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Abbreviation : CTHRC1
Long Form : collagen triple helix repeat containing 1
No. Year Title Co-occurring Abbreviation
2022 Adipose-derived stem cells promote the proliferation, migration, and invasion of oral squamous cell carcinoma cells by activating the Wnt/planar cell polarity signaling pathway. ADSCs, OSCC, p-c-Jun, PCP
2022 Application Potential of CTHRC1 as a Diagnostic and Prognostic Indicator for Colon Adenocarcinoma. COAD
2022 CTHRC1 expressed in periodontitis and human periodontal fibroblasts exposed to inflammatory stimuli. ---
2022 CTHRC1 is a prognosis-related biomarker correlated with immune infiltrates in colon adenocarcinoma. COAD, GSEA
2022 PRR11 Promotes Proliferation and Migration of Colorectal Cancer through Activating the EGFR/ERK/AKT Pathway via Increasing CTHRC1. CCK-8, CRC, EdU, PRR11, qRT-PCR
2021 Cancer-associated fibroblast-secreted collagen triple helix repeat containing-1 promotes breast cancer cell migration, invasiveness and epithelial-mesenchymal transition by activating the Wnt/beta-catenin pathway. BC, CAFs, EMT
2021 Collagen triple helix repeat containing-1 exerts antifibrotic effects on human skin fibroblast and bleomycin-induced dermal fibrosis models. BLM, SSc, TGF-beta
2021 CTHRC1 expression is a novel shared diagnostic and prognostic biomarker of survival in six different human cancer subtypes. HNSC, KIRC, LIHC, LUAD, OS, STAD, UCEC
2021 CTHRC1 Is a Prognostic Biomarker and Correlated With Immune Infiltrates in Kidney Renal Papillary Cell Carcinoma and Kidney Renal Clear Cell Carcinoma. CNV, KIRC, KIRP
10  2021 CTHRC1 Knockdown Promotes Inflammatory Responses Partially by p38 MAPK Activation in Human Periodontal Ligament Cells. GCF, MAPK, PDLCs, RA, siRNA, TNF-alpha
11  2021 CTHRC1 promotes growth, migration and invasion of trophoblasts via reciprocal Wnt/β-catenin regulation. PE
12  2021 CTHRC1 promotes liver metastasis by reshaping infiltrated macrophages through physical interactions with TGF-β receptors in colorectal cancer. CRC
13  2021 GPR180 is a component of TGFβ signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-secreted factor CTHRC1. ---
14  2021 Pan-cancer analysis combined with experiments predicts CTHRC1 as a therapeutic target for human cancers. ---
15  2021 Tgfβ1-Cthrc1 Signaling Plays an Important Role in the Short-Term Reparative Response to Heart Valve Endothelial Injury. TGF-beta1
16  2021 The Role of Collagen Triple Helix Repeat-Containing 1 Protein (CTHRC1) in Rheumatoid Arthritis. OA, RA
17  2020 Collagen triple helix repeat containing 1 promotes endometrial cancer cell migration by activating the focal adhesion kinase signaling pathway. EC, FAK
18  2020 Comprehensive analysis reveals CTHRC1, SERPINE1, VCAN and UPK1B as the novel prognostic markers in gastric cancer. AUC, DEGs, GC, GEO, GO, ROC, SERPINE1, UPK1B, VCAN
19  2020 CTHRC1 affects malignant tumor cell behavior and is regulated by miR-30e-5p in human prostate cancer. PCa
20  2020 CTHRC1 in Ovarian Cancer Promotes M2-Like Polarization of Tumor-Associated Macrophages via Regulation of the STAT6 Signaling Pathway. EOC, rCTHRC1, TAMs
21  2020 Cyclovirobuxine D inhibits colorectal cancer tumorigenesis via the CTHRC1‑AKT/ERK‑Snail signaling pathway. CRC
22  2020 Dynamic Evolution of the Cthrc1 Genes, a Newly Defined Collagen-Like Family. FZD6
23  2020 Loss of microRNA-30e induced by extracellular vesicles from cancer-associated fibroblasts promotes breast cancer progression by binding to CTHRC1. BC, CAF, EVs, miR
24  2020 Mir-30b-3p affects the migration and invasion function of ovarian cancer cells by targeting the CTHRC1 gene. 3'UTR, CCK-8, EMT
25  2020 Prolyl 4-hydroxylase subunit alpha 1 (P4HA1) is a biomarker of poor prognosis in primary melanomas, and its depletion inhibits melanoma cell invasion and disrupts tumor blood vessel walls. P4HA1
26  2020 The Distribution and Localization of Collagen Triple Helix Repeat Containing-1 in Naturally and Experimentally Avian Leukosis Virus Subgroup J-Infected Chickens. ALV-J
27  2020 The Role of CTHRC1 in Regulation of Multiple Signaling and Tumor Progression and Metastasis. ---
28  2020 Value of serum collagen triple helix repeat containing-1(CTHRC1) and 14-3-3η protein compared to anti-CCP antibodies and anti-MCV antibodies in the diagnosis of rheumatoid arthritis. AUC, ESR, RA
29  2019 Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-beta signaling. HSCs, mAb, TAA, WT
30  2019 CTHRC1 and PD‑1/PD‑L1 expression predicts tumor recurrence in prostate cancer. DFS, PC, PRAD, TIMER
31  2019 CTHRC1 expression in primary biliary cholangitis. CHB, HC, HSC, PBC, PSC
32  2019 CTHRC1 facilitates bladder cancer cell proliferation and invasion through regulating the PI3K/Akt signaling pathway. IHC, qRT-PCR
33  2019 CTHRC1 May Serve As A Prognostic Biomarker For Hepatocellular Carcinoma. ---
34  2019 CTHRC1 overexpression promotes cervical carcinoma progression by activating the Wnt/PCP signaling pathway. ---
35  2019 CTHRC1 overexpression promotes ectopic endometrial stromal cell proliferation, migration and invasion via activation of the Wnt/beta-catenin pathway. EESC
36  2019 CTHRC1 promotes gastric cancer metastasis via HIF-1alpha/CXCR4 signaling pathway. GC
37  2019 CTHRC1 promotes M2-like macrophage recruitment and myometrial invasion in endometrial carcinoma by integrin-Akt signaling pathway. EC, rCTHRC1, TAMs
38  2019 CTHRC1 promotes wound repair by increasing M2 macrophages via regulating the TGF-beta and notch pathways. PVA
39  2019 CTHRC1: A New Candidate Biomarker for Improved Rheumatoid Arthritis Diagnosis. ACPA, CRP, DAS28-CRP, ESR, IFN-gamma, IL-1beta, IL-6, IL-8, OA, RA, ReA, RF, ROC
40  2019 Deficiency in the phosphatase PHLPP1 suppresses osteoclast-mediated bone resorption and enhances bone formation in mice. M-CSF, PH, PKC
41  2019 Effect of calcium phosphate phases affecting the crosstalk between osteoblasts and osteoclasts in vitro. beta-TCP, C3a, HA, OCP
42  2019 Extracellular vesicles from human urine-derived stem cells prevent osteoporosis by transferring CTHRC1 and OPG. OPG, USC-EVs, USCs
43  2019 High CTHRC1 expression may be closely associated with angiogenesis and indicates poor prognosis in lung adenocarcinoma patients. GESA, LUAD, OS, PFS, VEGF
44  2019 Interplay between CTHRC1 and the SU protein of avian leukosis virus subgroup J (ALV-J) facilitates viral replication. ALV-J
45  2019 Pirfenidone attenuates lung fibrotic fibroblast responses to transforming growth factor-beta1. BMP4, FHL2, IPF, TGF
46  2019 TNF deficiency causes alterations in the spatial organization of neurogenic zones and alters the number of microglia and neurons in the cerebral cortex. FZD6, TNF, WT
47  2018 Array profiling reveals contribution of Cthrc1 to growth of the denervated rat urinary bladder. miRNAs, SMC
48  2018 Collagen Triple Helix Repeat Containing 1 Expression in Osteosarcoma: A New Predictor of Prognosis. ---
49  2018 Collagen triple helix repeat containing 1 promotes tumor angiogenesis in gastrointestinal stromal tumors. ERK, HUVECs, JNK
50  2018 Collagen triple helix repeat containing-1: a novel biomarker associated with disease activity in Systemic lupus erythematosus. IL, SLE, SLEDAI
51  2018 CTHRC1 as a novel biomarker in the diagnosis of cervical squamous cell carcinoma. ---
52  2018 CTHRC1 induces non-small cell lung cancer (NSCLC) invasion through upregulating MMP-7/MMP-9. MMP, NSCLC
53  2018 CTHRC1 mediates IL‑1beta‑induced apoptosis in chondrocytes via JNK1/2 signaling. Bcl, IL, MMP, OA, PARP, sh
54  2018 Elevated CTHRC1 expression is an indicator for poor prognosis and lymph node metastasis in cervical squamous cell carcinoma. CSCC
55  2018 Functional redundancy of frizzled 3 and frizzled 6 in planar cell polarity control of mouse hair follicles. FZD6, PCP
56  2018 Increased Cthrc1 Activates Normal Fibroblasts and Suppresses Keloid Fibroblasts by Inhibiting TGF-beta/Smad Signal Pathway and Modulating YAP Subcellular Location. KFs, LV, NFs
57  2018 Long non-coding RNA NONMMUG014387 promotes Schwann cell proliferation after peripheral nerve injury. ---
58  2018 microRNA-134 inhibits melanoma growth and metastasis by negatively regulating collagen triple helix repeat containing-1 (CTHRC1). WB
59  2018 MicroRNA-155 acts as a tumor suppressor in colorectal cancer by targeting CTHRC1 in vitro. miRNAs
60  2018 WAIF1 Is a Cell-Surface CTHRC1 Binding Protein Coupling Bone Resorption and Formation. TPBG, WAIF1
61  2017 Collagen triple helix repeat containing 1 (CTHRC1) activates Integrin beta3/FAK signaling and promotes metastasis in ovarian cancer. EOC
62  2017 Collagen triple helix repeat containing-1 negatively regulated by microRNA-30c promotes cell proliferation and metastasis and indicates poor prognosis in breast cancer. Mut, WT
63  2017 Cthrc1 lowers pulmonary collagen associated with bleomycin-induced fibrosis and protects lung function. BAL, IPF, TGF, WT
64  2017 CTHRC1 mediates multiple pathways regulating cell invasion, migration and adhesion in glioma. ---
65  2017 CTHRC1 promotes osteogenic differentiation of periodontal ligament stem cells by regulating TAZ. OTM
66  2017 E6/E7-P53-POU2F1-CTHRC1 axis promotes cervical cancer metastasis and activates Wnt/PCP pathway. ECM
67  2017 High expression of Collagen Triple Helix Repeat Containing 1 (CTHRC1) facilitates progression of oesophageal squamous cell carcinoma through MAPK/MEK/ERK/FRA-1 activation. ESCC
68  2017 Inhibition of osteoclast differentiation and collagen antibody-induced arthritis by CTHRC1. ---
69  2017 Integrated Bioinformatics Analysis Predicts the Key Genes Involved in Aortic Valve Calcification: From Hemodynamic Changes to Extracellular Remodeling. CAVD, GO, KEGG, PLPP3, WGCNA
70  2017 Knockdown of Collagen Triple Helix Repeat Containing 1 (CTHRC1) Inhibits Epithelial-Mesenchymal Transition and Cellular Migration in Glioblastoma Cells. EMT
71  2017 Knockdown of Collagen Triple Helix Repeat Containing-1 Inhibits the Proliferation and Epithelial-to-Mesenchymal Transition in Renal Cell Carcinoma Cells. EMT, RCC
72  2017 miR-155-5p modulates malignant behaviors of hepatocellular carcinoma by directly targeting CTHRC1 and indirectly regulating GSK-3β-involved Wnt/β-catenin signaling. HCC, miR-155
73  2017 Role of collagen triple helix repeat containing-1 in tumor and inflammatory diseases. ---
74  2016 Collagen triple helix repeat containing 1 is a new promigratory marker of arthritic pannus. alpha-SMA, CAIA, CDH11, FLS, RA
75  2016 Correlation of Collagen Triple Helix Repeat Containing 1 Overexpression With Lymph Node and Peritoneal Metastasis in Epithelial Ovarian Cancer. ---
76  2016 CTHRC1 promotes angiogenesis by recruiting Tie2-expressing monocytes to pancreatic tumors. Ang-2, EC, rCTHRC1, TEMs
77  2016 CTHRC1 promotes human colorectal cancer cell proliferation and invasiveness by activating Wnt/PCP signaling. CRC
78  2016 Elevated expression of CTHRC1 predicts unfavorable prognosis in patients with pancreatic ductal adenocarcinoma. PDAC
79  2016 Gene expression analyses of primary melanomas reveal CTHRC1 as an important player in melanoma progression. ---
80  2016 Lentivirus-Mediated Knockdown of CTHRC1 Inhibits Osteosarcoma Cell Proliferation and Migration. shRNA
81  2016 MicroRNA-98 suppresses cell proliferation, migration and invasion by targeting collagen triple helix repeat containing 1 in hepatocellular carcinoma. HCC, miRNAs
82  2016 Multidimensional Roles of Collagen Triple Helix Repeat Containing 1 (CTHRC1) in Malignant Cancers. ---
83  2016 Preliminary observations regarding the expression of collagen triple helix repeat-containing 1 is an independent prognostic factor for Wilms' tumor. qRT-PCR, WT
84  2016 The Influenza A Virus Non-structural Protein NS1 Upregulates The Expression of Collagen Triple Helix Repeat Containing 1 Protein. ELISA, IAV, RT-PCR
85  2016 Upregulated CTHRC1 promotes human epithelial ovarian cancer invasion through activating EGFR signaling. EOC
86  2015 Collagen Triple Helix Repeat Containing-1 (CTHRC1) Expression in Oral Squamous Cell Carcinoma (OSCC): Prognostic Value and Clinico-Pathological Implications. LNM, OSCC
87  2015 Hepatitis B virus hijacks CTHRC1 to evade host immunity and maintain replication. HBV, IFN, ISGs
88  2015 High expression of CTHRC1 promotes EMT of epithelial ovarian cancer (EOC) and is associated with poor prognosis. EOC
89  2015 The Crosstalk between Osteoclasts and Osteoblasts Is Dependent upon the Composition and Structure of Biphasic Calcium Phosphates. BCPs, beta-TCP, HA, OBs, OCs, SphK1
90  2015 Treatment of cholestatic fibrosis by altering gene expression of Cthrc1: Implications for autoimmune and non-autoimmune liver disease. CBDL, DDC, HSCs, shRNA
91  2015 [Role of CTHRC1 in proliferation, migration and invasion of human colorectal cancer cells]. CCK-8
92  2014 Collagen triple helix repeat containing 1 (CTHRC1) acts via ERK-dependent induction of MMP9 to promote invasion of colorectal cancer cells. ERK, MMP-9
93  2014 Collagen triple helix repeat containing 1 (Cthrc1) is an independently prognostic biomarker of non-small cell lung cancers with cigarette smoke. DFS, NSCLC, OS, TNM
94  2014 Collagen triple helix repeat containing 1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation and motility. HCC
95  2014 CTHRC1 acts as a prognostic factor and promotes invasiveness of gastrointestinal stromal tumors by activating Wnt/PCP-Rho signaling. GISTs
96  2014 Cthrc1 overexpression is an independent prognostic marker in gastric cancer. ---
97  2014 Let-7b inhibits cell proliferation, migration, and invasion through targeting Cthrc1 in gastric cancer. GC, miRNAs
98  2014 MiR-9 inhibits Schwann cell migration by targeting Cthrc1 following sciatic nerve injury. miRNAs
99  2014 Overexpression of collagen triple helix repeat containing 1 (CTHRC1) is associated with tumour aggressiveness and poor prognosis in human non-small cell lung cancer. NSCLC
100  2014 Role of Frizzled6 in the molecular mechanism of beta-carotene action in the lung. BC, Fzd6