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Abbreviation : DNJ
Long Form : 1-deoxynojirimycin
No. Year Title Co-occurring Abbreviation
2022 poly
2022 1-Deoxynojirimycin attenuates septic cardiomyopathy by regulating oxidative stress, apoptosis, and inflammation via the JAK2/STAT6 signaling pathway. JAK/STAT, LPS
2022 5-C-Branched Deoxynojirimycin: Strategy for Designing a 1-Deoxynojirimycin-Based Pharmacological Chaperone with a Nanomolar Affinity for Pompe Disease. GAA, rhGAA, Tm
2022 Antiviral effects of deoxynojirimycin (DNJ)-based iminosugars in dengue virus-infected primary dendritic cells. DCs, DENV, DGJ, ER, imDCs, MDMphis
2022 Bambus[4,6]urils as Dual Scaffolds for Multivalent Iminosugar Presentation and Ion Transport: Access to Unprecedented Glycosidase-Directed Anion Caging Agents. CuAAC
2022 Effect of 1-Deoxynojirimycin on insulin resistance in prediabetic mice based on next-generation sequencing and intestinal microbiota study. ELISA, IL-6, ITT, LPS, NGS, OGTT, STZ, T2DM, TLR4, TNF-alpha
2022 Hepatoprotective effects of different mulberry leaf extracts against acute liver injury in rats by alleviating oxidative stress and inflammatory response. D-GalN, LPS, MEE
2022 Metabolomic Profiling and Identification of Antioxidant and Antidiabetic Compounds from Leaves of Different Varieties of Morus alba Linn Grown in Kashmir. ---
2022 Mixed Mulberry Fruit and Mulberry Leaf Fermented Alcoholic Beverages: Assessment of Chemical Composition, Antioxidant Capacity In Vitro and Sensory Evaluation. GABA
10  2022 Molecular cloning, expression, and functional analysis of copper amine oxidase gene from mulberry (Morus alba L.). ---
11  2022 Mulberry-Derived 1-Deoxynojirimycin Prevents Type 2 Diabetes Mellitus Progression via Modulation of Retinol-Binding Protein 4 and Haptoglobin. Drp1, HDHD-3
12  2022 Novel active compounds and the anti-diabetic mechanism of mulberry leaves. ADORA1, AKT1, FA, GSK-3beta, MLF, MLP, PPARgamma, T2DM
13  2022 Rapid Screening of Nonalkaloid α-Glucosidase Inhibitors from a Mulberry Twig Extract Using Enzyme-Functionalized Magnetic Nanoparticles Coupled with UPLC-MS/MS. ---
14  2022 Structure of an iminosugar complex of a glycoside hydrolase family 5 lichenase provides insights into the active site. GH5_36
15  2021 An overview of therapeutic potential of N-alkylated 1-deoxynojirimycin congeners. ---
16  2021 Development and evaluation of 1-deoxynojirimycin sustained-release delivery system: In vitro and in vivo characterization studies. Cmax, Tmax
17  2021 Evaluation and development of a novel pre-treatment method for mulberry leaves to enhance their bioactivity via enzymatic degradation of GAL-DNJ to DNJ. GAL-DNJ
18  2021 Genome Analysis of Streptomyces nojiriensis JCM 3382 and Distribution of Gene Clusters for Three Antibiotics and an Azasugar across the Genus Streptomyces. NJ
19  2021 Hybrid Multivalent Jack Bean alpha-Mannosidase Inhibitors: The First Example of Gold Nanoparticles Decorated with Deoxynojirimycin Inhitopes. JBalpha-man
20  2021 In Vivo Functional Verification of Four Related Genes Involved in the 1-Deoxynojirimycin Biosynthetic Pathway in Mulberry Leaves. ---
21  2021 Morus alba L. (Sangzhi) alkaloids (SZ-A) exert anti-inflammatory effects via regulation of MAPK signaling in macrophages. Arg, BMDM, DAB, ELISA, FAG, LPS
22  2021 Mulberry leaves ameliorate diabetes via regulating metabolic profiling and AGEs/RAGE and p38 MAPK/NF-κB pathway. FBG, HK, PK, T2DM, TCHO, TG
23  2021 Pb contaminated soil influence on aboveground biomass and bioactive compounds in leaves of mulberry. PRD
24  2021 Study on the Synthesis and Biological Activities of N-Alkylated Deoxynojirimycin Derivatives with a Terminal Tertiary Amine. ---
25  2021 Synthesis and Structural Revision of Glyphaeaside C. ---
26  2021 [1-deoxynojirimycin alleviates liver fibrosis induced by type 2 diabetes in mice]. BW, ColA2, DHE, PSC, SOD, TC, TG
27  2020 1-Deoxynojirimycin from mulberry leaves changes gut digestion and microbiota composition in geese. ---
28  2020 A randomized controlled study of dose-finding, efficacy, and safety of mulberry leaves on glycemic profiles in obese persons with borderline diabetes. FPG
29  2020 Comparative Transcriptome Analysis of Key Reductase Genes Involved in the 1-Deoxynojirimycin Biosynthetic Pathway in Mulberry Leaves and Cloning, Prokaryotic Expression, and Functional Analysis of MaSDR1 and MaSDR2. ---
30  2020 Iminosugars With Endoplasmic Reticulum alpha-Glucosidase Inhibitor Activity Inhibit ZIKV Replication and Reverse Cytopathogenicity in vitro. ER-AGI, hpi, ZIKV
31  2020 Intestinal Absorption and Tissue Distribution of Aza-Sugars from Mulberry Leaves and Evaluation of Their Transport by Sugar Transporters. GAL-DNJ, GLUT
32  2020 Mulberry leaf attenuates atherosclerotic lesions in patients with coronary heart disease possibly via 1-Deoxynojirimycin: A placebo-controlled, double-blind clinical trial. CHD, HPLC, IMT, MLD, MLD
33  2020 N-Nonyloxypentyl-l-Deoxynojirimycin Inhibits Growth, Biofilm Formation and Virulence Factors Expression of Staphylococcus aureus. l-NPDNJ, MIC
34  2020 Strategy for Designing Selective Lysosomal Acid alpha-Glucosidase Inhibitors: Binding Orientation and Influence on Selectivity. ER, GAA, LAB
35  2020 Supplementation of Bacillus amyloliquefaciens AS385 culture broth powder containing 1-deoxynojirimycin in a high-fat diet altered the gene expressions related to lipid metabolism and insulin signaling in mice epididymal white adipose tissue. CBP, HFD
36  2020 Suppression of N-glycan processing enzymes by deoxynojirimycin in tomato (Solanum lycopersicum) fruit. ---
37  2020 Synthesis and Glycosidase Inhibition Properties of Calix[8]arene-Based Iminosugar Click Clusters. CuAAC, JBalpha-man
38  2020 The Gut Microbiota-Produced Indole-3-Propionic Acid Confers the Antihyperlipidemic Effect of Mulberry-Derived 1-Deoxynojirimycin. IPA, MLE, TCM
39  2020 Total flavonoids, total phenolics, 1-deoxynojirimycin content and alpha-glucosidase inhibitory activity of Thai silkworm races (Bombyx mori Linn.). ---
40  2019 1-Deoxynojirimycin improves high fat diet-induced nonalcoholic steatohepatitis by restoring gut dysbiosis. HFD, NASH
41  2019 1-Deoxynojirimycin in Mulberry (Morus indica L.) Leaves Ameliorates Stable Angina Pectoris in Patients With Coronary Heart Disease by Improving Antioxidant and Anti-inflammatory Capacities. BSS, CHD, CRP, HAMD, IkBalpha, IKK, IL-6, MDA, NF-kappaB, SAP, SAS, SOD, TNF-alpha
42  2019 1-Deoxynojirimycin modulates glucose homeostasis by regulating the combination of IR-GlUT4 and ADIPO-GLUT4 pathways in 3T3-L1 adipocytes. ADIPO, AMP, GLUT4, IR, PI3K, T2DM
43  2019 A Novel Strategy to Regulate 1-Deoxynojirimycin Production Based on Its Biosynthetic Pathway in Streptomyces lavendulae. ---
44  2019 Alpha-glucosidase inhibitor 1-Deoxynojirimycin promotes beige remodeling of 3T3-L1 preadipocytes via activating AMPK. PPARgamma, PRDM16, Pref-1, TMEM26, UCP1
45  2019 An overview of the biological production of 1-deoxynojirimycin: current status and future perspective. ---
46  2019 Effect of 1-Deoxynojirimycin Isolated from Mulberry Leaves on Glucose Metabolism and Gut Microbiota in a Streptozotocin-Induced Diabetic Mouse Model. ---
47  2019 Iminosugars: Effects of Stereochemistry, Ring Size, and N-Substituents on Glucosidase Activities. MARV
48  2019 Physiological Effects and Organ Distribution of Bacillus amyloliquefaciens AS385 Culture Broth Powder Containing 1-Deoxynojirimycin in C57BL/6J Mice. CBP
49  2019 Synthesis and glycosidase inhibition of conformationally locked DNJ and DMJ derivatives exploiting a 2-oxo-C-allyl iminosugar. DMJ
50  2019 Use of a deoxynojirimycin-fluorophore conjugate as a cell-specific imaging probe targeting alpha-glucosidase on cell membranes. ---
51  2018 1-Deoxynojirimycin (DNJ) Ameliorates Indomethacin-Induced Gastric Ulcer in Mice by Affecting NF-kappaB Signaling Pathway. CAT, CG, GU, MDA, MOT, SOD, SP, SS, VIP
52  2018 A toxicological, metabonomic and transcriptional analysis to investigate the property of mulberry 1-deoxynojirimycin against the growth of Samia cynthia ricini. LDH, NMR, PCA, RT-qPCR, TCA, THL
53  2018 Characterization of the PLP-dependent transaminase initiating azasugar biosynthesis. ---
54  2018 Cloning, expression, and functional analysis of lysine decarboxylase in mulberry (Morus alba L.). MaLDC
55  2018 Coating rice with mulberry leaves rich in deoxynojirimycin ameliorates hyperglycemia and dyslipidemia in C57BL/KsJ db/db mice. ML, NC
56  2018 Comparative transcriptome analysis reveals significant metabolic alterations in eri-silkworm (Samia cynthia ricini) haemolymph in response to 1-deoxynojirimycin. ddH2O, DEGs, RT-qPCR
57  2018 d-Fagomine Attenuates High Glucose-Induced Endothelial Cell Oxidative Damage by Upregulating the Expression of PGC-1alpha. GR, HUVECs, MDA, ROS, SOD
58  2018 Evaluation of the anti-hyperglycemic effect and safety of microorganism 1-deoxynojirimycin. CSE
59  2018 Functional analysis of a triplet deletion in the gene encoding the sodium glucose transporter 3, a potential risk factor for ADHD. ADHD, hSGLT3, SGLT, WES
60  2018 Improvement Activity of 1-Deoxynojirimycin in the Growth of Dairy Goat Primary Mammary Epithelial Cell through Upregulating LEF-1 Expression. ---
61  2018 Integrated multi-spectroscopic and molecular docking techniques to probe the interaction mechanism between maltase and 1-deoxynojirimycin, an alpha-glucosidase inhibitor. ---
62  2018 Mulberry leaf extract reduces the glycemic indexes of four common dietary carbohydrates. GI, MLE
63  2018 Mulberry leaves and their potential effects against cardiometabolic risks: a review of chemical compositions, biological properties and clinical efficacy. CVD
64  2018 Neuroprotective effect of 1-Deoxynojirimycin on cognitive impairment, beta-amyloid deposition, and neuroinflammation in the SAMP8 mice. BDNF, IL-1beta, IL-6, SAMP8, SAMR1, TNF-alpha
65  2018 Probing the Inhibitor versus Chaperone Properties of sp-Iminosugars towards Human beta-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease. GCase
66  2018 Proteomic-Based Approach to the Proteins Involved in 1-Deoxynojirimycin Accumulation in Silkworm Bombyx mori (Lepidoptera: Bombycidae). Ser, TPx
67  2018 Seasonal variations of iminosugars in mulberry leaves detected by hydrophilic interaction chromatography coupled with tandem mass spectrometry. FAG, Gal-DNJ, Glu-FAG
68  2018 Spectroscopic techniques investigation on the interaction of glucoamylase with 1-deoxynojirimycin: Mechanistic and conformational study. ---
69  2018 Transcriptome analysis and identification of key genes involved in 1-deoxynojirimycin biosynthesis of mulberry (Morus alba L.). ---
70  2017 A UPLC-MS/MS method for simultaneous determination of 1-deoxynojirimycin and N-methyl-1-deoxynojirimycin in rat plasma and its application in pharmacokinetic and absolute bioavailability studies. IS, MRM
71  2017 Central Administration of 1-Deoxynojirimycin Attenuates Hypothalamic Endoplasmic Reticulum Stress and Regulates Food Intake and Body Weight in Mice with High-Fat Diet-Induced Obesity. CNS, i.c.v, JAK2, STAT3
72  2017 Metabolic changes in the midgut of Eri silkworm after Oral administration of 1-deoxynojirimycin: A 1H-NMR-based metabonomic study. NMR, TCA
73  2017 Metabolic Effect of 1-Deoxynojirimycin from Mulberry Leaves on db/db Diabetic Mice Using Liquid Chromatography-Mass Spectrometry Based Metabolomics. ---
74  2017 Pharmacokinetics, Tissue Distribution, and Elimination of Three Active Alkaloids in Rats after Oral Administration of the Effective Fraction of Alkaloids from Ramulus Mori, an Innovative Hypoglycemic Agent. AUC, DAB, FGM
75  2016 1-Deoxynojirimycin Alleviates Liver Injury and Improves Hepatic Glucose Metabolism in db/db Mice. AST, G6Pase, GP, GS, GSK-3beta, HK, IL-1, IL-6, LDL-C, PEPCK, PI3K, PK, PKB, TC, TG, TNF-alpha
76  2016 A 28-Day Repeated Dose Toxicological Study of an Aqueous Extract of Morus Alba L. BW
77  2016 An Evaluation of 1-Deoxynojirimycin Oral Administration in Eri Silkworm through Fat Body Metabolomics Based on (1) H Nuclear Magnetic Resonance. TCA
78  2016 Comparison of Regulation Mechanisms of Five Mulberry Ingredients on Insulin Secretion under Oxidative Stress. C3G, C3R, GK, GLP-1R, OXY, RES
79  2016 CuAAC click chemistry with N-propargyl 1,5-dideoxy-1,5-imino-D-gulitol and N-propargyl 1,6-dideoxy-1,6-imino-D-mannitol provides access to triazole-linked piperidine and azepane pseudo-disaccharide iminosugars displaying glycosidase inhibitory properties. ---
80  2016 Decreased formation of branched-chain short fatty acids in Bacillus amyloliquefaciens by metabolic engineering. BCFAs, ptb
81  2016 Effect of solar radiation on the functional components of mulberry (Morus alba L.) leaves. ---
82  2016 Evaluation of monovalent and multivalent iminosugars to modulate Candida albicans beta-1,2-mannosyltransferase activities. DMJ
83  2016 Identification and Determination of the Polyhydroxylated Alkaloids Compounds with alpha-Glucosidase Inhibitor Activity in Mulberry Leaves of Different Origins. ELSD, HPLC
84  2016 One pot oxidative dehydration - oxidation of polyhydroxyhexanal oxime to polyhydroxy oxohexanenitrile: A versatile methodology for the facile access of azasugar alkaloids. ---
85  2016 Study of the Aminoglycoside Subsistence Phenotype of Bacteria Residing in the Gut of Humans and Zoo Animals. CFU
86  2016 Synthesis and characterization of novel, conjugated, fluorescent DNJ derivatives for alpha-glucosidase recognition. ---
87  2016 Use of Bacillus amyloliquefaciens HZ-12 for High-Level Production of the Blood Glucose Lowering Compound, 1-Deoxynojirimycin (DNJ), and Nutraceutical Enriched Soybeans via Fermentation. alpha-GI, TN, TRS
88  2015 1-Deoxynojirimycin Alleviates Insulin Resistance via Activation of Insulin Signaling PI3K/AKT Pathway in Skeletal Muscle of db/db Mice. AKT, GLUT4, IR-beta, IRS-1, PI3K
89  2015 A 1H-NMR Based Study on Hemolymph Metabolomics in Eri Silkworm after Oral Administration of 1-Deoxynojirimycin. NMR, PCA
90  2015 Azetidine- and N-carboxylic azetidine-iminosugars as amyloglucosidase inhibitors: synthesis, glycosidase inhibitory activity and molecular docking studies. ---
91  2015 Chronic adjunction of 1-deoxynojirimycin protects from age-related behavioral and biochemical changes in the SAMP8 mice. ---
92  2015 Inhibition of alpha-glucosidase activity by N-deoxynojirimycin analogs in several insect phloem sap feeders. NB-DNJ, NN-DNJ
93  2015 Isolation and SAR studies of bicyclic iminosugars from Castanospermum australe as glycosidase inhibitors. ---
94  2015 Mulberry 1-Deoxynojirimycin Inhibits Adipogenesis by Repression of the ERK/PPARgamma Signaling Pathway in Porcine Intramuscular Adipocytes. IMF, RSG
95  2015 Multiple Comparisons of Glucokinase Activation Mechanisms of Five Mulberry Bioactive Ingredients in Hepatocyte. C3G, C3R, GK, GKRP, OXY, RES
96  2015 Rapid determination of 1-deoxynojirimycin in Morus alba L. leaves by direct analysis in real time (DART) mass spectrometry. DART, LOD, SIM
97  2015 Simultaneous quantification of three active alkaloids from a traditional Chinese medicine Ramulus Mori (Sangzhi) in rat plasma using liquid chromatography-tandem mass spectrometry. DAB, ESI, LLOQs, MRM
98  2015 Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent alpha-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors. ---
99  2014 1-Deoxynojirimycin attenuates high glucose-accelerated senescence in human umbilical vein endothelial cells. HUVECs
100  2014 1-deoxynojirimycin isolated from Bacillus subtilis improves hepatic lipid metabolism and mitochondrial function in high-fat-fed mice. ---