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Abbreviation : HKII
Long Form : hexokinase II
No. Year Title Co-occurring Abbreviation
2022 Aspirin blocks AMPK/SIRT3-mediated glycolysis to inhibit NSCLC cell proliferation. CC, CypD, ECAR, MMP, NSCLC, OCR, SIRT3
2022 Bicalutamide may enhance kidney injury in diabetes by concomitantly damaging energy production from OXPHOS and glycolysis. ATP, BIC, GLUT, HIF, LDHA, p-AMPK, PDH, PFK, PK
2022 Hyperpolarized [1-13C]Pyruvate Magnetic Resonance Spectroscopic Imaging for Evaluation of Early Response to Tyrosine Kinase Inhibition Therapy in Gastric Cancer. GCa, LDHA, p-Akt, Pan-TKI, pMAPK
2022 Hypothermia Prevents Cardiac Dysfunction during Acute Ischemia Reperfusion by Maintaining Mitochondrial Bioenergetics and by Promoting Hexokinase II Binding to Mitochondria. CP, cyto c, IR, KR, TC
2022 Inhibition of Drp1 ameliorates diabetic retinopathy by regulating mitochondrial homeostasis. DM, DR, Drp1, HG, IRMA, PKCdelta, STZ
2022 Metabolic Reprogramming in Response to Alterations of Mitochondrial DNA and Mitochondrial Dysfunction in Gastric Adenocarcinoma. ECAR, GAC, KD, mtDNA, NC-GM, NGM, NT, OCR, p-PDH, PT
2022 Mitochondria-specific peptide amphiphiles induce mitochondrial dysfunction and peripheral T-cell lymphomas (PTCL) damage. ATP, Bax, Bcl-2, ERK, PTCL, VDAC1
2022 Novel Hydrazone Derivatives of 3-Bromopyruvate: Synthesis, Evaluation of the Cytotoxic Effects, Molecular Docking and ADME Studies. 3-BP
2022 Pepsin enhances glycolysis to promote malignant transformation of vocal fold leukoplakia epithelial cells with dysplasia. GLUT1, MCT4, VFL
10  2022 Phosphodiesterase 5 inhibitor sildenafil potentiates the antitumor activity of cisplatin by ROS-mediated apoptosis: a role of deregulated glucose metabolism. cyt c, GLUT1, HIF-1alpha, LDHA, OXPHOS, PDE5, PDK1, PKM2, ROS
11  2022 Potential of Novel Methyl Jasmonate Analogs as Anticancer Agents to Metabolically Target HK-2 Activity in Glioblastoma Cells. GBM, MJ
12  2022 Virtual Screening and Biological Activity Evaluation of New Potent Inhibitors Targeting Hexokinase-II. ---
13  2021 CRKL promotes hepatocarcinoma through enhancing glucose metabolism of cancer cells via activating PI3K/Akt. CRKL, GLUT1, GSK-3beta
14  2021 Expression and Clinical Significance of HKII and HIF-1alpha in Grade Groups of Prostate Cancer. HIF-1alpha, PCa
15  2021 Flavonoids Targeting HIF-1: Implications on Cancer Metabolism. GLUTs, HIF-1, LDHA, PDK, PFK-1, PKM2
16  2021 Glycolysis Rate-Limiting Enzymes: Novel Potential Regulators of Rheumatoid Arthritis Pathogenesis. PFK-1, PFKFB3, PKM2, RA
17  2021 Impact of Adenosine Analogue, Adenosine-5'-N-Ethyluronamide (NECA), on Insulin Signaling in Skeletal Muscle Cells. ACCbeta, CPT1B, IL-6, LCAD, NR4A, PDK4, PFK, qRT-PCR
18  2021 Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ. GSDME, LDHA, ROS, TPL
19  2021 Nuclear HKII-P-p53 (Ser15) Interaction is a Prognostic Biomarker for Chemoresponsiveness and Glycolytic Regulation in Epithelial Ovarian Cancer. AIF, EOC
20  2021 Potassium ions promote hexokinase-II dependent glycolysis. ---
21  2021 Preconditioning or Postconditioning with 8-Br-cAMP-AM Protects the Heart against Regional Ischemia and Reperfusion: A Role for Mitochondrial Permeability Transition. 8-Br, mPTP
22  2021 ROCK2 Promotes Osteosarcoma Growth and Glycolysis by Up-Regulating HKII via Phospho-PI3K/AKT Signalling. OS
23  2021 Sodium hydrosulfide reverses β2-microglobulin-induced depressive-like behaviors of male Sprague-Dawley rats: Involving improvement of synaptic plasticity and enhancement of Warburg effect in hippocampus. beta2m, FST, LDHA, NSFT, OFT, PDH, PDK1, PKM2, PSD-95, SYN1, TST
24  2021 Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II. BD, MD, OMM
25  2021 Targeted Inhibition of HK-II Reversed the Warburg Effect to Improve the Radiosensitivity of Laryngeal Carcinoma. CS, LD, PDH, PFKP, PKM2, siRNA
26  2020 3-Bromopyruvate regulates the status of glycolysis and BCNU sensitivity in human hepatocellular carcinoma cells. 3-BrPA, BCNU, CENUs, HCC, ICLs, MGMT
27  2020 Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome. AD, DS, DSAD, IR
28  2020 Gomisin J inhibits the glioma progression by inducing apoptosis and reducing HKII-regulated glycolysis. GomJ, MMP, VDAC
29  2020 Hexokinase II-Derived Cell-Penetrating Peptide Mediates Delivery of MicroRNA Mimic for Cancer-Selective Cytotoxicity. CPP, PAS
30  2020 Knockout of VDAC1 in H9c2 Cells Promotes Oxidative Stress-Induced Cell Apoptosis through Decreased Mitochondrial Hexokinase II Binding and Enhanced Glycolytic Stress. ECAR, MEFs, mES, ROT, TBHP, WT
31  2020 miR-125a-5p inhibits glycolysis by targeting hexokinase-II to improve pulmonary arterial hypertension. MCT, MCT-PH, mPAP, NMR, PASMCs
32  2020 Novel Anti-inflammatory Effects of Canagliflozin Involving Hexokinase II in Lipopolysaccharide-Stimulated Human Coronary Artery Endothelial Cells. Cana, DAPA, EMPA, HCAECs, IL-6, IL-6, LPS
33  2020 PD-L1 in Lung Adenocarcinoma: Insights into the Role of 18F-FDG PET/CT. 18F-FDG, CEA, CT, DFS, GLUT1, OS, PD-1, PD-L1, PET, PFS, TLG
34  2020 The Potential of Lonidamine in Combination with Chemotherapy and Physical Therapy in Cancer Treatment. ADD, HT, LND, MCT, MPC, PDT, PT, RT
35  2020 Virtual Screening for Potential Inhibitors of Human Hexokinase II for the Development of Anti-Dengue Therapeutics. 2-DG, BG6, DENV, GLC, USRCAT
36  2019 Coordinate Modulation of Glycolytic Enzymes and OXPHOS by Imatinib in BCR-ABL Driven Chronic Myelogenous Leukemia Cells. LDHA
37  2019 Dissociation of mitochondrial HK-II elicits mitophagy and confers cardioprotection against ischemia. BAG5
38  2019 Flavonoid GL-V9 induces apoptosis and inhibits glycolysis of breast cancer via disrupting GSK-3beta-modulated mitochondrial binding of HKII. VDAC
39  2019 Glucose-6-phosphatase Expression-Mediated [18F]FDG Efflux in Murine Inflammation and Cancer Models. G6Pase, LPS, PET/CT, qPCR
40  2019 Hexokinase II inhibition by 3-bromopyruvate sensitizes myeloid leukemic cells K-562 to anti-leukemic drug, daunorubicin. CT, DNR, GI, ROS
41  2019 Hexokinase II promotes the Warburg effect by phosphorylating alpha subunit of pyruvate dehydrogenase. ccRCC, PDH
42  2019 p53 Promotes chemoresponsiveness by regulating hexokinase II gene transcription and metabolic reprogramming in epithelial ovarian cancer. GEPIA, OvCa, PDK1
43  2019 Prognostic Significance of 18F-FDG PET/CT Metabolic Parameters and Tumor Galectin-1 Expression in Patients With Surgically Resected Lung Adenocarcinoma. 18F-FDG, CT, Gal-1, GLUT1, PET
44  2019 Reversal of the Warburg phenomenon in chemoprevention of prostate cancer by sulforaphane. LDHA, SFN, TRAMP
45  2019 Synergistic combination of DT-13 and Topotecan inhibits aerobic glycolysis in human gastric carcinoma BGC-823 cells via NM IIA/EGFR/HK II axis. EGFR, NMIIA, TPT
46  2019 The Warburg Effect Is Associated With Tumor Aggressiveness in Testicular Germ Cell Tumors. CAIX, GLUT1, LDHV, MCT4, TGCTs
47  2018 Astragaloside IV reduces neuronal apoptosis and parthanatos in ischemic injury by preserving mitochondrial hexokinase-II. AIF, AIV
48  2018 Chemical denervation using botulinum toxin increases Akt expression and reduces submaximal insulin-stimulated glucose transport in mouse muscle. ---
49  2018 Enhanced glycometabolism as a mechanism of NQO1 potentiated growth of NSCLC revealed by metabolomic profiling. NQO1, NSCLC
50  2018 EZH2, HIF-1, and Their Inhibitors: An Overview on Pediatric Cancers. CA, EZH2, HIF, HRE, PcG, PRCs, RAGE, VEGF
51  2018 LINK-A promotes cell proliferation through the regulation of aerobic glycolysis in non-small-cell lung cancer. LINK-A, NSCLC
52  2018 Melatonin improves neurological outcomes and preserves hippocampal mitochondrial function in a rat model of cardiac arrest. CA, CPR, HR, MAP, Post-M, Pre-M, ROSC
53  2018 Metabolic and molecular changes associated with the increased skeletal muscle insulin action 24-48 h after exercise in young and old humans. IMCL, SSL
54  2018 Molecular adaptations in human subcutaneous adipose tissue after ten weeks of endurance exercise training in healthy males. CON, GPCRs, IR, SCAT, SDHA, TR
55  2018 The effect of chronic high insulin exposure upon metabolic and myogenic markers in C2C12 skeletal muscle cells and myotubes. ---
56  2018 TIGAR inclusion pathology is specific for Lewy body diseases. DLB, HKI, MND, MSA, PD
57  2018 Up-regulation of hexokinase II contributes to rituximab-chemotherapy resistance and is a clinically relevant target for therapeutic development. OS, PFS, RRCL
58  2017 Acute detachment of hexokinase II from mitochondria modestly increases oxygen consumption of the intact mouse heart. mtHKII, Tat
59  2017 Aspirin induces cell death by directly modulating mitochondrial voltage-dependent anion channel (VDAC). VDAC
60  2017 Chlamydia trachomatis Prevents Apoptosis Via Activation of PDPK1-MYC and Enhanced Mitochondrial Binding of Hexokinase II. PDPK1
61  2017 CL 316, 243 mediated reductions in blood glucose are enhanced in RIP140-/- mice independent of alterations in lipolysis. RIP140
62  2017 Degradation of AMPK-alpha1 sensitizes BRAF inhibitor-resistant melanoma cells to arginine deprivation. ASS1, BR, BRAFi, MEKi, RNF44, UPS
63  2017 Evaluation of biological properties of 3,3',4,4'-benzophenonetetracarboxylic dianhydride derivatives and their ability to inhibit hexokinase activity. BDTA, vHTS
64  2017 Ginsenoside Rg5 increases cardiomyocyte resistance to ischemic injury through regulation of mitochondrial hexokinase-II and dynamin-related protein 1. Drp1, PA, PDH
65  2017 Hexokinase II-derived cell-penetrating peptide targets mitochondria and triggers apoptosis in cancer cells. PAS
66  2017 HPV-associated differential regulation of tumor metabolism in oropharyngeal head and neck cancer. CAIX, COX, HNSCC, PDKs, TCA
67  2017 Hydroxysafflor yellow A cardioprotection in ischemia-reperfusion (I/R) injury mainly via Akt/hexokinase II independent of ERK/GSK-3beta pathway. HSYA, I/R, RISK
68  2017 Mammalian target of rapamycin complex 2 regulates muscle glucose uptake during exercise in mice. AMPK, GLUT4, mTORC2, NDRG1, PKCalpha, Rac1
69  2017 Mangiferin protects mitochondrial function by preserving mitochondrial hexokinase-II in vessel endothelial cells. PA
70  2017 Role of mitochondrial function in the invasiveness of human colon cancer cells. COX-II, COXIV, CRC, EMT, GPI, LDH, mtDNA, ND6, OA, OCR, RCR
71  2017 Tetrandrine cardioprotection in ischemia-reperfusion (I/R) injury via JAK3/STAT3/Hexokinase II. HIF-alpha, I/R, JAK, Tet
72  2017 Upstream signalling of mTORC1 and its hyperactivation in type 2 diabetes (T2D). mTORC1, T2D, TOS
73  2016 Alterations in glucose metabolism proteins responsible for the Warburg effect in esophageal squamous cell carcinoma. ESCC, GLUT1
74  2016 Differential association of STAT3 and HK-II expression in hepatitis B virus- and hepatitis C virus-related hepatocellular carcinoma. HBV, HCC, HCV
75  2016 Dual time-point FDG PET/CT and FDG uptake and related enzymes in lymphadenopathies: preliminary results. DTP, G6Pase, GLUT1, HIF-1alpha, RI, SUV, TLG
76  2016 Fenofibrate Suppresses Oral Tumorigenesis via Reprogramming Metabolic Processes: Potential Drug Repurposing for Oral Cancer. ECAR, OCR, VDAC
77  2016 Long-term prognostic implications and therapeutic target role of hexokinase II in patients with nasopharyngeal carcinoma. NPC
78  2016 Metabolic reprogramming and AMPKalpha1 pathway activation by caulerpin in colorectal cancer cells. AMPK, GLUT1, OXPHOS, ROS
79  2016 Overexpression of ErbB2 renders breast cancer cells susceptible to 3-BrPA through the increased dissociation of hexokinase II from mitochondrial outer membrane. ---
80  2016 Preconditioning mice with activators of AMPK ameliorates ischemic acute kidney injury in vivo. AICAR, AKI, AMPK, CREB, PTCs
81  2016 Re-programming tumour cell metabolism to treat cancer: no lone target for lonidamine. PM
82  2016 Role of Mitochondrial DNA Copy Number Alteration in Human Renal Cell Carcinoma. cox2, GPI, LDHA, mtDNA, ND1, nDNA, NT, PDHA1, PDK1, PFK, qPCR, RCC, SDHA, TFAM-KD
83  2016 The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expression. 3-BP, CRC
84  2016 Warburg effect, hexokinase-II, and radioresistance of laryngeal carcinoma. ---
85  2015 Effects of topoisomerase inhibitors that induce DNA damage response on glucose metabolism and PI3K/Akt/mTOR signaling in multiple myeloma cells. DDR, GLUT, HK
86  2015 Identification of a mitochondrial-binding site on the N-terminal end of hexokinase II. MOM, PET, VDAC
87  2015 Insulin and hypoxia-inducible factor-1 cooperate in pancreatic cancer cells to increase cell viability. HIF-1, IR, VEGF, wt-MiaPaCa2
88  2015 Reversal of Warburg Effect and Reactivation of Oxidative Phosphorylation by Differential Inhibition of EGFR Signaling Pathways in Non-Small Cell Lung Cancer. NSCLC, p-PKM2, Tyr105
89  2015 RRAD inhibits aerobic glycolysis, invasion, and migration and is associated with poor prognosis in hepatocellular carcinoma. GLUT1, HCC, mRNA, RRAD
90  2015 SIRT3 Is Crucial for Maintaining Skeletal Muscle Insulin Action and Protects Against Severe Insulin Resistance in High-Fat-Fed Mice. HFD, KO, SIRT3
91  2015 Suppression of miR-181a attenuates H2O2-induced death of mesenchymal stem cells by maintaining hexokinase II expression. MSCs
92  2015 TGFbeta Triggers miR-143/145 Transfer From Smooth Muscle Cells to Endothelial Cells, Thereby Modulating Vessel Stabilization. ECs, itgbeta8, SMCs, TGF, TGF-beta
93  2015 TNFalpha driven HIF-1alpha-hexokinase II axis regulates MHC-I cluster stability through actin cytoskeleton. Arp2, HIF-1alpha, MHC-I, TNF-alpha
94  2015 Tumor cells switch to mitochondrial oxidative phosphorylation under radiation via mTOR-mediated hexokinase II inhibition--a Warburg-reversing effect. ---
95  2015 {2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic acid methyl ester (MIAM) inhibited human hepatocellular carcinoma growth through upregulation of Sirtuin-3 (SIRT3). HCC, MIAM, ROS, SIRT3
96  2014 3-Bromopyruvic acid, a hexokinase II inhibitor, is an effective antitumor agent on the hepatoma cells : in vitro and in vivo findings. ATP-TCA, RT-PCR
97  2014 Clinical correlations with (18)FDG PET scan patterns in solid pseudopapillary tumors of the pancreas: still a surgical enigma? GLUT1, SPT
98  2014 Correlation between expression of biological markers and [F]fluorodeoxyglucose uptake in endometrial cancer. CAIX, GLUT1, HIF-1alpha, PET/CT, VEGF
99  2014 Curcumin inhibits aerobic glycolysis and induces mitochondrial-mediated apoptosis through hexokinase II in human colorectal cancer cells in vitro. ---
100  2014 Hexokinase II inhibitor, 3-BrPA induced autophagy by stimulating ROS formation in human breast cancer cells. 3-BrPA