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Abbreviation : Cx26
Long Form : connexin 26
No. Year Title Co-occurring Abbreviation
2021 Activin/Nodal/TGF-β Pathway Inhibitor Accelerates BMP4-Induced Cochlear Gap Junction Formation During in vitro Differentiation of Embryonic Stem Cells. BMP4, GJB2, iPSCs
2021 CO2 sensing by connexin26 and its role in the control of breathing. ---
2021 Connexin26 Modulates the Radiosensitivity of Cutaneous Squamous Cell Carcinoma by Regulating the Activation of the MAPK/NF-κB Signaling Pathway. ---
2021 Functional Evaluation of a Rare Variant c.516G>C (p.Trp172Cys) in the GJB2 (Connexin 26) Gene Associated with Nonsyndromic Hearing Loss. ---
2021 Local Macrophage-Related Immune Response Is Involved in Cochlear Epithelial Damage in Distinct Gjb2-Related Hereditary Deafness Models. OHCs, SCs, SGNs
2021 Palmoplantar keratoderma with deafness phenotypic variability in a patient with an inherited GJB2 frameshift variant and novel missense variant. KID, PPK
2020 A heterozygous mutation in GJB2 (Cx26F142L) associated with deafness and recurrent skin rashes results in connexin assembly deficiencies. KID
2020 Analysis of miRNA-mRNA Interaction Network Reveals Gap Junction Beta 2 as a Potential Candidate Gene Involved in Psoriatic Hearing Loss Pathogenesis. GJB2, PASI
2020 Cisplatin-Induced Stria Vascularis Damage Is Associated with Inflammation and Fibrosis. ABR, BCs, Cx43, ECs, EP, HC, IL-1beta, MCs, SV, TEM, ZO-1
10  2020 Degradation and modification of cochlear gap junction proteins in the early development of age-related hearing loss. ARHL, Cx30
11  2020 High Rates of Three Common GJB2 Mutations c.516G>C, c.-23+1G>A, c.235delC in Deaf Patients from Southern Siberia Are Due to the Founder Effect. ---
12  2020 Moderate Changes in CO2 Modulate the Firing of Neurons in the VTA and Substantia Nigra. SN, VTA
13  2020 Organ-on-chip model shows that ATP release through connexin hemichannels drives spontaneous Ca2+ signaling in non-sensory cells of the greater epithelial ridge in the developing cochlea. COCs, Cx30, GER
14  2020 Outcome of cochlear implantation in children with congenital Cytomegalovirus infection: A retrospective case control study. SNHL
15  2020 Precise control of ion channel and gap junction expression is required for patterning of the regenerating axolotl limb. ---
16  2020 The Functional Role of CONNEXIN 26 Mutation in Nonsyndromic Hearing Loss, Demonstrated by Zebrafish Connexin 30.3 Homologue Model. NSHL
17  2020 Tricellular adherens junctions provide a cell surface delivery platform for connexin 26/30 oligomers in the cochlea. ---
18  2019 Expression pattern of Connexin 26 and Connexin 30 in mature cochlea of the monkey. ---
19  2019 G130V de novo mutation in an Iranian pedigree with nonsyndromic hearing loss without palmoplantar keratoderma. ---
20  2019 Generation of Functional CX26-Gap-Junction-Plaque-Forming Cells with Spontaneous Ca2+ Transients via a Gap Junction Characteristic of Developing Cochlea. Cx26GJCs, GJPs
21  2019 Intermittent restraint stress induces circadian misalignment in the mouse bladder, leading to nocturia. Piezo1, RS, TRPV4
22  2019 Reduced postnatal expression of cochlear Connexin26 induces hearing loss and affects the developmental status of pillar cells in a dose-dependent manner. HC, KD, SCs
23  2019 The p.Gly130Val mutation in the GJB2 gene: A familiar case of autosomal dominant non-syndromic hearing loss. SNHL
24  2018 A Cell Junctional Protein Network Associated with Connexin-26. Cx
25  2018 A novel compound heterozygous mutation in the GJB2 gene is associated with non-syndromic hearing loss in a Chinese family. AR, GJB2, NSHL
26  2018 Connexin 26 Immunohistochemistry in Temporal Bones With Cochlear Otosclerosis. CO, Cx30, HTB, IR
27  2018 Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase. CSCs, FAK, TNBC
28  2018 Cx26 partial loss causes accelerated presbycusis by redox imbalance and dysregulation of Nfr2 pathway. ABRs, ARHL, DPOAEs, Nrf2
29  2018 Developmental abnormalities in supporting cell phalangeal processes and cytoskeleton in the Gjb2 knockdown mouse model. ---
30  2018 DFNB1 Non-syndromic Hearing Impairment: Diversity of Mutations and Associated Phenotypes. HI
31  2018 Structure of native lens connexin 46/50 intercellular channels by cryo-EM. ---
32  2018 The connexin26 human mutation N14K disrupts cytosolic intersubunit interactions and promotes channel opening. CL, KID, KS test, NT, TM2
33  2018 The spatial distribution pattern of Connexin26 expression in supporting cells and its role in outer hair cell survival. DCs, KO, OHC, SCs
34  2018 The syndromic deafness mutation G12R impairs fast and slow gating in Cx26 hemichannels. ---
35  2018 The time-dependent variation of ATP release in mouse primary-cultured urothelial cells is regulated by the clock gene. MPCUCs, SBF
36  2018 Three novel GJB2 (connexin 26) variants associated with autosomal dominant syndromic and nonsyndromic hearing loss. ---
37  2018 Transforming Growth Factor Beta 1 Drives a Switch in Connexin Mediated Cell-to-Cell Communication in Tubular Cells of the Diabetic Kidney. Cx43, GJIC, hPTECs, IL-6
38  2017 Amplification mode differs along the length of the mouse cochlea as revealed by connexin 26 deletion from specific gap junctions. BM, Cx26 cKO, DCs, DPOAEs, OHCs, PCs
39  2017 Ca2+ signaling, apoptosis and autophagy in the developing cochlea: Milestones to hearing acquisition. Cx30
40  2017 Chronic prenatal hypoxia impairs cochlear development, a mechanism involving connexin26 expression and promoter methylation. ---
41  2017 Clock Genes Regulate the Circadian Expression of Piezo1, TRPV4, Connexin26, and VNUT in an Ex Vivo Mouse Bladder Mucosa. NOC, TRPV4, VNUT
42  2017 Connexin-Mediated Signaling in Nonsensory Cells Is Crucial for the Development of Sensory Inner Hair Cells in the Mouse Cochlea. Cx30, IHCs
43  2017 Design and Characterization of a Human Monoclonal Antibody that Modulates Mutant Connexin 26 Hemichannels Implicated in Deafness and Skin Disorders. KID/HID, scFv
44  2017 Disorders in barrier protein mRNA expression and placenta secretory activity under the influence of polychlorinated biphenyls invitro. COX-2, HIF1alpha, KRT8, PCBs, PGA, PGE2, PGF2 alpha, PLAC-1
45  2017 Endothelin-1 promotes human germinal vesicle-stage oocyte maturation by downregulating connexin-26 expression in cumulus cells. ET-1, ETRB, GV, GVBD
46  2017 Evolutionary adaptation of the sensitivity of connexin26 hemichannels to CO2. PaCO2
47  2017 Genomic instability induced in distant progeny of bystander cells depends on the connexins expressed in the irradiated cells. Cx32, Cx43
48  2017 In vivo genetic manipulation of inner ear connexin expression by bovine adeno-associated viral vectors. BAAV, Cx30
49  2017 Induction of cell death and gain-of-function properties of connexin26 mutants predict severity of skin disorders and hearing loss. ---
50  2017 Molecular composition and distribution of gap junctions in the sensory epithelium of the human cochlea-a super-resolution structured illumination microscopy (SR-SIM) study. GJ, SR-SIM
51  2017 Neonatal CX26 removal impairs neocortical development and leads to elevated anxiety. CX26-cKO, mEPSCs, mIPSCs
52  2017 Single nucleotide polymorphism rs2274084 of gap junction protein beta 2 gene among Epstein-Barr virus-associated tumors. EBVaGC, EBVnGC, GC, GJB2, NPC
53  2016 Altered cellular localization and hemichannel activities of KID syndrome associated connexin26 I30N and D50Y mutations. CBX, KID
54  2016 Altered CO2 sensitivity of connexin26 mutant hemichannels in vitro. KID
55  2016 Association of STAT3 with Cx26 and Cx43 in human uterine endometrioid adenocarcinoma. ER, STAT3
56  2016 Atomic structure of the innexin-6 gap junction channel determined by cryo-EM. INX-6
57  2016 Computational Studies of Molecular Permeation through Connexin26 Channels. ---
58  2016 Engineered Cx26 variants established functional heterotypic Cx26/Cx43 and Cx26/Cx40 gap junction channels. Cx40, Cx43, GJ, HB
59  2016 Gap-junctional channel and hemichannel activity of two recently identified connexin 26 mutants associated with deafness. GJCs
60  2016 InVitro Models of GJB2-Related Hearing Loss Recapitulate Ca2+ Transients via a Gap Junction Characteristic of Developing Cochlea. GJB2, GJP
61  2016 NMR and structural data for Connexin 32 and Connexin 26 N-terminal peptides. SSP
62  2016 Super-resolution structured illumination fluorescence microscopy of the lateral wall of the cochlea: the Connexin26/30 proteins are separately expressed in man. Cx30, GJ
63  2016 Syndromic deafness mutations at Asn 14 differentially alter the open stability of Cx26 hemichannels. WT
64  2016 The effect of dexamethasone/cell-penetrating peptide nanoparticles on gene delivery for inner ear therapy. Arg8, BDNF, DEX, GFP, PCA
65  2016 The pathological effects of connexin 26 variants related to hearing loss by in silico and in vitro analysis. GJs
66  2015 A Convenient and Efficient Method to Enrich and Maintain Highly Proliferative Human Fetal Liver Stem Cells. AFP, C3A4, CK18, Cldn3, EpCAM, hFLSCs, MACS, NCAM, OV-6, PEPCK, TRF
67  2015 Altered epidermal lipid processing and calcium distribution in the KID syndrome mouse model Cx26S17F. KID
68  2015 Connexin Type and Fluorescent Protein Fusion Tag Determine Structural Stability of Gap Junction Plaques. GJs
69  2015 Connexin26 gap junction mediates miRNA intercellular genetic communication in the cochlea and is required for inner ear development. KO, miRNAs
70  2015 Cx26 knockout predisposes the mammary gland to primary mammary tumors in a DMBA-induced mouse model of breast cancer. DMBA
71  2015 Deformation of the Outer Hair Cells and the Accumulation of Caveolin-2 in Connexin 26 Deficient Mice. CAV2, OHC
72  2015 Glutathione release through connexin hemichannels: Implications for chemical modification of pores permeable to large molecules. MTS
73  2015 Inner ear cell therapy targeting hereditary deafness by activation of stem cell homing factors. ---
74  2015 Keratitis-ichthyosis-deafness syndrome-associated Cx26 mutants produce nonfunctional gap junctions but hyperactive hemichannels when co-expressed with wild type Cx43. GJC, KID
75  2015 Mice with conditional deletion of Cx26 exhibit no vestibular phenotype despite secondary loss of Cx30 in the vestibular end organs. cKO
76  2015 Mir-27a promotes apoptosis of cochlear sensory epithelium in Cx26 knockout mice. ---
77  2015 Neural progenitor cells isolated from the subventricular zone present hemichannel activity and form functional gap junctions with glial cells. NPCs, Panx1, SVZ
78  2015 Non-syndromic hearing loss caused by the dominant cis mutation R75Q with the recessive mutation V37I of the GJB2 (Connexin 26) gene. ---
79  2015 Pannexin1 channels dominate ATP release in the cochlea ensuring endocochlear potential and auditory receptor potential generation and hearing. CM, EP, Panx1
80  2015 Perinatal Gjb2 gene transfer rescues hearing in a mouse model of hereditary deafness. GJB2
81  2015 Rational design of new NO and redox sensitivity into connexin26 hemichannels. ---
82  2015 Reciprocal positive regulation between Cx26 and PI3K/Akt pathway confers acquired gefitinib resistance in NSCLC cells via GJIC-independent induction of EMT. GJIC, GR, NSCLC
83  2015 The controversial p.Met34Thr variant in GJB2 gene: Two siblings, one genotype, two phenotypes. HL
84  2015 The p.Cys169Tyr variant of connexin 26 is not a polymorphism. ---
85  2015 Two molecular assays for the rapid and inexpensive detection of GJB2 and GJB6 mutations. Cx30
86  2015 [Expression of gap junction protein connexin 26 in human hepatocellular carcinoma and its significance]. HCC, NCL
87  2014 A novel compound heterozygous mutation (35delG, 363delC) in the Connexin 26 gene causes non-syndromic autosomal recessive hearing loss. NSHL
88  2014 Aberrant connexin26 hemichannels underlying keratitis-ichthyosis-deafness syndrome are potently inhibited by mefloquine. KID, MFQ
89  2014 Aberrant Cx26 hemichannels and keratitis-ichthyosis-deafness syndrome: insights into syndromic hearing loss. GJ, HCs, KID
90  2014 Assembly of the cochlear gap junction macromolecular complex requires connexin 26. GJP
91  2014 Atomic force microscopy shows connexin26 hemichannel clustering in purified membrane fragments. AFM, GJ
92  2014 Baicalein increases the cytotoxicity of cisplatin byenhancing gap junction intercellular communication. GJ, SRB
93  2014 Connexin26 hemichannels with a mutation that causes KID syndrome in humans lack sensitivity to CO2. ---
94  2014 Connexins and cyclooxygenase-2 crosstalk in the expression of radiation-induced bystander effects. COX-2, Cx, Cx32
95  2014 Connexins in colorectal cancer pathogenesis. ---
96  2014 Deficiency of transcription factor Brn4 disrupts cochlear gap junction plaques in a model of DFN3 non-syndromic deafness. Cx30, EP
97  2014 Down regulated connexin26 at different postnatal stage displayed different types of cellular degeneration and formation of organ of Corti. ---
98  2014 Dynamin 2 interacts with connexin 26 to regulate its degradation and function in gap junction formation. Dyn2, GJIC
99  2014 Mammary gland specific knockdown of the physiological surge in Cx26 during lactation retains normal mammary gland development and function. ---
100  2014 Molecular dynamics simulations highlight structural and functional alterations in deafness-related M34T mutation of connexin 26. NTH