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Abbreviation : IRP2
Long Form : iron regulatory protein 2
No. Year Title Co-occurring Abbreviation
2022 Aberrant Transferrin and Ferritin Upregulation Elicits Iron Accumulation and Oxidative Inflammaging Causing Ferroptosis and Undermines Estradiol Biosynthesis in Aging Rat Ovaries by Upregulating NF-Κb-Activated Inducible Nitric Oxide Synthase: First Demonstration of an Intricate Mechanism. GPX4, iNOS, NF-kappaB, Nrf2, TfR1, TNF-alpha
2022 Deubiquitylase OTUD3 prevents Parkinson's disease through stabilizing iron regulatory protein 2. OTUD3, PD
2022 Dihydroartemisinin Triggers Ferroptosis in Multidrug-Resistant Leukemia Cells. ADM, DHA, FTH1, MDR, p-mTOR, ROS, t-mTOR
2022 Novel melatonin-trientine conjugate as potential therapeutic agents for Alzheimer's disease. AD, IDE, LRP1, MT2, TM
2021 Activation of vitamin D receptor inhibits Tau phosphorylation is associated with reduction of iron accumulation in APP/PS1 transgenic mice. AD, BACE1, PAL, TfR, VDR
2021 Exosomes From miR-19b-3p-Modified ADSCs Inhibit Ferroptosis in Intracerebral Hemorrhage Mice. ADSCs, ICH
2021 Protective Effects of Hif2 Inhibitor PT-2385 on a Neurological Disorder Induced by Deficiency of Irp2. OXPHOS
2020 FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster. 2Fe2S, cryo-EM
2020 Iron overload induced by IRP2 gene knockout aggravates symptoms of Parkinson's disease. PD, SN
10  2020 Iron Regulatory Protein 2 Exerts its Oncogenic Activities by Suppressing TAp63 Expression. ---
11  2020 Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification. TfR1
12  2020 Mdm2 is a target and mediator of IRP2 in cell growth control. IRE
13  2020 Relieving ferroptosis may partially reverse neurodegeneration of the auditory cortex. CDs, d-gal, DFO, MDA, SOD, TfR1
14  2020 Transferrin receptor regulates malignancies and the stemness of hepatocellular carcinoma-derived cancer stem-like cells by affecting iron accumulation. CSCs, FPN, LIHC, ROS, TfR1
15  2019 Iron Dyshomeostasis Participated in Rat Hippocampus Toxicity Caused by Aluminum Chloride. Al, DMT1, FPN1, FTH
16  2019 Iron regulatory protein 2 is a suppressor of mutant p53 in tumorigenesis. ---
17  2019 Oxidative Stress Regulated Iron Regulatory Protein IRP2 Through FBXL5-Mediated Ubiquitination-Proteasome Way in SH-SY5Y Cells. DeltaPsim, FBXL5, ROS
18  2018 Perturbation of Iron Metabolism by Cisplatin through Inhibition of Iron Regulatory Protein 2. TfR1
19  2018 The role of transferrin receptor in the Helicobacter pylori pathogenesis; L-ferritin as a novel marker for intestinal metaplasia. CagA, FTL, TFRC, VacA
20  2018 [Mechanism of alpha-lipoic acid promoting iron efflux in substantia nigra cells of Parkinson's disease rats]. alpha-LA, FP1, PD, TH
21  2017 Activated Oncogenic Pathway Modifies Iron Network in Breast Epithelial Cells: A Dynamic Modeling Perspective. ---
22  2017 BRAF mutations are associated with increased iron regulatory protein-2 expression in colorectal tumorigenesis. LIP, TfR1
23  2017 Development of a complete human IgG monoclonal antibody to transferrin receptor 1 targeted for adult T-cell leukemia/lymphoma. ADCC, ATLL, FCM, Tf, TfR1
24  2017 Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells. HSCs
25  2017 FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells. mTOR, NSPCs
26  2017 Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2. FDXR
27  2017 Fumarate Mediates a Chronic Proliferative Signal in Fumarate Hydratase-Inactivated Cancer Cells by Increasing Transcription and Translation of Ferritin Genes. FH, HLRCC, TCA
28  2017 IRP2 as a potential modulator of cell proliferation, apoptosis and prognosis in nonsmall cell lung cancer. NSCLC, PBECs
29  2016 Circadian Clock in a Mouse Colon Tumor Regulates Intracellular Iron Levels to Promote Tumor Progression. BMAL1, CLOCK, Tfr1
30  2016 Hypobaric Hypoxia Regulates Brain Iron Homeostasis in Rats. DMT1, FPN1, IRP1, SD, TfR1
31  2016 Insights into the role of iron in immature rat model of hypoxic-ischemic brain injury. HI, HIBI, NC
32  2015 Possible involvement of iron-induced oxidative insults in neurodegeneration. Tg
33  2015 The role of iron in pulmonary pathology. ---
34  2014 F-box and leucine-rich repeat protein 5 (FBXL5): sensing intracellular iron and oxygen. FBXL5, Hr, ROS
35  2014 HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism. ---
36  2014 Hyperinsulinemia induces hepatic iron overload by increasing liver TFR1 via the PI3K/IRP2 pathway. DIOS, TfR1
37  2014 Regulatory effect of iron regulatory protein-2 on iron metabolism in lung cancer. ASODN, Fn, Tf, TfR
38  2013 Association of pro-inflammatory cytokines and iron regulatory protein 2 (IRP2) with Leishmania burden in canine visceral leishmaniasis. ---
39  2013 IRP2 regulates breast tumor growth. TfR1
40  2013 [Effects of different zinc nutritional status on iron metabolism in rats]. Fn, PF group, RT-PCR, TfR, ZE group
41  2012 F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis. FBXL5
42  2012 Genetic modification of iron metabolism in mice affects the gut microbiota. ---
43  2011 Iron regulatory protein 2 turnover through a nonproteasomal pathway. ---
44  2011 Redox control of iron regulatory protein 2 stability. IREs
45  2011 The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo. ---
46  2011 Vitamin A deficiency aggravates iron deficiency by upregulating the expression of iron regulatory protein-2. Fn, TfR
47  2011 [Regulating action of iron regulatory protein-2 in iron metabolism of lung cancer]. ASODN group, Fn, RT-PCR, Tf, TfR
48  2010 Tumorigenic properties of iron regulatory protein 2 (IRP2) mediated by its specific 73-amino acids insert. TfR1
49  2009 Control of iron homeostasis by an iron-regulated ubiquitin ligase. ---
50  2009 Cysteine oxidation regulates the RNA-binding activity of iron regulatory protein 2. ---
51  2008 Cell-autonomous and systemic context-dependent functions of iron regulatory protein 2 in mammalian iron metabolism. ---
52  2008 Iron-dependent degradation of IRP2 requires its C-terminal region and IRP structural integrity. ---
53  2008 Iron-dependent regulation of frataxin expression: implications for treatment of Friedreich ataxia. FA
54  2008 Iron-independent phosphorylation of iron regulatory protein 2 regulates ferritin during the cell cycle. IREs
55  2008 Neurons lacking iron regulatory protein-2 are highly resistant to the toxicity of hemoglobin. ---
56  2008 Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1. EpoR, TfR1
57  2007 Heme as a magnificent molecule with multiple missions: heme determines its own fate and governs cellular homeostasis. CP, HO, HRI
58  2007 HOIL-1 is not required for iron-mediated IRP2 degradation in HEK293 cells. aa, HEK293, HOIL-1, IREs
59  2007 Iron, copper, and iron regulatory protein 2 in Alzheimer's disease and related dementias. AD, GFAAS, NFT
60  2007 Sulfide increases labile iron pool in RD4 cells. LIP
61  2007 Zinc deficiency-induced iron accumulation, a consequence of alterations in iron regulatory protein-binding activity, iron transporters, and iron storage proteins. ---
62  2006 [Mechanism underlying ubiquitination of iron regulatory protein 2 (IRP2)]. ---
63  2005 Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2). TfR1
64  2005 Identification, expression, and assay of an oxidation-specific ubiquitin ligase, HOIL-1. ---
65  2005 Involvement of heme regulatory motif in heme-mediated ubiquitination and degradation of IRP2. HRM
66  2005 Loss of the von Hippel Lindau tumor suppressor disrupts iron homeostasis in renal carcinoma cells. HIF-1, LIP, VHL
67  2005 Neurochemical investigations of dopamine neuronal systems in iron-regulatory protein 2 (IRP-2) knockout mice. DA, DAT, TH
68  2005 Nitric oxide inhibits the degradation of IRP2. HA, NO, SNAP
69  2005 The pathway for IRP2 degradation involving 2-oxoglutarate-dependent oxygenase(s) does not require the E3 ubiquitin ligase activity of pVHL. ---
70  2004 Hereditary causes of disturbed iron homeostasis in the central nervous system. ---
71  2004 Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity. 73-aa, HIF-1 alpha
72  2003 Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2. ---
73  2003 MRI detection of ferritin iron overload and associated neuronal pathology in iron regulatory protein-2 knockout mice. ---
74  2003 Oxygen and iron regulation of iron regulatory protein 2. 2OG, DFO, DMOG, HIF-1 alpha
75  2003 S-nitrosylation of IRP2 regulates its stability via the ubiquitin-proteasome pathway. NO
76  2003 The role of endogenous heme synthesis and degradation domain cysteines in cellular iron-dependent degradation of IRP2. SNP, WT
77  2002 Lack of up-regulation of ferritin is associated with sustained iron regulatory protein-1 binding activity in the substantia nigra of patients with Parkinson's disease. IRP1
78  2002 Novel translational control through an iron-responsive element by interaction of multifunctional protein YB-1 and IRP2. UTR
79  2002 Numerous proteins in Mammalian cells are prone to iron-dependent oxidation and proteasomal degradation. ---
80  2002 Rare causes of hereditary iron overload. ---
81  2000 Mechanisms of differential transferrin receptor expression in normal hematopoiesis. EPO, HPCs, IRP, IRP1, TfR
82  1999 Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC. H-ferritin
83  1999 Stabilization of iron regulatory protein 2, IRP2, by aluminum. IREs
84  1998 Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: implications for degradation of oxidized proteins. ---
85  1996 The impact of oxidative stress on eukaryotic iron metabolism. IREs, IRP1
86  1995 Characterization and expression of iron regulatory protein 2 (IRP2). Presence of multiple IRP2 transcripts regulated by intracellular iron levels. IREs