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Abbreviation : HMGB1
Long Form : high mobility group box 1
No. Year Title Co-occurring Abbreviation
2021 5-LO-derived LTB4 plays a key role in MCP-1 expression in HMGB1-exposed VSMCs via a BLTR1 signaling axis. LO, LTB4, MCP-1, VSMCs
2021 A small molecule binding HMGB1 inhibits caspase-11-mediated lethality in sepsis. LPS
2021 A Unique Anti-Cancer 3-Styrylchromone Suppresses Inflammatory Response via HMGB1-RAGE Signaling. ---
2021 Abdominal paracentesis drainage attenuates intestinal inflammation in rats with severe acute pancreatitis by inhibiting the HMGB1-mediated TLR4 signaling pathway. AP, APD, SAP, TLR4
2021 AhR Ligands Differentially Regulate miRNA-132 Which Targets HMGB1 and to Control the Differentiation of Tregs and Th-17 Cells During Delayed-Type Hypersensitivity Response. AhR, DTH, mBSA
2021 AICAR decreases acute lung injury by phosphorylating AMPK and upregulating heme oxygenase-1. AICAR, AMP, AMPK, LKB1
2021 ALKBH5-modified HMGB1-STING Activation Contributes to Radiation Induced Liver Disease Via Innate Immune Response. ALKBH5, HSCs, m6A, MeRIP-seq, RILD, RNA-seq, RT, UTR
2021 Angiotensin II Increases HMGB1 Expression in the Myocardium Through AT1 and AT2 Receptors When Under Pressure Overload. Ang II, AT2, PO, TAC
2021 Anti-HMGB1 auto-Abs influence fatigue in patients with Crohn's disease. DS, FR, fVAS
10  2021 Arginine Deiminase Induces Immunogenic Cell Death and Is Enhanced by N-acetylcysteine in Murine MC38 Colorectal Cancer Cells and MDA-MB-231 Human Breast Cancer Cells In Vitro. ADI, ATP, BMDCs, CRT, ICD, NAC
11  2021 Argon Attenuates Multiorgan Failure in Relation with HMGB1 Inhibition. MOF
12  2021 Association between carotid plaque vulnerability and high mobility group box-1 serum levels in a diabetic population. ICAS
13  2021 Association of High-Mobility Group Box 1 (HMGB1) Gene Polymorphisms with Susceptibility and Better Survival Prognosis in Chinese Han Neonatal Necrotizing Enterocolitis. NEC, SNPs
14  2021 Association of plasma level of high-mobility group box-1 with necroptosis and sepsis outcomes. RIPK3
15  2021 Association of Polymorphism rs1045411 in the HMGB1 Gene with Cancer Risk: Evidence from a Meta-analysis. CIs, ORs
16  2021 Astragali Radix Contributes to the Inhibition of Liver Fibrosis via High-Mobility Group Box 1-Mediated Inflammatory Signaling Pathway. AR, AST, Bge, Col IV, HA, LN, PCIII
17  2021 Biapenem reduces sepsis mortality via barrier protective pathways against HMGB1-mediated septic responses. BIPM, CLP, HUVECs, LPS
18  2021 Bone marrow mesenchymal stem cell exosomes suppress phosphate-induced aortic calcification via SIRT6-HMGB1 deacetylation. BMSC, CKD, SIRT6
19  2021 CBP Bromodomain Inhibition Rescues Mice From Lethal Sepsis Through Blocking HMGB1-Mediated Inflammatory Responses. CBP, MKP-1, PP2A
20  2021 Celecoxib Decrease Seizures Susceptibility in a Rat Model of Inflammation by Inhibiting HMGB1 Translocation. LPS, PILO
21  2021 Cellular antioxidant mechanisms control immunoglobulin light chain-mediated proximal tubule injury. FoxO3a, SIRT1
22  2021 Chronic stress promotes acute myeloid leukemia progression through HMGB1/NLRP3/IL-1β signaling pathway. AML, IL-1beta, NLRP3
23  2021 Chrysophanol Exerts Anti-inflammatory Activity by Targeting Histone Deacetylase 3 Through the High Mobility Group Protein 1-Nuclear Transcription Factor-Kappa B Signaling Pathway in vivo and in vitro. ALI, CHR, HDAC3, LPS, NF-kappaB p65
24  2021 CircPTK2-miR-181c-5p-HMGB1: a new regulatory pathway for microglia activation and hippocampal neuronal apoptosis induced by sepsis. CLP, ELISA, LPS, MMP
25  2021 Circular RNA circ_0062389 modulates papillary thyroid carcinoma progression via the miR-1179/high mobility group box 1 axis. circRNAs, EMT, PTC, qRT-PCR
26  2021 Clara cell 16 KDa protein mitigates house dust mite-induced airway inflammation and damage via regulating airway epithelial cell apoptosis in a manner dependent on HMGB1-mediated signaling inhibition. CC16, HDM
27  2021 Co-treatment with disulfiram and glycyrrhizic acid suppresses the inflammatory response of chondrocytes. ALDH, ATP, CCK-8 assay, ELISA, GSDMD, LPS, OA, ROS
28  2021 Combination Chemo-Immunotherapy for Pancreatic Cancer Using the Immunogenic Effects of an Irinotecan Silicasome Nanocarrier Plus Anti-PD-1. ICD, KPC, PD-L1, PDAC
29  2021 Damage-associated molecular pattern (DAMP) activation in melanoma: investigation of the immunogenic activity of 15-deoxy, Δ12,14 prostamide J2. CRT, DAMP, DAMPs, DCs, ER, HSP70, ICD
30  2021 Design, Synthesis and Biological Evaluation of Steroidal Glycoconjugates as Potential Antiproliferative Agents. SAR
31  2021 Disulfide HMGB1 acts via TLR2/4 receptors to reduce the numbers of oligodendrocyte progenitor cells after traumatic injury in vitro. OPC, TBI
32  2021 Downregulation of high mobility group box 1 enhances the radiosensitivity of non-small cell lung cancer by acting as a crucial target of microRNA-107. miR, NSCLC, TLR4
33  2021 Effect of quadratus lumborum block on postoperative cognitive function in elderly patients undergoing laparoscopic radical gastrectomy: a randomized controlled trial. IL-6, MMSE, MoCA, POCD, QLB, TNF-alpha, VAS
34  2021 Effect of serum high mobility group box 1 protein on immune function and autophagy level of myocardial cells in rats with sepsis. CLP, ELISA, LC3
35  2021 Effects of Post-Resuscitation Normoxic Therapy on Oxygen-Sensitive Oxidative Stress in a Rat Model of Cardiac Arrest. CA
36  2021 Elevated HMGB1 expression induced by hepatitis B virus X protein promotes epithelial-mesenchymal transition and angiogenesis through STAT3/miR-34a/NF-κB in primary liver cancer. EMT, HBx, PVTT, qRT-PCR, RNAi
37  2021 Elevated plasma levels of galectin-3 binding protein are associated with post-stroke delirium - A pilot study. Gal-3BP
38  2021 Elevation of Proinflammatory Cytokine HMGB1 in the Synovial Fluid of Patients With Legg-Calvé-Perthes Disease and Correlation With IL-6. IL-1beta, IL-6, LCPD, ON, TNF-alpha
39  2021 Emerging mechanisms of immunocoagulation in sepsis and septic shock. GSDMD, SQSTM1, STING1
40  2021 ERK/Drp1-dependent mitochondrial fission contributes to HMGB1-induced autophagy in pulmonary arterial hypertension. BMPR2, CCK-8, Drp1, ID1, MCT, PAH, PASMCs, SD
41  2021 Ethyl Pyruvate Alleviates Pulmonary Hypertension through the Suppression of Pulmonary Artery Smooth Muscle Cell Proliferation via the High Mobility Group Protein B1/Receptor for Advanced Glycation End-Products Axis. EP, PAH, PBS, RAGE
42  2021 Ethyl pyruvate ameliorate inflammatory response of sinonasal mucosa by inhibiting HMGB1 in rats with acute rhinosinusitis. ARS, CFU, EP, SD
43  2021 Exosomal HMGB1 derived from hypoxia-conditioned bone marrow mesenchymal stem cells increases angiogenesis via the JNK/HIF-1α pathway. BMSCs, HUVECs, MSCs
44  2021 Exosomal HMGB1 Promoted Cancer Malignancy. LLC
45  2021 Expatiating the molecular approaches of HMGB1 in diabetes mellitus: Highlighting signalling pathways via RAGE and TLRs. DM, RAGE, TLRs
46  2021 Expression profiles of HMGB1 on B-CLL related leukocytes contribute to prediction of relapse. pts
47  2021 Extracellular HMGB1 blockade inhibits tumor growth through profoundly remodeling immune microenvironment and enhances checkpoint inhibitor-based immunotherapy. DC, MDSC, pDC
48  2021 Extracellular HMGB1 Contributes to the Chronic Cardiac Allograft Vasculopathy/Fibrosis by Modulating TGF-β1 Signaling. CAV, TGF
49  2021 Extracellular HMGB1 promotes CD44 expression in hepatocellular carcinoma via regulating miR-21. CD44, DAMPs, HCC
50  2021 Extracellular vesicle mediated feto-maternal HMGB1 signaling induces preterm birth. AECs, CFSE, eHMGB1, F-M, FMi, FMi-OOC, PTB
51  2021 Fluvastatin attenuated ischemia/reperfusion-induced autophagy and apoptosis in cardiomyocytes through down-regulation HMGB1/TLR4 signaling pathway. I/R, LC3, NF-kappaB, TLR4
52  2021 From nicotine to the cholinergic anti-inflammatory reflex - Can nicotine alleviate the dysregulated inflammation in COVID-19? ALI, ARDS
53  2021 Gefitinib initiates sterile inflammation by promoting IL-1β and HMGB1 release via two distinct mechanisms. IL-1beta, mtROS
54  2021 Gensenoside Rg1 protects against lipopolysaccharide- and d-galactose-induced acute liver failure via suppressing HMGB1-mediated TLR4-NF-κB pathway. ALF, ALI, AST, ELISA, GRg1, IL-6, MDA, qRT-PCR, SOD, TLR4-NF-kappaB, TNF-alpha
55  2021 Glycyrrhizin Attenuates Carcinogenesis by Inhibiting the Inflammatory Response in a Murine Model of Colorectal Cancer. AOM, CC, DSS, GL, IL, TNF
56  2021 Glycyrrhizin prevents SARS-CoV-2 S1 and Orf3a induced high mobility group box 1 (HMGB1) release and inhibits viral replication. ---
57  2021 High mobility group box 1 and angiogenetic growth factor levels in children with central nerve system infections. CNS, CSF, PDGF, VEGF
58  2021 High Mobility Group Box 1 and Interleukin 6 at Intensive Care Unit Admission as Biomarkers in Critically Ill COVID-19 Patients. COVID-19, ICU, IL-6, SOFA
59  2021 High mobility group box 1 is involved in the pathogenesis of passive transfer myasthenia gravis model. AChR, MG
60  2021 High mobility group box 1 mediates inflammatory response of astrocytes via cyclooxygenase 2/prostaglandin E2 signaling following spinal cord injury. COX-2, mPGES, PGE2, TLR4
61  2021 High Mobility Group Box 1 Promotes Lung Cancer Cell Migration and Motility via Regulation of Dynamin-Related Protein 1. Drp1, NSCLC
62  2021 High mobility group box 1 promotes the differentiation of spinal ependymal cells into astrocytes rather than neurons. ACM, SCI
63  2021 High mobility group box 1 regulates gastric cancer cell proliferation and migration via RAGE-mTOR/ERK feedback loop. GC, MMPs
64  2021 High-mobility group box 1 serves as an inflammation driver of cardiovascular disease. CVD
65  2021 High-mobility group box protein-1 induces acute pancreatitis through activation of neutrophil extracellular trap and subsequent production of IL-1β. AP, ATP, DNase, LPS
66  2021 High-mobility group box-1 and inter-alpha inhibitor proteins: In vitro binding and co-localization in cerebral cortex after hypoxic-ischemic injury. HI, IAIPs, SPR
67  2021 High-mobility group box-1 promotes vascular calcification in diabetic mice via endoplasmic reticulum stress. 4-PBA, AGEs, ALP, ERS, GLY, ICC, IHC, RT-PCR, STZ, VSMCs
68  2021 HMGB1 downregulation in retinal pigment epithelial cells protects against diabetic retinopathy through the autophagy-lysosome pathway. CTSB, CTSL, DR, HG, LMP, RPE, VEGF
69  2021 HMGB1 enhances chemotherapy resistance in multiple myeloma cells by activating the nuclear factor-κB pathway. MM, NF, sh
70  2021 HMGB1 expression in leukocytes as a biomarker of cellular damage induced by [99mTc]Tc-HMPAO-labelling procedure: A quality control study. CE, WBC
71  2021 HMGB1 is a key factor for tamoxifen resistance and has the potential to predict the efficacy of CDK4/6 inhibitors in breast cancer. NF-kappaB, PFS, TLR4
72  2021 HMGB1 knockdown increases the radiosensitivity of esophageal squamous cell carcinoma by regulating the expression of molecules involved in DNA repair. ESCC, NOX, ROS, si
73  2021 HMGB1 orchestrates STING-mediated senescence via TRIM30α modulation in cancer cells. STAT6, STING, TRIM30alpha
74  2021 HMGB1 Promotes the Release of Sonic Hedgehog From Astrocytes. EAE, MS, RAGE, SHH, TLR
75  2021 HMGB1 regulates ferroptosis through Nrf2 pathway in mesangial cells in response to high glucose. ACSL4, DN, GPX4, LDH, MDA, Nox1, Nrf2, PTGS2, ROS
76  2021 HMGB1 release by cholangiocytes governs biliary atresia pathogenesis and correlates with increases in afflicted infants. BA, RRV
77  2021 HMGB1-like dorsal switch protein 1 of the mealworm, Tenebrio molitor, acts as a damage-associated molecular pattern. DAMP, DSP1, RNAi
78  2021 HMGB1-mediated chromatin remodeling attenuates Il24 gene expression for the protection from allergic contact dermatitis. ACD, IL-24
79  2021 HMGB1-RAGE-moesin axis may be Indicted for Acne vulgaris. GAGS, RAGE
80  2021 HMGB1/TLR4 Signaling Affects Regulatory T Cells in Acute Lung Injury. ALI
81  2021 HMGB1: An overview of its roles in the pathogenesis of liver disease. RAGE, TLRs
82  2021 Human Herpesvirus 6A Induces Dendritic Cell Death and HMGB1 Release without Virus Replication. DC, HHV-6A
83  2021 Hydrogen gas alleviates sepsis-induced neuroinflammation and cognitive impairment through regulation of DNMT1 and DNMT3a-mediated BDNF promoter IV methylation in mice. BDNF, CLP, DNMTs, ELISA, IL-6, SAE, TNF-alpha
84  2021 Hyperinflammation: On the pathogenesis and treatment of macrophage activation syndrome. HLH, MAS, NK
85  2021 HΜGB1/sRAGE levels differ significantly between transudates and exudates. PEs, RAGE, sRAGE
86  2021 Immunoaffinity-Based Liquid Chromatography Mass Spectrometric Assay to Accurately Quantify the Protein Concentration of HMGB1 in EDTA Plasma. IA-LC-MSMS
87  2021 In schizophrenia, immune-inflammatory pathways are strongly associated with depressive and anxiety symptoms, which are part of a latent trait which comprises neurocognitive impairments and schizophrenia symptoms. DKK1, EOS, G-CoDe, HDRS, IL, IRS, OSOS
88  2021 In schizophrenia, non-remitters and partial remitters to treatment with antipsychotics are qualitatively distinct classes with respect to neurocognitive deficits and neuro-immune biomarkers: results of soft independent modeling of class analogy. DKK1, EM-2, NIOC, NRTT, PRTT, SIMCA
89  2021 In vitro and in vivo assessment of the protective effect of sufentanil in acute lung injury. ALI, LPS
90  2021 In vitro Crosslinking Reactions and Substrate Incorporation Assays for The Identification of Transglutaminase-2 Protein Substrates. ---
91  2021 Inflammation related to high-mobility group box-1 in endometrial ovarian cyst. EOC, EOC, Treg
92  2021 Inhibition of Cochlear HMGB1 Expression Attenuates Oxidative Stress and Inflammation in an Experimental Murine Model of Noise-Induced Hearing Loss. 4-HNE, ICAM-1, iNOS, NIHL, NOX4, RNS, ROS
93  2021 Inhibition of HMGB1 reduced high glucose-induced BMSCs apoptosis via activation of AMPK and regulation of mitochondrial functions. BMSCs, HG, NG
94  2021 Inhibition of the Receptor for Advanced Glycation End Products Enhances the Cytotoxic Effect of Gemcitabine in Murine Pancreatic Tumors. PDAC, RAGE
95  2021 Interferon Type I Regulates Inflammasome Activation and High Mobility Group Box 1 Translocation in Hepatocytes During Ehrlichia-Induced Acute Liver Injury. EM, GM-CSF, HCs, IL, IOE, KC, MCP-1, MIG, MIP-1alpha, RANTES
96  2021 IRGM promotes melanoma cell survival through autophagy and is a promising prognostic biomarker for clinical application. GTPase
97  2021 Lactobacillus acidophilus ATCC 4356 Alleviates Renal Ischemia-Reperfusion Injury Through Antioxidant Stress and Anti-inflammatory Responses and Improves Intestinal Microbial Distribution. BUN, CRE, HO-1, I/R, IFN, IL, IRI, MDA, Nrf2, SOD, TNF, TUNEL
98  2021 Laser nanobubbles induce immunogenic cell death in breast cancer. ATP, DAMPs, HSP70
99  2021 Long non-coding RNA GAS5 aggravates myocardial depression in mice with sepsis via the microRNA-449b/HMGB1 axis and the NF-κB signaling pathway. CLP, lncRNA, miRNA
100  2021 Long non-coding RNA LINC00704 promotes cell proliferation, migration, and invasion in papillary thyroid carcinoma via miR-204-5p/HMGB1 axis. PCNA, PTC, qRT-PCR