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Abbreviation : COX-1
Long Form : cyclooxygenase-1
No. Year Title Co-occurring Abbreviation
2023 FTIR Characterization of Sulfated Polysaccharides Obtained from Macrocystis integrifolia Algae and Verification of Their Antiangiogenic and Immunomodulatory Potency In Vitro and In Vivo. CAM, COX-2, IgE, NF-kappaB, NOS2, OVA
2023 In silico and in vitro anti-inflammatory study of phenolic compounds isolated from Eucalyptus maculata resin. EME
2022 Apolipoprotein E*Ɛ2 carriers exhibit high aspirin-treated platelet reactivity and low cardiovascular risk during long-term aspirin treatment. APOE, CV
2022 Benzoylpaeoniflorin Activates Anti-Inflammatory Mechanisms to Mitigate Sepsis in Cell-Culture and Mouse Sepsis Models. BPF, CLP, HUVECs, IL, iNOS, LPS, MAPKs, NF-kappaB, qPCR, TNF, XBJI
2022 Comparison of Absolute Expression and Turnover Number of COX-1 and COX-2 in Human and Rodent Cells and Tissues. COX-2, SCC
2022 Design, synthesis, biological assessment and in silico ADME prediction of new 2-(4-(methylsulfonyl) phenyl) benzimidazoles as selective cyclooxygenase-2 inhibitors. COX-2
2022 Diindolylmethane ameliorates platelet aggregation and thrombosis: In silico, in vitro, and in vivo studies. ADP, cAMP, DIM, GPVI, I3C, P2Y12, PGE2, ROS, TTO, TXB2
2022 Endoplasmic-reticulum-stress-induced lipotoxicity in human kidney epithelial cells. Cer, cPLA2, ER, GRP78, PGE2, PUFA, S1P, SM, TM, TUDCA
2022 In vitro, in vivo and in silico evaluation of the anti-inflammatory potential of Hyssopus officinalis L. subsp. aristatus (Godr.) Nyman (Lamiaceae). COX-2, NSAID, RA
10  2022 Low-Dose NSAIDs Efficacy in Orthopedic Applications. COX-2, NSAIDs
11  2022 Mechanism of Traditional Tibetan Medicine Grubthobrildkr Alleviated Gastric Ulcer Induced by Acute Systemic Hypoxia in Rats. COX-2, ET-1, GAS, GTB, MTL, PGE2, PLA2, UHPLC-Q-Orbitrap MS
12  2022 MiodesinTM Positively Modulates the Immune Response in Endometrial and Vaginal Cells. IL-1beta, LPS, MMP-2, NF-kappaB, PLA2, TNF-alpha, VEGF
13  2022 Nonsteroidal Anti-inflammatory Drugs Are Not Associated With Increased Bleeding in Blunt Solid Organ Injury. ---
14  2022 Pyrroloquinoline Quinone Disodium (PQQ2Na) Has an NLRP Inflammasome-Induced Caspase-1 Release Influence in UVB-Irradiated but Not ATP-Treated Human Keratinocytes but Has No Influence in Increasing Skin Cell Mitochondrial Biogenesis in Either Human Keratinocytes or Fibroblasts. NHDF, NHEKs, NLRP, SDHA
15  2022 Signaling Pathways Mediating Bradykinin-Induced Contraction in Murine and Human Detrusor Muscle. BK, KO, TP
16  2022 Study on the inhibition of inflammation by the cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) pathway and the promotion of wound healing of oral ulcer of Yangyin Shengji powder after chemotherapy. COX-2, EGF, EGFR, ELISA, GSH-Px, HE, IL-6, MDA, PGE2, RT-PCR, SOD, TNF-alpha, Tr
17  2022 Synthesis of Sugar and Nucleoside Analogs and Evaluation of Their Anticancer and Analgesic Potentials. CCK-8, COX-2
18  2022 The Hypertensive Effect of Amphotericin B-Containing Liposomes (Abelcet) in Mice: Dissecting the Roles of C3a and C5a Anaphylatoxins, Macrophages and Thromboxane. CVF, HR, MABP, TP
19  2022 Whole-Body PET Imaging in Humans Shows That 11C-PS13 Is Selective for Cyclooxygenase-1 and Can Measure the In Vivo Potency of Nonsteroidal Antiinflammatory Drugs. COX-2
20  2021 Adipose-derived stem cells inhibit dermal fibroblast growth and induce apoptosis in keloids through the arachidonic acid-derived cyclooxygenase-2/prostaglandin E2 cascade by paracrine. AA, ADSCs, Bcl-2, EdU, KFBs, PGE2
21  2021 Aspirin Actions in Treatment of NSAID-Exacerbated Respiratory Disease. NSAID
22  2021 Aspirin effects on platelet gene expression are associated with a paradoxical, increase in platelet function. ---
23  2021 Chemical Profiles and Pharmacological Properties with in Silico Studies on Elatostema papillosum Wedd. NF
24  2021 Choline Glycerophospholipid-Derived Prostaglandins Attenuate TNFalpha Gene Expression in Macrophages via a cPLA2alpha/COX-1 Pathway. AA, PI
25  2021 Development of a DHA-Losartan hybrid as a potent inhibitor of multiple pathway-induced platelet aggregation. CVDs, PAF, PAR-1, RAS
26  2021 Development of Fluorescence Imaging Probes for Labeling COX-1 in Live Ovarian Cancer Cells. ---
27  2021 Diagnostic Value of Serum Markers Combined with TVCDS in Ovarian Cancer Patients Treated with Bushen Yiqi Quyu Prescription. HE4, OC, TVCDS
28  2021 Discovery of Natural Product Inspired 3-Phenyl-1H-isochromen-1-ones as Highly Potent Antioxidant and Antiplatelet Agents: Design, Synthesis, Biological Evaluation, SAR and In Silico Studies. AA, DPPH
29  2021 Dynamics of Cyclooxygenase-1 Positive Microglia/Macrophage in the Retina of Pathological Model Mice as a Biomarker of the Retinal Inflammatory Diseases. EAU, LPS
30  2021 Electroacupuncture attenuates vascular hyporeactivity in a rat model of portal hypertension induced by bile duct ligation. 6-keto-PGF1 alpha, BDL, EA, NOS, PHT, PKCalpha, TGFbetaR, TNF-alpha, VEGF
31  2021 Evaluation of analgesic and anti-inflammatory activities and molecular docking analysis of steroidal lactones from Datura stramonium L. iNOS, LOX-1, LPS, NF-kappaB
32  2021 Exercise-Induced Modulation of Angiotensin II Responses in Femoral Veins From 2-Kidney-1-Clip Hypertensive Rats. 2K1C, Ang II, COX-2, ET-1, ETA, NO
33  2021 Experimental Periodontal Disease Triggers Coronary Endothelial Dysfunction in Middle-Aged Rats: Preventive Effect of a Prebiotic beta-Glucan. eNOS, IL-1beta, TNF-alpha
34  2021 Gastroprotective Effect of Myricetin on Ethanol-Induced Acute Gastric Injury in Rats. MDA, NF-kappaB, PGE2, SOD
35  2021 Genotoxic effects of Dukhan: A smoke bath from the wood of Acacia seyal used traditionally by Sudanese women. ---
36  2021 Green synthesis of selenium based N-heterocyclic carbene compounds; structural, in-vitro anticancer and molecular docking studies. HeLa, HIF, NHC
37  2021 Hepatoprotective Effect of Lactobacillus plantarum HFY09 on Ethanol-Induced Liver Injury in Mice. ADH, ALDH, BW, CAT, ERK, GSH-Px, HAase, IL-10, JNK, LP-HFY09, MDA, NADPH, PC III, SOD, TC, TG, TNF
38  2021 Indomethacin Treatment Post-irradiation Improves Mouse Parotid Salivary Gland Function via Modulation of Prostaglandin E2 Signaling. HNC, IR, JNK, NSAID, PGE2, SOCE
39  2021 Influence of Lipid Excipients on Platelet Function and the Pharmacodynamic Effects of Aspirin. ---
40  2021 Inhibitory Mechanisms of Lusianthridin on Human Platelet Aggregation. ADP, COX-2
41  2021 Lipid metabolism is a novel and practical source of potential targets for antiviral discovery against porcine parvovirus. DKGalpha, iPLA2beta, LDs, LPAATtheta, PGE2, PI3K, PKC, PLCgamma2, PPV
42  2021 Modulation of the PGE2-Mediated Pathway in the Eclosion Blocking Effect of Flumethrin and Terpenoid Subfraction Isolated from Artemesia nilagirica in Rhipicephalus annulatus. PGE2, PGES, Vg
43  2021 Non-steroidal anti-inflammatory drugs dampen the cytokine and antibody response to SARS-CoV-2 infection. ACE2, COVID-19, COX-2, NSAIDs, PGs, SARS-CoV-2
44  2021 Nonsteroidal anti-inflammatory drugs hypersensitivity in chronic spontaneous urticaria in the light of its pathogenesis. CSU, NECD
45  2021 Oleuropein attenuates the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-perturbing effects on pancreatic beta-cells. PGE2, TCDD
46  2021 Olmesartan niosomes ameliorates the Indomethacin-induced gastric ulcer in rats: Insights on MAPK and Nrf2/HO-1 signaling pathway. HO-1, IL-6, IND, Nrf2, OLM, OLM-NIO, p38 MAPK, PGE2, TNF-alpha
47  2021 Panax Notoginseng Saponin Attenuates Gastric Mucosal Epithelial Cell Injury Induced by Dual Antiplatelet Drugs through COX and PI3K/Akt/ VEGF-GSK-3beta-RhoA Network Pathway. 6-keto-PGF1 alpha, COX-2, DA, ELISA, GSK-3beta, p-Akt, p-PI3K, PGE2, PI3K, PNS, RhoA, VEGF
48  2021 Platelet ACKR3/CXCR7 favors antiplatelet lipids over anatherothrombotic lipidome and regulates thromboinflammation. 12-HETrE, 12-LOX, CAD, DGLA
49  2021 Profiling oxylipins released from human platelets activated through the GPVI collagen receptor. 12-LOX, GPVI
50  2021 Proliferation of bovine endometrial epithelial cells is promoted by prostaglandin E2-PTGER2 signaling through cell cycle regulation. bEEC, COX-2, EGF, PCNA, PGE2, PTGER2
51  2021 Selective intra-arterial brain cooling induces cerebral protection against ischemia/reperfusion injury through SENP1-Sirt3 signaling. I/R, IDH2, OGD, SI-AC, SOD2
52  2021 Structure-based screening for the discovery of 1,2,4-oxadiazoles as promising hits for the development of new anti-inflammatory agents interfering with eicosanoid biosynthesis pathways. 5-LO, mPGES-1
53  2021 Synthesis of [18F]PS13 and Evaluation as a PET Radioligand for Cyclooxygenase-1 in Monkey. PET
54  2021 Synthesis, Inhibitory Activity, and In Silico Modeling of Selective COX-1 Inhibitors with a Quinazoline Core. ---
55  2021 The essential oil from Baccharis trimera (Less.) DC improves gastric ulcer healing in rats through modulation of VEGF and MMP-2 activity. COX-2, EGF, EOBT, MMP-2, MPO, VEGF
56  2021 The Role of Celecoxib as a Potential Inhibitor in the Treatment of Inflammatory Diseases - A Review. COX, COX-2, NSAIDs
57  2020 6-Methoxyflavanone abates cisplatin-induced neuropathic pain apropos anti-inflammatory mechanisms: A behavioral and molecular simulation study. 6-MeOF, COX-2
58  2020 A randomized double-blind trial of 3 aspirin regimens to optimize antiplatelet therapy in essential thrombocythemia. ET, sTXB2, TXM
59  2020 An attempt to chemically state the cross-talk between monomers of COX homodimers by double/hybrid inhibitors mofezolac-spacer-mofezolac and mofezolac-spacer-arachidonic acid. AA, CVDs, mof-spacer-AA, mof-spacer-mof, NSAIDs, SI
60  2020 Analysis of the Activity and Expression of Cyclooxygenases COX1 and COX2 in THP-1 Monocytes and Macrophages Cultured with BiodentineTM Silicate Cement. COX-2, PGE2
61  2020 Anti-inflammatory effect of methoxyflavonoids from Chiliadenus montanus (Jasonia Montana) growing in Egypt. 5-LOX, COX-2, IL-1beta, LPS, NF-kappaB, TNF-alpha
62  2020 Association between High On-Aspirin Platelet Reactivity and Reduced Superoxide Dismutase Activity in Patients Affected by Type 2 Diabetes Mellitus or Primary Hypercholesterolemia. HC, SOD, T2DM
63  2020 Biological Evaluation of Naproxen-Dehydrodipeptide Conjugates with Self-Hydrogelation Capacity as Dual LOX/COX Inhibitors. COX-2, LOX, MRI, NSAID, SPIONs
64  2020 Cassia sieberiana DC. leaves modulate LPS-induced inflammatory response in THP-1cells and inhibit eicosanoid-metabolizing enzymes. 5-LOX, IL-6, TNF-alpha
65  2020 Chrysin Modulates Genes Related to Inflammation, Tissue Remodeling, and Cell Proliferation in the Gastric Ulcer Healing. EGF
66  2020 Cyclooxgenase-2 is induced by SARS-CoV-2 infection but does not affect viral entry or replication. ACE2, COVID-19, COX-2, NSAIDs, PGs, SARS-CoV-2
67  2020 Cyclooxygenase 1 (COX1) as an indicator of sperm quality in humans. ---
68  2020 Cyclooxygenase-1 mediates neuroinflammation and neurotoxicity in a mouse model of retinitis pigmentosa. PGE2, RP
69  2020 Cytotoxicity evaluation of ketoprofen found in pharmaceutical wastewater on HEK 293 cell growth and metabolism. ---
70  2020 Design, synthesis and biological assessment of new selective COX-2 inhibitors including methyl sulfonyl moiety. NSAIDs
71  2020 Design, Synthesis and Evaluation of 3-Substituted Coumarin Derivatives as Anti-inflammatory Agents. SARs
72  2020 Effects of Benidipine Hydrochloride on Ischemia Reperfusion Injury of Rat Brain. I/R, MDA, SOD
73  2020 Endogenous cannabinoids may regulate chronic inflammation in aspirin-exacerbated respiratory disease. AERD, PG
74  2020 Enhanced conditioning of adverse memories in the mouse modified swim test is associated with neuroinflammatory changes - Effects that are susceptible to antidepressants. GSK-3, IL-1beta, TNF
75  2020 Evaluation of Anti-Inflammatory Components of Guizhi Fuling Capsule, an Ancient Chinese Herbal Formula, in Human Umbilical Vein Endothelial Cells. GFC, HUVECs, LPS
76  2020 First-in-human evaluation of [11C]PS13, a novel PET radioligand, to quantify cyclooxygenase-1 in the brain. ---
77  2020 Gastroprotective effects of the nonsaponin fraction of Korean Red Ginseng through cyclooxygenase-1 upregulation. NSF
78  2020 Glycogen Synthase Kinase-3beta Mediates Proinflammatory Cytokine Secretion and Adipogenesis in Orbital Fibroblasts from Patients with Graves' Orbitopathy. GO, GSK-3beta, ICAM-1, MCP-1, NF, PPARgamma, RT-PCR
79  2020 Impact of antipyretics on acute asthma exacerbation during respiratory infection-A nationwide population-based study. AE, NSAIDs
80  2020 In Vivo Anti-Inflammation Potential of Aster koraiensis Extract for Dry Eye Syndrome by the Protection of Ocular Surface. AKE, COX-2, DES, ER, TG
81  2020 Increased PUFA levels in kidney epithelial cells in the course of diclofenac toxicity. cPLA2, DCL, PGE2, PUFAs, TQ
82  2020 Intake of aspirin prior to metamizole does not completely prevent high on treatment platelet reactivity. AA, HTPR, IA, LTA
83  2020 Kisspeptin/GnRH1 system in Leydig cells of horse (Equus caballus): Presence and function. Kiss, PGF2 alpha
84  2020 Mechanistic evaluation of gastro-protective effects of KangFuXinYe on indomethacin-induced gastric damage in rats. COX-2, EGF, IL-6, KFX, PGE2
85  2020 Outcomes from Experimental Testing of Nonsteroidal Anti-Inflammatory Drug (NSAID) Administration during the Transition Period of Dairy Cows. COX-2, NSAID
86  2020 Phytosterols demonstrate selective inhibition of COX-2: In-vivo and in-silico studies of Nicotiana tabacum. NSAIDs, NTPI, vHTS
87  2020 Polymyxin B prevents the development of adjuvant arthritis via modulation of TLR/Cox-2 signaling pathway. hs-CRP, NF-kappaB, RA, TGF-1beta, TLR, TNF-alpha
88  2020 Prostaglandin E2 stimulates the epithelial sodium channel (ENaC) in cultured mouse cortical collecting duct cells in an autocrine manner. CCD, ENaC, EP4, PGE2
89  2020 Prostaglandin F2alpha-PTGFR signaling promotes proliferation of endometrial epithelial cells of cattle through cell cycle regulation. CDKs, COX-2, EGF, PCNA, PGF2 alpha
90  2020 Repurposing 11C-PS13 for PET Imaging of Cyclooxygenase-1 in Ovarian Cancer Xenograft Mouse Models. OvCa
91  2020 Solidagenone from Solidago chilensis Meyen inhibits skin inflammation in experimental models. AA, COX-2, IL-6, MPO, NAG, NO, SOL, TNF-alpha
92  2020 Yunnan Baiyao diminishes lipopolysaccharide-induced inflammation in osteoclasts. AA, LPS, MAPK, YNBY
93  2020 [Study about neural inflammation in mental illness and development of drug screening using in vitro models of disease]. PGE2, TLR
94  2019 Altered Lipid Metabolism in Blood Mononuclear Cells of Psoriatic Patients Indicates Differential Changes in Psoriasis Vulgaris and Psoriatic Arthritis. 13-HODE, 15-HETE, 4-HNE, 8-iso-PGF2alpha, COX-2, LTB4, PGE1, TXB2
95  2019 Analgesic and Anti-Inflammatory Activities of Quercetin-3-methoxy-4'-glucosyl-7-glucoside Isolated from Indian Medicinal Plant Melothria heterophylla. ---
96  2019 Analgesic and anti-inflammatory effects and molecular mechanisms of Kadsura heteroclita stems, an anti-arthritic Chinese Tujia ethnomedicinal herb. COX-2, IL-1beta, IL-6, iNOS, KHS, RA
97  2019 Anti-inflammatory Compound Shows Therapeutic Safety and Efficacy against Flavivirus Infection. DENV, ZIKV
98  2019 Antitussive and Anti-inflammatory Dual-active Agents Developed from Natural Product Lead Compound 1-Methylhydantoin. COX-2
99  2019 Are All Oral COX-2 Selective Inhibitors the Same? A Consideration of Celecoxib, Etoricoxib, and Diclofenac. BP, COX-2, CV, GI, NSAIDs
100  2019 Aspirin & clopidogrel non-responsiveness & its association with genetic polymorphisms in patients with myocardial infarction. CI, DAPT, MI, OR, TXB2