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Abbreviation : HMGB1
Long Form : high mobility group box 1
No. Year Title Co-occurring Abbreviation
2021 2-O, 3-O desulfated heparin (ODSH) increases bacterial clearance and attenuates lung injury in cystic fibrosis by restoring HMGB1-compromised macrophage function. ARDS, CF, NO, ODSH, PA
2021 4-OI Attenuates Carbon Tetrachloride-Induced Hepatic Injury via Regulating Oxidative Stress and the Inflammatory Response. ALI, OI, TBARS
2021 5-LO-derived LTB4 plays a key role in MCP-1 expression in HMGB1-exposed VSMCs via a BLTR1 signaling axis. LO, LTB4, MCP-1, VSMCs
2021 A small molecule binding HMGB1 inhibits caspase-11-mediated lethality in sepsis. LPS
2021 A Unique Anti-Cancer 3-Styrylchromone Suppresses Inflammatory Response via HMGB1-RAGE Signaling. ---
2021 Abdominal paracentesis drainage attenuates intestinal inflammation in rats with severe acute pancreatitis by inhibiting the HMGB1-mediated TLR4 signaling pathway. AP, APD, SAP, TLR4
2021 Activation of Peripheral Blood Mononuclear Cells and Leptin Secretion: New Potential Role of Interleukin-2 and High Mobility Group Box (HMGB)1. HMGB, IL-2, NK, PBMCs, T2DM, TLR2, TLRs
2021 Activation of the Hippocampal LXRβ Improves Sleep-Deprived Cognitive Impairment by Inhibiting Neuroinflammation. GLY, LPS, LXRs, SD, TLR4
2021 ADAM10 attenuates the development of abdominal aortic aneurysms in a mouse model. AAA, ADAM10
10  2021 ADAM10 inhibits the interaction between IL-17 and HMGB1 in Buerger's disease. ADAM10, IL, NF-kB, PBMCs, Th
11  2021 Adiponectin inhibits D‑gal‑induced cardiomyocyte senescence via AdipoR1/APPL1. AdipoR1, HO, MDA, ROS, si
12  2021 Admission serum high mobility group box 1 (HMGB1) protein predicts delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage. aSAH
13  2021 AhR Ligands Differentially Regulate miRNA-132 Which Targets HMGB1 and to Control the Differentiation of Tregs and Th-17 Cells During Delayed-Type Hypersensitivity Response. AhR, DTH, mBSA
14  2021 AICAR decreases acute lung injury by phosphorylating AMPK and upregulating heme oxygenase-1. AICAR, AMP, AMPK, LKB1
15  2021 ALKBH5-Modified HMGB1-STING Activation Contributes to Radiation Induced Liver Disease via Innate Immune Response. ALKBH5, HSCs, m6A, RILD, STING
16  2021 An 8-Hydroxy-Quinoline Derivative Protects Against Lipopolysaccharide-Induced Lethality in Endotoxemia by Inhibiting HMGB1-Mediated Caspase-11 Signaling. LPS
17  2021 Analysis of HMGB-1 level before and after providing atorvastatin standard therapy in coronary artery disease patients with type-2 diabetes mellitus compared to without type-2 diabetes mellitus. CAD
18  2021 Angiotensin II Increases HMGB1 Expression in the Myocardium Through AT1 and AT2 Receptors When Under Pressure Overload. Ang II, AT2, PO, TAC
19  2021 Anti-high mobility group box 1 monoclonal antibody suppressed hyper-permeability and cytokine production in human pulmonary endothelial cells infected with influenza A virus. ARDS, HMVECs, TNF-alpha
20  2021 Anti-HMGB1 auto-Abs influence fatigue in patients with Crohn's disease. DS, FR, fVAS
21  2021 Arginine Deiminase Induces Immunogenic Cell Death and Is Enhanced by N-acetylcysteine in Murine MC38 Colorectal Cancer Cells and MDA-MB-231 Human Breast Cancer Cells In Vitro. ADI, ATP, BMDCs, CRT, ICD, NAC
22  2021 Argon Attenuates Multiorgan Failure in Relation with HMGB1 Inhibition. MOF
23  2021 Aromatherapy Plus Music Therapy Improve Pain Intensity and Anxiety Scores in Patients With Breast Cancer During Perioperative Periods: A Randomized Controlled Trial. AT, CT, IL, MT, UC
24  2021 Association between carotid plaque vulnerability and high mobility group box-1 serum levels in a diabetic population. ICAS
25  2021 Association between high mobility group box 1 protein and juvenile idiopathic arthritis: a prospective longitudinal study. JIA
26  2021 Association of High-Mobility Group Box 1 (HMGB1) Gene Polymorphisms with Susceptibility and Better Survival Prognosis in Chinese Han Neonatal Necrotizing Enterocolitis. NEC, SNPs
27  2021 Association of plasma level of high-mobility group box-1 with necroptosis and sepsis outcomes. RIPK3
28  2021 Association of Polymorphism rs1045411 in the HMGB1 Gene with Cancer Risk: Evidence from a Meta-analysis. CIs, ORs
29  2021 Astragali Radix Contributes to the Inhibition of Liver Fibrosis via High-Mobility Group Box 1-Mediated Inflammatory Signaling Pathway. AR, AST, Bge, Col IV, HA, LN, PCIII
30  2021 Biapenem reduces sepsis mortality via barrier protective pathways against HMGB1-mediated septic responses. BIPM, CLP, HUVECs, LPS
31  2021 Bicyclol Alleviates Signs of BDL-Induced Cholestasis by Regulating Bile Acids and Autophagy-Mediated HMGB1/p62/Nrf2 Pathway. BDL, Nrf2
32  2021 Blood high mobility group box 1 levels are not a suitable biomarker for disease activity or severity in nonsegmental vitiligo. ---
33  2021 Bone marrow mesenchymal stem cell exosomes suppress phosphate-induced aortic calcification via SIRT6-HMGB1 deacetylation. BMSC, CKD, SIRT6
34  2021 Calunduloside E inhibits HepG2 cell proliferation and migration via p38/JNK-HMGB1 signalling axis. CE, EMT, HCC
35  2021 CBP Bromodomain Inhibition Rescues Mice From Lethal Sepsis Through Blocking HMGB1-Mediated Inflammatory Responses. CBP, MKP-1, PP2A
36  2021 CD36 deficiency ameliorates drug-induced acute liver injury in mice. AKT, CYP2E1, DAMP, Erk, JNK, PCR
37  2021 Celastrol exerts a neuroprotective effect by directly binding to HMGB1 protein in cerebral ischemia-reperfusion. CEL, cel-p, CETSA, I/R, MCAO, OGD, TMT
38  2021 Celecoxib Decrease Seizures Susceptibility in a Rat Model of Inflammation by Inhibiting HMGB1 Translocation. LPS, PILO
39  2021 Cellular antioxidant mechanisms control immunoglobulin light chain-mediated proximal tubule injury. FOXO3a, SIRT1
40  2021 Chronic stress promotes acute myeloid leukemia progression through HMGB1/NLRP3/IL-1β signaling pathway. AML, IL-1beta, NLRP3
41  2021 Chrysophanol Exerts Anti-inflammatory Activity by Targeting Histone Deacetylase 3 Through the High Mobility Group Protein 1-Nuclear Transcription Factor-Kappa B Signaling Pathway in vivo and in vitro. ALI, CHR, HDAC3, LPS, NF-kappaB p65
42  2021 Circ-CSPP1 knockdown suppresses hepatocellular carcinoma progression through miR-493-5p releasing-mediated HMGB1 downregulation. CCK-8, circRNAs, GEO, HCC, MMP-9, qRT-PCR
43  2021 CircPTK2-miR-181c-5p-HMGB1: a new regulatory pathway for microglia activation and hippocampal neuronal apoptosis induced by sepsis. CLP, ELISA, LPS, MMP
44  2021 Circular RNA circ_0062389 modulates papillary thyroid carcinoma progression via the miR-1179/high mobility group box 1 axis. circRNAs, EMT, PTC, qRT-PCR
45  2021 Circ_0000491 Promotes Apoptosis, Inflammation, Oxidative Stress, and Fibrosis in High Glucose-Induced Mesangial Cells by Regulating miR-455-3p/Hmgb1 Axis. DN, HG, miR-455-3p
46  2021 Clara cell 16 KDa protein mitigates house dust mite-induced airway inflammation and damage via regulating airway epithelial cell apoptosis in a manner dependent on HMGB1-mediated signaling inhibition. CC16, HDM
47  2021 Class IIa HDAC Downregulation Contributes to Surgery-Induced Cognitive Impairment Through HMGB1-Mediated Inflammatory Response in the Hippocampi of Aged Mice. HDACs, MWM, PND
48  2021 CLEC14A protects against podocyte injury in mice with adriamycin nephropathy. ADR, Egr-1, FSGS
49  2021 Clinical signs, duodenal histopathological grades, and serum high-mobility group box 1 concentrations in dogs with inflammatory bowel disease. CIBDAI, CRP, IBD
50  2021 Co-treatment with disulfiram and glycyrrhizic acid suppresses the inflammatory response of chondrocytes. ALDH, ATP, CCK-8 assay, ELISA, GSDMD, LPS, OA, ROS
51  2021 Combination Chemo-Immunotherapy for Pancreatic Cancer Using the Immunogenic Effects of an Irinotecan Silicasome Nanocarrier Plus Anti-PD-1. ICD, KPC, PD-L1, PDAC
52  2021 Conditional Knock out of High-Mobility Group Box 1 (HMGB1) in Rods Reduces Autophagy Activation after Retinal Detachment. cKO, ONL, PR, RD
53  2021 Correlation of blood high mobility group box-1 protein with mortality of patients with sepsis: A meta-analysis. CIs, SMD, SMDs
54  2021 Curcumin improves memory deficits by inhibiting HMGB1-RAGE/TLR4-NF-κB signalling pathway in APPswe/PS1dE9 transgenic mice hippocampus. AD, NF-kappaB, RAGE, TLR4
55  2021 Damage associated molecular patterns in necrotic femoral head inhibit osteogenesis and promote fibrogenesis of mesenchymal stem cells. 4-HNE, DAMPs, LCPD, MSC, NBF, RANKL
56  2021 Damage-associated molecular pattern (DAMP) activation in melanoma: investigation of the immunogenic activity of 15-deoxy, Δ12,14 prostamide J2. CRT, DAMP, DAMPs, DCs, ER, HSP70, ICD
57  2021 Design, Synthesis and Biological Evaluation of Steroidal Glycoconjugates as Potential Antiproliferative Agents. SAR
58  2021 Dexmedetomidine preconditioning mitigates myocardial ischemia/reperfusion injury via inhibition of mast cell degranulation. cTnI, I/R, NF-kappaB p65, TLR4
59  2021 Dexmedetomidine relieved neuropathic pain and inflammation response induced by CCI through HMGB1/TLR4/NF-κB signal pathway. alpha2-AR, CCI, DEX, TLR4
60  2021 Diagnostic Tools and Biomarkers for Severe Drug Eruptions. ---
61  2021 Differential Regulation of Damage-Associated Molecular Pattern Release in a Mouse Model of Skeletal Muscle Ischemia/Reperfusion Injury. DAMPs, I/R
62  2021 Disulfide and Fully Reduced HMGB1 Induce Different Macrophage Polarization and Migration Patterns. BMDMs, ds-HMGB1, frHMGB1, TLR4
63  2021 Disulfide HMGB1 acts via TLR2/4 receptors to reduce the numbers of oligodendrocyte progenitor cells after traumatic injury in vitro. OPC, TBI
64  2021 DNA-Aptamer Raised against Receptor for Advanced Glycation End Products Improves Survival Rate in Septic Mice. RAGE
65  2021 Downregulation of high mobility group box 1 enhances the radiosensitivity of non-small cell lung cancer by acting as a crucial target of microRNA-107. miR, NSCLC, TLR4
66  2021 Early Prognosis Effect of Cellular Immune Paralysis on Brain Complications of Extracorporeal Membrane Oxygenation Children with Severe Sepsis. ECMO, Lac, LPS
67  2021 Effect of quadratus lumborum block on postoperative cognitive function in elderly patients undergoing laparoscopic radical gastrectomy: a randomized controlled trial. IL-6, MMSE, MoCA, POCD, QLB, TNF-alpha, VAS
68  2021 Effect of Rongchang capsule on seizure behavior, cognitive impairment, and hippocampal DNA damage and inflammatory factors in epileptic rat. IL-1beta, MG, NG, OTM, RG, TGF-beta, TL, VG
69  2021 Effect of serum high mobility group box 1 protein on immune function and autophagy level of myocardial cells in rats with sepsis. CLP, ELISA, LC3
70  2021 Effects of HMGB1 on Tricellular Tight Junctions via TGF-β Signaling in Human Nasal Epithelial Cells. ---
71  2021 Effects of Post-Resuscitation Normoxic Therapy on Oxygen-Sensitive Oxidative Stress in a Rat Model of Cardiac Arrest. CA
72  2021 Efficacy comparison of high-frequency oscillatory ventilation with continuous nasal positive airway pressure in neonatal respiratory distress syndrome treatment. HFOV, nCPAP, NRDS
73  2021 Electroacupuncture Pretreatment Ameliorates Anesthesia and Surgery-Induced Cognitive Dysfunction via Activation of an α7-nAChR Signal in Aged Rats. alpha-BGT, alpha7nAChR, AS, EA, IL-6, NF-kappaB, POCD
74  2021 Elevated HMGB1 expression induced by hepatitis B virus X protein promotes epithelial-mesenchymal transition and angiogenesis through STAT3/miR-34a/NF-κB in primary liver cancer. EMT, HBx, PVTT, qRT-PCR, RNAi
75  2021 Elevated plasma levels of galectin-3 binding protein are associated with post-stroke delirium - A pilot study. Gal-3BP
76  2021 Elevation of Proinflammatory Cytokine HMGB1 in the Synovial Fluid of Patients With Legg-Calvé-Perthes Disease and Correlation With IL-6. IL-1beta, IL-6, LCPD, ON, TNF-alpha
77  2021 Emerging mechanisms of immunocoagulation in sepsis and septic shock. GSDMD, SQSTM1, STING1
78  2021 ERK/Drp1-dependent mitochondrial fission contributes to HMGB1-induced autophagy in pulmonary arterial hypertension. BMPR2, CCK-8, Drp1, Id1, MCT, PAH, PASMCs, SD
79  2021 Ethyl Pyruvate Alleviates Pulmonary Hypertension through the Suppression of Pulmonary Artery Smooth Muscle Cell Proliferation via the High Mobility Group Protein B1/Receptor for Advanced Glycation End-Products Axis. EP, PAH, PBS, RAGE
80  2021 Ethyl pyruvate ameliorate inflammatory response of sinonasal mucosa by inhibiting HMGB1 in rats with acute rhinosinusitis. ARS, CFU, EP, SD
81  2021 Etiological Value of Sterile Inflammation in Preeclampsia: Is It a Non-Infectious Pregnancy Complication? DAMPs, e-PE, ER, GSDMD, NLRP3, PE
82  2021 Exosomal HMGB1 derived from hypoxia-conditioned bone marrow mesenchymal stem cells increases angiogenesis via the JNK/HIF-1α pathway. BMSCs, HUVECs, MSCs
83  2021 Exosomal HMGB1 Promoted Cancer Malignancy. LLC
84  2021 Expatiating the molecular approaches of HMGB1 in diabetes mellitus: Highlighting signalling pathways via RAGE and TLRs. DM, RAGE, TLRs
85  2021 Expression profiles of HMGB1 on B-CLL related leukocytes contribute to prediction of relapse. pts
86  2021 Extracellular HMGB1 blockade inhibits tumor growth through profoundly remodeling immune microenvironment and enhances checkpoint inhibitor-based immunotherapy. DC, MDSC, pDC
87  2021 Extracellular HMGB1 Contributes to the Chronic Cardiac Allograft Vasculopathy/Fibrosis by Modulating TGF-β1 Signaling. CAV, TGF
88  2021 Extracellular HMGB1 promotes CD44 expression in hepatocellular carcinoma via regulating miR-21. CD44, DAMPs, HCC
89  2021 Extracellular vesicle mediated feto-maternal HMGB1 signaling induces preterm birth. AECs, CFSE, eHMGB1, F-M, FMi, FMi-OOC, PTB
90  2021 Fabrication and Evaluation of Celecoxib Oral Oleogel to Reduce the Inflammation of Ulcerative Colitis. DSS, MPO, NF-KappaB, TFF3, TNF-alpha, UC
91  2021 Fecal High-Mobility Group Box 1 as a Marker of Early Stage of Necrotizing Enterocolitis in Preterm Neonates. DUS, NEC, NICU
92  2021 Fluvastatin attenuated ischemia/reperfusion-induced autophagy and apoptosis in cardiomyocytes through down-regulation HMGB1/TLR4 signaling pathway. I/R, LC3, NF-kappaB, TLR4
93  2021 From nicotine to the cholinergic anti-inflammatory reflex - Can nicotine alleviate the dysregulated inflammation in COVID-19? ALI, ARDS
94  2021 Gefitinib initiates sterile inflammation by promoting IL-1β and HMGB1 release via two distinct mechanisms. IL-1beta, mtROS
95  2021 Gensenoside Rg1 protects against lipopolysaccharide- and d-galactose-induced acute liver failure via suppressing HMGB1-mediated TLR4-NF-κB pathway. ALF, ALI, AST, ELISA, GRg1, IL-6, MDA, qRT-PCR, SOD, TLR4-NF-kappaB, TNF-alpha
96  2021 Gingival-Derived Mesenchymal Stem Cells Protect Against Sepsis and Its Complications. GMSCs, LPS, MODS
97  2021 Ginseng leaf extract ameliorates the survival of endotoxemic mice by inhibiting the release of high mobility group box 1. GLE, iNOS, LPS, NO
98  2021 Glycyrrhizic acid, as an inhibitor of HMGB1, alleviates bleomycin-induced pulmonary toxicity in mice through the MAPK and Smad3 pathways. alpha-SMA, IL, MAPK, MCP, TGF, TNF
99  2021 Glycyrrhizin ameliorates melanoma cell extravasation into mouse lungs by regulating signal transduction through HMGB1 and its receptors. RAGE, TLR
100  2021 Glycyrrhizin Attenuates Carcinogenesis by Inhibiting the Inflammatory Response in a Murine Model of Colorectal Cancer. AOM, CC, DSS, GL, IL, TNF