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Abbreviation : CDPPB
Long Form : 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
No. Year Title Co-occurring Abbreviation
1  2022 mGluR5 PAMs rescue cortical and behavioural defects in a mouse model of CDKL5 deficiency disorder. CDKL5, CVI, mGluR5, PAMs
2  2021 IP3R-mediated activation of BK channels contributes to mGluR5-induced protection against spinal cord ischemia-reperfusion injury. CHPG, Glu, LDH, mGluRs, SCIRI, WB
3  2021 Modulation of mGlu5 improves sensorimotor gating deficits in rats neonatally treated with quinpirole through changes in dopamine D2 signaling. DA, mGlu5, NQ, NS, PFC, PPI, s.c, SZ
4  2021 Positive Allosteric Modulators of Metabotropic Glutamate Receptor 5 as Tool Compounds to Study Signaling Bias. DHPG, mGlu5, mGlu5, MPPA, PAM, PAMs
5  2020 Striatal and cortical metabotropic glutamate 5 receptor expression and behavioral effects of the positive allosteric modulator CDPPB in a model of DYT1 dystonia. IHC, KI, mGlu5
6  2019 Expression of metabotropic glutamate 5 receptors in the striatum and cortex and effects of modulators on the severity of dystonia in the phenotypic dtsz model. mGlu5
7  2019 Identification of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Acting at Site Distinct from 2-Methyl-6-(phenylethynyl)-pyridine Binding. GPCR, mGlu, mGlu5, MPEP, NAM, PAMs, QSAR
8  2019 Lrrc7 mutant mice model developmental emotional dysregulation that can be alleviated by mGluR5 allosteric modulation. ---
9  2019 The cognitive cost of reducing relapse to cocaine-seeking with mGlu5 allosteric modulators. CUD, DMS, mGlu5, MTEP
10  2019 The Divergent Effects of CDPPB and Cannabidiol on Fear Extinction and Anxiety in a Predator Scent Stress Model of PTSD in Rats. CBD, PTSD
11  2018 A novel rat model of comorbid PTSD and addiction reveals intersections between stress susceptibility and enhanced cocaine seeking with a role for mGlu5 receptors. CUD, TMT
12  2014 mGluR5 positive allosteric modulation and its effects on MK-801 induced set-shifting impairments in a rat operant delayed matching/non-matching-to-sample task. NMDA, PAMs
13  2014 Pharmacological enhancement of mGluR5 facilitates contextual fear memory extinction. mGluR5
14  2014 Stress hormone exposure reduces mGluR5 expression in the nucleus accumbens: functional implications for interoceptive sensitivity to alcohol. CORT, mGluR5
15  2012 Enhancement of social novelty discrimination by positive allosteric modulators at metabotropic glutamate 5 receptors: adolescent administration prevents adult-onset deficits induced by neonatal treatment with phencyclidine. mGluR5, NMDA, PAMs, SND
16  2012 Protective effects of mGluR5 positive modulators against traumatic neuronal injury through PKC-dependent activation of MEK/ERK pathway. ERK, JNK, PKC, TBI
17  2012 The mGluR5 Positive Allosteric Modulator CDPPB Does Not Alter Extinction or Contextual Reinstatement of Methamphetamine-Seeking Behavior in Rats. PAM
18  2011 mGluR5 positive allosteric modulation enhances extinction learning following cocaine self-administration. ---
19  2011 mGluR5 positive modulators both potentiate activation and restore inhibition in NMDA receptors by PKC dependent pathway. CHPG, CTC, DFB, MED, mGluR5, NMDA, PKC
20  2011 Quantitative analysis reveals multiple mechanisms of allosteric modulation of the mGlu5 receptor in rat astroglia. DFB, M-5MPEP, MPEP
21  2011 Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome. FMRP, mGluRs, MPEP
22  2010 Activation of type 5 metabotropic glutamate receptors attenuates deficits in cognitive flexibility induced by NMDA receptor blockade. mGlu
23  2010 Functional interaction of mGlu5 and NMDA receptors in aversive learning in rats. mGlu5
24  2010 Loss of object recognition memory produced by extended access to methamphetamine self-administration is reversed by positive allosteric modulation of metabotropic glutamate receptor 5. METH, mGluR, SA
25  2009 Effects of positive allosteric modulators on single-cell oscillatory Ca2+ signaling initiated by the type 5 metabotropic glutamate receptor. PAMs
26  2008 Positive allosteric modulation of mGluR5 receptors facilitates extinction of a cocaine contextual memory. CPP, NMDA
27  2007 Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses. mGluR, MPEP
28  2007 Positive allosteric modulation of metabotropic glutamate 5 (mGlu5) receptors reverses N-Methyl-D-aspartate antagonist-induced alteration of neuronal firing in prefrontal cortex. mGlu5, mPFC, NAc, NMDA, PFC
29  2006 A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. mGluR
30  2005 A close structural analog of 2-methyl-6-(phenylethynyl)-pyridine acts as a neutral allosteric site ligand on metabotropic glutamate receptor subtype 5 and blocks the effects of multiple allosteric modulators. 5MPEP, Br-5MPEPy, M-5MPEP, mGlu5, MPEP
31  2004 A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models. mGluR5