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Abbreviation : ERK
Long Form : extracellular signal-regulated kinase
No. Year Title Co-occurring Abbreviation
2021 (Pro)renin Receptor Knockdown Attenuates Liver Fibrosis Through Inactivation of ERK/TGF-β1/SMAD3 Pathway. HSCs, MCD, TAA, TGF
2021 14-3-3 epsilon is an intracellular component of TNFR2 receptor complex and its activation protects against osteoarthritis. NF-kappaB, OA, PGRN
2021 7,8-Dihydroxyflavone protects retinal ganglion cells against chronic intermittent hypoxia-induced oxidative stress damage via activation of the BDNF/TrkB signaling pathway. 7,8-DHF, Akt, BDNF, CIH, OS, OSA, RGCs, ROS, TrkB
2021 7,8-Dihydroxyflavone suppresses proliferation and induces apoptosis of human osteosarcoma cells. 7,8-DHF, Bad, JNK, MAPK, MTT, OS, TdT
2021 A conserved klo-1-mpk-1 pathway regulates autophagy and modulates longevity in Caenorhabditis elegans. ---
2021 A JAK of all trades: how global phosphoproteomics reveal the Achilles heel of MPNs. JAK, JAK2, MKNK1, MPN
2021 A Rare p.T599dup BRAF Mutant NSCLC in a Non-Smoker. MEK, NSCLC, RAF
2021 A Synthetic Peptide Designed to Neutralize Lipopolysaccharides Attenuates Metaflammation and Diet-Induced Metabolic Derangements in Mice. AMPs, CD36, HFD, IKK, iNOS, NF-B, NLRP3, T2DM
2021 ABCA8-mediated efflux of taurocholic acid contributes to gemcitabine insensitivity in human pancreatic cancer via the S1PR2-ERK pathway. ABC, GEM, Gem-R, PC, S1PR2, TCA
10  2021 Abnormal Pressure Stress Reduces Interleukin-1β-Induced Cyclooxygenase-2 Expression in Cultured Rat Vascular Smooth Muscle Cells. COX-2, IL, PKC, PMA, VSMCs
11  2021 Acetate stimulates lipogenesis via AMPKα signaling in rabbit adipose-derived stem cells. ADSCs, AMPK, JNK, MAPKs
12  2021 Activation of ERK-Drp1 signaling promotes hypoxia-induced Aβ accumulation by upregulating mitochondrial fission and BACE1 activity. AD, APP, BACE1, Drp1, Mdivi-1
13  2021 Activation of Galanin Receptor 1 with M617 Attenuates Neuronal Apoptosis via ERK/GSK-3β/TIP60 Pathway After Subarachnoid Hemorrhage in Rats. GAL, GalR1, GSK3-beta, SAH, TIP60
14  2021 Activation of PTP1B/EGFR signaling and cytotoxicity during combined exposure to ambient electrophiles in A431 cells. BQ, EGFR, HPTP1B, NQ, PTP
15  2021 Activation of SphK1 by adipocytes mediates epithelial ovarian cancer cell proliferation. EOC, S1PR, SphK
16  2021 Activation of the ERK1/2 signaling pathway enhances proliferation and apoptosis of trophoblast in preeclampsia rats. HE, MDA, SOD
17  2021 Activation of the extracellular signal-regulated kinase pathway is required for replication of Newcastle disease virus. NDV
18  2021 Activation of the extracellular-signal-regulated kinase (ERK)/c-Jun N-terminal kinase (JNK) signal pathway and osteogenic factors in subchondral bone of patients with knee osteoarthritis. JNK, OA, OCN, OMD, p-ERK, p-JNK
19  2021 Activation of the mitogen-activated protein kinase ERK1/2 signaling pathway suppresses the expression of ChREBPα and β in HepG2 cells. ChREBP, STS, TPA
20  2021 Adropin-based dual treatment enhances the therapeutic potential of mesenchymal stem cells in rat myocardial infarction. BrdU, MSCs
21  2021 Advantages of Tyrosine Kinase Anti-Angiogenic Cediranib over Bevacizumab: Cell Cycle Abrogation and Synergy with Chemotherapy. ---
22  2021 AITC inhibits fibroblast-myofibroblast transition via TRPA1-independent MAPK and NRF2/HO-1 pathways and reverses corticosteroids insensitivity in human lung fibroblasts. AITC, alpha-SMA, FMT, HO, MAPK, Nrf2, TGF-beta1, TRPA1
23  2021 AKAP2 overexpression modulates growth plate chondrocyte functions through ERK1/2 signaling. AIS, AKAP2, ECM, GPCs
24  2021 Alcohol amplifies cingulate cortex signaling and facilitates immobilization-induced hyperalgesia in female rats. AFAB, CREB, CRPS
25  2021 Alginate/poloxamer hydrogel obtained by thiol-acrylate photopolymerization for the alleviation of the inflammatory response of human keratinocytes. LPS, NF, TNF
26  2021 Alisol A 24-acetate stimulates lipolysis in 3 T3-L1 adipocytes. AA-24-a, PKA
27  2021 Alleviation of LPS-Induced Inflammation and Septic Shock by Lactiplantibacillus plantarum K8 Lysates. AIM2, AST, IL, JNK, LPS, MAPK, NF-kappaB, TLR, TNF
28  2021 Alterations in thymocyte populations under conditions of endotoxin tolerance. CDR3, DP, ET, LPS, SP, TCR
29  2021 Analgesic Effect of Combined Therapy with the Japanese Herbal Medicine "Yokukansan" and Electroacupuncture in Rats with Acute Inflammatory Pain. EA, YKS, YKS
30  2021 Anisodamine ameliorates ischemia/reperfusion-induced renal injury in rats through activation of the extracellular signal-regulated kinase (ERK) pathway and anti-apoptotic effect. I/R, SD
31  2021 Anti-angiogenesis Function of Ononin via Suppressing the MEK/Erk Signaling Pathway. cyto c, HIF-1alpha, MEK, VEGF, VEGFR2
32  2021 Anti-Cancer Effects of Zotarolimus Combined with 5-Fluorouracil Treatment in HCT-116 Colorectal Cancer-Bearing BALB/c Nude Mice. COX-2, EGFR, mTOR, TGF-beta, VEGF
33  2021 Anti-Inflammatory and Anti-Allergic Effects of Saponarin and Its Impact on Signaling Pathways of RAW 264.7, RBL-2H3, and HaCaT Cells. COX, IFN, IL, RBL-2H3, STAT1, TNF
34  2021 Anti-Inflammatory and Mineralization Effects of Bromelain on Lipopolysaccharide-Induced Inflammation of Human Dental Pulp Cells. hDPCs, ICAM-1, LPS, VCAM-1
35  2021 Anti-inflammatory effect of Ailanthus altissima (Mill.) Swingle leaves in lipopolysaccharide-stimulated astrocytes. AAE, CNS, COX-2, iNOS, JNK, LPS, MAPK, NF-kappaB, NO
36  2021 Anti-Metastatic and Anti-Inflammatory Effects of Matrix Metalloproteinase Inhibition by Ginsenosides. ECM, JNK, MAPKs, MMPs
37  2021 Anti-photoaging activities of Sorbaria kirilowii ethanol extract in UVB-damaged cells. AP, COL1A1, COX, FLG, HAS, JNK, MMPs
38  2021 Antioxidative effects of polypyrimidine tract-binding protein-associated splicing factor against pathological retinal angiogenesis through promotion of mitochondrial function. 4-HNE, ATF4, CHOP, eIF2alpha, ER, HO-1, HRMECs, IRNV, PDI, PKR, PSF, ROS
39  2021 Antiplatelet and Antithrombotic Effects of Epimedium koreanum Nakai. ---
40  2021 Antipsychotic potential of the type 1 cannabinoid receptor positive allosteric modulator GAT211: preclinical in vitro and in vivo studies. NMDA
41  2021 Antitumor activity and mechanism of resistance of the novel HDAC and PI3K dual inhibitor CUDC-907 in pancreatic cancer. HDACs, PI3K
42  2021 Antitumor effects of 3-bromoascochlorin on small cell lung cancer via inhibiting MAPK pathway. BAS, MAPK, MNPs, SCLC, WB
43  2021 Antrodia salmonea induces apoptosis and enhances cytoprotective autophagy in colon cancer cells. 3-MA, AOM, AS, ATG4B, AVOs, Bax, LC3-II, NAC, PI, ROS
44  2021 Apoptotic effects of dehydrocrenatidine via JNK and ERK pathway regulation in oral squamous cell carcinoma. JNK, MAPK
45  2021 Arachidonic Acid 15-Lipoxygenase: Effects of Its Expression, Metabolites, and Genetic and Epigenetic Variations on Airway Inflammation. 15-HETE, ALOX15, IL, MEK, PEBP1, STATs
46  2021 Asarylaldehyde enhances osteogenic differentiation of human periodontal ligament stem cells through the ERK/p38 MAPK signaling pathway. ALP, hPDLSCs
47  2021 ASIC1 inhibition impairs the proliferation and migration of pancreatic stellate cells induced by pancreatic cancer cells. ASIC1, Panc-1-CM, pERK, PSCs
48  2021 Association of Extracellular Signal-Regulated Kinase Genes With Myopia: A Longitudinal Study of Chinese Children. AL, CCT, CVC, LT, miRNA, PPI, SE, SNPs
49  2021 Astaxanthin Inhibits Autophagic Cell Death Induced by Bisphenol A in Human Dermal Fibroblasts. BPA, JNK, MAPK, NF-kappaB, NHDF, ROS
50  2021 Autocrine regulation of airway smooth muscle contraction by diacylglycerol kinase. ASM, COX, DAG, DGK, MLC20, PGE2, PKA, PKC
51  2021 Autophagy Controls Nrf2-Mediated Dichotomy in Pressure Overloaded Hearts. ATG, CR, KO, Nrf2, PO
52  2021 Baicalin ameliorates chronic unpredictable mild stress-induced depression through the BDNF/ERK/CREB signaling pathway. BA, BDNF, CON, CREB, CUMS, FLU, IOD, MWM, NSF, OFT, SPT, TST
53  2021 Baicalin Attenuates Oxygen-Glucose Deprivation/Reoxygenation-Induced Injury by Modulating the BDNF-TrkB/PI3K/Akt and MAPK/Erk1/2 Signaling Axes in Neuron-Astrocyte Cocultures. BCL, BDNF, CREB, MAPK, OGD/R, PI3K, TrkB
54  2021 Baoyuan decoction (BYD) attenuates cardiac hypertrophy through ANKRD1-ERK/GATA4 pathway in heart failure after acute myocardial infarction. AMI, ANKRD1, BYD, CH, GATA4, HF, LADCA
55  2021 BC-N102 suppress breast cancer tumorigenesis by interfering with cell cycle regulatory proteins and hormonal signaling, and induction of time-course arrest of cell cycle at G1/G0 phase. AR, ER, MAPK, MR, PI3K, PR
56  2021 Betulinic Acid Alleviates Spleen Oxidative Damage Induced by Acute Intraperitoneal Exposure to T-2 Toxin by Activating Nrf2 and Inhibiting MAPK Signaling Pathways. BA, ECH, HO-1, JNK, MAPK, MDA, NF-E2, ROS, SOD, T-AOC, TC, TG
57  2021 Biochemical Activity Architectures Visualized-Using Genetically Encoded Fluorescent Biosensors to Map the Spatial Boundaries of Signaling Compartments. cAMP, mTORC1
58  2021 Blockage of Extracellular Signal-Regulated Kinase Exerts an Antitumor Effect via Regulating Energy Metabolism and Enhances the Efficacy of Autophagy Inhibitors by Regulating Transcription Factor EB Nuclear Translocation in Osteosarcoma. OS, TFEB
59  2021 Blocking hsa_circ_0006168 suppresses cell proliferation and motility of human glioblastoma cells by regulating hsa_circ_0006168/miR-628-5p/IGF1R ceRNA axis. GBM, IGF1R, miR
60  2021 Blocking the JAK2/STAT3 and ERK pathways suppresses the proliferation of gastrointestinal cancers by inducing apoptosis. GC, JAK2, MEK, PDAC, STAT3
61  2021 Bloodletting Puncture at Hand Twelve Jing-Well Points Relieves Brain Edema after Severe Traumatic Brain Injury in Rats via Inhibiting MAPK Signaling Pathway. AQP4, BBB, HTWP, MAPK, MMP-9, mNSS, SHAM, TBI
62  2021 Bromamine T (BAT) Exerts Stronger Anti-Cancer Properties than Taurine (Tau). BAT, JNK, MAPK, Tau
63  2021 C-terminal-truncated hepatitis B virus X protein promotes hepatocarcinogenesis by activating the MAPK pathway. CCK-8, Cdc25C, ctHBx, HBV, HCC, JNK, MAPK, WB
64  2021 Ca mobilization and signaling pathways induced by rRgpB in human gingival fibroblast. HGF, JNK, p38 MAPK, PAR
65  2021 Cadmium exposure induces mitochondrial pathway apoptosis in swine myocardium through xenobiotic receptors-mediated CYP450s activation. Cd, CYP450s, JNK, MAPK, ROS
66  2021 Cadmium induced inflammation and apoptosis of porcine epididymis via activating RAF1/MEK/ERK and NF-κB pathways. Bax, Bcl-2, Cd, COX-2, cyt c, IL-1beta, IL-6, IL-8, iNOS, MEK, NF-kappaB, TNF-alpha
67  2021 Calcium Phosphate Cement Causes Nucleus Pulposus Cell Degeneration through the ERK Signaling Pathway. CPC, HNPC, HNPCs, PMMA
68  2021 Calcium-sensing receptor promotes calcium oxalate crystal adhesion and renal injury in Wistar rats by promoting ROS production and subsequent regulation of PS ectropion, OPN, KIM-1, and ERK expression. CaSRs, OS, PS, ROS
69  2021 Calcium-Sensing Receptors Control CYP27B1-Luciferase Expression: Transcriptional and Posttranscriptional Mechanisms. CaSRs, PKC
70  2021 Calmodulin influences MAPK signaling by binding KSR1. EGF, KSR1, MAPK
71  2021 Cancer-Associated Fibroblast-Mediated Cellular Crosstalk Supports Hepatocellular Carcinoma Progression. CAFs, CLCF1, TANs, TME
72  2021 Cannabinoid 2 receptors regulate dopamine 2 receptor expression by a beta-arrestin 2 and GRK5-dependent mechanism in neuronal cells. GRK5, shRNA
73  2021 Cardamonin Attenuates Inflammation and Oxidative Stress in Interleukin-1β-Stimulated Osteoarthritis Chondrocyte through the Nrf2 Pathway. COX-2, HO-1, iNOS, MMPs, mTOR, NF-kappaB, NO, NQO1, Nrf2, OA, PGE2
74  2021 CD137 (4-1BB) stimulation leads to metabolic and functional reprogramming of human monocytes/macrophages enhancing their tumoricidal activity. ADPC
75  2021 CD40 Cross-Linking Induces Migration of Renal Tumor Cell through Nuclear Factor of Activated T Cells (NFAT) Activation. NFAT, RCC
76  2021 Celecoxib enhances apoptosis of the liver cancer cells via regulating ERK/JNK/P38 pathway. caspase 3, HE, JNK, mRNAs, qPCR
77  2021 Cellular Effects of Rhynchophylline and Relevance to Sleep Regulation. MAPK, NF-kappaB, NMDA, PI3K, Rhy
78  2021 Characterization and Proteomic Analysis of Endometrial Stromal Cell-Derived Small Extracellular Vesicles. ANXA2, EC, EcESCs-sEVs, ESCs, EU, sEVs
79  2021 Chloroquine ameliorates bone loss induced by d-galactose in male rats via inhibition of ERK associated osteoclastogenesis and antioxidant effect. BALP, CAT, CQ, CTSK, CTSK, D-gal, OCN, OPG, RANKL, SOD, TRAP
80  2021 Chordoma-Current Understanding and Modern Treatment Paradigms. EGFR, FGF, MEK, mTOR, PDGFR, PI3K
81  2021 Chronic Blockade of NMDAR Subunit 2A in the Hypothalamic Paraventricular Nucleus Alleviates Hypertension Through Suppression of MEK/ERK/CREB Pathway. CREB, MEK, NMDAR, PVN
82  2021 Chronic Exercise Protects against the Progression of Renal Cyst Growth and Dysfunction in Rats with Polycystic Kidney Disease. AVP, mTOR, PCK, PKD
83  2021 Chronic restraint stress promotes the mobilization and recruitment of myeloid-derived suppressor cells through β-adrenergic-activated CXCL5-CXCR2-Erk signaling cascades. CORT, CXCR2, EPI, HCC, MDSCs, NE
84  2021 Chrysin Inhibits TNFα-Induced TSLP Expression through Downregulation of EGR1 Expression in Keratinocytes. AD, JNK, TNF-alpha, TSLP
85  2021 Cichorium pumilum Jacq Extract Inhibits LPS-Induced Inflammation via MAPK Signaling Pathway and Protects Rats From Hepatic Fibrosis Caused by Abnormalities in the Gut-Liver Axis. COX-2, IL, iNOS, LPS, MAPK, NO
86  2021 Cinnamtannin B1 attenuates rosacea-like signs via inhibition of pro-inflammatory cytokine production and down-regulation of the MAPK pathway. CB1, ELISA, IL-8, MAPK, MIP-2, MPO
87  2021 Cip2A modulates osteogenic differentiation via the ERK-Runx2 pathway in MG63 cells. ALP, CIP2A
88  2021 Circular RNA _NLRP1 targets mouse microRNA-199b-3p to regulate apoptosis and pyroptosis of hippocampal neuron under oxygen-glucose deprivation exposure. GSDMD, IF, LDH, MAPK, OGD, sh
89  2021 Circ_0030586 inhibits cell proliferation and stemness in bladder cancer by inactivating the ERK signaling via miR-665/NR4A3 axis. BCa, ceRNA, circRNAs, NR4A3
90  2021 Clinical and Morphologic Characteristics of Extracellular Signal-Regulated Kinase Inhibitor-Associated Retinopathy. MEK, VA
91  2021 COL11A1 activates cancer-associated fibroblasts by modulating TGF-β3 through the NF-κB/IGFBP2 axis in ovarian cancer cells. CAFs, EOC, HOFs, IGFBP2, TME
92  2021 Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival. AKT, EGFR, EH, MMP
93  2021 Combination of Polygoni Multiflori Radix Praeparata and Acori Tatarinowii Rhizoma Alleviates Learning and Memory Impairment in Scopolamine-Treated Mice by Regulating Synaptic-Related Proteins. AD, BDNF, CREB, GC, HPLC-MS, p90RSK, PSD
94  2021 Combined effect of co-exposure to di (2-ethylhexyl) phthalates and 50-Hz magnetic-fields on promoting human amniotic cells proliferation. Akt, ELF-EMFs, MFs, SphK1
95  2021 Comparative proteomic analysis to identify the novel target gene of angiotensin II in adrenocortical H295R cells. Ang II, MAPK, PFKP, SILAC
96  2021 Constitutive activation of ERK1/2 signaling protects against myocardial ischemia via inhibition of mitochondrial fragmentation in the aging heart. AAV9, Drp1, MEK
97  2021 Constitutive activation of MEK5 promotes a mesenchymal and migratory cell phenotype in triple negative breast cancer. MAPK, MEK5, TNBC
98  2021 Contributions of Sodium-Hydrogen Exchanger 1 and Mitogen-Activated Protein Kinases to Enhanced Retinal Venular Constriction to Endothelin-1 in Diabetes. ET-1, JNK, MAPKs, PKC
99  2021 Correlation between urinary KIM-1 and kidney protein expression of p-ERK following damage in rats exposed to gentamicin or lead acetate. KIM-1, pERK
100  2021 Costunolide, a Sesquiterpene Lactone, Suppresses Skin Cancer via Induction of Apoptosis and Blockage of Cell Proliferation. NF-kappaB, STAT3