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Abbreviation : FTH1
Long Form : ferritin heavy chain 1
No. Year Title Co-occurring Abbreviation
2023 Berberine hydrochloride alleviates imatinib mesylate - induced cardiotoxicity through the inhibition of Nrf2-dependent ferroptosis. Ber, GPX4, HO-1, IMA, LIP, MDA, MMP, NQO1, Nrf2, ROS, TfR
2023 Ferroptosis-related genes with post-transcriptional regulation mechanisms in hepatocellular carcinoma determined by bioinformatics and experimental validation. GPX4, GSVA, HCC, OS, RT-qPCR
2022 Acrylamide induces ferroptosis in HSC-T6 cells by causing antioxidant imbalance of the XCT-GSH-GPX4 signaling and mitochondrial dysfunction. AA, ACSL4, COX-2, Fer-1, MMP, mtROS
2022 Activation of the P62-Keap1-NRF2 Pathway Protects against Ferroptosis in Radiation-Induced Lung Injury. Fer-1, HO1, Keap1, NQO1, RILI, ROS
2022 Aluminum, Arsenic, Beryllium, Cadmium, Chromium, Cobalt, Copper, Iron, Lead, Mercury, Molybdenum, Nickel, Platinum, Thallium, Titanium, Vanadium, and Zinc: Molecular Aspects in Experimental Liver Injury. COX-2, HMs, LPS, MRP2, NCOA4, Ni, OAT3, ROS
2022 Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1. CQ, ROS
2022 Bisphenol A induces testicular oxidative stress in mice leading to ferroptosis. ACSL4, COX-2, GPX4, ICR
2022 Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis. lncRNA H19
2022 Dihydroartemisinin Triggers Ferroptosis in Multidrug-Resistant Leukemia Cells. ADM, DHA, IRP2, MDR, p-mTOR, ROS, t-mTOR
10  2022 Dihydroquercetin Attenuates Silica-Induced Pulmonary Fibrosis by Inhibiting Ferroptosis Signaling Pathway. DHQ, GPX4, HBE, LC3, NCOA4, RAPA
11  2022 Effect and mechanism of paclitaxel loaded on magnetic Fe3O4@mSiO2-NH2-FA nanocomposites to MCF-7 cells. GPX4, ROS
12  2022 Effects of ferroptosis in myocardial ischemia/reperfusion model of rat and its association with Sestrin 1. AMI, Fer-1, GPX4, I/R, IRI, MDA, SD, SESN1
13  2022 Empagliflozin attenuates the renal tubular ferroptosis in diabetic kidney disease through AMPK/NRF2 pathway. AMPK, DKD, GPX4, HG, MDA, NDRD, Nrf2, SLC7A11
14  2022 Endothelial cell ferroptosis mediates monocrotaline-induced pulmonary hypertension in rats by modulating NLRP3 inflammasome activation. Fer-1, GPX4, HMGB1, LIP, MCT, NLRP3, NOX4, PAECs, PH, TLR4
15  2022 Ferroptosis contributes to methylmercury-induced cytotoxicity in rat primary astrocytes and Buffalo rat liver cells. AST, BRL, DFO, Fer-1, GPX4, ROS, SLC7A11
16  2022 Glycine increased ferroptosis via SAM-mediated GPX4 promoter methylation in rheumatoid arthritis. ACSL4, FLS, GPX4, SAM, SLC7A11
17  2022 HMOX1 Promotes Ferroptosis in Mammary Epithelial Cells via FTH1 and Is Involved in the Development of Clinical Mastitis in Dairy Cows. CM, DEPs, ERA, HMOX1, MECs
18  2022 IGF2BP3 is an essential N6-methyladenosine biotarget for suppressing ferroptosis in lung adenocarcinoma cells. ACSL3, GPX4, IGF2BP3, LUAD, m6A, SLC3A2
19  2022 Inhibition of cell survival and invasion by Tanshinone IIA via FTH1: A key therapeutic target and biomarker in head and neck squamous cell carcinoma. HNSCC, Tan IIA, Tf
20  2022 Inhibition of YAP by lenvatinib in endothelial cells increases blood pressure through ferroptosis. EDR, Fer-1, GPX4, HO-1, HUVECs, LDH, MDA, SAT1, t-YAP, TKI, YAP
21  2022 L-F001, a Multifunctional Fasudil-Lipoic Acid Dimer Prevents RSL3-Induced Ferroptosis via Maintaining Iron Homeostasis and Inhibiting JNK in HT22 Cells. GCLM, GPX4, JNK, RSL3, TEM
22  2022 Lipocalin-2 silencing suppresses inflammation and oxidative stress of acute respiratory distress syndrome by ferroptosis via inhibition of MAPK/ERK pathway in neonatal mice. ARDS, ERK, GPX4, LCN2, MAPK
23  2022 Lycopene alleviates multiple-mycotoxin-induced toxicity by inhibiting mitochondrial damage and ferroptosis in the mouse jejunum. AFB1, DON, Fis1, GPX4, LYC, MDA, Mfn1, ROS, SLC3A2, T-AOC, TfR1, ZEN, ZO-1
24  2022 Mechanism of HBV-positive liver cancer cell exosomal miR-142-3p by inducing ferroptosis of M1 macrophages to promote liver cancer progression. ATF4, GPX4, HBV, HCC, SLC3A2, TfR1
25  2022 Ophiopogonin B induces gastric cancer cell death by blocking the GPX4/xCT-dependent ferroptosis pathway. CHAC1, Fer-1, GC, GPX4, NCOA4, OP-B, PTGS2
26  2022 Patulin Induces Acute Kidney Injury in Mice through Autophagy-Ferroptosis Pathway. 3-MA, ACSL4, AKI, DEGs, DFO, Fer-1, FTL, GPX4, NCOA4, PAT, SLC7A11, Tf
27  2022 PRDX6-mediated pulmonary artery endothelial cell ferroptosis contributes to monocrotaline-induced pulmonary hypertension. GPX4, HMGB1, LIP, LV-PRDX6, MCT, NOX4, PAEC, PH, PRDX6, ROS
28  2022 Propofol Protects Myocardium From Ischemia/Reperfusion Injury by Inhibiting Ferroptosis Through the AKT/p53 Signaling Pathway. GPX4, I/R, ROS
29  2022 Research Note: Metabolic utilization of iron from different iron sources in primary cultured hepatocytes of broiler embryos. SDH
30  2022 ROS and iron homeostasis dependent ferroptosis play a vital role in 5-Fluorouracil induced cardiotoxicity in vitro and in vivo. 5-FU, CK, Fer-1, GPX4, LDH, MDA, ROS, TfR1
31  2022 Tetrandrine Ameliorates Traumatic Brain Injury by Regulating Autophagy to Reduce Ferroptosis. ELISA, GPX4, IF, LC3, MDA, TBI
32  2022 Tetrandrine Citrate Suppresses Breast Cancer via Depletion of Glutathione Peroxidase 4 and Activation of Nuclear Receptor Coactivator 4-Mediated Ferritinophagy. BC, GPX4, NCOA4, PTGS2, RSL3, TetC
33  2022 The role of ferroptosis mediated by NRF2/ERK-regulated ferritinophagy in CdTe QDs-induced inflammation in macrophage. CdTe QDs, NPs, Nrf2
34  2022 [Effects of aerobic exercise on Nrf2/GPX4/Ferroptosis pathway in myocardial injury in high-fat diet mice]. 8-OHdG, FPN1, GPX4, Nrf2, T-AOC, T-SOD
35  2022 [Multimodal Magnetic Resonance and Fluorescence Imaging of the Induced Pluripotent Stem Cell Transplantation in the Brain]. EGFP, iPSCs, iRFP, MRI, NIF
36  2021 Activation of pyroptosis and ferroptosis is involved in the hepatotoxicity induced by polystyrene microplastics in mice. ACSL4, ALP, ASC, AST, GPX4, LDH, MDA, MPs, NLRP3, SOD, TFRC
37  2021 Dexmedetomidine reverses MTX-induced neurotoxicity and inflammation in hippocampal HT22 cell lines via NCOA4-mediated ferritinophagy. CICI, DEX, MTX, NCOA4
38  2021 Electroacupuncture Ameliorates Cerebral Ischemic Injury by Inhibiting Ferroptosis. EA, GPX4, MCAO, MDA, SOD, Tf, TfR1
39  2021 GPX4-Regulated Ferroptosis Mediates S100-Induced Experimental Autoimmune Hepatitis Associated with the Nrf2/HO-1 Signaling Pathway. ACSL4, AIH, COX-2, GPX4, HO-1, Nrf2
40  2021 Hepcidin-regulating iron metabolism genes and pancreatic ductal adenocarcinoma: a pathway analysis of genome-wide association studies. BMP-2, BMP6, FTL, HJV, Nrf2, PDAC, SNP, TfR1, TfR2
41  2021 Human Parainfluenza Virus Type 2 V Protein Modulates Iron Homeostasis. hPIV-2, NCOA4
42  2021 Inhibition of keratinocyte ferroptosis suppresses psoriatic inflammation. ACSL4, Fer-1, FTL, GPX4, IMQ, PTGS2, TFRC
43  2021 Iron regulatory protein 1 promotes ferroptosis by sustaining cellular iron homeostasis in melanoma. FPN, IRP, ROS, TFRC
44  2021 miR‑335 promotes ferroptosis by targeting ferritin heavy chain 1 in invivo and invitro models of Parkinson's disease. GPX4, MMP, PD, ROS, SN, TH
45  2021 Mitochondria damage and ferroptosis involved in Ni-induced hepatotoxicity in mice. COX-2, MDA, MMP, mtROS, NCOA4, Ni, T-AOC
46  2021 Moxibustion Protects Dopaminergic Neurons in Parkinson's Disease through Antiferroptosis. GPX4, PD, ROS
47  2021 N2L, a novel lipoic acid-niacin dimer, attenuates ferroptosis and decreases lipid peroxidation in HT22 cells. ACSL4, COX-2, ERK, GPX4, JNK, ROS, RSL3
48  2021 Resveratrol protects against myocardial ischemia-reperfusion injury via attenuating ferroptosis. GPX4, I/R, OGD/R, RES, TfR1, USP19
49  2021 Scalp Acupuncture Protects Against Neuronal Ferroptosis by Activating The p62-Keap1-Nrf2 Pathway in Rat Models of Intracranial Haemorrhage. GPX4, ICH, Keap1, MDA, Nrf2, SA
50  2021 Static Magnetic Field (0.2-0.4 T) Stimulates the Self-Renewal Ability of Osteosarcoma Stem Cells Through Autophagic Degradation of Ferritin. CSCs, LC3, NCOA4, OSCs, ROS, siRNA, SMF
51  2020 Fostered Nrf2 expression antagonizes iron overload and glutathione depletion to promote resistance of neuron-like cells to ferroptosis. Nrf2, SLC7A11
52  2020 FTH1 Inhibits Ferroptosis Through Ferritinophagy in the 6-OHDA Model of Parkinson's Disease. PD
53  2020 Saponin Formosanin C-induced Ferritinophagy and Ferroptosis in Human Hepatocellular Carcinoma Cells. FC, ROS
54  2020 Study on the attenuated effect of Ginkgolide B on ferroptosis in high fat diet induced nonalcoholic fatty liver disease. GB, GPX4, HFD, HO-1, NAFLD, Nrf2, PA/OA, TfR1
55  2020 Tetrachlorobenzoquinone exposure triggers ferroptosis contributing to its neurotoxicity. GPX4, HCB, Nrf2, PCD, PCP, ROS, TCBQ
56  2020 TFAP2A is a novel regulator that modulates ferroptosis in gallbladder carcinoma cells via the Nrf2 signalling axis. DEGs, GBC, GEO, HO-1, KEGG, MDA, NQO1, Nrf2, PPI, ROS, TFAP2A
57  2020 The Inhibitory Effect of 6-Gingerol on Ubiquitin-Specific Peptidase 14 Enhances Autophagy-Dependent Ferroptosis and Anti-Tumor in vivo and in vitro. ATF4, GPX4, LC3, NCOA4, ROS, TfR1, USP14
58  2019 Ferroptosis is controlled by the coordinated transcriptional regulation of glutathione and labile iron metabolism by the transcription factor BACH1. BACH1, Ftl1, GCLM, SLC40A1, SLC7A11
59  2019 Liposomal delivery of ferritin heavy chain 1 (FTH1) siRNA in patient xenograft derived glioblastoma initiating cells suggests different sensitivities to radiation and distinct survival mechanisms. GICs
60  2019 Moxibustion Exerts a Neuroprotective Effect through Antiferroptosis in Parkinson's Disease. DEGs, GPX4, PD, SN, TH
61  2019 MRI Tracking of SPIO- and Fth1-Labeled Bone Marrow Mesenchymal Stromal Cell Transplantation for Treatment of Stroke. BMSCs, DWI, MRI, SWI, T2WI
62  2019 Sigma-1 receptor protects against ferroptosis in hepatocellular carcinoma cells. GPX4, HCC, HIF1alpha, Nrf2, ROS, S1R, TfR1
63  2018 A piRNA utilizes HILI and HIWI2 mediated pathway to down-regulate ferritin heavy chain 1 mRNA in human somatic cells. piRNAs, TNBC
64  2018 In Vitro Neural Differentiation of Bone Marrow Mesenchymal Stem Cells Carrying the FTH1 Reporter Gene and Detection with MRI. MRI, MSCs
65  2018 Methionine supply alters mammary gland antioxidant gene networks via phosphorylation of nuclear factor erythroid 2-like 2 (NFE2L2) protein in dairy cows during the periparturient period. FECH, GCLC, GCLM, GPX1, GSR, HMOX1, Keap1, ME1, NFE2L2, NQO1
66  2017 A FTH1 gene:pseudogene:microRNA network regulates tumorigenesis in prostate cancer. ceRNAs, miRNAs, PCa
67  2016 Evaluating the effectiveness of transferrin receptor-1 (TfR1) as a magnetic resonance reporter gene. MR, TfR1
68  2016 Sensory systems and ionocytes are targets for silver nanoparticle effects in fish. gstp, NPs, WISH
69  2015 Overexpression of the MRI Reporter Genes Ferritin and Transferrin Receptor Affect Iron Homeostasis and Produce Limited Contrast in Mesenchymal Stem Cells. MRI, TfR1
70  2015 Use of Ferritin Expression, Regulated by Neural Cell-Specific Promoters in Human Adipose Tissue-Derived Mesenchymal Stem Cells, to Monitor Differentiation with Magnetic Resonance Imaging In Vitro. hADMSCs, MRI, NDIFE
71  2014 Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. ---
72  2012 Proteomic profiling of cancer stem cells derived from primary tumors of HER2/Neu transgenic mice. CSCs, HER2