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Abbreviation : ClfA
Long Form : clumping factor A
No. Year Title Co-occurring Abbreviation
2023 Antibacterial Mechanism of 2R,3R-Dihydromyricetin Against Staphylococcus aureus: Deciphering Inhibitory Effect on Biofilm and Virulence Based on Transcriptomic and Proteomic Analyses. DMY
2022 Bioassay-guided isolation and characterization of lead antimicrobial compounds from Acacia hydaspica plant extract. Atl, CG, FnBP, MG
2022 Fibrin(ogen) engagement of S. aureus promotes the host antimicrobial response and suppression of microbe dissemination following peritoneal infection. ---
2022 Molecular Detection of Clumping factor A gene and Antibiotic Susceptibility Evaluation of Staphylococcus Aureus Isolated from Urinary Tract Infections. S. aureus
2022 Protein-conjugated microbubbles for the selective targeting of S. aureus biofilms. MBs, S. aureus
2021 Adaptation of Staphylococcus aureus to the Human Skin Environment Identified Using an ex vivo Tissue Model. fnbA, SigB, WTA
2021 Influence of Nisin-Biogel at Subinhibitory Concentrations on Virulence Expression in Staphylococcus aureus Isolates from Diabetic Foot Infections. agrI, AMP, Atl, coa, DFIs, icaA, icaD, MIC, SpA
2021 PIA and rSesC Mixture Arisen Antibodies Could Inhibit the Biofilm-Formation in Staphylococcus aureus. BAIs, FTIR, PIA
2020 Evaluation of the Efficacy of a Cholera-Toxin-Based Staphylococcus aureus Vaccine against Bovine Intramammary Challenge. IFN-gamma, IgG, IsdA, S. aureus, SCC
10  2019 Liposomal and CpG-ODN formulation elicits strong humoral immune responses to recombinant Staphylococcus aureus antigens in heifer calves. CpG ODN, FnBPA, Lip
11  2019 Mechanostability of the Fibrinogen Bridge between Staphylococcal Surface Protein ClfA and Endothelial Cell Integrin alphaVbeta3. Fg
12  2018 Assessment of the Dual Role of Clumping Factor A in S. Aureus Adhesion to Endothelium in Absence and Presence of Plasma. ECs, Fg, FN, FnBPA, vWbp, vWF
13  2018 Immunogenicity of a Staphylococcus aureus-cholera toxin A2/B vaccine for bovine mastitis. IsdA
14  2018 Marginal role of von Willebrand factor-binding protein and coagulase in the initiation of endocarditis in rats with catheter-induced aortic vegetations. Coa, IE, vWbp
15  2018 Staphylococcus aureus clumping factor A is a force-sensitive molecular switch that activates bacterial adhesion. Fg
16  2017 Adaptive Upregulation of Clumping Factor A (ClfA) by Staphylococcus aureus in the Obese, Type 2 Diabetic Host Mediates Increased Virulence. PAI-1, T2D
17  2017 Clumping factor A of Staphylococcus aureus interacts with AnnexinA2 on mammary epithelial cells. ---
18  2017 Clumping factor A, von Willebrand factor-binding protein and von Willebrand factor anchor Staphylococcus aureus to the vessel wall. S. aureus, SrtA, vWbp, vWF
19  2017 Mouse model of hematogenous implant-related Staphylococcus aureus biofilm infection reveals therapeutic targets. AT
20  2017 Multimechanistic Monoclonal Antibodies (MAbs) Targeting Staphylococcus aureus Alpha-Toxin and Clumping Factor A: Activity and Efficacy Comparisons of a MAb Combination and an Engineered Bispecific Antibody Approach. BiSAbs, mAb, mAbs, MRSA
21  2017 The Staphylococcus aureus Cell Wall-Anchored Protein Clumping Factor A Is an Important T Cell Antigen. ---
22  2016 Contribution of Staphylococcus aureus Coagulases and Clumping Factor A to Abscess Formation in a Rabbit Model of Skin and Soft Tissue Infection. coa, vWbp
23  2016 Inhibition of major integrin alphaV beta3 reduces Staphylococcus aureus attachment to sheared human endothelial cells. EC, S. aureus
24  2016 Preclinical Efficacy of Clumping Factor A in Prevention of Staphylococcus aureus Infection. ---
25  2016 Protective efficacy of the chimeric Staphylococcus aureus vaccine candidate IC in sepsis and pneumonia models. IC, IsdB, OPA
26  2016 Safety and immunogenicity of a booster dose of a 3-antigen Staphylococcus aureus vaccine (SA3Ag) in healthy adults: A randomized phase 1 study. CP5 and CP8
27  2016 Safety, tolerability, and immunogenicity of a single dose 4-antigen or 3-antigen Staphylococcus aureus vaccine in healthy older adults: Results of a randomised trial. cLIA, FBI, ICS, OPA, S. aureus
28  2016 Staphylococcus aureus Clumping Factor A Remains a Viable Vaccine Target for Prevention of S. aureus Infection. ---
29  2016 Targeting Alpha Toxin and ClfA with a Multimechanistic Monoclonal-Antibody-Based Approach for Prophylaxis of Serious Staphylococcusaureus Disease. AT, mAb, OPK
30  2015 A randomized phase I study of the safety and immunogenicity of three ascending dose levels of a 3-antigen Staphylococcus aureus vaccine (SA3Ag) in healthy adults. CP5 and CP8, CRM197
31  2015 Construction of scFv that bind both fibronectin-binding protein A and clumping factor A of Stapylococcus aureus. BM, FnBPA, VH, VL
32  2015 Demonstration of the preclinical correlate of protection for Staphylococcus aureus clumping factor A in a murine model of infection. FBI
33  2015 Evaluation of approaches to monitor Staphylococcus aureus virulence factor expression during human disease. MntC, qRT-PCR, SA4Ag
34  2015 In silico analysis for identifying potential vaccine candidates against Staphylococcus aureus. ---
35  2015 New potential role of serum apolipoprotein E mediated by its binding to clumping factor A during Staphylococcus aureus invasive infections to humans. APOE
36  2015 Protection of mice against Staphylococcus aureus infection by a recombinant protein ClfA-IsdB-Hlg as a vaccine candidate. IsdB
37  2015 Safety and immunogenicity of an investigational 4-component Staphylococcus aureus vaccine with or without AS03B adjuvant: Results of a randomized phase I trial. AEs, AT, GMCs, pIMDs, SAEs, TT
38  2015 Vaccination against Staphylococcus aureus experimental endocarditis using recombinant Lactococcus lactis expressing ClfA or FnbpA. FnBPA, IE
39  2014 A short sequence within subdomain N1 of region A of the Staphylococcus aureus MSCRAMM clumping factor A is required for export and surface display. MSCRAMM
40  2013 Immunogenicity analysis of Staphylococcus aureus clumping factor A genetic variants. ---
41  2013 Novel staphylococcal glycosyltransferases SdgA and SdgB mediate immunogenicity and protection of virulence-associated cell wall proteins. GlcNAc, SDR
42  2013 Protein antigens increase the protective efficacy of a capsule-based vaccine against Staphylococcus aureus in a rat model of osteomyelitis. CPS, dHla
43  2013 Two Dimensional Structural Analysis and Expression of a New Staphylococcus aureus Adhesin Based Fusion Protein. FnBPA, HGF, VRSA
44  2012 A recombinant clumping factor A-containing vaccine induces functional antibodies to Staphylococcus aureus that are not observed after natural exposure. Fg
45  2012 Protective immunization against Staphylococcus aureus infection in a novel experimental wound model in mice. Eap, Efb, FnBP
46  2012 Synthesis and evaluation of a conjugate vaccine composed of Staphylococcus aureus poly-N-acetyl-glucosamine and clumping factor A. dPNAG
47  2011 Challenges for the evaluation of Staphylococcus aureus protein based vaccines: monitoring antigenic diversity. ---
48  2011 Evaluation of a novel chimeric B cell epitope-based vaccine against mastitis induced by either Streptococcus agalactiae or Staphylococcus aureus in mice. IgG, rSip-ClfA, Sip
49  2011 Preventing Staphylococcus aureus sepsis through the inhibition of its agglutination in blood. Coa, vWbp
50  2010 Clumping factor A interaction with complement factor I increases C3b cleavage on the bacterial surface of Staphylococcus aureus and decreases complement-mediated phagocytosis. ---
51  2010 Role of interleukin-17A in cell-mediated protection against Staphylococcus aureus infection in mice immunized with the fibrinogen-binding domain of clumping factor A. IL-17A
52  2009 c-di-GMP as a vaccine adjuvant enhances protection against systemic methicillin-resistant Staphylococcus aureus (MRSA) infection. i.v, IgG1, MRSA, mSEC, s.c
53  2009 Differential binding of biofilm-derived and suspension-grown Staphylococcus aureus to immobilized platelets in shear flow. ---
54  2009 Heterogeneous in vivo expression of clumping factor A and capsular polysaccharide by Staphylococcus aureus: implications for vaccine design. S. aureus
55  2009 Regional profiling for determination of genotype diversity of mastitis-specific Staphylococcus aureus lineage in Canada by use of clumping factor A, pulsed-field gel electrophoresis, and spa typing. PFGE
56  2009 Relationship between virulence factor genes in bovine Staphylococcus aureus subclinical mastitis isolates and binding to anti-adhesin antibodies. Efb, FnBPA
57  2009 [Immunogenicity of Staphylococcus aureus recombinant clumping factor A]. S. aureus
58  2008 A new feasible method for fibrinogen purification based on the affinity of Staphylococcus aureus clumping factor A to fibrinogen. GST
59  2008 A structural model of the Staphylococcus aureus ClfA-fibrinogen interaction opens new avenues for the design of anti-staphylococcal therapeutics. Fg, IIb
60  2008 Antibodies to capsular polysaccharide and clumping factor A prevent mastitis and the emergence of unencapsulated and small-colony variants of Staphylococcus aureus in mice. CP, SCVs
61  2008 Fibrinogen binding sites P336 and Y338 of clumping factor A are crucial for Staphylococcus aureus virulence. ---
62  2008 Genotypic screening of atypical Staphylococcus aureus strains isolated from clinical samples for presence of selected adhesin genes. bbp, cna, fnbA, fnbB
63  2008 Repeat-based subtyping and grouping of Staphylococcus aureus from human infections and bovine mastitis using the R-domain of the clumping factor A gene. ---
64  2008 Signal peptides direct surface proteins to two distinct envelope locations of Staphylococcus aureus. FnBPB, SasA
65  2008 Staphylococcus aureus clumping factor A binds to complement regulator factor I and increases factor I cleavage of C3b. rClfA
66  2008 Vaccination with clumping factor A and fibronectin binding protein A to prevent Staphylococcus aureus infection of an aortic patch in mice. FnBPA
67  2007 A segment of Staphylococcus aureus clumping factor A with fibrinogen-binding activity (ClfA221-550) inhibits platelet-plug formation in mice. ---
68  2007 Bacterial c-di-GMP is an immunostimulatory molecule. DCs
69  2007 Both complement- and fibrinogen-dependent mechanisms contribute to platelet aggregation mediated by Staphylococcus aureus clumping factor B. ---
70  2007 Capsular polysaccharide masks clumping factor A-mediated adherence of Staphylococcus aureus to fibrinogen and platelets. CP
71  2007 Fibrinogen and elastin bind to the same region within the A domain of fibronectin binding protein A, an MSCRAMM of Staphylococcus aureus. MSCRAMM
72  2007 Fibronectin-binding proteins and clumping factor A in Staphylococcus aureus experimental endocarditis: FnBPA is sufficient to activate human endothelial cells. ECs, FnBPA, IE
73  2007 In vivo sortase A and clumping factor A mRNA expression during Staphylococcus aureus infection. GyrB, SrtA
74  2007 Molecular basis for Staphylococcus aureus-mediated platelet aggregate formation under arterial shear in vitro. FnBPA, IE
75  2006 Clumping factor A of Staphylococcus aureus inhibits phagocytosis by human polymorphonuclear leucocytes. ---
76  2006 DNA immunization of dairy cows with the clumping factor A of Staphylococcus aureus. IRES
77  2005 ClfA(221-550), a fibrinogen-binding segment of Staphylococcus aureus clumping factor A, disrupts fibrinogen function. ---
78  2005 Fibrinogen and fibronectin binding cooperate for valve infection and invasion in Staphylococcus aureus experimental endocarditis. FnBPA
79  2005 Multicenter study to determine antibody concentrations and assess the safety of administration of INH-A21, a donor-selected human Staphylococcal immune globulin, in low-birth-weight infants. IVIG, PKs, SdrG
80  2004 A fibrinogen-binding protein of Staphylococcus lugdunensis. ---
81  2004 Characterization of the fibrinogen-binding surface protein Fbl of Staphylococcus lugdunensis. ---
82  2004 Clumping factor A-mediated virulence during Staphylococcus aureus infection is retained despite fibrinogen depletion. ---
83  2004 Expression of staphylococcal clumping factor A impedes macrophage phagocytosis. ---
84  2004 Immune responses to a DNA/protein vaccination strategy against Staphylococcus aureus induced mastitis in dairy cows. FnBP, IRES, pCI-bGM-CSF
85  2003 Anti-clumping factor A immunoglobulin reduces the duration of methicillin-resistant Staphylococcus aureus bacteremia in an experimental model of infective endocarditis. IE, MRSA
86  2003 Characterization of a protective monoclonal antibody recognizing Staphylococcus aureus MSCRAMM protein clumping factor A. mAb
87  2002 DNA immunization against the clumping factor A (ClfA) of Staphylococcus aureus. ---
88  2002 Staphylococcus and biofilms. Aap, Bap, dltA, IS, PIA
89  2001 Clumping factor A mediates binding of Staphylococcus aureus to human platelets. ---
90  2001 Protection against experimental Staphylococcus aureus arthritis by vaccination with clumping factor A, a novel virulence determinant. ---
91  2001 Reassessing the role of Staphylococcus aureus clumping factor and fibronectin-binding protein by expression in Lactococcus lactis. fnbA
92  2001 Study of Staphylococcus aureus pathogenic genes by transfer and expression in the less virulent organism Streptococcus gordonii. ---
93  2000 Expression of Staphylococcus aureus clumping factor A in Lactococcus lactis subsp. cremoris using a new shuttle vector. ---
94  2000 Heterologously expressed Staphylococcus aureus fibronectin-binding proteins are sufficient for invasion of host cells. FnBPs
95  2000 Identification of residues in the Staphylococcus aureus fibrinogen-binding MSCRAMM clumping factor A (ClfA) that are important for ligand binding. Fg
96  1998 The fibrinogen-binding MSCRAMM (clumping factor) of Staphylococcus aureus has a Ca2+-dependent inhibitory site. ---
97  1997 Characterization of the interaction between the Staphylococcus aureus clumping factor (ClfA) and fibrinogen. ---