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Abbreviation : BCNU
Long Form : 1,3-bis(2-chloroethyl)-1-nitrosourea
No. Year Title Co-occurring Abbreviation
2022 2-Deoxy-D-glucose increases the sensitivity of glioblastoma cells to BCNU through the regulation of glycolysis, ROS and ERS pathways: In vitro and in vivo validation. 2-DG, CENUs, ERS, ICLs, ROS
2022 Dual-sensitive drug-loaded hydrogel system for local inhibition of post-surgical glioma recurrence. NPs, ROS, TMZ
2022 Interstitial Control-Released Polymer Carrying a Targeting Small-Molecule Drug Reduces PD-L1 and MGMT Expression in Recurrent High-Grade Gliomas with TMZ Resistance. AEs, BP, IFN-gamma, MGMT, OS, PD-L1, PFS, SAEs, TMZ
2021 Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells. IR, KYN, pS33, RPA, RSR, TDO
2020 3-Bromopyruvate regulates the status of glycolysis and BCNU sensitivity in human hepatocellular carcinoma cells. 3-BrPA, CENUs, HCC, HKII, ICLs, MGMT
2020 Glycolytic inhibition by 3-bromopyruvate increases the cytotoxic effects of chloroethylnitrosoureas to human glioma cells and the DNA interstrand cross-links formation. 3-BrPA, CENUs, ICLs, MGMT
2020 Knockdown of milk-fat globule EGF factor-8 suppresses glioma progression in GL261 glioma cells by repressing microglial M2 polarization. Arg-1, LPS, MFG-E8, MGL-2, STAT3
2020 Treatment with intravenous busulfan, melphalan, and etoposide followed by autologous stem cell transplantation in patients with non-Hodgkin's lymphoma: a multicenter study from the consortium for improving survival of lymphoma. ASCT, BEAC, BuME, HDT, NHL, OS, PFS
2019 Targeted Integration and High-Level Transgene Expression in AAVS1 Transgenic Mice after In Vivo HSC Transduction with HDAd5/35++ Vectors. AAVS1, HSC
10  2019 Total Methionine Restriction Treatment of Cancer. Met, rMETase, TMZ
11  2018 A Comparison of the Conditioning Regimens BEAM and FEAM for Autologous Hematopoietic Stem Cell Transplantation in Lymphoma: An Observational Study on 1038 Patients From Fondazione Italiana Linfomi. ASCT, CI, FEAM, HL, NHL
12  2018 Adverse Event with the Use of Carmustine Wafers and Postoperative Radiochemotherapy for the Treatment of High-grade Glioma. AEs, TMZ
13  2018 Incomplete copolymer degradation of in situ chemotherapy. ---
14  2018 Symptomatic Remote Cyst after BCNU Wafer Implantation for Malignant Glioma. ---
15  2018 Ubiquitin-conjugating enzyme E2 B regulates the ubiquitination of O6-methylguanine-DNA methyltransferase and BCNU sensitivity in human nasopharyngeal carcinoma cells. MGMT, NPC, UBE2B
16  2018 Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling. GBM, TMZ, VP
17  2017 Examining a role for PKG Iα oxidation in the pathogenesis of cardiovascular dysfunction during diet-induced obesity. BAECs, cGMP, DAHP, KI, MTX, NO, PKG, SMCs, WT
18  2017 Inhibitors of GLUT/SLC2A Enhance the Action of BCNU and Temozolomide against High-Grade Gliomas. IDV, PHZ, RTV, TMZ
19  2017 Pivotal role of glutathione depletion in eNOS uncoupling of LPS-Treated HUVECs. DMEM, DTT, eNOS, HUVECs, LPS, MDA, OS, VEC
20  2017 Safety and Effectiveness of Bis-Chloroethylnitrosourea Wafer Chemotherapy in Elderly Patients with Recurrent Glioblastoma. GBM
21  2016 1,3-Bis(2-chloroethyl)-1-nitrosourea-loaded bovine serum albumin nanoparticles with dual magnetic resonance-fluorescence imaging for tracking of chemotherapeutic agents. BSA, FITC, MR, NPs
22  2016 Current and Future Drug Treatments for Glioblastomas. TMZ
23  2016 Patterns of Recurrence After Resection of Malignant Gliomas With BCNU Wafer Implants: Retrospective Review in a Single Institution. ---
24  2016 Resistance to DNA Damaging Agents Produced Invasive Phenotype of Rat Glioma Cells-Characterization of a New in Vivo Model. TMZ
25  2015 Increased pCREB expression and the spontaneous epileptiform activity in a BCNU-treated rat model of cortical dysplasia. CDs, CREB
26  2015 Knockdown of Gli1 by small-interfering RNA enhances the effects of BCNU on the proliferation and apoptosis of glioma U251 cells. siRNA
27  2015 Methyl-Guanine-Methyl-Transferase Transgenic Bone Marrow Transplantation Allows N,N-bis(2-chloroethyl)-Nitrosourea Driven Donor Mixed-Chimerism Without Graft-Versus-Host Disease, and With Donor-Specific Allograft Tolerance. BM, BMT, GVHD, MGMT
28  2015 Models of cortical malformation--Chemical and physical. MAM
29  2015 Uveal Melanoma Metastatic to the Liver: Chemoembolization With 1,3-Bis-(2-Chloroethyl)-1-Nitrosourea. LDH, OS, PFS
30  2014 Antiproliferative activity of the isofuranonaphthoquinone isolated from Bulbine frutescens against Jurkat T cells. GST, IFNQ
31  2014 NMR structure of an ethylene interstrand cross-linked DNA which mimics the lesion formed by 1,3-bis(2-chloroethyl)-1-nitrosourea. ICLs
32  2014 Redox proteomics reveal stress responsive proteins linking peroxiredoxin-1 status in glioma to chemosensitivity and oxidative stress. PRDX1, ROS
33  2014 Risk of premature menopause after treatment for Hodgkin's lymphoma. ABVD, HL
34  2013 1,3-Bis(2-chloroethyl)-1-nitrosourea enhances the inhibitory effect of resveratrol on 5-fluorouracil sensitive/resistant colon cancer cells. 5-FU, 5-FU-R, 5-FU-R, DDB2, FEN1, pol beta, RES
35  2013 Combined delivery of BCNU and VEGF siRNA using amphiphilic peptides for glioblastoma. VEGF
36  2013 Genesis of heterotopia in BCNU model of cortical dysplasia, detected by means of in utero electroporation. GFP, VZ
37  2013 Genomic phenotyping by barcode sequencing broadly distinguishes between alkylating agents, oxidizing agents, and non-genotoxic agents, and reveals a role for aromatic amino acids in cellular recovery after quinone exposure. DMSO, ENU, MC, MMS, MNU
38  2013 Growth pattern of tumor recurrence following bis-chloroethylnitrosourea (BCNU) wafer implantation in malignant glioma. ---
39  2013 Lowering the alemtuzumab dose in reduced intensity conditioning allogeneic hematopoietic cell transplantation is associated with a favorable early intense natural killer cell recovery. allo-HCT, GVHD, NK, PB, RIC
40  2013 MGMT promoter methylation status and prognosis of patients with primary or recurrent glioblastoma treated with carmustine wafers. OS, TMZ
41  2013 Predictive value of the SLC22A18 protein expression in glioblastoma patients receiving temozolomide therapy. GBM, MSP, TMZ
42  2013 Sustainable release of carmustine from biodegradable poly[((D,L))-lactide-co-glycolide] nanofibrous membranes in the cerebral cavity: in vitro and in vivo studies. GBM
43  2013 Synergistic suppression of noscapine and conventional chemotherapeutics on human glioblastoma cell growth. CI, CIS, NOS, TMZ
44  2013 The combination of carmustine wafers and temozolomide for the treatment of malignant gliomas. A comprehensive review of the rationale and clinical experience. MGMT
45  2012 Chemoselection of allogeneic HSC after murine neonatal transplantation without myeloablation or post-transplant immunosuppression. BG, EGFP, GCV, GVHD, HSCs, HSV, MAGIT, MHC
46  2012 Concurrent treatment with BCNU and Gamma Knife radiosurgery in the rat malignant glioma model. GBM, GKRS, MR
47  2012 Hydroxyapatite nanoparticles inhibit the growth of human glioma cells in vitro and in vivo. ---
48  2012 Improving thermal stability and efficacy of BCNU in treating glioma cells using PAA-functionalized graphene oxide. GO, PAA
49  2012 Integrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling. eNOS
50  2012 Protection by Salvia extracts against oxidative and alkylation damage to DNA in human HCT15 and CO115 cells. MNU, RA, SF, SL, SO
51  2012 The role of BCNU polymer wafers (Gliadel) in the treatment of malignant glioma. ---
52  2011 Characterization of hydrophobic anti-cancer drug-loaded amphiphilic peptides as a gene carrier. pDNA, PLL, R3L6, R3V6
53  2011 Combination of arsenic trioxide and BCNU synergistically triggers redox-mediated autophagic cell death in human solid tumors. APL, ROS
54  2011 Concurrent blood-brain barrier opening and local drug delivery using drug-carrying microbubbles and focused ultrasound for brain glioma treatment. BBB, FUS, GBM, MB
55  2011 d-Amphetamine-induced cytotoxicity and oxidative stress in isolated rat hepatocytes. AMP, AST, BSO, CAT, CDNB, Cys, DFO, DMSO, DTT, LDH, MT, SOD, TBARS
56  2011 In vivo detection of cortical abnormalities in BCNU-treated rats, model of cortical dysplasia, using manganese-enhanced magnetic resonance imaging. CD, MEMRI, MRI
57  2011 Inhibition of C6 glioma in vivo by combination chemotherapy of implantation of polymer wafer and intracarotid perfusion of transferrin-decorated nanoparticles. PLA, SPECT, Tf
58  2011 Knockdown of the potential cancer stem-like cell marker Rex-1 improves chemotherapeutic effects in gliomas. GBM, siRNA
59  2011 miR-200c is upregulated by oxidative stress and induces endothelial cell apoptosis and senescence via ZEB1 inhibition. HUVEC, miRNAs, ROS
60  2011 Pro-apoptotic role of integrin beta3 in glioma cells. ITGB3
61  2011 Self-protecting core-shell magnetic nanoparticles for targeted, traceable, long half-life delivery of BCNU to gliomas. HMNC, MRI
62  2011 Silencing of MGMT with small interference RNA reversed resistance in human BCUN-resistant glioma cell lines. MGMT
63  2010 Analysis of self-inactivating lentiviral vector integration sites and flanking gene expression in human peripheral blood progenitor cells after alkylator chemotherapy. LM-PCR, MGMT, SIN
64  2010 Blood-brain barrier disruption with focused ultrasound enhances delivery of chemotherapeutic drugs for glioblastoma treatment. BBB, MR
65  2010 CHOD/BVAM chemotherapy and whole-brain radiotherapy for newly diagnosed primary central nervous system lymphoma. PCNSL, WBRT
66  2010 Efficient and stable MGMT-mediated selection of long-term repopulating stem cells in nonhuman primates. O6-BG
67  2010 Evaluation of treatment-associated inflammatory response on diffusion-weighted magnetic resonance imaging and 2-[18F]-fluoro-2-deoxy-D-glucose-positron emission tomography imaging biomarkers. DEX, FDG-PET
68  2010 Extended O6-methylguanine methyltransferase promoter hypermethylation following n-butylidenephthalide combined with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on inhibition of human hepatocellular carcinoma cell growth. BP, PCR
69  2010 HDMX regulates p53 activity and confers chemoresistance to 3-bis(2-chloroethyl)-1-nitrosourea. GBM
70  2010 Molecular evolution of Theta-class glutathione transferase for enhanced activity with the anticancer drug 1,3-bis-(2-chloroethyl)-1-nitrosourea and other alkylating agents. GST, NPB
71  2010 N,N'-Bis(2-chloroethyl)-N-nitrosourea (BCNU)-induced Apoptosis of Neural Progenitor Cells in the Developing Fetal Rat Brain. GD 13
72  2010 The effectiveness of a magnetic nanoparticle-based delivery system for BCNU in the treatment of gliomas. bound-BCNU-3, MNPs
73  2010 Wilms' tumor 1 silencing decreases the viability and chemoresistance of glioblastoma cells in vitro: a potential role for IGF-1R de-repression. WT1
74  2009 Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway. ATM, ATR, Chk, MMR
75  2009 Effect of O6-chloroethylguanine DNA lesions on the kinetics and mechanism of micronucleus induction in vivo. DMSO, MNPCE, O6-BG, O6-ChlEt-G
76  2009 Enhancing the antitumor activity of adriamycin and ionizing radiation. AdMnSOD, MnSOD
77  2009 Glial cell-line derived neurotrophic factor (GDNF) family of ligands confer chemoresistance in a ligand-specific fashion in malignant gliomas. GDNF
78  2009 Glutathione homeostasis in ventricular myocytes from rat hearts with chronic myocardial infarction. BSO, MI
79  2009 In vitro comparison of O4-benzylfolate modulated, BCNU-induced toxicity in human bone marrow using CFU-GM and tumor cell lines. BM, CFU-GM, ICs, O4BF
80  2009 In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene. BG, HOXB4, TMZ
81  2009 Indoleamine 2,3-dioxygenase as a new target for malignant glioma therapy. Laboratory investigation. 1-MT, IDO, IFN-gamma, KP, Trp
82  2009 Possible novel therapy for malignant gliomas with secretable trimeric TRAIL. MRI, stTRAIL, TRAIL
83  2008 Adjuvant dibromodulcitol and BCNU chemotherapy in anaplastic astrocytoma: results of a randomised European Organisation for Research and Treatment of Cancer phase III study (EORTC study 26882). AA, CI, DBD, GBM, OS, PFS, RT
84  2008 Bone marrow-derived cells exhibiting lung epithelial cell characteristics are enriched in vivo using methylguanine DNA methyltransferase-mediated drug resistance. MGMT, SP-C
85  2008 Pharmacologic blockade of chloride channel synergistically enhances apoptosis of chemotherapeutic drug-resistant cancer stem cells. CLIC1, CSCs, DIDS, GBM
86  2008 Transcriptional repression of O6-methylguanine DNA methyltransferase gene rendering cells hypersensitive to N,N'-bis(2-chloroethyl)-N-nitrosurea in camptothecin-resistant cells. CPT, MeCP2
87  2008 Valproic acid increases the in vitro effects of nitrosureas on human glioma cell lines. CI, VPA
88  2007 Co-expression of MGMT(P140K) and alpha-L-iduronidase in primary hepatocytes from mucopolysaccharidosis type I mice enables efficient selection with metabolic correction. HSC, MPS I
89  2007 Generation and functional characterization of mice with a disrupted glutathione S-transferase, theta 1 gene. DCM, EPNP, GST
90  2007 Glutaredoxin mediates Akt and eNOS activation by flow in a glutathione reductase-dependent manner. ECs, GR, Grx
91  2007 Higher glioblastoma tumour burden reduces efficacy of chemotherapeutic agents: in vitro evidence. ---
92  2007 Imaging response in malignant glioma, RTOG 90-06. RTOG
93  2007 In vivo imaging in a murine model of glioblastoma. MRI
94  2007 In vivo selection and chemoprotection after drug resistance gene therapy in a nonmyeloablative allogeneic transplantation setting in dogs. ---
95  2007 Increased oxidative stress created by adenoviral MnSOD or CuZnSOD plus BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) inhibits breast cancer cell growth. GR, SODs
96  2007 Nitric oxide donors attenuate clongenic potential in rat C6 glioma cells treated with alkylating chemotherapeutic agents. DEA/NO, ENU, GBM, iNOS, MMS, MNU, NO, SNP
97  2007 Prooxidant cytotoxicity of chromate in mammalian cells: the opposite roles of DT-diaphorase and glutathione reductase. ---
98  2007 Resorbable polymer microchips releasing BCNU inhibit tumor growth in the rat 9L flank model. ---
99  2007 Stable differentiation and clonality of murine long-term hematopoiesis after extended reduced-intensity selection for MGMT P140K transgene expression. HSCs, O6-BG
100  2007 Tamoxifen accelerates proteasomal degradation of O6-methylguanine DNA methyltransferase in human cancer cells. ---