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Abbreviation : CENUs
Long Form : chloroethylnitrosoureas
No. Year Title Co-occurring Abbreviation
1  2022 2-Deoxy-D-glucose increases the sensitivity of glioblastoma cells to BCNU through the regulation of glycolysis, ROS and ERS pathways: In vitro and in vivo validation. 2-DG, BCNU, ERS, ICLs, ROS
2  2021 Development and biological evaluation of AzoBGNU: A novel hypoxia-activated DNA crosslinking prodrug with AGT-inhibitory activity. O6-BG
3  2020 3-Bromopyruvate regulates the status of glycolysis and BCNU sensitivity in human hepatocellular carcinoma cells. 3-BrPA, BCNU, HCC, HKII, ICLs, MGMT
4  2020 Glycolytic inhibition by 3-bromopyruvate increases the cytotoxic effects of chloroethylnitrosoureas to human glioma cells and the DNA interstrand cross-links formation. 3-BrPA, BCNU, ICLs, MGMT
5  2017 Synthesis and Antitumor Activity Evaluation of a Novel Combi-nitrosourea Prodrug: BGCNU. BGCNU, ICLs, O6-BG
6  2015 Influence of the Expression Level of O6-Alkylguanine-DNA Alkyltransferase on the Formation of DNA Interstrand Crosslinks Induced by Chloroethylnitrosoureas in Cells: A Quantitation Using High-Performance Liquid Chromatography-Mass Spectrometry. FTMS
7  2014 Investigations on the effect of O(6)-benzylguanine on the formation of dG-dC interstrand cross-links induced by chloroethylnitrosoureas in human glioma cells using stable isotope dilution high-performance liquid chromatography electrospray ionization tandem mass spectrometry. ACNU, ICLs
8  2014 Quantification of DNA interstrand crosslinks induced by ACNU in NIH/3T3 and L1210 cells using high-performance liquid chromatography/electrospray ionization tandem mass spectrometry. ACNU, dG-dC, ICLs, LOD, LOQ, RSD
9  2011 An accurate nonlinear QSAR model for the antitumor activities of chloroethylnitrosoureas using neural networks. MLR, NNs, QSAR
10  2011 Quantification of meCCNU-induced dG-dC crosslinks in oligonucleotide duplexes by liquid chromatography/electrospray ionization tandem mass spectrometry. CF, LOD, LOQ, SRM
11  2002 Inhibition of O6-alkylguanine-DNA alkyltransferase by O6-benzyl-N2-acetylguanosine increases chloroethylnitrosourea-induced apoptosis in Mer+ human melanoma cells. BCNU, Mer, TUNEL
12  2001 Antitumor efficacy of SarCNU in a human glioma xenograft model expressing both MGMT and extraneuronal monoamine transporter. BCNU, EMT, MGMT, O6-BG, RT-PCR, SarCNU
13  2001 Circadian variation in O6-alkylguanine-DNA alkyltransferase activity in circulating blood mononuclear cells of healthy human subjects. MNCs
14  2001 O6-(fluorobenzyl)guanine and chloroethylnitrosourea in xenografted rat brain tumor in vivo. ACNU, MGMT
15  2000 Actinomycin D and staurosporine, potent apoptosis inducers in vitro, are potentially effective chemotherapeutic agents against glioblastoma multiforme. ACNU, BCNU
16  1999 O(6)-methylguanine-DNA methyltransferase gene (MGMT) expression in human glioblastomas in relation to patient characteristics and p53 accumulation. GBM
17  1998 O6-Methylguanine-DNA methyltransferase protein levels in pediatric brain tumors. CNS, MGMT
18  1997 Enhancement by O6-benzyl-N2-acetylguanosine of N'-[2-chloroethyl]-N-[2-(methylsulphonyl)ethyl]-N'-nitrosourea therapeutic index on nude mice bearing resistant human melanoma. BNAG
19  1996 Quantification of O6-methylguanine-DNA methyltransferase mRNA in human brain tumors. MGMT, RT-PCR
20  1995 Differential inactivation of O6-methylguanine-DNA methyltransferase activity by O6-arylmethylguanines. ACNU, MGMT
21  1995 Retroviral transfer of a bacterial alkyltransferase gene into murine bone marrow protects against chloroethylnitrosourea cytotoxicity. ATase, BCNU, O6-BG
22  1994 O6-alkylguanine-DNA alkyltransferase activity of human malignant glioma and its clinical implications. ---
23  1993 Influence of O6-methylguanine-DNA methyltransferase activity on chloroethylnitrosourea chemotherapy in brain tumors. ACNU, MGMT
24  1992 Cross-resistance pattern in brain tumour cells resistant to antitumour chloroethylnitrosoureas. ACNU, BLM, MCNU, MTX
25  1992 Development of resistance to antitumor chloroethylnitrosoureas in vitro in brain tumor cells. ACNU, MCNU
26  1992 Expression of O6-methylguanine-DNA methyltransferase and chloroethylnitrosourea resistance of human brain tumors. ACNU, MGMT
27  1992 Intrathecal chemotherapy with ACNU for meningeal gliomatosis. C6MG, MG, MST
28  1992 Phase I study of streptozocin- and carmustine-sequenced administration in patients with advanced cancer. MGMT, MTD, PBMC, STZ
29  1991 O6-alkylguanine-DNA alkyltransferase activity in human brain tumors. O6-AT
30  1991 Positive therapeutic interaction between thiopurines and alkylating drugs in human glioma xenografts. 6-MP, 6-TG, BCNU, IC, PCNU, s.c
31  1990 Evidence that covalent complex formation between BCNU-treated oligonucleotides and E. coli alkyltransferases requires the O6-alkylguanine function. ---
32  1989 Decreased DNA interstrand cross-linking and cytotoxicity induced in human brain tumor cells by 1,3-bis(2-chloroethyl)-1-nitrosourea after in vitro reaction with glutathione. BCNU, EL, GST
33  1989 Quenching of DNA cross-link precursors of chloroethylnitrosoureas and attenuation of DNA interstrand cross-linking by glutathione. ---
34  1989 Response of cultured human cell lines from rhabdomyosarcoma xenografts to treatment with chloroethylnitrosoureas. ---
35  1988 [Mechanisms of cellular resistance to chloroethylnitrosourea in cell lines derived from human brain tumors]. ACNU, SCEs
36  1986 A comparative analysis of drug-induced DNA effects in a nitrogen mustard resistant cell line expressing sensitivity to nitrosoureas. CCNU, CLZ, NM, PM, SCE
37  1985 Investigation of resistance to DNA cross-linking agents in 9L cell lines with different sensitivities to chloroethylnitrosoureas. ---
38  1985 Repair of O6-(2-chloroethyl)guanine mediates the biological effects of chloroethylnitrosoureas. SCEs