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Abbreviation : EAAT2
Long Form : excitatory amino acid transporter 2
No. Year Title Co-occurring Abbreviation
2021 Critical amino acids in the TM2 of EAAT2 are essential for membrane-bound localization, substrate binding, transporter function and anion currents. CNS, HP2, SLC1A2, TM2, Vmax
2021 Single step nanospray drying preparation technique of gabapentin-loaded nanoparticles-mediated brain delivery for effective treatment of PTZ-induced seizures. GABA, GBP, NPs, PTZ
2021 Upregulation of Glutamatergic Receptors in Hippocampus and Locomotor Hyperactivity in Aged Spontaneous Hypertensive Rat. AMPA, mPFC, NMDA, SHR, WKY
2020 A computational approach yields selective inhibitors of human excitatory amino acid transporter 2 (EAAT2). EAATs
2020 Adenosine Metabolism in the Cerebral Cortex from Several Mice Models during Aging. 5'-NT, AD, ADA, AMP, AMPK
2020 Anakinra Reduces Epileptogenesis, Provides Neuroprotection, and Attenuates Behavioral Impairments in Rats in the Lithium-Pilocarpine Model of Epilepsy. GFAP, IL1B, Itpr2, TNFA
2020 Dysregulation of EAAT2 and VGLUT2 Spinal Glutamate Transports via Histone Deacetylase 2 (HDAC2) Contributes to Paclitaxel-induced Painful Neuropathy. CIPN, HDAC2, VGAT, VGLUT2
2020 EAAT2 as a Research Target in Bipolar Disorder and Unipolar Depression: A Systematic Review. ---
2020 Epigenetic Regulation of Excitatory Amino Acid Transporter 2 in Neurological Disorders. AD, ALS, BD, CNS, GBM, PD
10  2020 Erythrocytic α-synuclein contained in microvesicles regulates astrocytic glutamate homeostasis: a new perspective on Parkinson's disease pathogenesis. BBB, EVs
11  2020 Molecular Mechanisms Underlying the Circadian Rhythm of Blood Pressure in Normotensive Subjects. BP, CR, GS, p-GSK3beta, SCN
12  2020 NDRG2 Expression Correlates with Neurofibrillary Tangles and Microglial Pathology in the Ageing Brain. AD, CFAS, GFAP, GS, NDRG2
13  2020 Positive allosteric activation of glial EAAT-2 transporter protein: A novel strategy for Alzheimer's disease. AD
14  2019 5-HT1A Receptor Agonist Promotes Retinal Ganglion Cell Function by Inhibiting OFF-Type Presynaptic Glutamatergic Activity in a Chronic Glaucoma Model. GABA, GS, RGCs
15  2019 Association study of the excitatory amino acid transporter 2 (EAAT2) and glycine transporter 1 (GlyT1) gene polymorphism with schizophrenia in a Polish population. GlyT1, NMDAR, PANSS
16  2019 Ceftriaxone Treatment Affects EAAT2 Expression and Glutamatergic Neurotransmission and Exerts a Weak Anticonvulsant Effect in Young Rats. CTX, EPSPs, fEPSP, MEST, PTZ, qPCR
17  2019 Divergent roles of astrocytic versus neuronal EAAT2 deficiency on cognition and overlap with aging and Alzheimer's molecular signatures. AD
18  2019 Genetically Encoded Halide Sensor-Based Fluorescent Assay for Rapid Screening of Glutamate Transport and Inhibition. EAAC1, EAATs, YFP
19  2019 Glutamate Transport and Preterm Brain Injury. ---
20  2019 Role of Glutamatergic Excitotoxicity in Neuromyelitis Optica Spectrum Disorders. AQP4, CNS, IgG, NMOSD
21  2019 Study on ceramide modulates EAAT-2 participation in the immunoinflammatory response in schizophrenia. DNR, IL-1beta, NF-kappaB, PDTC, TNF-alpha
22  2019 Up-regulation of astrocyte excitatory amino acid transporter 2 alleviates central sensitization in a rat model of chronic migraine. CM, SP, TEM
23  2018 Astrocyte elevated gene-1 is a novel regulator of astrogliosis and excitatory amino acid transporter-2 via interplaying with nuclear factor-kappaB signaling in astrocytes from amyotrophic lateral sclerosis mouse model with hSOD1G93A mutation. ALS, YY1
24  2018 Axon-terminals expressing EAAT2 (GLT-1; Slc1a2) are common in the forebrain and not limited to the hippocampus. ---
25  2018 Blood glutamate EAAT2-cell grabbing therapy in cerebral ischemia. MSCs
26  2018 Effects of the excitatory amino acid transporter subtype 2 (EAAT-2) inducer ceftriaxone on different pain modalities in rat. SNL
27  2018 Effects of the excitatory amino acid transporter subtype 2 (EAAT-2) transporter inducer ceftriaxone (an antibiotic) on different pain modalities in rat. ---
28  2018 Motor neuron-derived microRNAs cause astrocyte dysfunction in amyotrophic lateral sclerosis. miR-218
29  2018 Nerve Growth Factor Increases Glutamate in Sensory Fibres Innervating the Masseter Muscles of Female Rats. NGF, SP
30  2018 Neurobiology of cognitive remediation in schizophrenia: Effects of EAAT2 polymorphism. AP, CRT
31  2018 Neuroprotection of rhGLP-1 in diabetic rats with cerebral ischemia/reperfusion injury via regulation of oxidative stress, EAAT2, and apoptosis. MCAO, rhGLP-1
32  2018 Pyridazine-derivatives Enhance Structural and Functional Plasticity of Tripartite Synapse Via Activation of Local Translation in Astrocytic Processes. PAP
33  2018 Quantitative proteomics of forebrain subcellular fractions in fragile X mental retardation 1 knockout mice following acute treatment with 2-Methyl-6-(phenylethynyl)pyridine: Relevance to developmental study of schizophrenia. CNP, MPEP, NEFL
34  2018 Targeting Protein Kinase CK1delta with Riluzole: Could It Be One of the Possible Missing Bricks to Interpret Its Effect in the Treatment of ALS from a Molecular Point of View? ALS, FDA, TDP-43
35  2018 [Effect of dopamine on intracerebral glutamate uptake ability in rats with minimal hepatic encephalopathy and the pathogenesis of minimal hepatic encephalopathy]. DA, Glu, MHE, TAA, TAAR1
36  2017 Autoantibody-induced internalization of CNS AQP4 water channel and EAAT2 glutamate transporter requires astrocytic Fc receptor. AQP4, CNS, FcgammaR, NMO
37  2017 Differential SLC1A2 Promoter Methylation in Bipolar Disorder With or Without Addiction. BD, HRM-PCR, TA
38  2017 Functional Expression of Organic Ion Transporters in Astrocytes and Their Potential as a Drug Target in the Treatment of Central Nervous System Diseases. CNS, OATPs, OCTNs
39  2017 Glial EAAT2 regulation of extracellular nTS glutamate critically controls neuronal activity and cardiorespiratory reflexes. DHK, EAATs, nTS
40  2017 Glutamate Deregulation in Ketamine-Induced Psychosis-A Potential Role of PSD95, NMDA Receptor and PMCA Interaction. NMDA, PMCA, PSD-95
41  2017 HIV-1 Tat inhibits EAAT-2 through AEG-1 upregulation in models of HIV-associated neurocognitive disorder. HAND, SHIV, YY-1
42  2017 Metabotropic glutamate receptor 5 may be involved in macrophage plasticity. HMGB1, PPARgamma
43  2017 Shaping of Signal Transmission at the Photoreceptor Synapse by EAAT2 Glutamate Transporters. ---
44  2017 Synthesis and Biological Evaluation of Novel Neuroprotective Pyridazine Derivatives as Excitatory Amino Acid Transporter 2 (EAAT2) Activators. ---
45  2017 Variants of the EAAT2 Glutamate Transporter Gene Promoter Are Associated with Cerebral Palsy in Preterm Infants. ---
46  2016 Astrocytes gate Hebbian synaptic plasticity in the striatum. STDP
47  2016 Astrocytic GAP43 Induced by the TLR4/NF-kappaB/STAT3 Axis Attenuates Astrogliosis-Mediated Microglial Activation and Neurotoxicity. GAP43, LPS, MKL1, NF-kappaB, PKC, STAT3
48  2016 Biomarkers related with seizure risk in glioma patients: A systematic review. ADK, EGFR, IDH1, RINT1, VLGR1
49  2016 Decrease of aquaporin-4 and excitatory amino acid transporter-2 indicate astrocyte dysfunction for pathogenesis of cortical degeneration in HIV-associated neurocognitive disorders. AQP4, HAND, HIV, SHIV
50  2016 Excitatory Amino acid transporter expression in the essential tremor dentate nucleus and cerebellar cortex: A postmortem study. ET
51  2016 Hippocampus-based contextual memory alters the morphological characteristics of astrocytes in the dentate gyrus. Cx43, GFAP
52  2016 TM4 of the glutamate transporter GLT-1 experiences substrate-induced motion during the transport cycle. GLT-1
53  2015 Ceftriaxone reverses ketamine-induced lasting EEG and astrocyte alterations in juvenile mice. EEG, GFAP
54  2015 Designing Novel Nanoformulations Targeting Glutamate Transporter Excitatory Amino Acid Transporter 2: Implications in Treating Drug Addiction. GLT-1
55  2015 Expression of Glutamate Transporters in Alcohol Withdrawal. RT-PCR
56  2015 Glutamate transporter EAAT2: regulation, function, and potential as a therapeutic target for neurological and psychiatric disease. ---
57  2015 HIV protease inhibitors disrupt astrocytic glutamate transporter function and neurobehavioral performance. APV, cART, CNS, LPV, PCNA
58  2015 Regulation of brain glutamate metabolism by nitric oxide and S-nitrosylation. CNS, NO
59  2015 Targeted Overexpression of Astrocytic Endothelin-1 Attenuates Neuropathic Pain by Upregulating Spinal Excitatory Amino Acid Transporter-2. ET-1, NTG, SNL
60  2015 The peroxisome proliferator activated receptor gamma agonist pioglitazone increases functional expression of the glutamate transporter excitatory amino acid transporter 2 (EAAT2) in human glioblastoma cells. PPARgamma, TAE
61  2014 A novel treatment strategy for glioblastoma multiforme and glioma associated seizures: increasing glutamate uptake with PPARgamma agonists. GAS, PPAR
62  2014 Abnormal partitioning of hexokinase 1 suggests disruption of a glutamate transport protein complex in schizophrenia. HK1
63  2014 Adenosine and glutamate in neuroglial interaction: implications for circadian disorders and alcoholism. ATP
64  2014 Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy. AAV, GS, miR-ADK
65  2014 Aquaporin-4 knockout exacerbates corticosterone-induced depression by inhibiting astrocyte function and hippocampal neurogenesis. aNSCs, AQP4, ELISA, FST, GDNF, TST
66  2014 Association of rare variation in the glutamate receptor gene SLC1A2 with susceptibility to bipolar disorder and schizophrenia. BD, SZ, UTR
67  2014 Ceftriaxone alleviates early brain injury after subarachnoid hemorrhage by increasing excitatory amino acid transporter 2 expression via the PI3K/Akt/NF-kappaB signaling pathway. CEF, EBI, MWM, SAH, TUNEL
68  2014 Decreased EAAT2 protein expression in the essential tremor cerebellar cortex. ---
69  2014 Excitatory amino acid transporter 2 downregulation correlates with thalamic neuronal death following kainic acid-induced status epilepticus in rat. IL-1beta, iNOS
70  2014 Extensive dysregulations of oligodendrocytic and astrocytic connexins are associated with disease progression in an amyotrophic lateral sclerosis mouse model. ALS, AQP4, Cxs, GFAP, GJs, MOG, mSOD1, mSOD1-Tg, non-Tg
71  2014 Methamphetamine and HIV-1-induced neurotoxicity: role of trace amine associated receptor 1 cAMP signaling in astrocytes. beta-PEA, cAMP, HAND, HIV-1, METH, TAAR1
72  2014 Neuronal influences are necessary to produce mitochondrial co-localization with glutamate transporters in astrocytes. ---
73  2014 Safety and efficacy of ceftriaxone for amyotrophic lateral sclerosis: a multi-stage, randomised, double-blind, placebo-controlled trial. ALSFRS-R
74  2014 The intrinsic pathogenic role of autoantibodies to aquaporin 4 mediating spinal cord disease in a rat passive-transfer model. Abs, AQP4, GFAP, i.th, IgG, MRI, NMO
75  2014 Trafficking of excitatory amino acid transporter 2-laden vesicles in cultured astrocytes: a comparison between approximate and exact determination of trajectory angles. EGFP
76  2014 Type 1 equilibrative nucleoside transporter regulates astrocyte-specific glial fibrillary acidic protein expression in the striatum. AQP4, CPu, EGFP, GFAP, NAc
77  2013 Involvement of pGluR1, EAAT2 and EAAT3 in offspring depression induced by prenatal stress. AMPAR, PS
78  2012 4-Hydroxyhexenal (HHE) impairs glutamate transport in astrocyte cultures. AD, HHE, HPG, LAD, MCI, PCAD
79  2012 Chronic restraint stress decreases glial fibrillary acidic protein and glutamate transporter in the periaqueductal gray matter. GFAP, PAG
80  2012 Cognitive dysfunction and glutamate reuptake: effect of EAAT2 polymorphism in schizophrenia. GRM3
81  2012 Long lasting effects of early-life stress on glutamatergic/GABAergic circuitry in the rat hippocampus. EAAT1, GAD65
82  2011 Human nasal olfactory epithelium as a dynamic marker for CNS therapy development. CNS
83  2011 PGC-1alpha protects neurons and alters disease progression in an amyotrophic lateral sclerosis mouse model. ALS, PGC-1alpha
84  2011 Polymorphism of the Glutamate Transporter Protein EAAT2 and Migraine Transformation into Chronic Daily Headache. M-CDH, M-E
85  2011 Polymorphisms associated with normal memory variation also affect memory impairment in schizophrenia. SNP
86  2011 Role of excitatory amino acid transporter-2 (EAAT2) and glutamate in neurodegeneration: opportunities for developing novel therapeutics. CEF, EAAT
87  2011 Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators. ---
88  2011 Study on the correlation between synaptic reconstruction and astrocyte after ischemia and the influence of electroacupuncture on rats. Cx43, EA, GFAP
89  2010 Aberrant detergent-insoluble excitatory amino acid transporter 2 accumulates in Alzheimer disease. AD
90  2010 An essential role for adenosine signaling in alcohol abuse. CNS
91  2010 ENT1 regulates ethanol-sensitive EAAT2 expression and function in astrocytes. ENT1
92  2010 Exon-skipping splice variants of excitatory amino acid transporter-2 (EAAT2) form heteromeric complexes with full-length EAAT2. FRET
93  2010 Functional expression, purification and high sequence coverage mass spectrometric characterization of human excitatory amino acid transporter EAAT2. MS
94  2010 Glutamate transporter variants reduce glutamate uptake in Alzheimer's disease. AD
95  2010 Increased expression of cholesterol 24S-hydroxylase results in disruption of glial glutamate transporter EAAT2 association with lipid rafts: a potential role in Alzheimer's disease. AD
96  2010 Regulation of glial glutamate transporters by C-terminal domains. ---
97  2009 Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signaling. AD, MCI, NFAT
98  2009 Ethanol disrupts NMDA receptor and astroglial EAAT2 modulation of Kv2.1 potassium channels in hippocampus. ---
99  2009 Excitatory amino acid transporter 2 associates with phosphorylated tau and is localized in neurofibrillary tangles of tauopathic brains. AD, CBD, p-tau, PSP
100  2009 Molecular mechanisms of necrosis in glioblastoma: the role of glutamate excitotoxicity. AEG-1, NF-kappaB, PTEN, TNF-alpha