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Abbreviation : GLO1
Long Form : glyoxalase 1
No. Year Title Co-occurring Abbreviation
2022 A Link Between Methylglyoxal and Heart Failure During HIV-1 Infection. DD, HF, hu-mice, MG
2022 Accumulation of acetaldehyde in aldh2.1-/- zebrafish causes increased retinal angiogenesis and impaired glucose metabolism. AA, Akr1a1a, Aldh3a1, G6PC, GCK, JNK, RCS
2022 Clinical Implications of Glyoxalase1 Gene Polymorphism and Elevated Levels of the Reactive Metabolite Methylglyoxal in the Susceptibility of Type 2 Diabetes Mellitus in the Patients from Asir and Tabuk Regions of Saudi Arabia. MG, SNP, T2DM
2022 Emerging Glycation-Based Therapeutics-Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors. BBGD, MG, tRES-HESP
2022 Evaluation of Fructosamine 3-kinase and Glyoxalase 1 activity in normal and breast cancer tissues. AGEs, FN3K, MG
2022 GLO1 Contributes to the Drug Resistance of Escherichia coli Through Inducing PER Type of Extended-Spectrum β-Lactamases. AMR, ELISA, ESBLs
2022 Methylglyoxal Scavengers Attenuate Angiogenesis Dysfunction Induced by Methylglyoxal and Oxygen-Glucose Deprivation. AG, CAM, HBMECs, MG, NAC, OGD, RAGE, ROS
2022 Salicylate metal-binding isosteres as fragments for metalloenzyme inhibition. FBDD, MBIs, MBP, MMP-3
2021 Accumulation of Carbonyl Proteins in the Brain of Mouse Model for Methylglyoxal Detoxification Deficits. AGEs, CS-SCZ, MGO
10  2021 Defective Glyoxalase 1 Contributes to Pathogenic Inflammation in Cystic Fibrosis. CF
11  2021 Dicarbonyl stress, protein glycation and the unfolded protein response. MG, UPR
12  2021 Eugenol and its liposome-based nano carrier reduce anxiety by inhibiting glyoxylase-1 expression in mice. MG
13  2021 Fentanyl-induced acute and conditioned behaviors in two inbred mouse lines: Potential role for Glyoxalase. Sapcd1
14  2021 Genetic and Pharmacological Manipulations of Glyoxalase 1 Mediate Ethanol Withdrawal Seizure Susceptibility in Mice. CNS, FVB, HICs
15  2021 GLO 1 and PKCλ Regulate ALDH1-positive Breast Cancer Stem Cell Survival. ALDH1, CSCs, PKC, TNBC
16  2021 Glyoxal-Lysine Dimer, an Advanced Glycation End Product, Induces Oxidative Damage and Inflammatory Response by Interacting with RAGE. AGE, GO, GOLD, MAPK, Nrf2, ROS
17  2021 Glyoxalase 1 and protein kinase Clamda as potential therapeutic targets for late-stage breast cancer. PKClamda
18  2021 Glyoxalase 1 Confers Susceptibility to Schizophrenia: From Genetic Variants to Phenotypes of Neural Function. eQTL, FDR, fMRI, mRNA, PCR, ROC
19  2021 Glyoxalase 1 Expression as a Novel Diagnostic Marker of High-Grade Prostatic Intraepithelial Neoplasia in Prostate Cancer. HGPIN, MG, PCa
20  2021 Glyoxalase-1-Dependent Methylglyoxal Depletion Sustains PD-L1 Expression in Metastatic Prostate Cancer Cells: A Novel Mechanism in Cancer Immunosurveillance Escape and a Potential Novel Target to Overcome PD-L1 Blockade Resistance. AGEs, MG, mPCa
21  2021 Hesperetin ameliorates diabetes-associated anxiety and depression-like behaviors in rats via activating Nrf2/ARE pathway. gamma-GCS
22  2021 High-sucrose diets contribute to brain angiopathy with impaired glucose uptake and psychosis-related higher brain dysfunctions in mice. ---
23  2021 Methylglyoxal-Dependent Glycative Stress Is Prevented by the Natural Antioxidant Oleuropein in Human Dental Pulp Stem Cells through Nrf2/Glo1 Pathway. DPSCs, MG, OP
24  2021 Phenethyl isothiocyanate attenuates diabetic nephropathy via modulation of glycative/oxidative/inflammatory signaling in diabetic rats. AGEs, DN, gamma-GCS, HO-1, Nrf2, PEITC
25  2021 Polydatin protects Schwann cells from methylglyoxal induced cytotoxicity and promotes crushed sciatic nerves regeneration of diabetic rats. PD, RAGE
26  2021 Polymorphisms in Glyoxalase I Gene Are Not Associated with Glyoxalase I Expression in Whole Blood or Markers of Methylglyoxal Stress: The CODAM Study. AGEs, MGO
27  2021 Pyridoxamine ameliorates methylglyoxal-induced macrophage dysfunction to facilitate tissue repair in diabetic wounds. AGEs, IL-4, LPS, MGO, PM, T2DM
28  2021 Role of glyoxalase 1 in methylglyoxal detoxification-the broad player of psychiatric disorders. MG
29  2021 Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Spliceosome. HR, MDR, MG
30  2021 The Glyoxalase System in Age-Related Diseases: Nutritional Intervention as Anti-Ageing Strategy. AGEs
31  2021 TNF-ɑ Induces Methylglyoxal Accumulation in Lumbar Herniated Disc of Patients With Radicular Pain. LDH, MG, NP
32  2021 γ-Glutamyl-Transpeptidase-Resistant Glutathione Analog Attenuates Progression of Alzheimer's Disease-like Pathology and Neurodegeneration in a Mouse Model. AD, GGT, LC
33  2020 Adeno-Associated Viral Transfer of Glyoxalase-1 Blunts Carbonyl and Oxidative Stresses in Hearts of Type 1 Diabetic Rats. DC, MG, T1DM
34  2020 Association between carbonyl stress markers and the risk of acute coronary syndrome in patients with type 2 diabetes mellitus-A pilot study. ACS, CK-MB, CK-T, CML, GAPDH, MG, MG-H1, T2DM
35  2020 Associations of dicarbonyl stress with complement activation: the CODAM study. 3-DG, CODAM, GO, MGO, sC5b-9
36  2020 Bombax ceiba (Linn.) calyxes ameliorate methylglyoxal-induced oxidative stress via modulation of RAGE expression: identification of active phytometabolites by GC-MS analysis. AGEs, BCCE, GC-MS, MG, NOX, ROS
37  2020 Chebulic Acid Prevents Methylglyoxal-Induced Mitochondrial Dysfunction in INS-1 Pancreatic beta-Cells. ATP, CA, GSIS, MG, MMP, ROS
38  2020 Chemoproteomic Profiling of a Pharmacophore-Focused Chemical Library. ---
39  2020 Classically activated mouse macrophages produce methylglyoxal that induces a TLR4- and RAGE-independent proinflammatory response. MG, RAGE
40  2020 Cyanidin Attenuates Methylglyoxal-Induced Oxidative Stress and Apoptosis in INS-1 Pancreatic beta-Cells by Increasing Glyoxalase-1 Activity. AGEs, MG, ROS
41  2020 Discovery of GLO1 New Related Genes and Pathways by RNA-Seq on A2E-Stressed Retinal Epithelial Cells Could Improve Knowledge on Retinitis Pigmentosa. MG, ROS
42  2020 Effect of prednisolone on glyoxalase 1 in an inbred mouse model of aristolochic acid nephropathy using a proteomics method with fluorogenic derivatization-liquid chromatography-tandem mass spectrometry. AA, TPI
43  2020 Glyoxalase 1 Inhibitor Alleviates Autism-like Phenotype in a Prenatal Valproic Acid-Induced Mouse Model. ASD, VPA
44  2020 Glyoxalase system: A systematic review of its biological activity, related-diseases, screening methods and small molecule regulators. AGEs, Glo2, MG
45  2020 LncRNA OIP5-AS1 Promotes Breast Cancer Progression by Regulating miR-216a-5p/GLO1. OIP5-AS1
46  2020 Long-term intake of the reactive metabolite methylglyoxal is not toxic in mice. AGEs, MG, RAGE
47  2020 Morroniside attenuates high glucose-induced BMSC dysfunction by regulating the Glo1/AGE/RAGE axis. ALP, BMSC, HG, RAGE, T1DM, WB
48  2020 Pentoxifylline mitigates renal glycoxidative stress in obese mice by inhibiting AGE/RAGE signaling and increasing glyoxalase levels. AGEs, RAGE
49  2020 Phosphorylation of T107 by CamKIIdelta Regulates the Detoxification Efficiency and Proteomic Integrity of Glyoxalase 1. CamKIIdelta, MG
50  2020 Psoralea corylifolia L. Seed Extract Attenuates Methylglyoxal-Induced Insulin Resistance by Inhibition of Advanced Glycation End Product Formation. AGEs, MGO, PCS
51  2020 Redox-Sensitive Glyoxalase 1 Up-Regulation Is Crucial for Protecting Human Lung Cells from Gold Nanoparticles Toxicity. EMT
52  2020 Resveratrol, Curcumin and Piperine Alter Human Glyoxalase 1 in MCF-7 Breast Cancer Cells. DeltaPsim, R-C-P
53  2020 Spectrophotometric Method for Determining Glyoxalase 1 Activity in Cerebral Cavernous Malformation (CCM) Disease. CCM, HBMEC, MEF, MG, PBS, SLG
54  2020 The Antidepressant-Like Effects of Hesperidin in Streptozotocin-Induced Diabetic Rats by Activating Nrf2/ARE/Glyoxalase 1 Pathway. HG, Nrf2
55  2019 A novel compound AB-38b improves diabetes-associated cognitive decline in mice via activation of Nrf2/ARE pathway. AGEs, DACD, Nrf2
56  2019 Activation of the unfolded protein response in high glucose treated endothelial cells is mediated by methylglyoxal. HAECs, HK2, MG, tRES-HESP, UPR
57  2019 Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes. BMPC, IRE1alpha, MGO, PC
58  2019 Effect of dietary vitamin E on oxidative stress-related gene-mediated differences in anxiety-like behavior in inbred strains of mice. ---
59  2019 Gene doubling increases glyoxalase 1 expression in RAGE knockout mice. RAGE, RAGE-KO
60  2019 Glycine increases glyoxalase-1 function by promoting nuclear factor erythroid 2-related factor 2 translocation into the nucleus of kidney cells of streptozotocin-induced diabetic rats. mRNA, Nrf2
61  2019 Glycine Suppresses AGE/RAGE Signaling Pathway and Subsequent Oxidative Stress by Restoring Glo1 Function in the Aorta of Diabetic Rats and in HUVECs. AGEs, HUVECs, MG, RAGE
62  2019 Glyoxalase 1 Prevents Chronic Hyperglycemia Induced Heart-Explant Derived Cell Dysfunction. EDC
63  2019 Hesperetin ameliorates diabetic nephropathy in rats by activating Nrf2/ARE/glyoxalase 1 pathway. AGEs, DN, Nrf2
64  2019 Imaging Tumorous Methylglyoxal by an Activatable Near-Infrared Fluorescent Probe for Monitoring Glyoxalase 1 Activity. MGO, NIR
65  2019 Indole-4-carboxaldehyde Isolated from Seaweed, Sargassum thunbergii, Attenuates Methylglyoxal-Induced Hepatic Inflammation. MGO, NF-kappaB, RAGE, ST-I4C, TNF
66  2019 Investigation of betaine as a novel psychotherapeutic for schizophrenia. MAP, QTL
67  2019 Metal-Binding Pharmacophore Library Yields the Discovery of a Glyoxalase 1 Inhibitor. ---
68  2019 Methylglyoxal Acts as a Tumor-Promoting Factor in Anaplastic Thyroid Cancer. AG, AGEs, ATC, MG, PTC
69  2019 Methylglyoxal triggers human aortic endothelial cell dysfunction via modulation of the KATP/MAPK pathway. AGEs, ERK, HAECs, JNK, MGO
70  2019 Methylglyoxal, a glycolysis metabolite, triggers metastasis through MEK/ERK/SMAD1 pathway activation in breast cancer. AGEs, ECM, MAPK, MG
71  2019 Reduction of glyoxalase 1 (GLO1) aggravates cerebrovascular remodeling via promoting the proliferation of basilar smooth muscle cells in hypertension. Ang II, BASMC
72  2019 SIRT1 participates in the response to methylglyoxal-dependent glycative stress in mouse oocytes and ovary. AGEs, Glo2, MG
73  2019 Tanshinone IIa protects retinal endothelial cells against mitochondrial fission induced by methylglyoxal through glyoxalase 1. AGEs, BRECs, MGO, NO, TanIIa
74  2019 The attenuating effects of pyridoxamine on adipocyte hypertrophy and inflammation differ by adipocyte location. HFD, NFD, RAGE
75  2019 Therapeutic Potential of Lespedeza bicolor to Prevent Methylglyoxal-Induced Glucotoxicity in Familiar Diabetic Nephropathy. AGEs, LB, MGO, Nrf2, RAGE, ROS
76  2018 Advanced glycation end products in the pathogenesis of chronic kidney disease. AGEs, CKD, CML, DKD, MG
77  2018 Age-related alteration in the distribution of methylglyoxal and its metabolic enzymes in the mouse brain. AGEs, AR, MG
78  2018 Biophysical and biochemical studies on glycoxidatively modified human low density lipoprotein. LDL, MGO, ROS, T2DM
79  2018 Data in support of sustained upregulation of adaptive redox homeostasis mechanisms caused by KRIT1 loss-of-function. HBMEC
80  2018 Deleterious Effect of Advanced CKD on Glyoxalase System Activity not Limited to Diabetes Aetiology. ---
81  2018 Dicarbonyl Stress and Glyoxalase-1 in Skeletal Muscle: Implications for Insulin Resistance and Type 2 Diabetes. ---
82  2018 Effect of metformin treatment in patients with type 2 diabetes with respect to glyoxalase 1 activity in atherosclerotic lesions. MG
83  2018 Enhancement of glyoxalase 1, a polyfunctional defense enzyme, by quercetin in the brain in streptozotocin-induced diabetic rats. AGEs, MG, RAGE
84  2018 Eucommia ulmoides Ameliorates Glucotoxicity by Suppressing Advanced Glycation End-Products in Diabetic Mice Kidney. AGEs, MGO, Nrf2, PAS, RAGE, STZ
85  2018 Fabrication of an electrochemical biosensor with ZnO nanoflakes interface for methylglyoxal quantification in food samples. MG, ZnO
86  2018 GLO1 gene polymorphisms and their association with retinitis pigmentosa: a case-control study in a Sicilian population. MGO, RP, SNPs
87  2018 Glyoxalase 1 (GLO1) Inhibition or Genetic Overexpression Does Not Alter Ethanol's Locomotor Effects: Implications for GLO1 as a Therapeutic Target in Alcohol Use Disorders. EtOH, MG
88  2018 Glyoxalase 1 gene is highly expressed in basal-like human breast cancers and contributes to survival of ALDH1-positive breast cancer stem cells. ---
89  2018 Glyoxalase 1 sustains the metastatic phenotype of prostate cancer cells via EMT control. AGEs, AP, EMT, MG, PCa
90  2018 Glyoxalases in Urological Malignancies. Glo2, MG, PCa
91  2018 Gromwell (Lithospermum erythrorhizon) root extract protects against glycation and related inflammatory and oxidative stress while offering UV absorption capability. AGE, NF-kappaB, Nrf2, UV
92  2018 Inhibition of GLO1 in Glioblastoma Multiforme Increases DNA-AGEs, Stimulates RAGE Expression, and Inhibits Brain Tumor Growth in Orthotopic Mouse Models. AGEs, GBM, MG, RAGE, shRNA
93  2018 Inhibition of Glyoxalase 1 reduces alcohol self-administration in dependent and nondependent rats. ---
94  2018 Intermittent hypoxia, brain glyoxalase-1 and glutathione reductase-1, and anxiety-like behavior in mice. GR1
95  2018 Isoferulic acid attenuates methylglyoxal-induced apoptosis in INS-1 rat pancreatic beta-cell through mitochondrial survival pathways and increasing glyoxalase-1 activity. AGEs, GSIS, IFA, MG, ROS, UCP2
96  2018 Methylglyoxal accumulation de-regulates HoxA5 expression, thereby impairing angiogenesis in glyoxalase 1 knock-down mouse aortic endothelial cells. DM, MCECs, MGO
97  2018 miR-137 inhibits melanoma cell proliferation through downregulation of GLO1. MG, miRNAs, qRT-PCR
98  2018 Neuronal damage and shortening of lifespan in C. elegans by peritoneal dialysis fluid: Protection by glyoxalase-1. AGEs, C. elegans, GDPs, PD
99  2018 Neuroprotection of quercetin on central neurons against chronic high glucose through enhancement of Nrf2/ARE/glyoxalase-1 pathway mediated by phosphorylation regulation. gamma-GCS, HG
100  2018 Nicotine induces apoptosis in human osteoblasts via a novel mechanism driven by H2O2 and entailing Glyoxalase 1-dependent MG-H1 accumulation leading to TG2-mediated NF-kB desensitization: Implication for smokers-related osteoporosis. AGEs, MG, RAGE, TG2