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Abbreviation : DCT
Long Form : dopachrome tautomerase
No. Year Title Co-occurring Abbreviation
2022 Antimelanogenesis Effect of Methyl Gallate through the Regulation of PI3K/Akt and MEK/ERK in B16F10 Melanoma Cells. MITF, TRP1
2022 AP-3 complex subunit delta gene, ap3d1, regulates melanogenesis and melanophore survival via autophagy in zebrafish (Danio rerio). GAGE, HPS, HPS10, Tyr, tyrp1b
2022 Clinical and molecular change induced by repeated low-dose visible light exposure in both light-skinned and dark-skinned individuals. BCL2A1, COMP, FST, MLANA, PMEL, SLC24A5, TYR, TYRP1, VL
2022 Dopachrome tautomerase is a retinoblastoma-specific gene, and its proximal promoter is preferentially active in human retinoblastoma cells. Rb
2022 Identification of Biomarkers Associated with Cancerous Change in Oral Leukoplakia Based on Integrated Transcriptome Analysis. DEGs, FAM3B, GEO, GO, KEGG, KRT3, KRT76, OLK, OSCC, WGCNA
2022 Interferon-gamma induces melanogenesis via post-translational regulation of tyrosinase. alpha-MSH, IFNG, MITF, TYR, TYRP1
2022 MiR-382 Functions on the Regulation of Melanogenesis via Targeting dct in Rainbow Trout (Oncorhynchus mykiss). miRNAs, PMEL, TYRP-1
2022 Molecular Analysis of the Melanogenesis Inhibitory Effect of Saponins-Rich Fraction of Argania spinosa Leaves Extract. ALS, MITF, TRP1, TYR
2022 QTL Mapping for Age-Related Eye Pigmentation in the Pink-Eyed Dilution Castaneus Mutant Mouse. MITF, TYR, TYRP1
10  2022 The Dct-/- Mouse Model to Unravel Retinogenesis Misregulation in Patients with Albinism. OCA, RPE
11  2021 A prepared platelet-rich plasma extract, namely Self-Growth Colony, inhibits melanogenesis by down-regulating microphthalmia-associated transcription factor in skin melanocyte. MITF, PRP, SGC, TRP1, TYR
12  2021 Analysis of how obtaining melanocytes by magnetic cell separation contributes to autoepidermal transplantation technology in treating leucoderma. CCK-8, FCM, MCs, MITF, RT-PCR
13  2021 Comparative transcriptome and histological analyses provide insights into the skin pigmentation in Minxian black fur sheep (Ovis aries). MBF, MC1R, OCA2, PMEL, TYR
14  2021 Epigenetic regulation of melanogenesis. circRNAs, ET-1, lncRNAs, MeCP2, miRNAs, MITF, SCF, TYR, TYRP1
15  2021 Factors affecting gene expression associated with the skin color of black-bone chicken in Thailand. ASIP, MC1R, TYR, TYRP1
16  2021 Identification of potential hub genes associated with skin wound healing based on time course bioinformatic analyses. DEGs, GEO, GO, KEGG, PCA, PPI, TYR, TYRP1
17  2021 Kaempferol, the melanogenic component of Sanguisorba officinalis, enhances dendricity and melanosome maturation/transport in melanocytes. MITF, TYR
18  2021 Melanogenesis Promoting Effect, Antioxidant Activity, and UPLC-ESI-HRMS Characterization of Phenolic Compounds of Argan Leaves Extract. ALE, TRP-1, TYR
19  2020 Argania Spinosa Fruit Shell Extract-Induced Melanogenesis via cAMP Signaling Pathway Activation. AFSEE, cAMP, ERK, MAPKs, MITF, TRP1, TRY
20  2020 Dopachrome tautomerase variants in patients with oculocutaneous albinism. RPE
21  2020 Lactobacillus helveticus-Fermented Milk Whey Suppresses Melanin Production by Inhibiting Tyrosinase through Decreasing MITF Expression. alpha-MSH, MITF, TRP1
22  2020 MicroRNA-206 Regulation of Skin Pigmentation in Koi Carp (Cyprinus carpio L.). miR-NC, miRNAs, TYR, UTR
23  2020 miRNA-183∼96∼182 regulates melanogenesis, cell proliferation and migration in B16 cells. CREB, MEK1, MITF, TYR, TYRP1
24  2019 Detection of melanocyte lineage-specific genes in vitiligo lesions. ACTB, PCR, RT, TYR
25  2019 Identification of pathogenic genes and transcription factors in vitiligo. DEGs, FOXJ2, GEO, GO, KEGG, MC1R, MLANA, PMEL, SOX10, TYRP1
26  2019 Isoorientin derived from Gentiana veitchiorum Hemsl. flowers inhibits melanogenesis by down-regulating MITF-induced tyrosinase expression. CREB, MITF, TRP1, TYR
27  2019 Knockdown of microRNA‑143‑5p by STTM technology affects eumelanin and pheomelanin production in melanocytes. ASM, EM, miRNAs, MITF, MLPH, PM, STTM, TYRP1, TYRP2
28  2019 Leathesia difformis Extract Inhibits alpha-MSH-Induced Melanogenesis in B16F10 Cells via Down-Regulation of CREB Signaling Pathway. alpha-MSH, MC1R, MITF, TRP-1, TYR
29  2019 miR-380-3p regulates melanogenesis by targeting SOX6 in melanocytes from alpacas (Vicugna pacos). lncRNAs, miRNAs, MITF, TYR, TYRP1
30  2019 Synaptotagmin-4 promotes dendrite extension and melanogenesis in alpaca melanocytes by regulating Ca2+ influx via TRPM1 channels. CREB, ERK, MITF, pCREB, SYT4, TRPM1, TYR, TYRP1
31  2018 A wide variety of Mitf transcript variants are expressed in the Xenopus laevis periodic albino mutant. MITF, RPE
32  2018 Comparative transcriptome profiles of Lindian chicken eyelids identify melanin genes controlling eyelid pigmentation. DEGs, PMEL, TYR
33  2018 Depigmenting effect of argan press-cake extract through the down-regulation of Mitf and melanogenic enzymes expression in B16 murine melanoma cells. APC, MITF, TRP1, TYR
34  2018 Mechanism underlying inhibitory effect of six dicaffeoylquinic acid isomers on melanogenesis and the computational molecular modeling studies. CREB, DCQA, MITF, TRP1
35  2018 Partial Rescue of Ocular Pigment Cells and Structure by Inducible Ectopic Expression of Mitf-M in MITF-Deficient Mice. MITF, RPE
36  2018 Pulsed Electromagnetic Fields Increase Pigmentation through the p-ERK/p-p38 Pathway in Zebrafish (Danio rerio). ERK, PEMFs, TRP1
37  2018 The role of sex-determining region Y-box 6 in melanogenesis in alpaca melanocytes. Co-IP, MITF, SOX, TYR, TYRP1
38  2018 Upregulation of Mitf by Phenolic Compounds-Rich Cymbopogon schoenanthus Treatment Promotes Melanogenesis in B16 Melanoma Cells and Human Epidermal Melanocytes. CYM, HEM, MITF, MSH, TRP1, TYR
39  2017 Identification of polymorphisms in MITF and DCT genes and their associations with plumage colors in Asian duck breeds. MITF, SNPs
40  2017 Inhibition of NAT10 Suppresses Melanogenesis and Melanoma Growth by Attenuating Microphthalmia-Associated Transcription Factor (MITF) Expression. MITF, NAT10
41  2017 The Role of DCT in HPV16 Infection of HaCaTs. HPV, ROS
42  2016 Interferon-gamma Attenuates 5-Hydroxytryptamine-Induced Melanogenesis in Primary Melanocyte. 5-HT, IFN-gamma, MITF, NHEM, TRP-1, TYR
43  2016 Small conductance calcium-activated potassium current and the mechanism of atrial arrhythmia in mice with dysfunctional melanocyte-like cells. AA, APD, CI
44  2015 Cardiac melanocytes influence atrial reactive oxygen species involved with electrical and structural remodeling in mice. APD, CMLCs, ROS
45  2014 A closer look at evolution: Variants (SNPs) of genes involved in skin pigmentation, including EXOC2, TYR, TYRP1, and DCT, are associated with 25(OH)D serum concentration. ASIP, CDH1, CTNNB1, EDN1, EDN3, EDNRB, EXOC2, FGF-2, IRF4, KITLG, MITF, NGF, POMC, PRKACB, PRKACG, SLC24A4, SLC45A2, SNPs, TP53, TPCN2, TYR, TYRP1
46  2014 Accelerated differentiation of melanocyte stem cells contributes to the formation of hyperpigmented maculae. McSCs, NHEMs, SLs
47  2014 DCT protects human melanocytic cells from UVR and ROS damage and increases cell viability. MB
48  2014 Establishment of a melanogenesis regulation assay system using a fluorescent protein reporter combined with the promoters for the melanogenesis-related genes in human melanoma cells. MITF, TYR
49  2014 Role of epidermal gammadelta T-cell-derived interleukin 13 in the skin-whitening effect of Ginsenoside F1. GF1, IL-13, NHEMs
50  2014 Value of dopachrome tautomerase detection in the assessment of melanocytic tumors. TYR
51  2013 Activation of MITF by Argan Oil Leads to the Inhibition of the Tyrosinase and Dopachrome Tautomerase Expressions in B16 Murine Melanoma Cells. TRP1, TYR
52  2013 Enhancement of the p38 MAPK and PKA signaling pathways is associated with the pro-melanogenic activity of Interleukin 33 in primary melanocytes. CREB, IL-33, MAPKs, MITF, NHEM, PKA, TRP-1, TYR
53  2013 Inhibition of melanogenesis by gallic acid: possible involvement of the PI3K/Akt, MEK/ERK and Wnt/beta-catenin signaling pathways in B16F10 cells. ERK, MEK, MITF, TRP1
54  2012 I-SceI-mediated double-strand break does not increase the frequency of homologous recombination at the Dct locus in mouse embryonic stem cells. DSBs
55  2012 Inhibitory effects of Asterina pectinifera extracts on melanin biosynthesis through tyrosinase activity. A.pectinifera, TRP-1
56  2012 The changes of microRNA expression profiles and tyrosinase related proteins in MITF knocked down melanocytes. miRNA, MITF, MITF-KD, TRPs, TYR, TYRP1, TYRP2
57  2012 The eumelanin intermediate 5,6-dihydroxyindole-2-carboxylic acid is a messenger in the cross-talk among epidermal cells. DHICA
58  2011 Contrasting signals of positive selection in genes involved in human skin-color variation from tests based on SNP scans and resequencing. KITLG, SNPs, TYRP1
59  2011 Effect of MC1R variant allele status on MSH-ligand induction of dopachrome tautomerase in melanocytes co-cultured with keratinocytes. WT
60  2011 Induction of ambicoloration by exogenous cortisol during metamorphosis of spotted halibut Verasper variegatus. ---
61  2011 Maintenance of immune hyporesponsiveness to melanosomal proteins by DHICA-mediated antioxidation: Possible implications for autoimmune vitiligo. DHI, DHICA
62  2011 Partially purified components of Nardostachys chinensis suppress melanin synthesis through ERK and Akt signaling pathway with cAMP down-regulation in B16F10 cells. ERK, MEK, MITF, PI3K, TRP
63  2010 A new transgenic mouse line for tetracycline inducible transgene expression in mature melanocytes and the melanocyte stem cells using the Dopachrome tautomerase promoter. ---
64  2010 Antioxidant and antimelanogenic properties of chestnut flower extract. preM, TRP1, UV
65  2010 Immunotherapy can reject intracranial tumor cells without damaging the brain despite sharing the target antigen. ---
66  2010 Novel insights into the cellular basis of atrial fibrillation. ---
67  2010 Purification and N-glycosylation analysis of melanoma antigen dopachrome tautomerase. ---
68  2010 Regulation of DHICA-mediated antioxidation by dopachrome tautomerase: implication for skin photoprotection against UVA radiation. DHI, DHICA, ROS
69  2010 Targeted delivery of NRASQ61R and Cre-recombinase to post-natal melanocytes induces melanoma in Ink4a/Arflox/lox mice. TVA
70  2009 Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers. ---
71  2009 [Effects of mutation in dopachrome tautomerase on melanosome maturation and anti-oxidative potential in cultured melanocytes]. DCFDA, MCs, ROS, Slt, TEM
72  2008 Timeline and distribution of melanocyte precursors in the mouse heart. AV
73  2007 Excess tyrosine stimulates eumelanin and pheomelanin synthesis in cultured slaty melanocytes from neonatal mouse epidermis. Tyr
74  2007 Gene profiling in murine corneas challenged with Aspergillus fumigatus. Egr4, FK, MBL-A, RT-PCR
75  2007 Molecular analysis of vitiligo lesions reveals sporadic melanocyte survival. RT-PCR
76  2007 Post-transcriptional regulation of melanin biosynthetic enzymes by cAMP and resveratrol in human melanocytes. MITF
77  2007 Tyrosinase gene family and Vogt-Koyanagi-Harada disease in Japanese patients. MS, RFLP, VKH
78  2006 Dopachrome tautomerase (Dct) regulates neural progenitor cell proliferation. DHICA, MITF, OB, RMS, SVZ, VZ
79  2006 Isolation of the Atlantic salmon tyrosinase gene family reveals heterogenous transcripts in a leukocyte cell line. TYR, Tyrp1
80  2006 The slaty mutation affects eumelanin and pheomelanin synthesis in mouse melanocytes. TYR
81  2005 Altered melanocyte differentiation and retinal pigmented epithelium transdifferentiation induced by Mash1 expression in pigment cell precursors. bHLH, RPE
82  2005 Dynamic regulation of the human dopachrome tautomerase promoter by MITF, ER-alpha and chromatin remodelers during proliferation and senescence of human melanocytes. ERalpha, TPA
83  2005 Gene expression profiling of cultured human NF1 heterozygous (NF1+/-) melanocytes reveals downregulation of a transcriptional cis-regulatory network mediating activation of the melanocyte-specific dopachrome tautomerase (DCT) gene. ---
84  2005 Melanocyte-specific proteins are aberrantly trafficked in melanocytes of Hermansky-Pudlak syndrome-type 3. DOPA, HPS-3, TYRP1
85  2005 Mutations in dopachrome tautomerase (Dct) affect eumelanin/pheomelanin synthesis, but do not affect intracellular trafficking of the mutant protein. ---
86  2004 Direct interaction of Sox10 with the promoter of murine Dopachrome Tautomerase (Dct) and synergistic activation of Dct expression with Mitf. ---
87  2004 Long-range activation of Sox9 in Odd Sex (Ods) mice. Ods
88  2004 Melanocytes and pigmentation are affected in dopachrome tautomerase knockout mice. TYR, TYRP1
89  2004 Radiation resistance of human melanoma analysed by retroviral insertional mutagenesis reveals a possible role for dopachrome tautomerase. CDDP, TYRP2
90  2004 Touchtone promotes survival of embryonic melanophores in zebrafish. ---
91  2004 Tyrosinase-related proteins suppress tyrosinase-mediated cell death of melanocytes and melanoma cells. TYR, TYRP1
92  2003 Agouti signal protein regulation in human melanoma cells. alpha-MSH, ASIP, Itf2, MC1R, MCM6, TYR, TYRP1
93  2003 Microphthalmia-associated transcription factor in the Wnt signaling pathway. bHLH-LZ, LEF1, M promoter, MITF, MITF-M, WS2
94  2003 OTX2 regulates expression of DOPAchrome tautomerase in human retinal pigment epithelium. RPE
95  2003 Pmel17 expression is Mitf-dependent and reveals cranial melanoblast migration during murine development. MITF, RPE
96  2003 The IFPCS presidential lecture: a chemist's view of melanogenesis. DHICA
97  2002 Expression of Cre recombinase in pigment cells. RPE
98  2002 Genomic structure and evolutionary conservation of the tyrosinase gene family from Fugu. TYRP1
99  2002 Microphthalmia-associated transcription factor interacts with LEF-1, a mediator of Wnt signaling. LEF1, MITF, TCFs
100  2002 The oculocutaneous albinism type IV gene Matp is a new marker of pigment cell precursors during mouse embryonic development. MATP, MITF, TYRP1