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Abbreviation : FMRP
Long Form : fragile X mental retardation protein
No. Year Title Co-occurring Abbreviation
2022 Agmatine relieves behavioral impairments in Fragile X mice model. FXS, KO
2022 Altered brown adipose tissue mitochondrial function in newborn fragile X syndrome mice. BAT, UCPs
2022 Amyloid beta induces Fmr1-dependent translational suppression and hyposynchrony of neural activity via phosphorylation of eIF2α and eEF2. AD, eEF2, eIF2alpha, FMR1, PP1, PP2A
2022 Basolateral amygdala hyperexcitability is associated with precocious developmental emergence of fear-learning in Fragile X Syndrome. ASDs, BLA, CP, FXS, PNs
2022 Cellular distribution of the Fragile X mental retardation protein in the inner ear: a developmental and comparative study in the mouse, rat, gerbil, and chicken. AG, FXS
2022 CMTr cap-adjacent 2'-O-ribose mRNA methyltransferases are required for reward learning and mRNA localization to synapses. cOMe
2022 Combining Lovastatin and Minocycline for the Treatment of Fragile X Syndrome: Results From the LovaMiX Clinical Trial. ABC-C, ABC-C, ADAMS, BRIEF, FXS, SRS, VABS-II
2022 Daily Living Skills in Adolescent and Young Adult Males With Fragile X Syndrome. FXS
2022 Deletion of Fmr1 in parvalbumin-expressing neurons results in dysregulated translation and selective behavioral deficits associated with fragile X syndrome. FXS
10  2022 Dissecting Cell-Autonomous Function of Fragile X Mental Retardation Protein in an Auditory Circuit by In Ovo Electroporation. AG, FXS, NM, shRNA
11  2022 Drosophila FMRP controls miR-276-mediated regulation of nejire mRNA for space filling dendrite development. miRNAs, nej, RBPs
12  2022 FMR protein: Evidence of an emerging role in retinal aging? ---
13  2022 FMRP promotes transcription-coupled homologous recombination via facilitating TET1-mediated m5C RNA modification demethylation. DSBs, HR, m5C, mRNA, TET1
14  2022 FMRP protects the lung from xenobiotic stress by facilitating the integrated stress response. ISR
15  2022 FMRP regulates GABAA receptor channel activity to control signal integration in hippocampal granule cells. GABAAR, KO
16  2022 FMRP Sustains Presynaptic Function via Control of Activity-Dependent Bulk Endocytosis. ADBE, FXS, KO, SV
17  2022 Folding Mechanism and Aggregation Propensity of the KH0 Domain of FMRP and Its R138Q Pathological Variant. FXS, KH
18  2022 Fragile X Mental Retardation Protein and Cerebral Expression of Metabotropic Glutamate Receptor Subtype 5 in Men with Fragile X Syndrome: A Pilot Study. ASD, FM, FXS, ID, mGluR5
19  2022 Fragile X Mental Retardation Protein Mediates the Effects of Androgen on Hippocampal PSD95 Expression and Dendritic Spines Density/Morphology and Autism-Like Behaviors Through miR-125a. DHT, KO, PSD-95, WT
20  2022 Fragile X Syndrome: From Molecular Aspect to Clinical Treatment. FMR1, FXS
21  2022 Function of FMRP Domains in Regulating Distinct Roles of Neuronal Protein Synthesis. ---
22  2022 Influence of Gestational Chlorpyrifos Exposure on ASD-like Behaviors in an fmr1-KO Rat Model. ASD, CPF, KO
23  2022 Inhibitory effect of aptamer-carbon dot nanomaterial-siRNA complex on the metastasis of hepatocellular carcinoma cells by interfering with FMRP. CDs, HCC, siRNA
24  2022 Intercepting IRE1 kinase-FMRP signaling prevents atherosclerosis progression. ER, IRE1, RBP
25  2022 Maturation Delay of Human GABAergic Neurogenesis in Fragile X Syndrome Pluripotent Stem Cells. FMR1, FXS, hPSC
26  2022 Pten heterozygosity restores neuronal morphology in fragile X syndrome mice. KO
27  2022 Reelin central fragment supplementation improves cognitive deficits in a mouse model of Fragile X Syndrome. FXS, KO
28  2022 RNA-binding FMRP and Staufen sequentially regulate the Coracle scaffold to control synaptic glutamate receptor and bouton development. GluR, NMJ
29  2022 Temporally and Spatially Localized PKA Activity within Learning and Memory Circuitry Regulated by Network Feedback. MB, NBEA, OE, PKA
30  2022 The Drosophila fragile X mental retardation protein modulates the neuronal cytoskeleton to limit dendritic arborization. chic
31  2022 The Fragile X Protein Disordered Regions Bind a Novel RNA Target. FXPs, FXS
32  2022 The Primary Ciliary Deficits in Cerebellar Bergmann Glia of the Mouse Model of Fragile X Syndrome. EGL, FMR1, FXS, GNP, Shh
33  2022 Transcriptomic Analysis of Human Fragile X Syndrome Neurons Reveals Neurite Outgrowth Modulation by the TGFβ/BMP Pathway. FXS, hESC
34  2022 Up-regulation of cell division cycle 20 expression alters the morphology of neuronal dendritic spines in the nucleus accumbens by promoting FMRP ubiquitination. CDC20, NAc
35  2021 A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies. FXS
36  2021 Adenosine A2A receptor inhibition reduces synaptic and cognitive hippocampal alterations in Fmr1 KO mice. A2ARs, fEPSPs, FXS, LTD, mGlu5Rs
37  2021 An "Omic" Overview of Fragile X Syndrome. FMR1, FXS
38  2021 Astrocytes deliver CK1 to neurons via extracellular vesicles in response to inflammation promoting the translation and amyloidogenic processing of APP. AD, astrocyte derived EVs, CK1
39  2021 Channelopathies in fragile X syndrome. FXS
40  2021 Cytoplasmic FMR1 interacting protein (CYFIP) family members and their function in neural development and disorders. WRC
41  2021 Development of a Quantitative FMRP Assay for Mouse Tissue Applications. qFMRPm
42  2021 Differential Retinoic Acid Signaling in the Hippocampus of Aged Rats with and without Memory Impairment. AI, AU, RA, RBP4
43  2021 DNA Methylation, Mechanisms of FMR1 Inactivation and Therapeutic Perspectives for Fragile X Syndrome. FXS
44  2021 Do Autism Spectrum and Autoimmune Disorders Share Predisposition Gene Signature Due to mTOR Signaling Pathway Controlling Expression? AID, ASD
45  2021 Dysregulated CRMP Mediates Circadian Deficits in a Drosophila Model of Fragile X Syndrome. CRMP, FXS
46  2021 FMRP and MOV10 regulate Dicer1 expression and dendrite development. AGO, CLIP, MOV10
47  2021 FMRP attenuates activity dependent modifications in the mitochondrial proteome. ---
48  2021 FMRP Interacts with RARα in Synaptic Retinoic Acid Signaling and Homeostatic Synaptic Plasticity. FMR1, FXS, RA
49  2021 FMRP Levels in Human Peripheral Blood Leukocytes Correlates with Intellectual Disability. FXS, IQ, PBMCs, UTR
50  2021 Fmrp regulates oligodendrocyte lineage cell specification and differentiation. FXS, OLs, OPCs, RBPs
51  2021 FMRP regulates STAT3 mRNA localization to cellular protrusions and local translation to promote hepatocellular carcinoma metastasis. HCC
52  2021 FMRP-Driven Neuropathology in Autistic Spectrum Disorder and Alzheimer's disease: A Losing Game. AD, FXS, RBP
53  2021 Fragile X mental retardation protein (FMRP) and metabotropic glutamate receptor subtype 5 (mGlu5) control stress granule formation in astrocytes. DHPG, FXS, KO, mGlu, mGlu5, MPEP, NAM, SGs, WT
54  2021 Fragile X mental retardation protein in intrahepatic cholangiocarcinoma: regulating the cancer cell behavior plasticity at the leading edge. FXS, iCCA
55  2021 Fragile X mental retardation protein-regulated proinflammatory cytokine expression in the spinal cord contributes to the pathogenesis of inflammatory pain induced by complete Freund's adjuvant. CFA, IL-6, SDH, TNF-alpha
56  2021 Fragile X premutation and associated health conditions: A review. CGG, FMR1, FXPAC, FXS
57  2021 FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation. ALS, FUS, RBP
58  2021 GABA Measurement in a Neonatal Fragile X Syndrome Mouse Model Using 1H-Magnetic Resonance Spectroscopy and Mass Spectrometry. 1H-MRS, FXS
59  2021 GABAA Alpha 2,3 Modulation Improves Select Phenotypes in a Mouse Model of Fragile X Syndrome. FXP, FXS, KO
60  2021 Gene therapy using an ortholog of human fragile X mental retardation protein partially rescues behavioral abnormalities and EEG activity. EEG, FXS
61  2021 Genetic removal of p70 S6K1 corrects coding sequence length-dependent alterations in mRNA translation in fragile X syndrome mice. FXS, mRNA, RF, S6K1
62  2021 In vivo imaging of mGlu5 receptor expression in humans with Fragile X Syndrome towards development of a potential biomarker. FXS, mGluR5
63  2021 Local Protein Translation and RNA Processing of Synaptic Proteins in Autism Spectrum Disorder. ASD
64  2021 Loss of Tsc1 in cerebellar Purkinje cells induces transcriptional and translation changes in FMRP target transcripts. PCs, TSC
65  2021 Missense mutation of Fmr1 results in impaired AMPAR-mediated plasticity and socio-cognitive deficits in mice. FXS
66  2021 Mitochondrial bioenergetics of astrocytes in Fragile X syndrome: new perspectives on culture conditions and sex effects. CNS, FXS
67  2021 Mosaicism in Fragile X syndrome: A family case series. FM, FMR1, FXS, PM
68  2021 ncRNA BC1 influences translation in the oocyte. BC1, GV, ncRNAs
69  2021 Neuron-Specific FMRP Roles in Experience-Dependent Remodeling of Olfactory Brain Innervation during an Early-Life Critical Period. AL, ASD, FXS, OSN
70  2021 Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance. FXS
71  2021 Neurovirulence of avian influenza virus is dependent on the interaction of viral NP protein with host factor FMRP in the murine brain. AIVs, CNS, HA, NP, SA
72  2021 Novel fragile X syndrome 2D and 3D brain models based on human isogenic FMRP-KO iPSCs. FXS, hiPSC
73  2021 Rates of protein synthesis are reduced in peripheral blood mononuclear cells (PBMCs) from fragile X individuals. FXS, PBMCs
74  2021 Reciprocal regulation of spontaneous synaptic vesicle fusion by Fragile X mental retardation protein and group I metabotropic glutamate receptors. FXS, KO, mGlu, sEPSCs, SV, WT
75  2021 Rett Syndrome and Fragile X Syndrome: Different Etiology With Common Molecular Dysfunctions. FXS, MeCP2, RTT
76  2021 RNA-binding protein dysfunction in neurodegeneration. FUS, RBPs, TDP-43
77  2021 Role of FMRP in rapid antidepressant effects and synapse regulation. FXS, MDD, mTORC1, NMDARs
78  2021 SENP1 in the retrosplenial agranular cortex regulates core autistic-like symptoms in mice. ASD, RSA, SENP1
79  2021 Symptomatic, Genetic, and Mechanistic Overlaps between Autism and Alzheimer's Disease. AD, APP, ASD, IRP
80  2021 Targeting NUFIP1 Suppresses Growth and Induces Senescence of Colorectal Cancer Cells. CRC, mRNP, SA-beta-gal, SAHF, UA
81  2021 The fragile X mental retardation protein promotes adjustments in cocaine self-administration that preserve reinforcement level. Arc, FR, IVSA, KO, WT
82  2021 The Fragile X Proteins Differentially Regulate Translation of Reporter mRNAs with G-quadruplex Structures. FXPs
83  2021 The molecular biology of FMRP: new insights into fragile X syndrome. FMR1, FXS
84  2021 The RNA Binding Proteins YTHDC1 and FMRP Regulate the Nuclear Export of N6-Methyladenosine-Modified Hepatitis B Virus Transcripts and Affect the Viral Life Cycle. cccDNA, HBV, m6A, pgRNA
85  2021 The safety and efficacy of metformin in fragile X syndrome: An open-label study. AE, FXS, IGF-1, TMS
86  2021 Transcriptome analysis of human neural cells derived from isogenic embryonic stem cells with 16p11.2 deletion. ASD, CNVs, hES
87  2021 Variable Expressivity in Fragile X Syndrome: Towards the Identification of Molecular Characteristics That Modify the Phenotype. FXS
88  2020 A simple procedure for bacterial expression and purification of the fragile X protein family. ---
89  2020 Advances in Human Stem Cells and Genome Editing to Understand and Develop Treatment for Fragile X Syndrome. FXS, hPSCs
90  2020 Astroglial FMRP deficiency cell-autonomously up-regulates miR-128 and disrupts developmental astroglial mGluR5 signaling. FXS, mGluR5
91  2020 Ataxin-2 Dysregulation Triggers a Compensatory Fragile X Mental Retardation Protein Decrease in Drosophila C4da Neurons. ATX2, eIF4E, PABP, RBPs, RNP
92  2020 ATP Synthase c-Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X Syndrome. FXS, TCA, WT
93  2020 Carbamazepine Restores Neuronal Signaling, Protein Synthesis, and Cognitive Function in a Mouse Model of Fragile X Syndrome. FXS
94  2020 Cataloguing and Selection of mRNAs Localized to Dendrites in Neurons and Regulated by RNA-Binding Proteins in RNA Granules. CPEB1, G3BP
95  2020 Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism. ---
96  2020 Cellular localization of the FMRP in rat retina. ACs, BCs, CB, ChAT, GC, HCs, INL, ipRGCs, IR, OPL
97  2020 Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns. FXS
98  2020 Differential regulation of BK channels by fragile X mental retardation protein. STORM
99  2020 Disrupted inhibitory plasticity and homeostasis in Fragile X syndrome. FXS, I-LTD
100  2020 Dynamics of the fragile X mental retardation protein correlates with cellular and synaptic properties in primary auditory neurons following afferent deprivation. NM