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Abbreviation : Cdk5
Long Form : cyclin-dependent kinase 5
No. Year Title Co-occurring Abbreviation
2021 Adhesion GPCR Latrophilin-2 Specifies Cardiac Lineage Commitment through CDK5, Src, and P38MAPK. CMCs, CPCs, LPHN2, PSC
2021 CDK5 inhibition protects against OGDR induced mitochondrial fragmentation and apoptosis through regulation of Drp1S616 phosphorylation. Drp1, OGD, OGDR
2021 CDK5 Knockdown inhibits proliferation and induces apoptosis and Cell Cycle Arrest in Human Glioblastoma. GSEA, LGG
2021 CDK5 positively regulates Notch1 signaling in pancreatic cancer cells by phosphorylation. PDAC
2021 Differential regulation of excitatory synaptic transmission in the hippocampus and anterior temporal lobe by cyclin dependent kinase 5 (Cdk5) in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). ATL, DRE, EPSCs, MTLE-HS
2021 Extracellular CIRP Activates the IL-6Rα/STAT3/Cdk5 Pathway in Neurons. eCIRP, N2a
2021 Fusobacterium nucleatum Promotes the Progression of Colorectal Cancer Through Cdk5-Activated Wnt/β-Catenin Signaling. CRC
2021 Glucose-Dependent Insulinotropic Polypeptide Suppresses Foam Cell Formation of Macrophages through Inhibition of the Cyclin-Dependent Kinase 5-CD36 Pathway. GIP
2021 Inhibition of the CDK5/caspase-3 Pathway by p5-TAT Protects Hippocampal Neurogenesis and Alleviates Radiation-induced Cognitive Dysfunction. ---
10  2021 Lipopolysaccharide-induced inflammation in human peritoneal mesothelial cells is controlled by ERK1/2-CDK5-PPARγ axis. CDK, ELISA, IL-12, IL-1beta, IL-6, LPS, PPAR
11  2021 Melatonin reduces proliferation and promotes apoptosis of bladder cancer cells by suppressing O-GlcNAcylation of cyclin-dependent-like kinase 5. ---
12  2021 MiR-26a regulated adipogenic differentiation of ADSCs induced by insulin through CDK5/FOXC2 pathway. ADSCs, FOXC2, PPARgamma
13  2021 Neuronal Nitric Oxide Synthase in Nucleus Accumbens Specifically Mediates Susceptibility to Social Defeat Stress through Cyclin-Dependent Kinase 5. CSDS, NAcSh, nNOS, NO
14  2021 Novel and atypical pathways for serotonin signaling. GIPs, GPCRs, GPRIN1
15  2021 Protective Effect of Hydroxysafflor Yellow A against Chronic Mild Stress-induced Memory Impairments by Suppressing Tau Phosphorylation in Mice. AD, BDNF, CMS, GSK-3beta, HSYA, mTOR, PI3K, RCAN1-1L, TrkB
16  2021 Protective effects of a small molecule inhibitor ligand against hyperphosphorylated tau-induced mitochondrial and synaptic toxicities in Alzheimer disease. AD, DYRK1A, GSK-3beta, NFTs, p-tau, PHFs
17  2021 Regional specific activations of ERK1/2 and CDK5 differently regulate astroglial responses to ER stress in the rat hippocampus following status epilepticus. ER
18  2021 Regulation of CRMP2 by Cdk5 and GSK-3β participates in sevoflurane-induced dendritic development abnormalities and cognitive dysfunction in developing rats. CRMP2, GSK-3beta, LTP, PND7
19  2021 Requirement of CRMP2 Phosphorylation in Neuronal Migration of Developing Mouse Cerebral Cortex and Hippocampus and Redundant Roles of CRMP1 and CRMP4. CRMP, KI, KO
20  2021 RET Regulates Human Medullary Thyroid Cancer Cell Proliferation through CDK5 and STAT3 Activation. MTC
21  2021 Roscovitine, a Cyclin-Dependent Kinase-5 Inhibitor, Decreases Phosphorylated Tau Formation and Death of Retinal Ganglion Cells of Rats after Optic Nerve Crush. ONC, RGCs
22  2021 Somatostatin Ameliorates β-Amyloid-Induced Cytotoxicity via the Regulation of CRMP2 Phosphorylation and Calcium Homeostasis in SH-SY5Y Cells. CRMP2, SST
23  2021 Targeting MicroRNA-125b Promotes Neurite Outgrowth but Represses Cell Apoptosis and Inflammation via Blocking PTGS2 and CDK5 in a FOXQ1-Dependent Way in Alzheimer Disease. AD, FOXQ1, miR-125b, NC, PTGS2
24  2021 The risk variant of CDKAL1 (rs7756992) impairs fasting glucose levels and insulin resistance improvements after a partial meal-replacement hypocaloric diet. BMI, pMRHD
25  2021 The Role of CDK5 in Tumours and Tumour Microenvironments. ---
26  2021 The S. pombe CDK5 Orthologue Pef1 Cooperates with Three Cyclins, Clg1, Pas1 and Psl1, to Promote Pre-Meiotic DNA Replication. ---
27  2021 The type 2 diabetes mellitus susceptibility gene CDKAL1 polymorphism is associated with depressive symptom in first-episode drug-naive schizophrenic patients. FDSP, PANSS
28  2020 A kinase of many talents: non-neuronal functions of CDK5 in development and disease. ---
29  2020 A Novel NMDA Receptor Antagonist Protects against Cognitive Decline Presented by Senescent Mice. AD, BCL-2, GPX1, LOAD, mBDNF, NMDA, NORT, OLT, PSD-95, SAMP8, SOD1, SYN, TCT, TrkB-FL
30  2020 Aberrant Dopamine Receptor Signaling Plays Critical Role in the Impairment of Striatal Neurons in Experimental Cerebral Malaria. ARM, CaMKIIalpha, CM, DARPP, ECM, MSNs, PbA
31  2020 Activity- and memory training-induced acetylation of α-tubulin in the hippocampus. ---
32  2020 AGE-RAGE Axis Stimulates Oxidized LDL Uptake into Macrophages through Cyclin-Dependent Kinase 5-CD36 Pathway via Oxidative Stress Generation. AGEs, oxLDL
33  2020 Association of the CDKAL1 polymorphism rs10946398 with type 2 diabetes mellitus in adults: A meta-analysis. OR, T2DM
34  2020 Brain delivery of quercetin-loaded exosomes improved cognitive function in AD mice by inhibiting phosphorylated tau-mediated neurofibrillary tangles. AD, Exo, NFTs, OA, QUE
35  2020 Calpain-mediated cleavage of Fbxw7 during excitotoxicity. FBXW7
36  2020 CDK5 Activates Hippo Signaling to Confer Resistance to Radiation Therapy Via Upregulating TAZ in Lung Cancer. ---
37  2020 Cdk5 Inhibitory Peptide Prevents Loss of Neurons and Alleviates Behavioral Changes in p25 Transgenic Mice. AAV9, AD, Tg
38  2020 Cdk5 knocking out mediated by CRISPR-Cas9 genome editing for PD-L1 attenuation and enhanced antitumor immunity. PD-L1
39  2020 Cdk5 Phosphorylation of STAT3 in Dorsal Root Ganglion Neurons Is Involved in Promoting Axonal Regeneration After Peripheral Nerve Injury. dnCdk5, DRG, SNI
40  2020 CDK5 Targeting as a Therapy for Recovering Neurovascular Unit Integrity in Alzheimer's Disease. AD, NVU
41  2020 Cdk5-mediated Drp1 phosphorylation drives mitochondrial defects and neuronal apoptosis in radiation-induced optic neuropathy. Drp1, EBRT, Fis1, RION, ROS
42  2020 Cdk5-Mediated Phosphorylation of Sirt1 Contributes to Podocyte Mitochondrial Dysfunction in Diabetic Nephropathy. DN, HG, S47A
43  2020 Changes in the prefrontal cortex after the hippocampus was injected with Aβ25-35 via the P35/P25-CDK5-Tau hyperphosphorylation signaling pathway. AD, PFC
44  2020 Chronic Corticosterone Elevation Suppresses Adult Hippocampal Neurogenesis by Hyperphosphorylating Huntingtin. BDNF, CORT, DXM, HTT
45  2020 Cyclin-dependent Kinase 5 Regulates Cortical Neurotransmission and Neural Circuits Associated with Motor Control in the Secondary Motor Cortex in the Mouse. GFP
46  2020 Cyclin-Dependent Kinase 5-Dependent BAG3 Degradation Modulates Synaptic Protein Turnover. AD
47  2020 Diabetes-Induced H3K9 Hyperacetylation Promotes Development of Alzheimer's Disease Through CDK5. AD, HFD, STZ
48  2020 Dopamine and cAMP-regulated phosphoprotein 32kDa (DARPP-32), protein phosphatase-1 and cyclin-dependent kinase 5 expression in ovarian cancer. CI, DARPP-32, HR, PKA, PP1
49  2020 Downregulation of CDK5 Restores Sevoflurane-Induced Cognitive Dysfunction by Promoting SIRT1-Mediated Autophagy. SIRT1
50  2020 Dynamic interactions of the 5-HT6 receptor with protein partners control dendritic tree morphogenesis. GPRIN1, PKA
51  2020 Emerging Roles of Inhibitor of Differentiation-1 in Alzheimer's Disease: Cell Cycle Reentry and Beyond. AD, HIF-1, HLH, Id, Shh
52  2020 Ginsenoside Rg1 reduces β‑amyloid levels by inhibiting CDΚ5‑induced PPARγ phosphorylation in a neuron model of Alzheimer's disease. AD, APP, Ide
53  2020 Hypoxia induces HT-22 neuronal cell death via Orai1/CDK5 pathway-mediated Tau hyperphosphorylation. AD, siOrai1
54  2020 Identification of differentially expressed microRNAs and their target genes in the hippocampal tissues of Fmr1 knockout mice. Fmr1 KO, FMRP, FXS, miRNAs, qRT-PCR, Syt1, WT
55  2020 IRE1-XBP1 Pathway of the Unfolded Protein Response Is Required during Early Differentiation of C2C12 Myoblasts. UPRs
56  2020 Lnc-ATG9B-4 aggravates progress of hepatocellular carcinoma through cell proliferation and migration by upregulating CDK5. PVTT
57  2020 Long Noncoding RNA H19 Induces Neuropathic Pain by Upregulating Cyclin-Dependent Kinase 5-Mediated Phosphorylation of cAMP Response Element Binding Protein. CCI, CREB, GFAP, LV, NP, PWL, PWT, si
58  2020 Metformin Ameliorates Synaptic Defects in a Mouse Model of AD by Inhibiting Cdk5 Activity. AD, LTP
59  2020 Nicotine encourages oxidative stress and impairment of rats' brain mitigated by Spirulina platensis lipopolysaccharides and low-dose ionizing radiation. CAT, IL-17, LDIR, MDA, NF-kappaB, pTau, S.LPS, SOD, TLR4, TNF-alpha
60  2020 Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Mice. AD, GSK-3beta, LTP, MC-I, PP2A
61  2020 Phosphorylation of CRMP2 is required for migration and positioning of Purkinje cells: Redundant roles of CRMP1 and CRMP4. CRMP2, KO
62  2020 Phosphorylation of STAT3 by axonal Cdk5 promotes axonal regeneration by modulating mitochondrial activity. DRG, MTS, STAT3
63  2020 Physiological and Pathological Roles of Cdk5: Potential Directions for Therapeutic Targeting in Neurodegenerative Disease. Ser, Thr
64  2020 PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPARγ at Ser273. DIO, ERK, GTEx, PPARgamma, PPM1A, pSer273
65  2020 Quantitative Phosphoproteomic Analysis in Alpha-Synuclein Transgenic Mice Reveals the Involvement of Aberrant p25/Cdk5 Signaling in Early-stage Parkinson's Disease. PD, SNpc
66  2020 R-Roscovitine Improves Motoneuron Function in Mouse Models for Spinal Muscular Atrophy. ---
67  2020 Retrospective assessment of cyclin-dependent kinase 5 mRNA and protein expression and its association with patient survival in breast cancer. CI, HR
68  2020 RPS23RG1 modulates tau phosphorylation and axon outgrowth through regulating p35 proteasomal degradation. AD, KO, Tg
69  2020 Targeting Tau Hyperphosphorylation via Kinase Inhibition: Strategy to Address Alzheimer's Disease. GSK-3beta, JNKs, MARK
70  2020 Targeting the cyclin-dependent kinase 5 in metastatic melanoma. PDX
71  2020 The role of cyclin-dependent kinase 5 in neuropathic pain. ---
72  2020 Tolfenamic acid inhibits GSK-3β and PP2A mediated tau hyperphosphorylation in Alzheimer's disease models. AD, GFX, GSK-3beta, i.c.v, OA, PP2A, Sp1, WT
73  2020 TP5, a Peptide Inhibitor of Aberrant and Hyperactive CDK5/p25: A Novel Therapeutic Approach against Glioblastoma. ---
74  2020 VGLUT2/Cdk5/p25 Signaling Pathway Contributed to Inflammatory Pain by Complete Freund's Adjuvant. CFA, DRG, VGLUT2
75  2020 Vitamin D deficiency exacerbates Alzheimer-like pathologies by reducing antioxidant capacity. AD, APP, BACE1, GPX4, SOD1, VD
76  2020 [Effect of electroacupuncture on the P35/P25-cyclin-dependent kinase 5-Tau pathway in hippocampus of rats with Alzheimer's disease]. AD
77  2019 AAV9-Mediated Cdk5 Inhibitory Peptide Reduces Hyperphosphorylated Tau and Inflammation and Ameliorates Behavioral Changes Caused by Overexpression of p25 in the Brain. AAV9, i.c.v
78  2019 Abnormal Mitochondria in a Non-human Primate Model of MPTP-induced Parkinson's Disease: Drp1 and CDK5/p25 Signaling. Drp1, ERK, MPTP, PD
79  2019 alpha-lipoic acid attenuates spatial learning and memory impairment induced by hepatectomy. ALA, POCD, WT
80  2019 ARNTL hypermethylation promotes tumorigenesis and inhibits cisplatin sensitivity by activating CDK5 transcription in nasopharyngeal carcinoma. ARNTL, GSEA, NPC
81  2019 Both GSK-3beta/CRMP2 and CDK5/CRMP2 pathways participate in the protection of dexmedetomidine against propofol-induced learning and memory impairment in neonatal rats. GABA, GSK-3beta, RhoA
82  2019 Brain targeting of 9c,11t-Conjugated Linoleic Acid, a natural calpain inhibitor, preserves memory and reduces Aβ and P25 accumulation in 5XFAD mice. AD, CJD, CLA, PA, PSO
83  2019 Cdk5 Deletion Enhances the Anti-inflammatory Potential of GC-Mediated GR Activation During Inflammation. DEX, GC, GR, iNOS, NO
84  2019 Cdk5 increases MARK4 activity and augments pathological tau accumulation and toxicity through tau phosphorylation at Ser262. LKB1, MARK
85  2019 CDK5 inhibits the clathrin-dependent internalization of TRPV1 by phosphorylating the clathrin adaptor protein AP2mu2. AP-2, AP2, CFA, TRPV1
86  2019 CDK5 neutralizes the tumor suppressing effect of BIN1 via mediating phosphorylation of c-MYC at Ser-62 site in NSCLC. BIN1, EMT, NSCLC
87  2019 CDK5 Participates in Amyloid-beta Production by Regulating PPARgamma Phosphorylation in Primary Rat Hippocampal Neurons. AbetaPP, AD, BACE1, IDE, PPARgamma
88  2019 Cdk5 regulates N-cadherin-dependent neuronal migration during cortical development. CP, IZ, N-cad
89  2019 Cdk5-Dependent Phosphorylation of CaV3.2 T-Type Channels: Possible Role in Nerve Ligation-Induced Neuropathic Allodynia and the Compound Action Potential in Primary Afferent C Fibers. DRG, SNL
90  2019 Cdk5-mediated CRMP2 phosphorylation is necessary and sufficient for peripheral neuropathic pain. CRMP2, DRG, siRNA, SNI
91  2019 CDK5: A Unique CDK and Its Multiple Roles in the Nervous System. ---
92  2019 CDK5: Key Regulator of Apoptosis and Cell Survival. ---
93  2019 Complement C3a receptor antagonist attenuates tau hyperphosphorylation via glycogen synthase kinase 3beta signaling pathways. AD, GSK-3beta, OA, PP2Ac
94  2019 Computational Simulations Identify Pyrrolidine-2,3-Dione Derivatives as Novel Inhibitors of Cdk5/p25 Complex to Attenuate Alzheimer's Pathology. ---
95  2019 Crosstalk between Cdk5/p35 and ERK1/2 signalling mediates spinal astrocyte activity via the PPARgamma pathway in a rat model of chronic constriction injury. CCI, ELISA, IL, MEK, pPPARgamma
96  2019 Curcumin Downregulates GSK3 and Cdk5 in Scopolamine-Induced Alzheimer's Disease Rats Abrogating Abeta40/42 and Tau Hyperphosphorylation. AD, GSK-3
97  2019 Cyclin-dependent kinase 5 (CDK5) regulates the circadian clock. CRY1, Per2, SCN
98  2019 Cyclin-Dependent Kinase 5 (CDK5)-Mediated Phosphorylation of Upstream Stimulatory Factor 2 (USF2) Contributes to Carcinogenesis. USF2
99  2019 Cyclin-Dependent Kinase 5 Dysfunction Contributes to Depressive-like Behaviors in Huntington's Disease by Altering the DARPP-32 Phosphorylation Status in the Nucleus Accumbens. DARPP-32, HD
100  2019 Cyclin-dependent kinase 5 promotes proteasomal degradation of the 5-HT1A receptor via phosphorylation. 5-HT1AR, Gi, GPCR