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Abbreviation : ITSN1
Long Form : Intersectin 1
No. Year Title Co-occurring Abbreviation
2021 Endocytic protein intersectin1-S shuttles into nucleus to suppress the DNA replication in breast cancer. NDH II, NES
2020 Endothelial cell sprouting driven by RhoJ directly activated by a membrane-anchored Intersectin 1 (ITSN1) RhoGEF module. FAK, RhoGEFs
2020 ITSN1 regulates SAM68 solubility through SH3 domain interactions with SAM68 proline-rich motifs. PRMs, SH3A, SH3D
2020 Liquid Biopsy of Extracellular Vesicle-Derived miR-193a-5p in Colorectal Cancer and Discovery of Its Tumor-Suppressor Functions. AUC, CA, CRC, CUX1, EV, NC, RT-qPCR
2019 Alternative splicing-derived intersectin1-L and intersectin1-S exert opposite function in glioma progression. ---
2019 Intersectin 1 (ITSN1) identified by comprehensive bioinformatic analysis and experimental validation as a key candidate biological target in breast cancer. DEGs, PPI
2019 The Down Syndrome-Associated Protein, Regulator of Calcineurin-1, is Altered in Alzheimer's Disease and Dementia with Lewy Bodies. AD, AIBL, DLB, DS, RCAN1, WBCs
2018 Ubiquitin-ligase AIP4 controls differential ubiquitination and stability of isoforms of the scaffold protein ITSN1. ---
2017 Intersectin 1 is a component of the Reelin pathway to regulate neuronal migration and synaptic plasticity in the hippocampus. ApoER2, KO, LTP, VLDLR
10  2017 Perfluorooctanoic acid affects endocytosis involving clathrin light chain A and microRNA-133b-3p in mouse testes. ApoA1, BTB, CLTA, Eps8, PFOA, Serpina3k
11  2017 Silencing Intersectin 1 Slows Orthotopic Neuroblastoma Growth in Mice. PI3K
12  2017 VGLUT1 Binding to Endophilin or Intersectin1 and Dynamin Phosphorylation in a Diurnal Context. Enph, SV, VGLUT, ZT
13  2013 Cdc42 and the Rho GEF intersectin-1 collaborate with Nck to promote N-WASP-dependent actin polymerisation. GEF
14  2013 MicroRNA-194 (miR-194) regulates ROMK channel activity by targeting intersectin 1. HK, miR-194
15  2013 Receptor tyrosine kinase ubiquitylation involves the dynamic regulation of Cbl-Spry2 by intersectin 1 and the Shp2 tyrosine phosphatase. EGFR, RTKs
16  2012 A new dimension to Ras function: a novel role for nucleotide-free Ras in Class II phosphatidylinositol 3-kinase beta (PI3KC2beta) regulation. DN, RBD
17  2012 Endocytic adaptor protein intersectin 1 forms a complex with microtubule stabilizer STOP in neurons. STOP
18  2012 Intersectin 1 is required for neuroblastoma tumorigenesis. PI3K-C2beta
19  2012 The LMP2A protein of Epstein-Barr virus regulates phosphorylation of ITSN1 and Shb adaptors by tyrosine kinases. LMP2A
20  2011 Identification and characterization of a novel mammalian isoform of the endocytic adaptor ITSN1. CTD
21  2011 Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome. Hsa21
22  2011 Intersectin 1 enhances Cbl ubiquitylation of epidermal growth factor receptor through regulation of Sprouty2-Cbl interaction. EGFR, Spry2
23  2011 Intersectin1-s is involved in migration and invasion of human glioma cells. ---
24  2010 Intersectin 1 forms complexes with SGIP1 and Reps1 in clathrin-coated pits. ---
25  2009 Intersectin 1 forms a complex with adaptor protein Ruk/CIN85 in vivo independently of epidermal growth factor stimulation. ---
26  2009 Structural diversity and differential expression of novel human intersectin 1 isoforms. DH, ITSN1-s, PH, SH3
27  2008 Alternative splicing affecting the SH3A domain controls the binding properties of intersectin 1 in neurons. SH3A
28  2008 Mice deficient for the chromosome 21 ortholog Itsn1 exhibit vesicle-trafficking abnormalities. AD, DS
29  2008 SHIP2 associates with intersectin and recruits it to the plasma membrane in response to EGF. ITSN1-S, SHIP2
30  2006 Alzheimer's disease and endocytic dysfunction: clues from the Down syndrome-related proteins, DSCR1 and ITSN1. AD, DS, DSCR1
31  2006 MNB/DYRK1A phosphorylation regulates the interactions of synaptojanin 1 with endocytic accessory proteins. DS, SJ1
32  2004 Alternative splicing of mammalian Intersectin 1: domain associations and tissue specificities. ---
33  2000 Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis. ---