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Abbreviation : HLE
Long Form : human lens epithelial
No. Year Title Co-occurring Abbreviation
2023 Ghrelin Mitigates High-Glucose-Induced Oxidative Damage and Apoptosis in Lens Epithelial Cells. HG
2022 Function of mitochondrial cytochrome c oxidase is enhanced in human lens epithelial cells at high temperatures. ATP
2022 Nitro Dihydrocapsaicin, a Non-Pungent Capsaicin Analogue, Inhibits Cellular Senescence of Lens Epithelial Cells via Upregulation of SIRT1. HG, n-DHC, ROS
2022 Protective effect of Glutaredoxin 1 against oxidative stress in lens epithelial cells of age-related nuclear cataracts. ARN, ERK, Grx1, ROS
2021 H2S-Releasing Composite: a Gasotransmitter Platform for Potential Biomedical Applications. EDS, FESEM, HUVEC, XRD
2020 Association of IGF1R polymorphisms (rs1546713) with susceptibility to age-related cataract in a Han Chinese population. ARC, CCK-8, IGF1R, qPCR, SNP
2020 Decorin inhibits glucose-induced lens epithelial cell apoptosis via suppressing p22phox-p38 MAPK signaling pathway. GSH, MAPK, ROS, SOD
2020 Ginsenosides induce extensive changes in gene expression and inhibit oxidative stress-induced apoptosis in human lens epithelial cells. ---
2020 HMGB1 enhances epithelial permeability via p63/TGF-beta signaling in lung and terminal bronchial epithelial cells. COPD, HMGB1, IPF, TGF-beta1
10  2020 In vitro exposure of human lens epithelial cells to X-rays at varied dose-rates leads to protein-level changes relevant to cataractogenesis. ---
11  2019 Protective Effects of Lanosterol Synthase Up-Regulation in UV-B-Induced Oxidative Stress. HMGCR, LSS, SIRT1, SREBF2
12  2019 SP1-mediated lncRNA PVT1 modulates the proliferation and apoptosis of lens epithelial cells in diabetic cataract via miR-214-3p/MMP2 axis. DC, HG, lncRNAs
13  2019 Topical administration of a ROCK inhibitor prevents anterior subcapsular cataract induced by UV-B irradiation. ASCs, ECM, EMT, LECs, TGF, UVR
14  2018 Downregulation of microRNA-181a attenuates hydrogen peroxide-induced human lens epithelial cell apoptosis invitro. CASP3, CAT, MDA, miR, sh, SNAI2, SOD
15  2018 Effect of Exogenous Zinc on MsrB1 Expression and Protein Oxidation in Human Lens Epithelial Cells. Msr, MsrB1, ROS
16  2018 Effects of ionizing radiation on telomere length and telomerase activity in cultured human lens epithelium cells. ---
17  2018 Hydrogen peroxide-induced apoptosis of human lens epithelial cells is inhibited by parthenolide. MAPK, NF-kappaB
18  2018 Oxidative and nitrative stress-related changes in human lens epithelial cells following exposure to X-rays. cl-tyrosine, IR
19  2018 p-Coumaric Acid Protects Human Lens Epithelial Cells against Oxidative Stress-Induced Apoptosis by MAPK Signaling. p-CA
20  2018 The use of in vitro transcriptional data to identify thresholds of effects in a human lens epithelial cell-line exposed to ionizing radiation. BMD, DEGs, HDR, ICRP, LDR
21  2017 A positive feedback loop between nitric oxide and amyloid beta (1-42) accelerates mitochondrial damage in human lens epithelial cells. APP, CcO, IFN-gamma, iNOS, LPS, NF-kappaB, NO, ROS
22  2017 Electric field exposure promotes epithelial‑mesenchymal transition in human lens epithelial cells via integrin beta1‑FAK signaling. EF, EMT, FAK, PCO
23  2017 Ferulic Acid Suppresses Amyloid beta Production in the Human Lens Epithelial Cell Stimulated with Hydrogen Peroxide. ---
24  2017 Functional non-coding polymorphism in an EPHA2 promoter PAX2 binding site modifies expression and alters the MAPK and AKT pathways. ECM, EPHA2
25  2017 Raman micro-spectroscopy analysis of human lens epithelial cells exposed to a low-dose-range of ionizing radiation. IR
26  2017 Ultraviolet B Radiation Stimulates the Interaction between Nuclear Factor of Activated T Cells 5 (NFAT5) and Nuclear Factor-Kappa B (NF-kappaB) in Human Lens Epithelial Cells. alpha-SMA, CCK-8, HLE-B3, NF-kappaB, NFAT5, qPCR, UVB
27  2016 Effects of lentiviral RNA interference-mediated downregulation of integrin-linked kinase on biological behaviors of human lens epithelial cells. ILK, LECs, LV, RNAi, RT-PCR, shRNA, SMA, TGF-beta
28  2016 Protective effects of Semiaquilegia adoxoides n-butanol extract against hydrogen peroxide-induced oxidative stress in human lens epithelial cells. nSA
29  2016 Relationship Between the Altered Expression and Epigenetics of GSTM3 and Age-Related Cataract. ARC, GSTM3, LECs
30  2016 Selenoprotein R Protects Human Lens Epithelial Cells against D-Galactose-Induced Apoptosis by Regulating Oxidative Stress and Endoplasmic Reticulum Stress. ER, GRP78, MsrB1, SelR
31  2016 The core structure of a Dendrobium huoshanense polysaccharide required for the inhibition of human lens epithelial cell apoptosis. ---
32  2016 The P20R mutation of alphaB-crystallin diminishes its anti-apoptotic activity in human lens epithelial cells. alphaB-wt, P20R, TdT
33  2015 Inhibition of hypoxia inducible factor-1alpha downregulates the expression of epithelial to mesenchymal transition early marker proteins without undermining cell survival in hypoxic lens epithelial cells. ELISA, EMT, GSK-3beta, HIF-1alpha, VEGF
34  2015 Inhibition of p38 mitogen-activated protein kinase phosphorylation decreases H₂O₂-induced apoptosis in human lens epithelial cells. MAPK, ROS
35  2015 Knockdown of 15-kDa selenoprotein (Sep15) increases hLE cells' susceptibility to tunicamycin-induced apoptosis. ER, KO, TM
36  2015 Mutant connexin 50 (S276F) inhibits channel and hemichannel functions inducing cataract. Cx50
37  2015 Protective Effect of Rutin Against H2O2-Induced Oxidative Stress and Apoptosis in Human Lens Epithelial Cells. MDA, ROS, RT-PCR, SOD
38  2015 TGF-beta2 induces epithelial-mesenchymal transition in cultured human lens epithelial cells through activation of the PI3K/Akt/mTOR signaling pathway. EMT, mTOR, PI3K, TGF-beta2
39  2014 Enhanced cellular uptake and anti-proliferating effect of chitosan hydrochlorides modified genistein loaded NLC on human lens epithelial cells. CLSM, NLC, PCO
40  2014 Zinc chloride inhibits human lens epithelial cell migration and proliferation involved in TGF-beta1 and TNF-alpha signaling pathways in HLE B-3 cells. TGF-beta1, TNF-alpha
41  2013 Biological effects of passive versus active scanning proton beams on human lung epithelial cells. ABS, RT-PCR
42  2013 Effect of methionine sulfoxide reductase B1 (SelR) gene silencing on peroxynitrite-induced F-actin disruption in human lens epithelial cells. ERK, Msr, RNS, ROS
43  2013 Hypericin-mediated photooxidative damage of alpha-crystallin in human lens epithelial cells. NFK
44  2013 Study of oxidative stress in human lens epithelial cells exposed to 1.8 GHz radiofrequency fields. CCK-8, DCFH-DA, RF, ROS, SAR
45  2012 Dysfunction in cytochrome c oxidase caused by excessive nitric oxide in human lens epithelial cells stimulated with interferon-gamma and lipopolysaccharide. AG, ATP, CcO, DDC, iNOS, NO
46  2012 Effect of methionine sulfoxide reductase B1 silencing on high-glucose-induced apoptosis of human lens epithelial cells. MDA, MsrB1, ROS, siRNA
47  2012 Ganglioside GM3 participates in the TGF-beta1-induced epithelial-mesenchymal transition of human lens epithelial cells. EMT
48  2012 Involvement of MsrB1 in the regulation of redox balance and inhibition of peroxynitrite-induced apoptosis in human lens epithelial cells. ER, Msrs, siRNA
49  2012 Wnt3a promotes epithelial-mesenchymal transition, migration, and proliferation of lens epithelial cells. EMT, PCO
50  2011 Regulation of cytosolic phospholipase A2 (cPLA2alpha) and its association with cell proliferation in human lens epithelial cells. AA, BAPTA, C2D, ER, ERK, MAPK, PDGF, ROS, S228A, Vec
51  2011 SiRNA targeting EGFR effectively prevents posterior capsular opacification after cataract surgery. EGF, EGFR, PCO
52  2011 Ultraviolet B-induced expression of amphiregulin and growth differentiation factor 15 in human lens epithelial cells. AREG, EGF, EGFR, GDF15, UVB
53  2010 Effects of AG490 on lens epithelial cell death induced by H(2)O(2). ERK, JAK, LECs, MAPK, STAT
54  2010 Honokiol inhibits H(2)O(2)-induced apoptosis in human lens epithelial cells via inhibition of the mitogen-activated protein kinase and Akt pathways. MAPK, NF-kappaB
55  2009 Protective effect of magnolol against hydrogen peroxide-induced oxidative stress in human lens epithelial cells. ROS
56  2008 Epigallocatechin gallate protects against oxidative stress-induced mitochondria-dependent apoptosis in human lens epithelial cells. DCF, EGCG, MAPK, ROS
57  2007 Effect of magnesium deficiency on intracellular ATP levels in human lens epithelial cells. iNOS
58  2007 Parthenolide protects human lens epithelial cells from oxidative stress-induced apoptosis via inhibition of activation of caspase-3 and caspase-9. ---
59  2006 Inhibition of nuclear factor-kappa B activation attenuates hydrogen peroxide-induced cytotoxicity in human lens epithelial cells. NF-kappaB, PDTC
60  2005 Inhibitory effects of Arg-Gly-Asp (RGD) peptide on cell attachment and migration in a human lens epithelial cell line. ECM, PCO
61  2005 The presence of a transsulfuration pathway in the lens: a new oxidative stress defense system. CBS, PGG
62  2005 The xenobiotic-metabolizing enzymes arylamine N-acetyltransferases in human lens epithelial cells: inactivation by cellular oxidants and UVB-induced oxidative stress. ---
63  2004 Apoptotic and necrotic mechanisms of stress-induced human lens epithelial cell death. DFF45, JNK, LDH, LEC, ROS, TBHP, UVB, UVR
64  2004 Xanthophylls and alpha-tocopherol decrease UVB-induced lipid peroxidation and stress signaling in human lens epithelial cells. alpha-TC, AST, LUT, UVB, Zea
65  2003 Proteome analysis of lens epithelia, fibers, and the HLE B-3 cell line. ATP, LCQ
66  2003 Spectrum and range of oxidative stress responses of human lens epithelial cells to H2O2 insult. OS
67  2003 Ultraviolet radiation modulates nuclear factor kappa B activation in human lens epithelial cells. AP-1, IL-1beta, NF-kappaB, UVAR, UVR
68  2002 Effect of H(2)O(2)on human lens epithelial cells and the possible mechanism for oxidative damage repair by thioltransferase. FBS, G3PD, GPx, GR, GST, MEM, PSSC, PSSG, RHLT, TTase
69  2002 Enhanced expression of transglutaminase 2 in anterior polar cataracts and its induction by TGF-beta in vitro. TGase 2
70  2002 Modulation of lens cell adhesion molecules by particle beams. CAMs, ECM
71  2002 Selective induction of mitogen-activated protein kinases in human lens epithelial cells by ultraviolet radiation. MAPK, UVR
72  2001 Molecular basis of ocular abnormalities associated with proximal renal tubular acidosis. ---
73  2000 Differential protective activity of alpha A- and alphaB-crystallin in lens epithelial cells. ---
74  2000 Growth and differentiation of human lens epithelial cells in vitro on matrix. BCE, ECM, FGFR1, RT-PCR
75  2000 Particle irradiation induces FGF2 expression in normal human lens cells. ECM
76  2000 The effects of extracellular matrix on cell attachment, proliferation and migration in a human lens epithelial cell line. ECM
77  1999 Human lens epithelial cell line. mRNA, RT-PCR
78  1996 A study of growth factor receptors in human lens epithelial cells and their relationship to fiber differentiation. ---
79  1995 Effects of growth factors on proliferation and differentiation in human lens epithelial cells in early subculture. EGF, IGF-I
80  1995 Ultraviolet action spectra for photobiological effects in cultured human lens epithelial cells. PGE2
81  1993 Hypertonic stress increases NaK ATPase, taurine, and myoinositol in human lens and retinal pigment epithelial cultures. hRPE
82  1993 Synthesis of lens capsule in long-term culture of human lens epithelial cells. ---
83  1992 Study of the polyol pathway and cell permeability changes in human lens and retinal pigment epithelium in tissue culture. hRPE, TEM
84  1992 The efficacy of aldose reductase inhibitors on polyol accumulation in human lens and retinal pigment epithelium in tissue culture. AR, ARIs, DLE, hRPE
85  1991 Polyol accumulation in cultured human lens epithelial cells. ---
86  1990 Cellular injury from sustained vs. acute hydrogen peroxide exposure in cultured human corneal endothelium and human lens epithelium. 86RbCl, HCE
87  1990 Enhancement of differentiation of human lens epithelium in tissue culture by changes in cell-substrate adhesion. ---
88  1988 Crystallins and their synthesis in human lens epithelial cells in tissue culture. ---
89  1988 Fresh and cultured human lens epithelial cells: an electrophysiological study of cell coupling and membrane properties. ---
90  1988 Human retinal extract stimulates the proliferation of human lens epithelial cells. ---
91  1987 Human lens epithelial cells in culture: a quantitative evaluation of growth rate and proliferative capacity. FCS, PDL