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Abbreviation : KKS
Long Form : kallikrein-kinin system
No. Year Title Co-occurring Abbreviation
2021 A modular map of Bradykinin-mediated inflammatory signaling network. B2R, GPCR
2021 Angiotensin-Converting Enzyme 2 in the Pathogenesis of Renal Abnormalities Observed in COVID-19 Patients. AKI, Ang, COVID-19, KRT, RAS, SARS-CoV-2
2021 Association of Ang-(1-7) and des-Arg9BK as new biomarkers of obesity and cardiometabolic risk factors in adolescents. BK, MO, NW, OB, OW, RAS, WHR
2021 Contact System Activation in Plasma from Dengue Patients Might Harness Endothelial Virus Replication through the Signaling of Bradykinin Receptors. DENV, HBMECs, HK, PKa, ZIKV
2021 Identification of Human Kinin-Forming Enzyme Inhibitors from Medicinal Herbs. ACEI, BK, FXIIa, HK
2021 Intermittent hypoxia changes the interaction of the kinin-VEGF system and impairs myocardial angiogenesis in the hypertrophic heart. IH, OSA, VEGF
2021 Kinins and Their Receptors as Potential Therapeutic Targets in Retinal Pathologies. AMD, B1R, DR, RAS
2021 Myocardial angiogenesis induced by exercise training involves a regulatory mechanism mediated by kinin receptors. B1Ant, B2Ant, EC
2021 Obesity and COVID-19: the ominous duet affecting the renin-angiotensin system. ACE2, ACEi, RAAS
10  2021 Role of ACE2 in pregnancy and potential implications for COVID-19 susceptibility. ACE, COVID-19, RAS, SARS
11  2021 SARS-CoV-2 Exacerbates COVID-19 Pathology Through Activation of the Complement and Kinin Systems. gC1q, HK, SARS, SPR
12  2021 Targeted LC-MS/MS platform for the comprehensive determination of peptides in the kallikrein-kinin system. ---
13  2021 Tissue Kallikrein Exacerbating Sepsis-Induced Endothelial Hyperpermeability is Highly Predictive of Severity and Mortality in Sepsis. SIRS, TK, VE, ZO-1
14  2020 Carbon-Coated Stent and the Role of the Kallikrein-Kinin System in Peripheral Angioplasty. PAD
15  2020 COVID-19 Usurps Host Regulatory Networks. ACE2, COVID-19, RAAS, SARS-CoV-2
16  2020 Haplotype-based association study between PRCP gene polymorphisms and essential hypertension in Hani minority group from a remote region of China. BP, EH, PRCP, RAAS, SNPs
17  2020 Kinin B2 Receptor Activation Prevents the Evolution of Alzheimer's Disease Pathological Characteristics in a Transgenic Mouse Model. AD, B2R, Tg, WT
18  2020 Role of Kinins in Hypertension and Heart Failure. ACE, EDHF, NO, RAS, tPa
19  2020 SARS-CoV-2 and ACE2: The biology and clinical data settling the ARB and ACEI controversy. ACE2, ACEIs, ARBs, RAS
20  2020 The evolution of factor XI and the kallikrein-kinin system. FIX, FXI, FXIIa, HK
21  2019 Airborne Fine Particles Induce Hematological Effects through Regulating the Crosstalk of the Kallikrein-Kinin, Complement, and Coagulation Systems. FXII, PM
22  2019 Blockade of the kallikrein-kinin system reduces endothelial complement activation in vascular inflammation. ---
23  2019 Bradykinin contributes to immune liver injury via B2R receptor-mediated pathways in trichloroethylene sensitized mice: A role in Kupffer cell activation. BK, KCs, OMLDT, TCE
24  2019 Genetic Variation of Kallikrein-Kinin System and Related Genes in Patients With Hereditary Angioedema. HAE
25  2019 Interactions between carboxypeptidase M and kinin B1 receptor in endothelial cells. B1R, CPM
26  2019 Kallikrein-kinin system and oxidative stress in cisplatin-induced ovarian toxicity. ---
27  2019 Kinins Released by Erythrocytic Stages of Plasmodium falciparum Enhance Adhesion of Infected Erythrocytes to Endothelial Cells and Increase Blood Brain Barrier Permeability via Activation of Bradykinin Receptors. B1R, B2R, BBB, CM, CNS
28  2019 Knockdown of circulating C1 inhibitor induces neurovascular impairment, glial cell activation, neuroinflammation, and behavioral deficits. ASO, BBB, C1-INH, WT
29  2019 Neuroprotective Effects of Kinin B2 Receptor in Organotypic Hippocampal Cultures of Middle-Aged Mice. BK, OHCs
30  2019 Plasma kallikrein contributes to ambient particulate matter-induced lung injury. BALF, FXII, HK, KAL, pKal, PM, TAT
31  2019 The bradykinin system in stress and anxiety in humans and mice. SIH
32  2018 Bradykinin receptor in immune-mediated renal tubular injury in trichloroethylene-sensitized mice: Impact on NF-kappaB signaling pathway. BK, Cr, TCE
33  2018 Bradykinin Receptors in Ischemic Injury. BK
34  2018 Genetically‑modified stem cells in treatment of human diseases: Tissue kallikrein (KLK1)‑based targeted therapy (Review). EPCs, MSCs
35  2018 IL-17 Receptor Signaling Negatively Regulates the Development of Tubulointerstitial Fibrosis in the Kidney. IL-17, TF, UUO
36  2018 Implication of the Kallikrein-Kinin system in neurological disorders: Quest for potential biomarkers and mechanisms. ---
37  2018 Inhibition of plasma kallikrein-kinin system to alleviate renal injury and arthritis symptoms in rats with adjuvant-induced arthritis. KIM-1, NGAL, PK, RA
38  2018 Kallikrein-Kinin System Suppresses Type I Interferon Responses: A Novel Pathway of Interferon Regulation. ACE, BKs, DCs, ISGs, KLKs
39  2018 Role of selective blocking of bradykinin B1 receptor in attenuating immune liver injury in trichloroethylene-sensitized mice. B1R, TCE, THS
40  2018 Subverting bradykinin-evoked inflammation by co-opting the contact system: lessons from survival strategies of Trypanosoma cruzi. ACE, B2R
41  2018 The kallikrein-Kinin system modulates the progression of colorectal liver metastases in a mouse model. B1R, B2R, CRLM, MoCR
42  2018 The Plasma Kallikrein-Kininogen Pathway Is Critical in the Pathogenesis of Colitis in Mice. DSS, FXII, HK, IBD, pKal, TNBS
43  2018 Unexpected kidney-restricted role for IL-17 receptor signaling in defense against systemic Candida albicans infection. IL-17R, IL-17RA, RTEC
44  2017 A critical role for plasma kallikrein in the pathogenesis of autoantibody-induced arthritis. FXII, HK, pKal, STIA
45  2017 Blockade of Bradykinin receptors worsens the dystrophic phenotype of mdx mice: differential effects for B1 and B2 receptors. B1R, B2R, BK, DMD
46  2017 Bradykinin/B2 receptor activation regulates renin in M-1 cells via protein kinase C and nitric oxide. B2R, BK, CD, NO, PKA, PKC, RAS
47  2017 G Protein-Coupled Kinin Receptors and Immunity Against Pathogens. BK, FXII, HK, PK
48  2017 Kallikrein-kinin system as the dominant mechanism to counteract hyperactive renin-angiotensin system. ACE, ACEIs, Ang II, CVDs, RAS
49  2017 Mast Cell Coupling to the Kallikrein-Kinin System Fuels Intracardiac Parasitism and Worsens Heart Pathology in Experimental Chagas Disease. B2Rs, BK, DXS, ETAR, ETBR, FXII, HCP, MCs, TLR2
50  2017 Perfluorohexadecanoic acid increases paracellular permeability in endothelial cells through the activation of plasma kallikrein-kinin system. HRECs, PFASs, PFHxDA, PFOA, PFOS
51  2017 Prolylcarboxypeptidase (PrCP) inhibitors and the therapeutic uses thereof: a patent review. POMC, PRCP, RAS
52  2017 Structure-Dependent Hematological Effects of Per- and Polyfluoroalkyl Substances on Activation of Plasma Kallikrein-Kinin System Cascade. FXII, PFASs
53  2017 The kallikrein-kinin system in diabetic kidney disease. DKD
54  2016 Host kinin B1 receptor plays a protective role against melanoma progression. ---
55  2016 Interaction between bradykinin B2 and Ang-(1-7) Mas receptors regulates erythrocyte invasion by Plasmodium falciparum. ACE, BK, PKA, RAS
56  2016 Involvement of skeletal renin-angiotensin system and kallikrein-kinin system in bone deteriorations of type 1 diabetic mice with estrogen deficiency. RAS, STZ
57  2016 Kinin receptors: Key regulators of autoimmunity. BKRs
58  2016 Plasma Kallikrein-Kinin system mediates immune-mediated renal injury in trichloroethylene-sensitized mice. BK, BUN, Cr, PK, TCE
59  2016 The Role of Plasma Kallikrein-Kinin Pathway in the Development of Diabetic Retinopathy: Pathophysiology and Therapeutic Approaches. DME, DR, VEGF
60  2016 Utero-placental cellular and nuclear expression of bradykinin B2 receptors in normal and preeclamptic pregnancies. B2R
61  2015 C1-inhibitor polymers activate the FXII-dependent kallikrein-kinin system: Implication for a role in hereditary angioedema. HAE
62  2015 Characterization of the Kallikrein-Kinin System Post Chemical Neuronal Injury: An In Vitro Biochemical and Neuroproteomics Assessment. STS, TBI
63  2015 Critical insights into the beneficial and protective actions of the kallikrein-kinin system. ACEIs, RAS
64  2015 Human Tissue Kallikrein Activity in Angiographically Documented Chronic Stable Coronary Artery Disease. CAD, CATH, HF
65  2015 Kinins and peptide receptors. ACEIs, AT1-R, B2R, CVDs, EDHF, NO, RAS
66  2015 Local bone interaction between renin-angiotensin system and kallikrein-kinin system in diabetic rat. RAS
67  2015 Negatively charged silver nanoparticles cause retinal vascular permeability by activating plasma contact system and disrupting adherens junction. ---
68  2015 Roles of kinins in the nervous system. ---
69  2015 The contact activation and kallikrein/kinin systems: pathophysiologic and physiologic activities. CAS, FXII, PK
70  2015 The renin-angiotensin system and its blockers. ACE, RAS
71  2015 [Kallikrein-Kinin System. Long History and Present. (To 90th Anniversary of Discovery of the System)]. ---
72  2014 Administration of angiotensin II and a bradykinin B2 receptor blocker in midpregnancy impairs gestational outcome in guinea pigs. AII, B2R, BDZ, C NP, RAS
73  2014 Amelioration of cardiac function and activation of anti-inflammatory vasoactive peptides expression in the rat myocardium by low level laser therapy. iNOS, LLLT, MI, NO, NOx, RAS, VEGF
74  2014 Autoimmune diabetes is suppressed by treatment with recombinant human tissue Kallikrein-1. T1D
75  2014 B1 but not B2 bradykinin receptor agonists promote DU145 prostate cancer cell proliferation and migration. MTT
76  2014 Characterization of the kallikrein-kinin system, metalloproteinases, and their tissue inhibitors in the in-stent restenosis after peripheral percutaneous angioplasty. ECM, MMPs, PAD, TIMPs
77  2014 Ecotin-like ISP of L. major promastigotes fine-tunes macrophage phagocytosis by limiting the pericellular release of bradykinin from surface-bound kininogens: a survival strategy based on the silencing of proinflammatory G-protein coupled kinin B2 and B1 receptors. B2R, ISPs, NE
78  2014 Genetic manipulation and genetic variation of the kallikrein-kinin system: impact on cardiovascular and renal diseases. ---
79  2014 Preclinical characterization of recombinant human tissue kallikrein-1 as a novel treatment for type 2 diabetes mellitus. rhKLK-1, T2D
80  2014 Renal (tissue) kallikrein-kinin system in the kidney and novel potential drugs for salt-sensitive hypertension. BK, CD, CPY, NEP
81  2014 The kallikrein-kinin system in diabetic retinopathy. BK, DR, PK, TK
82  2014 The kinin B1 receptor regulates muscle-specific E3 ligases expression and is involved in skeletal muscle mass control. COPD, LA
83  2014 Tissue kallikrein mediates pro-inflammatory pathways and activation of protease-activated receptor-4 in proximal tubular epithelial cells. AGE, HG, PARs, PTEC
84  2014 Tissue kallikrein-kinin therapy in hypertension and organ damage. ---
85  2014 What have we learned about the kallikrein-kinin and renin-angiotensin systems in neurological disorders? RAS
86  2013 Angiotensin type 1a receptor-deficient mice develop diabetes-induced cardiac dysfunction, which is prevented by renin-angiotensin system inhibitors. Ang, RAS
87  2013 Different cross-talk sites between the renin-angiotensin and the kallikrein-kinin systems. RAS
88  2013 Endothelial cell permeability during hantavirus infection involves factor XII-dependent increased activation of the kallikrein-kinin system. BK, EC, ECIS, FXII, HFRS, HK, HPS, KAL, PK, VE, VEGF, VSMC
89  2013 Lack of plasma kallikrein-kinin system cascade in teleosts. BK, HMW, KLKs, KNG, LMW
90  2013 Plasma kallikrein-kinin system and diabetic retinopathy. DR, PK
91  2013 Spatial reference memory deficits precede motor dysfunction in an experimental autoimmune encephalomyelitis model: the role of kallikrein-kinin system. ChAT, CNS, EAE, MS
92  2013 Structure of plasma and tissue kallikreins. HK, KLKs, LK, PK
93  2013 Targeting the 'Janus face' of the B2-bradykinin receptor. ACEI, ARB, B1R, BK, RAS
94  2013 [Unilateral renal denervation and the renal kallikrein-bradykinin system in the rat]. BK, CV, KA, pNA
95  2012 Altered glucose homeostasis and hepatic function in obese mice deficient for both kinin receptor genes. ---
96  2012 Bradykinin inhibits hepatic gluconeogenesis in obese mice. BK
97  2012 Bradykinin prevents the apoptosis of NIT-1 cells induced by TNF-alpha via the PI3K/Akt and MAPK signaling pathways. BK
98  2012 Cardiac inflammation after local irradiation is influenced by the kallikrein-kinin system. BN, RIHD
99  2012 Local inflammatory response induced by scorpionfish Scorpaena plumieri venom in mice. SpV
100  2012 Role of plasma kallikrein-kinin system activation in synovial recruitment of endothelial progenitor cells in experimental arthritis. B2R, EPCs