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Abbreviation : JNK
Long Form : c-Jun N-terminal kinase
No. Year Title Co-occurring Abbreviation
2021 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) Urea Exerts Neuro-Protective Effects Against Ischemic Injury via Suppressing JNK/p38 MAPK-Mediated Mitochondrial Apoptosis Pathway. MAPK, MRCC, OGD/R, TPPU
2021 17-β Estradiol Rescued Immature Rat Brain against Glutamate-Induced Oxidative Stress and Neurodegeneration via Regulating Nrf2/HO-1 and MAP-Kinase Signaling Pathway. ---
2021 2,5-Hexanedione induced apoptosis in rat spinal cord neurons and VSC4.1 cells via the proNGF/p75NTR and JNK pathways. Bax, Bcl-2, HD, mNGF, p75NTR, proNGF, SD
2021 7,8-Dihydroxyflavone suppresses proliferation and induces apoptosis of human osteosarcoma cells. 7,8-DHF, Bad, ERK, MAPK, MTT, OS, TdT
2021 A carbazole compound, 9-ethyl-9H-carbazole-3-carbaldehyde, plays an antitumor function through reactivation of the p53 pathway in human melanoma cells. ECCA
2021 A chinese herbal formula ameliorates COPD by inhibiting the inflammatory response via downregulation of p65, JNK, and p38. BYF, COPD, FVC, IL-6, KAM, KAM-BYF, MMP-9, NF-kappaB, TCM, TNF-alpha
2021 A new synthetic antitumor naphthoquinone induces ROS-mediated apoptosis with activation of the JNK and p38 signaling pathways. MAPKs
2021 A novel injury paradigm in the central nervous system of adult Drosophila: molecular, cellular and functional aspects. CNS, Drpr
2021 A novel JNK induces innate immune response by activating the expression of antimicrobial peptides in Chinese mitten crab Eriocheir sinensis. AMPs, MAPKs, ORF, S_TKc
10  2021 A phase I study of the anaplastic lymphoma kinase inhibitor ceritinib in combination with gemcitabine-based chemotherapy in patients with advanced solid tumors. DLT, MTD
11  2021 Abnormal Mitochondria-Endoplasmic Reticulum Communication Promotes Myocardial Infarction. BAP31, Fis1, mtROS
12  2021 Acetate stimulates lipogenesis via AMPKα signaling in rabbit adipose-derived stem cells. ADSCs, AMPK, ERK, MAPKs
13  2021 Activation of the extracellular-signal-regulated kinase (ERK)/c-Jun N-terminal kinase (JNK) signal pathway and osteogenic factors in subchondral bone of patients with knee osteoarthritis. ERK, OA, OCN, OMD, p-ERK, p-JNK
14  2021 Active elimination of intestinal cells drives oncogenic growth in organoids. ---
15  2021 Adipocyte Fatty Acid Binding Protein Promotes the Onset and Progression of Liver Fibrosis via Mediating the Crosstalk between Liver Sinusoidal Endothelial Cells and Hepatic Stellate Cells. A-FABP, BDL, HSC, LSECs, TGF-beta1
16  2021 Adipocyte Fatty Acid-Binding Protein, Cardiovascular Diseases and Mortality. A-FABP, AP-1, CVD
17  2021 Adiponectin receptor agonist AdipoRon ameliorates renal inflammation in diet-induced obese mice and endotoxin-treated human glomeruli ex vivo. HFD, LPS, p38 MAPK
18  2021 Adipose Tissue SIRT1 Regulates Insulin Sensitizing and Anti-Inflammatory Effects of Berberine. AMPK, BBR
19  2021 Advanced Oxidation Protein Products Induce G1/G0-Phase Arrest in Ovarian Granulosa Cells via the ROS-JNK/p38 MAPK-p21 Pathway in Premature Ovarian Insufficiency. AOPPs, MAPK, NAC, POI, ROS, SD
20  2021 All-Trans Retinoic Acid Attenuates Blue Light-Induced Apoptosis of Retinal Photoreceptors by Upregulating MKP-1 Expression. BCI, MKP-1, ONL, RA, RAR
21  2021 Alleviation of LPS-Induced Inflammation and Septic Shock by Lactiplantibacillus plantarum K8 Lysates. AIM2, AST, ERK, IL, LPS, MAPK, NF-kappaB, TLR, TNF
22  2021 Alpinia oxyphylla Miq extract reduces cerebral infarction by downregulating JNK-mediated TLR4/T3JAM- and ASK1-related inflammatory signaling in the acute phase of transient focal cerebral ischemia in rats. GFAP, I/R, Iba1, MCAO, NF-kappaB, pASK1, T3JAM, TLR4, TRAF3, YZR, YZR-0.2g
23  2021 Analysis of differentially expressed genes responsible for the suppressive effect of anisomycin on cell proliferation of DLD-1 cells. DEGs
24  2021 Anti-Inflammatory Activity and Mechanism of Isookanin, Isolated by Bioassay-Guided Fractionation from Bidens pilosa L. AP-1, COX-2, IL-1beta, IL-6, IL-8, iNOS, LPS, MAPK
25  2021 Anti-Inflammatory and Anti-Oxidant Effects of Korean Ginseng Berry Extract in LPS-Activated RAW264.7 Macrophages. CAT, COX-2, GSH-Px, IL, iNOS, KGB, LPS, MAPKs, NO, ROS, SOD
26  2021 Anti-inflammatory effect of Ailanthus altissima (Mill.) Swingle leaves in lipopolysaccharide-stimulated astrocytes. AAE, CNS, COX-2, ERK, iNOS, LPS, MAPK, NF-kappaB, NO
27  2021 Anti-inflammatory effect of phenylpropanoids from Dendropanax dentiger in TNF-α-induced MH7A cells via inhibition of NF-κB, Akt and JNK signaling pathways. IFN-gamma, IkBalpha, IL, NF-kappaB, NO, RA, TNF
28  2021 Anti-Metastatic and Anti-Inflammatory Effects of Matrix Metalloproteinase Inhibition by Ginsenosides. ECM, ERK, MAPKs, MMPs
29  2021 Anti-photoaging activities of Sorbaria kirilowii ethanol extract in UVB-damaged cells. AP, COL1A1, COX, ERK, FLG, HAS, MMPs
30  2021 Apocynin attenuates diabetic cardiomyopathy by suppressing ASK1-p38/JNK signaling. APO, ASK1, CFs, CON, DCM, NRCMs
31  2021 Apoptosis Inducing Activity of Rhinacanthin-C in Doxorubicin-Resistant Breast Cancer MCF-7 Cells. DCFH-DA, HO-1, MAPK, NADP, PARP, ROS
32  2021 Apoptotic effects of dehydrocrenatidine via JNK and ERK pathway regulation in oral squamous cell carcinoma. ERK, MAPK
33  2021 Artemisia annua L. Polyphenol-Induced Cell Death Is ROS-Independently Enhanced by Inhibition of JNK in HCT116 Colorectal Cancer Cells. AO, DCF, GM130, LC3B, PI, ROS, SSC-H
34  2021 Astaxanthin Inhibits Autophagic Cell Death Induced by Bisphenol A in Human Dermal Fibroblasts. BPA, ERK, MAPK, NF-kappaB, NHDF, ROS
35  2021 Astragalus membranaceus Injection Protects Retinal Ganglion Cells by Regulating the Nerve Growth Factor Signaling Pathway in Experimental Rat Traumatic Optic Neuropathy. A. mem, ML, NF-kappaB, NGF, ON, p75NTR, RGC, TON, TrkA
36  2021 Astrocytic c-Jun N-terminal kinase-histone deacetylase-2 cascade contributes to glutamate transporter-1 decrease and mechanical allodynia following peripheral nerve injury in rats. GLT-1, HDACs, SNL, TNF-alpha
37  2021 ATP Facilitates Staphylococcal Enterotoxin O Induced Neutrophil IL-1β Secretion via NLRP3 Inflammasome Dependent Pathways. IL-1beta, NF-kappaB, S. aureus, SEO, TLR4
38  2021 Attenuation of diethyl nitrosamine-induced hepatocellular carcinoma by taxifolin and/or alogliptin: The interplay between toll-like receptor 4, transforming growth factor beta-1, and apoptosis. AFP, AFU, HCC, IL-1alpha, MDA, TGF-beta1, TLR4
39  2021 Avenanthramide C as a novel candidate to alleviate osteoarthritic pathogenesis. Avn, DMM, IL-1beta, MMPs, OA
40  2021 Betulinic Acid Alleviates Spleen Oxidative Damage Induced by Acute Intraperitoneal Exposure to T-2 Toxin by Activating Nrf2 and Inhibiting MAPK Signaling Pathways. BA, ECH, ERK, HO-1, MAPK, MDA, NF-E2, ROS, SOD, T-AOC, TC, TG
41  2021 Biological Activity of a Thiobarbituric Acid Compound in Neuroblastomas. CC-I, HSP27
42  2021 Bromamine T (BAT) Exerts Stronger Anti-Cancer Properties than Taurine (Tau). BAT, ERK, MAPK, Tau
43  2021 Butylphthalide inhibits nerve cell apoptosis in cerebral infarction rats via the JNK/p38 MAPK signaling pathway. MAPK
44  2021 c-Jun Amino Terminal Kinase Signaling Promotes Aristolochic Acid-Induced Acute Kidney Injury. AA
45  2021 C-Jun N-terminal kinase (JNK) pathway activation is essential for dental papilla cells polarization. mDPCs
46  2021 C-Jun N-terminal kinase post-translational regulation of pain-related Acid-Sensing Ion Channels 1b and 3. ASICs, ASICs, MAPKs
47  2021 c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1 (JSAP1) attenuates curcumin-induced cell death differently from its family member, JNK-associated leucine zipper protein (JLP). JLP, JSAP1, MAPK
48  2021 C-terminal-truncated hepatitis B virus X protein promotes hepatocarcinogenesis by activating the MAPK pathway. CCK-8, Cdc25C, ctHBx, ERK, HBV, HCC, MAPK, WB
49  2021 Ca mobilization and signaling pathways induced by rRgpB in human gingival fibroblast. ERK, HGF, p38 MAPK, PAR
50  2021 Cadmium exposure induces mitochondrial pathway apoptosis in swine myocardium through xenobiotic receptors-mediated CYP450s activation. Cd, CYP450s, ERK, MAPK, ROS
51  2021 Camellia japonica diminishes acetaminophen-induced acute liver failure by attenuating oxidative stress in mice. 4-HNE, ALF, AMPK, CJ, COX-2, MDA, NF-kappaB
52  2021 Can the interplay between autophagy and apoptosis be targeted as a novel therapy for Parkinson's disease? PD
53  2021 CASK Silence Overcomes Sorafenib Resistance of Hepatocellular Carcinoma Through Activating Apoptosis and Autophagic Cell Death. 3-MA, HCC, siRNA
54  2021 CD36 deficiency ameliorates drug-induced acute liver injury in mice. AKT, CYP2E1, DAMP, Erk, HMGB1, PCR
55  2021 CDKN2A deregulation in fatty liver disease and its accelerative role in the process of lipogenesis. CDKN2A, PIAS1, PRMT1
56  2021 Celecoxib enhances apoptosis of the liver cancer cells via regulating ERK/JNK/P38 pathway. caspase 3, ERK, HE, mRNAs, qPCR
57  2021 Chemotherapy-induced cognitive impairment: focus on the intersection of oxidative stress and TNFα. CICI, JAK/STAT, ROS, TNF-alpha
58  2021 Chlorpyrifos caused necroptosis via MAPK/NF-κB/TNF-α pathway in common carp (Cyprinus carpio L.) gills. CPF
59  2021 Chronic Wound Healing by Amniotic Membrane: TGF-β and EGF Signaling Modulation in Re-epithelialization. AM, EGF, MAP, TGF
60  2021 Chrysin Inhibits TNFα-Induced TSLP Expression through Downregulation of EGR1 Expression in Keratinocytes. AD, ERK, TNF-alpha, TSLP
61  2021 Ciclopirox and bortezomib synergistically inhibits glioblastoma multiforme growth via simultaneously enhancing JNK/p38 MAPK and NF-κB signaling. BTZ, CPX, GBM, MAPK, NF-kappaB, OXPHOS, ROS
62  2021 Cigarette smoke extract promotes DNA methyltransferase 3a expression in dendritic cells, inducing Th-17/Treg imbalance via the c-Jun/allograft inflammatory factor 1 axis. AIF1, ChIP, COPD, CSE, DCs, DNMT3A, iDCs
63  2021 Combination of Melatonin and Small Molecules Improved Reprogramming Neural Cell Fates via Autophagy Activation. ASCL1, BRN2, GSK-3, HDAC, LC3, MYT1L, NeuN, NSC, SOX2, VPA
64  2021 Compensatory combination of mTOR and TrxR inhibitors to cause oxidative stress and regression of tumors. AF, ER, mTOR, TrxR
65  2021 Conophylline Suppresses Angiotensin II-Induced Myocardial Fibrosis In Vitro via the BMP4/JNK Pathway. alpha-SMA, BMP4
66  2021 Constitutive immune activity promotes JNK- and FoxO-dependent remodeling of Drosophila airways. COPD, NF-kappaB
67  2021 Contributions of Sodium-Hydrogen Exchanger 1 and Mitogen-Activated Protein Kinases to Enhanced Retinal Venular Constriction to Endothelin-1 in Diabetes. ERK, ET-1, MAPKs, PKC
68  2021 Crizotinib and Doxorubicin Cooperatively Reduces Drug Resistance by Mitigating MDR1 to Increase Hepatocellular Carcinoma Cells Death. DOX, HCC, MDR1, PERK
69  2021 Cudrania tricuspidata Root Extract Prevents Methylglyoxal-Induced Inflammation and Oxidative Stress via Regulation of the PKC-NOX4 Pathway in Human Kidney Cells. CT, CTRE, ERK, MAPK, MGO, NF-kappaB, NOX4, PKC, ROS
70  2021 Curcumin attenuates renal ischemia reperfusion injury via JNK pathway with the involvement of p300/CBP-mediated histone acetylation. CBP, HATs, IRI
71  2021 Darbepoetin alfa reduces cell death due to radiocontrast media in human renal proximal tubular cells. ESA, PARP, RCM
72  2021 Deactivation of the JNK Pathway by GSTP1 Is Essential to Maintain Sperm Functionality. CASA, GSTs
73  2021 Dexmedetomidine attenuates cerebral ischemia-reperfusion injury in rats by inhibiting the JNK pathway. CI/RI, DEX, I/R, IF, SD, TTC, WB, YOH
74  2021 Di-(2-ethylhexyl) phthalate-induced hepatotoxicity exacerbated type 2 diabetes mellitus (T2DM) in female pubertal T2DM mice. DEHP, P-T2DM, T2DM
75  2021 Dietary n-3 PUFA Deficiency Increases Vulnerability to Scopolamine-Induced Cognitive Impairment in Male C57BL/6 Mice. ALA, Bcl-2
76  2021 Distinct Group B Streptococcus Sequence and Capsule Types Differentially Impact Macrophage Stress and Inflammatory Signaling Responses. CPS, GBS, STs
77  2021 Does oxidatively damaged DNA drive amyloid-β generation in Alzheimer's disease? A hypothesis. AD, AIM2, BACE1, LPS, MAP4K4, MyD88, NF-kappaB, Nrf2, PKR
78  2021 Downregulation of Snail by DUSP1 Impairs Cell Migration and Invasion through the Inactivation of JNK and ERK and Is Useful as a Predictive Factor in the Prognosis of Prostate Cancer. DUSP1, ERK, MAPKs, PC
79  2021 Dpp and Hedgehog promote the glial response to neuronal apoptosis in the developing Drosophila visual system. Dpp, Hh, PNS
80  2021 Drosophila to Explore Nucleolar Stress. CBs, DCP1, MB, ME31B, NBs, Nopp140, RBF, TCS
81  2021 Drug-induced liver injury: Oltipraz and C2-ceramide intervene HNF-1α/GSTA1 expression via JNK signaling pathway. DILI, GSTA1, HNF-1alpha
82  2021 DUSP12 acts as a novel endogenous protective signal against hepatic ischemia-reperfusion damage by inhibiting ASK1 pathway. ASK1, DUSP12, IR, IRI, MAPK
83  2021 Effect of dapagliflozin and/or L-arginine on solid tumor model in mice: The interaction between nitric oxide, transforming growth factor-beta 1, autophagy, and apoptosis. IL-1alpha, SEC, TGF-beta1
84  2021 Effect of Doxofylline on Reducing the Inflammatory Response in Mechanically Ventilated Rats with Chronic Obstructive Pulmonary Disease. COPD, IL-10, p-JNK, TNF-alpha
85  2021 Effect of endoplasmic reticulum stress-induced apoptosis in the role of periodontitis on vascular calcification in a rat model. Caspase-3, CHOP, ERS, GRP78
86  2021 Effect of L-thyroxine administration on long-term potentiation and accompanying mitogen-activated protein kinases in rats. EPSP, LTP, p38 MAPK, PS
87  2021 Effect of maternal overnutrition on predisposition to insulin resistance in the foal: Foal skeletal muscle development and insulin signaling. BCS, GLUT4, IGF1R, INSR-A, INSR-B
88  2021 Effect of taxifolin/dapagliflozin combination on colistin-induced nephrotoxicity in rats. CMC, NF-kappaB, NGF-beta, STAT3, TGF-beta1, TLR4
89  2021 Effect of zymosan on the expression and function of the gap-junction protein connexin 43 in human corneal fibroblasts. Cx43, ERK, GJIC, HCFs, IKK2, MAPK, NF-kappaB, qRT-PCR
90  2021 Effects of chitinase-3-like protein 1 on brain death-induced hepatocyte apoptosis via PAR2-JNK-caspase-3. BD, CHI3L1, PAR2
91  2021 Effects of decreased Rac activity and malignant state on oral squamous cell carcinoma in vitro. ---
92  2021 Effects of ML351 and tissue plasminogen activator combination therapy in a rat model of focal embolic stroke. CD68, HT, IgG, tPA
93  2021 Effects of SP600125 and hypothermic machine perfusion on livers donated after cardiac death in a pig allograft transplantation model. CS 4h, DCD, HMP, IRI
94  2021 Efficacy of Cigu Xiaozhi pill on non-alcoholic steatohepatitis-associated lipoapoptosis through stress-activated c-Jun N-terminal kinase signalling pathway. NASH
95  2021 Electroacupuncture inhibits IL-17/IL-17R and post-receptor MAPK signaling pathways in a rat model of chronic obstructive pulmonary disease. BALF, COPD, EA, ELISA, ERK, IL, IL-17R, MAPK, PCR, Th17, TNF
96  2021 Electroacupuncture stimulation at Yanglingquan acupoint ameliorates hepatic ischemia-reperfusion injury by down-regulating ET-1 to inhibit TAK1-JNK/p38 pathway. AST, EA, ET-1, HIRI, IL, MPO, TAK1, TNF-alpha
97  2021 Emetine exerts anticancer effects in U2OS human osteosarcoma cells via activation of p38 and inhibition of ERK, JNK, and β-catenin signaling pathways. ERK, MMP-2, OS
98  2021 Endoplasmic Reticulum Stress Contributes to Gefitinib-Induced Apoptosis in Glioma. ASK1, ATF6, EGFR, ER, IRE1, PKR, ROS, TNF, UPR
99  2021 Epigallocatechin-3-Gallate Suppresses the Expression of TNF-α-Induced MMP-1 via MAPK/ERK Signaling Pathways in Human Dermal Fibroblasts. EGCG, ERK, MEK, MMP-1, ROS, TNF-alpha
100  2021 ErbB4 mediates amyloid β-induced neurotoxicity through JNK/tau pathway activation: Implications for Alzheimer's disease. AD, DG, NRG1, PV