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Abbreviation : JNK
Long Form : Jun kinase
No. Year Title Co-occurring Abbreviation
2021 Alterations in mitochondrial biogenesis and respiratory activity, inflammation of the senescence-associated secretory phenotype, and lipolysis in the perirenal fat and liver of rats following lifelong exercise and detraining. HIF-1alpha, hs-CRP, NF-kappaB, p-Akt, p38 MAPK, SASP
2021 β2M Signals Monocytes Through Non-Canonical TGFβ Receptor Signal Transduction. ---
2020 EI24 alleviates renal interstitial fibrosis through inhibition of epithelial-mesenchymal transition and fibroblast activation. NF-kappaB, RIF, UUO
2020 Endoplasmic Reticulum Stress (ER Stress) and Unfolded Protein Response (UPR) Occur in a Rat Varicocele Testis Model. ER, ER Stress, IRE1, UPR, VCL
2020 Fatty acid β-oxidation is required for the differentiation of larval hematopoietic progenitors in Drosophila. FAO
2020 Interleukin-17 Reduces βENaC via MAPK Signaling in Vascular Smooth Muscle Cells. betaENaC, IL-17, MAPK, NF-kappaB, VSMC
2020 Loss of the spectraplakin gene Short stop induces a DNA damage response in Drosophila epithelia. ASK1, DSB, Shot
2020 Mud Loss Restricts Yki-Dependent Hyperplasia in Drosophila Epithelia. BM, ECM, Mud
2020 Tumor necrosis factor-α impairs cerebral blood flow in pregnant rats: role of vascular β-epithelial Na+ channel. betaENaC, CBF, TNF-alpha
10  2019 FBXW5 reduction alleviates spinal cord injury (SCI) by blocking microglia activity: A mechanism involving p38 and JNK. ERK, FBXW5, IL, SCI, TNF-alpha
11  2019 Quantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell death. Akt, Cdk5, CK2, GSK-3, iGluRs, MEK, Rock, SGK1
12  2019 Somatic support cells regulate germ cell survival through the Baz/aPKC/Par6 complex. ---
13  2019 Stanniocalcin-1 mediates negative regulatory action of epidermal layer on expression of matrix-related genes in dermal fibroblasts. MMP-1, STC1
14  2018 Inhibition of autophagy promoted high glucose/ROS-mediated apoptosis in ADSCs. 3-MA, ADSCs, ROS
15  2018 miR-5591-5p regulates the effect of ADSCs in repairing diabetic wound via targeting AGEs/AGER/JNK signaling axis. ADSCs, miRNAs, ROS
16  2018 Shotgun Proteomics and Quantitative Pathway Analysis of the Mechanisms of Action of Dehydroeffusol, a Bioactive Phytochemical with Anticancer Activity from Juncus effusus. ATF2, DHE
17  2017 A Kinome RNAi Screen in Drosophila Identifies Novel Genes Interacting with Lgl, aPKC, and Crb Cell Polarity Genes in Epithelial Tissues. PI3K, SIK2 and 3
18  2017 A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice. HD, muHtt, NTR
19  2017 Lemur Tyrosine Kinase-3 Suppresses Growth of Prostate Cancer Via the AKT and MAPK Signaling Pathways. LMTK, RTK
20  2017 TMEFF2 shedding is regulated by oxidative stress and mediated by ADAMs and transmembrane serine proteases implicated in prostate cancer. FS, TTSPs
21  2016 CXCL13 inhibits microRNA-23a through PI3K/AKT signaling pathway in adipose tissue derived-mesenchymal stem cells. AMSCs, PI3K, SAPK
22  2016 Inactivation of CYLD in intestinal epithelial cells exacerbates colitis-associated colorectal carcinogenesis - a short report. IEC, NF-kappaB
23  2016 Mapping signaling pathway cross-talk in Drosophila cells. BMP, EGFR
24  2016 Two different specific JNK activators are required to trigger apoptosis or compensatory proliferation in response to Rbf1 in Drosophila. JNKK, JNKKK
25  2015 Activated p38 MAPK in Peripheral Blood Monocytes of Steroid Resistant Asthmatics. ERK, MSK1, PBMC
26  2015 Apelin-13 upregulates Egr-1 expression in rat vascular smooth muscle cells through the PI3K/Akt and PKC signaling pathways. Egr-1, ERK, MAPK, OPN, PI3K, PKC, PTX, VSMCs
27  2015 Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM. MAPK, TMZ
28  2015 NMDA Receptors and Oxidative Stress Induced by the Major Metabolites Accumulating in HMG Lyase Deficiency Mediate Hypophosphorylation of Cytoskeletal Proteins in Brain From Adolescent Rats: Potential Mechanisms Contributing to the Neuropathology of This Disease. GFAP, HMG, HMG lyase, MGA, MGT, PKA
29  2015 Oxidation resistance 1 (OXR1) participates in silkworm defense against bacterial infection through the JNK pathway. OXR1, ROS
30  2015 Widespread JNK-dependent alternative splicing induces a positive feedback loop through CELF2-mediated regulation of MKK7 during T-cell activation. MKK7
31  2014 All-trans retinoic acid induces cell-cycle arrest in human cutaneous squamous carcinoma cells by inhibiting the mitogen-activated protein kinase-activated protein 1 pathway. AP, ATRA, CDK, cSCC, ERK, MAPK, MTT
32  2014 Domain specificity of MAP3K family members, MLK and Tak1, for JNK signaling in Drosophila. ---
33  2014 Inhibition of basal JNK activity by small interfering RNAs enhances cisplatin sensitivity and decreases DNA repair in T98G glioblastoma cells. JNKs, siRNAs
34  2013 Identification of small molecule inhibitors of RANKL and TNF signalling as anti-inflammatory and antiresorptive agents in mice. ERK, MAPKs, NF, TNF
35  2013 In Drosophila, RhoGEF2 cooperates with activated Ras in tumorigenesis through a pathway involving Rho1-Rok-Myosin-II and JNK signalling. ACT, ACT, ACT, F-actin, ROK, TNF
36  2013 Isoquercetin protects cortical neurons from oxygen-glucose deprivation-reperfusion induced injury via suppression of TLR4-NF-кB signal pathway. ERK, I/R, LDH, NF-kappaB, OGD/R, TLR4
37  2013 Mechanisms of palmitate-induced cell death in human osteoblasts. ---
38  2013 Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events. AbetaO, AD, CCEs, TNF-alpha
39  2013 Modulation of the response of prostate cancer cell lines to cisplatin treatment using small interfering RNA. RT-PCR, siRNA
40  2013 Telomere-homologous G-rich oligonucleotides sensitize human ovarian cancer cells to TRAIL-induced growth inhibition and apoptosis. FLIPs, TRAIL
41  2013 The BTB-zinc finger transcription factor abrupt acts as an epithelial oncogene in Drosophila melanogaster through maintaining a progenitor-like cell state. ---
42  2013 Vasoconstriction induced by G1, a G-protein-coupled oestrogen receptor1 (GPER-1) agonist, in the isolated perfused rat kidney. EGF, GPER1, PI3K, PKC
43  2012 ADAP regulates cell cycle progression of T cells via control of cyclin E and Cdk2 expression through two distinct CARMA1-dependent signaling pathways. ADAP, CDK2, MAP, PKCtheta, TAK1
44  2012 Antibody Microarray Analysis of Signaling Networks Regulated by Cxcl13 and Cxcr5 in Prostate Cancer. CDKN1B, Fak, MMP, PCa, PI3K, PXN, SAPK
45  2012 Characterization of a novel activated Ran GTPase mutant and its ability to induce cellular transformation. ERK, SMOC-2
46  2012 Drosophila heat shock response requires the JNK pathway and phosphorylation of mixed lineage kinase at a conserved serine-proline motif. SAPK
47  2012 Endoplasmic reticulum stress contributes to CRH-induced hippocampal neuron apoptosis. ASK1, CHOP, CRH, CRHR1, ER, GRP78, HPA, IRE1
48  2012 Genetic dissection of neurotrophin signaling through the p75 neurotrophin receptor. DD, TNFRSF
49  2012 Growth cone MKK7 mRNA targeting regulates MAP1b-dependent microtubule bundling to control neurite elongation. DLK, MAPKK, MKK7
50  2012 Hippocampal proNGF signaling pathways and β-amyloid levels in mild cognitive impairment and Alzheimer disease. AD, MCI, proNGF
51  2012 NADPH oxidase 4 is required for interleukin-1β-mediated activation of protein kinase Cδ and downstream activation of c-jun N-terminal kinase signaling in smooth muscle. NOX, ROS, VSM
52  2012 Oxidative stress and autophagy: mediators of synapse growth? LSD, ROS
53  2012 Retinopathy of prematurity promising newer modalities of treatment. anti-VEGF, G-CSF, IGF, ROP
54  2012 TAT-apoptosis repressor with caspase recruitment domain protein transduction rescues mice from fulminant liver failure. ALF, ARC, CARD, Con A, HIV-1, TNF
55  2011 Disruption of planar cell polarity activity leads to developmental biliary defects. PCP, pk1a
56  2011 Evidence that membrane-bound G protein-coupled melatonin receptors MT1 and MT2 are not involved in the neuroprotective effects of melatonin in focal cerebral ischemia. iNOS, WT
57  2011 Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: a RhoGEF/Rho-family/JNK pathway is a central driver of tumorigenesis. ACT, ACT
58  2011 Multiple ways to die: delineation of the unfolded protein response and apoptosis induced by Surfactant Protein C BRICHOS mutants. SP-C, UPR
59  2011 Role of TRAIL and the pro-apoptotic Bcl-2 homolog Bim in acetaminophen-induced liver damage. TRAIL
60  2011 Solidago chilensis Meyen hydroalcoholic extract reduces JNK/IkappaB pathway activation and ameliorates insulin resistance in diet-induced obesity mice. HFD, PEPCK, Sc
61  2010 Endothelin-1 is elevated in Alzheimer's disease brain microvessels and is neuroprotective. AD, ET-1
62  2010 Lgl, the SWH pathway and tumorigenesis: It's a matter of context & competition! aPKC, SWH
63  2010 Stereoselective effects of 4-hydroxynonenal in cultured mouse hepatocytes. FAK, GCL, HNE
64  2010 Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: role of reactive oxygen species. AR, NAC, ROS, TQ
65  2010 The Anopheles gambiae oxidation resistance 1 (OXR1) gene regulates expression of enzymes that detoxify reactive oxygen species. CAT, GPx, OXR1, ROS
66  2009 Paraquat activates the IRE1/ASK1/JNK cascade associated with apoptosis in human neuroblastoma SH-SY5Y cells. ASK1, CHOP, EDEM, ER, GRP78, IRE1, PD
67  2009 POSH misexpression induces caspase-dependent cell death in Drosophila. MLK
68  2009 Signal transduction pathways involved in drug-induced liver injury. DILI, TNF
69  2008 Differential activation of mitogen-activated protein kinase signalling pathways in the hippocampus of CRND8 transgenic mouse, a model of Alzheimer's disease. ERK, MAPK, TgCRND8, WT
70  2008 Mechanism of synergy of N-(4-hydroxyphenyl)retinamide and ABT-737 in acute lymphoblastic leukemia cell lines: Mcl-1 inactivation. 4-HPR, ALL, CIn, Mcl-1, ROS, siRNA
71  2008 Role of the RUNX1-EVI1 fusion gene in leukemogenesis. CNS
72  2008 TLR7 and CD40 cooperate in IL-6 production via enhanced JNK and AP-1 activation. ---
73  2007 AP1- and NF-kappaB-binding sites conserved among mammalian WNT10B orthologs elucidate the TNFalpha-WNT10B signaling loop implicated in carcinogenesis and adipogenesis. IKK
74  2007 The tyrosine kinase sf-Stk and its downstream signals are required for maintenance of friend spleen focus-forming virus-induced fibroblast transformation. EpoR, MAPK, PI3K, sf-Stk, SFFV
75  2006 AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70. HSP70, p75NTR
76  2006 Bortezomib (Velcade)--a new therapeutic strategy for patients with refractory multiple myeloma. ---
77  2006 Differential effects of IRS1 phosphorylated on Ser307 or Ser632 in the induction of insulin resistance by oxidative stress. IKKbeta, PI3K
78  2006 DNA damage-induced cell death by apoptosis. ATM, DSBs
79  2006 Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1. ERK
80  2006 Sharp boundaries of Dpp signalling trigger local cell death required for Drosophila leg morphogenesis. Dpp, TGF-beta
81  2006 Soluble factors from LPS- and PHA-activated PBMC induce MAPK, Stat1 and Stat3 phosphorylation in primary cultures of human term placental trophoblasts: implications for infection and prematurity. MAPK, PBMC
82  2006 The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. TNF
83  2005 Antimony trioxide-induced apoptosis is dependent on SEK1/JNK signaling. APL, ROS
84  2005 Dissecting JNK signaling, one KKKinase at a time. JNKKK
85  2005 Fasudil hydrochloride hydrate, a Rho-kinase (ROCK) inhibitor, suppresses collagen production and enhances collagenase activity in hepatic stellate cells. alpha-SMA, HSCs, MAPKs, MMP-1, TIMP-1
86  2005 Protective effects of Ginkgo biloba extract on the ethanol-induced gastric ulcer in rats. GBE, MDA, NP-SH
87  2005 Tau phosphorylation increases in symptomatic mice overexpressing A30P alpha-synuclein. PD
88  2004 Activation of activator protein-1 DNA binding activity due to low level manganese exposure in pheochromocytoma cells. AP-1, EMSA, MAPK, NF-kappaB
89  2004 AgC10, a mucin from Trypanosoma cruzi, destabilizes TNF and cyclooxygenase-2 mRNA by inhibiting mitogen-activated protein kinase p38. COX-2, ERK, iNOS, MAPK
90  2004 Inflammatory cytokines and fatty acids regulate endothelial cell heparanase expression. IL-1beta, LDL, NF-kappaB, TNF-alpha, VEGF
91  2004 Inhibition of phosphatidylinostol 3-kinase uncouples H2O2-induced senescent phenotype and cell cycle arrest in normal human diploid fibroblasts. HDFs, MAPK, PI 3-kinase, Rb, SA-beta-gal
92  2004 Insulin-like growth factor-I plays a pathogenetic role in diabetic retinopathy. IGF, NF, PI3K, VEGF
93  2004 MAPK and JNK transduction pathways can phosphorylate Sp1 to activate the uPA minimal promoter element and endogenous gene transcription. MAPK, MP, SAPK, uPA
94  2004 Regulation of the membrane-localized prostaglandin E synthases mPGES-1 and mPGES-2 in cardiac myocytes and fibroblasts. COX, VM
95  2004 RIP kinase is involved in arsenic-induced apoptosis in multiple myeloma cells. RIP
96  2004 Signal transduction pathways involved in melatonin-induced neuroprotection after focal cerebral ischemia in mice. ERK, sham
97  2004 Sphingomyelinase of Helicobacter pylori-induced cytotoxicity in AGS gastric epithelial cells via activation of JNK kinase. ERK, MAP, SMase
98  2004 Two discrete events, human T-cell leukemia virus type I Tax oncoprotein expression and a separate stress stimulus, are required for induction of apoptosis in T-cells. Cd, SAPK, Zn
99  2003 Apoptosis induced by p75NTR overexpression requires Jun kinase-dependent phosphorylation of Bad. p75NTR
100  2003 Crocin prevents the death of PC-12 cells through sphingomyelinase-ceramide signaling by increasing glutathione synthesis. gamma-GCS, nSMase