deposition of basement membrane proteins by primary brain capillary endothelial cells in a murine model of the blood-brain barrier. BBB, mBCECs, TEER
33  2015 A novel LDL-mimic nanocarrier for the targeted delivery of curcumin into the brain to treat Alzheimer's disease. AD, CUR, LDL, LF, Lf-mNLC, NLC
34  2015 Enhanced anti-ischemic stroke of ZL006 by T7-conjugated PEGylated liposomes drug delivery system. BBB, T7-P-LPs, TfR
35  2015 Tissue Non-specific Alkaline Phosphatase (TNAP) in Vessels of the Brain. AP, BBB, TNAP
36  2015 Transfection of brain capillary endothelial cells in primary culture with defined blood-brain barrier properties. BBB, TEER
37  2015 Transferrin and cell-penetrating peptide dual-functioned liposome for targeted drug delivery to glioma. DOX, TAT-lip, Tf
38  2014 In vitro discrimination of the role of LRP1 at the BBB cellular level: focus on brain capillary endothelial cells and brain pericytes. AD, BBB, LRP
39  2014 Involvement of moesin in the development of morphine analgesic tolerance through P-glycoprotein at the blood-brain barrier. ERM, P-gp
40  2014 Lactoferrin-modified poly(ethylene glycol)-grafted BSA nanoparticles as a dual-targeting carrier for treating brain gliomas. BBB, BSA NPs, DOX, LF, Lf-NPs, P2000H-NPs
41  2014 Marked differences in the effect of antiepileptic and cytostatic drugs on the functionality of P-glycoprotein in human and rat brain capillary endothelial cell lines. AEDs, P-gp, Rho123
42  2013 LDLR-mediated peptide-22-conjugated nanoparticles for dual-targeting therapy of brain glioma. BBB, ELISA, LDLR, PNP-PTX
43  2013 Short interfering RNA and the central nervous system: development of nonviral delivery systems. CNS, siRNA
44  2013 The use of borneol as an enhancer for targeting aprotinin-conjugated PEG-PLGA nanoparticles to the brain. HupA
45  2013 Uptake and transport of superparamagnetic iron oxide nanoparticles through human brain capillary endothelial cells. BBB, SPIONs
46  2012 Impacts of blood-brain barrier in drug delivery and targeting of brain tumors. BBB
47  2012 TNAP and EHD1 are over-expressed in bovine brain capillary endothelial cells after the re-induction of blood-brain barrier properties. BBB, EDH1, TNAP
48  2011 A differential proteomic approach identifies structural and functional components that contribute to the differentiation of brain capillary endothelial cells. BBB
49  2011 Barrier functionality of porcine and bovine brain capillary endothelial cells. BBB
50  2011 Comparison of four different peptides to enhance accumulation of liposomes into the brain. ---
51  2011 Lactoferrin modified doxorubicin-loaded procationic liposomes for the treatment of gliomas. DOX-Lf-PCL, DOX-Lips, NS
52  2011 Liposome formulated with TAT-modified cholesterol for enhancing the brain delivery. BBB, TAT-LIP
53  2011 Liposome formulated with TAT-modified cholesterol for improving brain delivery and therapeutic efficacy on brain glioma in animals. BBB
54  2011 Up-regulation of K(ir)2.1 by ER stress facilitates cell death of brain capillary endothelial cells. BBB, ER
55  2010 A large-scale electrophoresis- and chromatography-based determination of gene expression profiles in bovine brain capillary endothelial cells after the re-induction of blood-brain barrier properties. BBB
56  2010 A leptin derived 30-amino-acid peptide modified pegylated poly-L-lysine dendrigraft for brain targeted gene delivery. DGL, NPs
57  2010 Apical-to-basolateral transport of amyloid-beta peptides through blood-brain barrier cells is mediated by the receptor for advanced glycation end-products and is restricted by P-glycoprotein. AD, BBB, BCRP, P-gp, RAGE
58  2010 Catalpol increases brain angiogenesis and up-regulates VEGF and EPO in the rat after permanent middle cerebral artery occlusion. pMCAO
59  2010 Contribution of K(ir)2 potassium channels to ATP-induced cell death in brain capillary endothelial cells and reconstructed HEK293 cell model. ---
60  2010 Homocysteine enhances transmigration of rat monocytes through a brain capillary endothelial cell monolayer via ICAM-1. BBB, Hcy, ICAM-1, LDH
61  2010 In vitro and in vivo investigation of glucose-mediated brain-targeting liposomes. ACs, CLP
62  2010 Lactoferrin-modified procationic liposomes as a novel drug carrier for brain delivery. ACs, BBB, CL, LF, Lf-PCLs, PCLs
63  2010 Loop 2 of Ophiophagus hannah toxin b binds with neuronal nicotinic acetylcholine receptors and enhances intracranial drug delivery. nAChRs
64  2009 Brain-targeting gene delivery and cellular internalization mechanisms for modified rabies virus glycoprotein RVG29 nanoparticles. BBB, nAChR, NPs, PAMAM
65  2009 Brain-targeting mechanisms of lactoferrin-modified DNA-loaded nanoparticles. LF, NPs
66  2009 Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modified polyamidoamine dendrimer. BBB, LRP1, NPs, PAMAM, RAP
67  2009 Interleukin-25 expressed by brain capillary endothelial cells maintains blood-brain barrier function in a protein kinase Cepsilon-dependent manner. BBB, IL, MS, PKCepsilon, TNF
68  2008 Interferon-beta stabilizes barrier characteristics of the blood-brain barrier in four different species in vitro. BBB, IFNbeta-1a, MS, TEER
69  2008 Transcriptional profiles of receptors and transporters involved in brain cholesterol homeostasis at the blood-brain barrier: use of an in vitro model. ABC, BBB, LDLR
70  2007 Efficient gene delivery targeted to the brain using a transferrin-conjugated polyethyleneglycol-modified polyamidoamine dendrimer. BBB, NMR, PAMAM, PEG, Tf
71  2007 Enhanced gene transfer into brain capillary endothelial cells using Antp-modified DNA-loaded nanoparticles. Antp, PAMAM, PEI
72  2007 Establishing a method to isolate rat brain capillary endothelial cells by magnetic cell sorting and dominant mRNA expression of multidrug resistance-associated protein 1 and 4 in highly purified rat brain capillary endothelial cells. MRP
73  2007 Iron trafficking inside the brain. ---
74  2007 mRNA expression levels of tight junction protein genes in mouse brain capillary endothelial cells highly purified by magnetic cell sorting. TJs
75  2007 Negative relationship between morphine analgesia and P-glycoprotein expression levels in the brain. BBB, P-gp
76  2007 The use of lactoferrin as a ligand for targeting the polyamidoamine-based gene delivery system to the brain. LF, PAMAM, PEG, Tf
77  2006 Brain capillary endothelial cells mediate iron transport into the brain by segregating iron from transferrin without the involvement of divalent metal transporter 1. ---
78  2006 Correlation between quinolone uptakes by BCECs in vitro and brain-to-plasma concentration ratios in rats. BBB
79  2006 Establishment of coculture model of blood-brain barrier in vitro for nanoparticle's transcytosis and toxicity evaluation. BBB
80  2006 Gene delivery into brain capillary endothelial cells using Antp-modified DNA-loaded nanoparticles. Antp, CH, PAMAM, PEI
81  2006 Novel functions of small conductance Ca2+-activated K+ channel in enhanced cell proliferation by ATP in brain endothelial cells. BBB
82  2005 Cationic albumin conjugated pegylated nanoparticle with its transcytosis ability and little toxicity against blood-brain barrier. BBB, BSA, C-BSA, PEG, PEG-PLA
83  2005 Cationic albumin-conjugated pegylated nanoparticles as novel drug carrier for brain delivery. BSA, BSA-NP, C-BSA, PEG-PLA, TEM, XPS
84  2005 In vivo delivery of small interfering RNA targeting brain capillary endothelial cells. BBB, OAT3, siRNA
85  2005 Permeability properties of a three-cell type in vitro model of blood-brain barrier. BBB
86  2005 [In intro delivery of gene encoding neurotrophic (GDNF) into brain by gene transfer]. ---
87  2004 Characterization and modulation of the transferrin receptor on brain capillary endothelial cells. 125I-Tf, DFO, LPS, NAC, TfR
88  2004 Evaluation of blood-brain barrier transporters by co-culture of brain capillary endothelial cells with astrocytes. BBB, MCT1, P-gp
89  2004 New aspects of the blood-brain barrier transporters; its physiological roles in the central nervous system. BBB, OAT3
90  2004 Targeting anti-transferrin receptor antibody (OX26) and OX26-conjugated liposomes to brain capillary endothelial cells using in situ perfusion. Ni-IgG2a
91  2004 [Physiological function of blood-brain barrier transporters as the CNS supporting and protecting system]. BBB, CNS, OAT3
92  2003 Functional role of adenosine receptor subtypes in the regulation of blood-brain barrier permeability: possible implications for the design of synthetic adenosine derivatives. BBB, RAs, TEER
93  2003 In vivo delivery of glial cell-derived neurotrophic factor across the blood-brain barrier by gene transfer into brain capillary endothelial cells. ELISA, HVJ
94  2003 The significance of the mutated divalent metal transporter (DMT1) on iron transport into the Belgrade rat brain. i.v
95  2002 A morphological study of the developmentally regulated transport of iron into the brain. IR
96  2002 Effects of lipoprotein lipase on uptake and transcytosis of low density lipoprotein (LDL) and LDL-associated alpha-tocopherol in a porcine in vitro blood-brain barrier model. alpha-TocH, BBB, LDL, LPL, SR-BI
97  2002 Mechanism and developmental changes in iron transport across the blood-brain barrier. Vd
98  2002 Transluminal gene transfer into brain capillary endothelial cells in vivo with HVJ-liposomes. HVJ
99  2001 Functional relevance of carnitine transporter OCTN2 to brain distribution of L-carnitine and acetyl-L-carnitine across the blood-brain barrier. BBB, JVS
100  2001 Molecular and functional identification of large neutral amino acid transporters LAT1 and LAT2 and their pharmacological relevance at the blood-brain barrier. ---