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Abbreviation : CUL4B
Long Form : Cullin 4B
No. Year Title Co-occurring Abbreviation
2022 CUL4B Upregulates RUNX2 to Promote the Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Epigenetically Repressing the Expression of miR-320c and miR-372/373-3p. CRL4B, MSCs, PDL, PDLSCs, TF
2022 Exosomal circKDM4A Induces CUL4B to Promote Prostate Cancer Cell Malignancy in a miR-338-3p-Dependent Manner. miR-338-3p, PC
2022 RUNX2 recruits the NuRD(MTA1)/CRL4B complex to promote breast cancer progression and bone metastasis. EMT, MTA1, PPARalpha, SOD2
2021 CUL4B renders breast cancer cells tamoxifen-resistant via miR-32-5p/ER-α36 axis. CRL4B, ER, TAM
2021 Cullin-4B promotes cell proliferation and invasion through inactivation of p53 signaling pathway in colorectal cancer. CRC, EMT
2021 Discovery and characterization of potent And-1 inhibitors for cancer treatment. And-1, BZA, DNA, HTS, LOPAC
2021 Effect and mechanism of miR-217 on drug resistance, invasion and metastasis of ovarian cancer cells through a regulatory axis of CUL4B gene silencing/inhibited Wnt/beta-catenin signaling pathway activation. oe
2021 Inhibition of MicroRNA miR-101-3p on prostate cancer progression by regulating Cullin 4B (CUL4B) and PI3K/AKT/mTOR signaling pathways. NC, PCa
2021 Roles of the ubiquitin ligase CUL4B and ADP-ribosyltransferase TiPARP in TCDD-induced nuclear export and proteasomal degradation of the transcription factor AHR. AhR, MEF, TiPARP
10  2021 SIRT1 coordinates with the CRL4B complex to regulate pancreatic cancer stem cells to promote tumorigenesis. CSCs, H2AK119ub1, SIRT1
11  2021 Tetramethylpyrazine Improves Cognitive Function of Alzheimer's Disease Mice by Regulating SSTR4 Ubiquitination. AD, SSTR4, TMP
12  2021 The Traditional Chinese Medicine Compound Huangqin Qingre Chubi Capsule Inhibits the Pathogenesis of Rheumatoid Arthritis Through the CUL4B/Wnt Pathway. FLS, HQC, RA
13  2020 Circ_0015756 promotes the progression of ovarian cancer by regulating miR-942-5p/CUL4B pathway. CCK-8, circRNAs, miR-942-5p, OC, qRT-PCR
14  2020 Circ_0074027 Contributes to Non-Small Cell Lung Cancer Progression by Upregulating CUL4B Expression Through miR-335-5p. CCK-8, circRNAs, miR-335-5p, NSCLC, qRT-PCR
15  2020 CUL4B contributes to cancer stemness by repressing tumor suppressor miR34a in colorectal cancer. CCSCs
16  2020 CUL4B promotes aggressive phenotypes of renal cell carcinoma via upregulating c-Met expression. RCC
17  2020 Cullin 4B regulates cell survival and apoptosis in clear cell renal cell carcinoma as a target of microRNA-217. ccRCC, miR-217
18  2020 Downregulation of lncRNA ZEB1-AS1 Represses Cell Proliferation, Migration, and Invasion Through Mediating PI3K/AKT/mTOR Signaling by miR-342-3p/CUL4B Axis in Prostate Cancer. miR-342-3p, MMP-9, mTOR, p-Akt, p-PI3K, PCa, ZEB1-AS1
19  2020 Upregulation of Cullin 4B Promotes Gastric Cancer and Predicts Poor Prognosis. GC
20  2019 Alu-mediated Xq24 deletion encompassing CUL4B, LAMP2, ATP1B4, TMEM255A, and ZBTB33 genes causes Danon disease in a female patient. CS, DD, LAMP2, XCI
21  2019 Circular RNA ZFR accelerates non-small cell lung cancer progression by acting as a miR-101-3p sponge to enhance CUL4B expression. circRNA, circZFR, FISH, miR-101-3p, NSCLC
22  2019 CUL4B negatively regulates Toll-like receptor-triggered proinflammatory responses by repressing Pten transcription. CRL4B, TLRs
23  2019 CUL4B promotes prostate cancer progression by forming positive feedback loop with SOX4. PCa
24  2019 CUL4B regulates cancer stem-like traits of prostate cancer cells by targeting BMI1 via miR200b/c. PCa
25  2019 CUL4B/miR-33b/C-MYC axis promotes prostate cancer progression. ChIP, miRNAs, PCa
26  2019 NCBP1 promotes the development of lung adenocarcinoma through up-regulation of CUL4B. NCBP1, NCBP3
27  2019 Small molecule TSC01682 inhibits osteosarcoma cell growth by specifically disrupting the CUL4B-DDB1 interaction and decreasing the ubiquitination of CRL4B E3 ligase substrates. CRL4B, DCAF11, DDB1, HTS
28  2018 CRL4 antagonizes SCFFbxo7-mediated turnover of cereblon and BK channel to regulate learning and memory. CRBN, ID
29  2018 MicroRNA-133b inhibits cell proliferation and promotes apoptosis by targeting cullin 4B in esophageal squamous cell carcinoma. ESCC, miRs
30  2018 MiR-431 inhibits colorectal cancer cell invasion via repressing CUL4B. EMT, FN, miR-431, RT-PCR
31  2017 A cullin 4B-RING E3 ligase complex fine-tunes pancreatic delta cell paracrine interactions. AC6, CRL4B, HHEX, PRC2, UCN3
32  2017 CRL4BDCAF11 E3 ligase targets p21 for degradation to control cell cycle progression in human osteosarcoma cells. CDKs, CKIs, CRL4B, DDB1, RBX1, shRNAs
33  2017 Cul4B is a novel prognostic marker in cholangiocarcinoma. CCA, EHCC, EMT
34  2017 CUL4B promotes bladder cancer metastasis and induces epithelial-to-mesenchymal transition by activating the Wnt/beta-catenin signaling pathway. BC, EMT, qRT-PCR, siRNA-NC, WIF-1
35  2017 CUL4B promotes gastric cancer invasion and metastasis-involvement of upregulation of HER2. EMT, GC
36  2017 CUL4B promotes metastasis and proliferation in pancreatic cancer cells by inducing epithelial-mesenchymal transition via the Wnt/beta-catenin signaling pathway. EMT, PC
37  2017 Dysregulation of the miR-194-CUL4B negative feedback loop drives tumorigenesis in non-small-cell lung carcinoma. miR-194, NSCLC
38  2017 Proteomic analysis of the cullin 4B interactome using proximity-dependent biotinylation in living cells. ---
39  2017 The role of cullin4B in human cancers. CRL4B
40  2016 Knockdown of CUL4B Suppresses the Proliferation and Invasion in Non-Small Cell Lung Cancer Cells. EMT, NSCLC
41  2015 Accelerated hepatocellular carcinoma development in CUL4B transgenic mice. CRL4B
42  2015 CUL4B: a novel epigenetic driver in Wnt/beta-catenin-dependent hepatocarcinogenesis. EZH2, HCC
43  2015 Decreased CUL4B expression inhibits malignant proliferation of glioma in vitro and in vivo. CRL4B, RNAi
44  2015 FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex. DDB1, FBXO44, RGS2
45  2015 Knockdown of CUL4B inhibits proliferation and promotes apoptosis of colorectal cancer cells through suppressing the Wnt/beta-catenin signaling pathway. ---
46  2015 The CUL4B/AKT/beta-Catenin Axis Restricts the Accumulation of Myeloid-Derived Suppressor Cells to Prohibit the Establishment of a Tumor-Permissive Microenvironment. CRL4B, MDSC
47  2014 CUL4B activates Wnt/beta-catenin signalling in hepatocellular carcinoma by repressing Wnt antagonists. HCC
48  2014 CUL4B promotes proliferation and inhibits apoptosis of human osteosarcoma cells. CRL4B, RNAi
49  2014 E3 ubiquitin ligase Cullin4B mediated polyubiquitination of p53 for its degradation. CUL4A
50  2014 Enhanced LPS-induced peritonitis in mice deficiency of cullin 4B in macrophages. LPS
51  2014 SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway. DCAF1, DDB1
52  2014 Variants in CUL4B are associated with cerebral malformations. MCD
53  2013 CRL4B promotes tumorigenesis by coordinating with SUV39H1/HP1/DNMT3A in DNA methylation-based epigenetic silencing. CRL4B, DNMT3A, HP1
54  2013 Cullin 4B is a novel prognostic marker that correlates with colon cancer progression and pathogenesis. ---
55  2013 X-linked intellectual disability gene CUL4B targets Jab1/CSN5 for degradation and regulates bone morphogenetic protein signaling. BMP, XLID
56  2013 XLID CUL4B mutants are defective in promoting TSC2 degradation and positively regulating mTOR signaling in neocortical neurons. XLID
57  2012 Cullin 4B is recruited to tristetraprolin-containing messenger ribonucleoproteins and regulates TNF-alpha mRNA polysome loading. TTP
58  2012 Pathogenic Role of the CRL4 Ubiquitin Ligase in Human Disease. CRL4, CUL4A
59  2011 Cullin 4B protein ubiquitin ligase targets peroxiredoxin III for degradation. PrxIII, ROS
60  2008 The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A. CUL4A, NER, UV-DDB, XP-E