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Abbreviation : MAGL
Long Form : monoacylglycerol lipase
No. Year Title Co-occurring Abbreviation
2021 A role for the endocannabinoid enzymes monoacylglycerol and diacylglycerol lipases in cue-induced cocaine craving following prolonged abstinence. DAGL, NAc
2021 Analgesic and Anticancer Activity of Benzoxazole Clubbed 2-Pyrrolidinones as Novel Inhibitors of Monoacylglycerol Lipase. FAAH, GBP
2021 Anticancer Potential of Small-Molecule Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase. 2-AG, AEA, FAAH
2021 Behavioral Battery for Testing Candidate Analgesics in Mice. II. Effects of Endocannabinoid Catabolic Enzyme Inhibitors and ∆9-Tetrahydrocannabinol. eCB, FAAH
2021 Characterization of Estrogenic Activity and Site-Specific Accumulation of Bisphenol-A in Epididymal Fat Pad: Interfering Effects on the Endocannabinoid System and Temporal Progression of Germ Cells. BPA, ECS
2021 Circulating prostaglandin E2: a novel potential prognostic biomarker in patients with hepatocellular carcinoma. COX-2, HCC, PGE2
2021 Discovery of novel reversible monoacylglycerol lipase inhibitors via docking-based virtual screening. 2-AG, AA, MAGs
2021 Distinct Activity of Endocannabinoid-Hydrolyzing Enzymes MAGL and FAAH in Key Regions of Peripheral and Central Nervous System Implicated in Migraine. ABPP, ECS, FAAH
2021 Effects of Chlorpyrifos on Serine Hydrolase Activities, Lipid Mediators, and Immune Responses in Lungs of Neonatal and Adult Mice. ABPP, AChE, CES, CPF, eCB, FAAH, LPS, OP, WT
10  2021 Endocannabinoid signaling in the lateral habenula regulates pain and alcohol consumption. eCBs, LHb
11  2021 Heterocyclic Compounds as Monoacylglycerol Lipase (MAGL) Inhibitors. ---
12  2021 Inhibiting Monoacylglycerol Lipase Suppresses RANKL-Induced Osteoclastogenesis and Alleviates Ovariectomy-Induced Bone Loss. 2-AG, MAPK, NF-kappaB
13  2021 Inhibition of 2-Arachidonoylglycerol Metabolism Alleviates Neuropathology and Improves Cognitive Function in a Tau Mouse Model of Alzheimer's Disease. 2-AG, AD
14  2021 Novel Oxazine Monoacylglycerol Lipase (MAGL) Inhibitors. ---
15  2021 Positron Emission Tomography Imaging of the Endocannabinoid System: Opportunities and Challenges in Radiotracer Development. CB1R, ECS, FAAH, PET
16  2021 Selective inhibition of monoacylglycerol lipase is associated with passive coping behavior and attenuation of stress-induced dopamine release in the medial prefrontal cortex. 2-AG, AEA, DA, EPM, FAAH, FST, LDT, mPFC, TST
17  2021 Targeting 2-arachidonoylglycerol (2-AG) signalling the neurobiology and treatment of depression. 2-AG, MDD
18  2021 The Absence of the Transient Receptor Potential Vanilloid 1 Directly Impacts on the Expression and Localization of the Endocannabinoid System in the Mouse Hippocampus. CB1R, CRIP1a, FAAH, ML, MPP, TRPV1
19  2021 The effects of fatty acid amide hydrolase inhibition and monoacylglycerol lipase inhibition on habit formation in mice. 2-AG, CB1R, FAAH
20  2021 The endocannabinoid 2-arachidonoylglycerol and dual ABHD6/MAGL enzyme inhibitors display neuroprotective and anti-inflammatory actions in the in vivo retinal model of AMPA excitotoxicity. 2-AG, ABHD6, PI3K
21  2021 The Monoacylglycerol Lipase Inhibitor JZL184 Inhibits Lung Cancer Cell Invasion and Metastasis via the CB1 Cannabinoid Receptor. 2-AG, TIMP-1
22  2021 Untapped endocannabinoid pharmacological targets: pipe dream or pipeline? 2-AG, ABHD6, DAGL-beta, DAGLalpha, FAAH
23  2020 2-Arachidonoylglycerol Modulation of Anxiety and Stress Adaptation: From Grass Roots to Novel Therapeutics. 2-AG
24  2020 Adolescent binge-ethanol accelerates cognitive impairment and β-amyloid production and dysregulates endocannabinoid signaling in the hippocampus of APP/PSE mice. AD, CB2, DAGLalpha, ECS, EtOH
25  2020 An optimized spectrophotometric assay reveals increased activity of enzymes involved in 2-arachidonoyl glycerol turnover in the cerebral cortex of a rat model of Alzheimer's disease. 2-AG, 4-NPB, AD, DAGLalpha
26  2020 An updated patent review of monoacylglycerol lipase (MAGL) inhibitors (2018-present). PET
27  2020 Antidepressant-like effects of URB597 and JZL184 in male and female rats exposed to early life stress. BDNF, eCB, ELS, FAAH, NAc
28  2020 ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages. ARS2, GBM, GSCs, PGE2, TAMs
29  2020 Brain region-dependent changes in the expression of endocannabinoid-metabolizing enzymes in rats following antidepressant drugs. DAGLalpha, eCB, FAAH, NAPE-PLD
30  2020 Characterization of a monoacylglycerol lipase in the medicinal leech, Hirudo verbana. 2-AG, HirMAGL
31  2020 Classics in Neuroimaging: Imaging the Endocannabinoid Pathway with PET. ECS, FAAH, PET
32  2020 Combatting joint pain and inflammation by dual inhibition of monoacylglycerol lipase and cyclooxygenase-2 in a rat model of osteoarthritis. 2-AG, COX-2, CXB, MIA, OA
33  2020 Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors. 2-AG
34  2020 Discovery of Aryl Formyl Piperidine Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase Inhibitors. ---
35  2020 Discovery of Monoacylglycerol Lipase (MAGL) Inhibitors Based on a Pharmacophore-Guided Virtual Screening Study. 2-AG
36  2020 Divergent Synthesis of Monosubstituted and Unsymmetrical 3,6-Disubstituted Tetrazines from Carboxylic Ester Precursors. ---
37  2020 Dose- and time-related effects of acute diisopropylfluorophosphate intoxication on forced swim behavior and sucrose preference in rats. ChE, FAAH, OPs
38  2020 Effect of monoacylglycerol lipase inhibition on intestinal permeability in chronic stress model. 2-AG, CB1, CB2, i.p, WAS
39  2020 Effects of the monoacylglycerol lipase inhibitor JZL184 on chickens infected with avian pathogenic Escherichia coli O78: A preliminary pharmacokinetic and infection study. APEC, BW, eCB
40  2020 Endocannabinoid degradation inhibitors ameliorate neuronal and synaptic alterations following traumatic brain injury. EC, FAAH, SMC, TBI
41  2020 Endocannabinoid metabolism and transport as targets to regulate intraocular pressure. FAAH, IOP
42  2020 Endocannabinoid signaling regulates the reinforcing and psychostimulant effects of ketamine in mice. 2-AG
43  2020 Endocannabinoid system alterations in Alzheimer's disease: A systematic review of human studies. 2-AG, AD, AEA, ECS, FAAH, MCI, TRPV1
44  2020 High-intensity swimming exercise reduces inflammatory pain in mice by activation of the endocannabinoid system. CFA, eCB, FAAH, HISE, i.p, i.pl, i.t
45  2020 Hippocampal 2-Arachidonoyl Glycerol Signaling Regulates Time-of-Day- and Stress-Dependent Effects on Rat Short-Term Memory. 2-AG, AEA, FAAH
46  2020 Hypoxia training improves hepatic steatosis partly by downregulation of CB1 receptor in obese mice. 2-AG, AEA, ATGL, CPT-1, DAGLalpha, ECS, HT, PPARgamma, SREBP-1
47  2020 Imbalance of Endocannabinoid/Lysophosphatidylinositol Receptors Marks the Severity of Alzheimer's Disease in a Preclinical Model: A Therapeutic Opportunity. AD, DAGL, eCB, HTZ, HZ
48  2020 Impact of tetrahydrocannabinol on the endocannabinoid 2-arachidonoylglycerol metabolism: ABHD6 and ABHD12 as novel players in human placenta. 2-AG, ABHD6, AEA, DAGLalpha
49  2020 Inhibition of monoacylglycerol lipase reduces nicotine reward in the conditioned place preference test in male mice. 2-AG, AA, CPP, LiCl
50  2020 JZL184 protects hippocampal neurons from oxygen-glucose deprivation-induced injury via activating Nrf2/ARE signaling pathway. GPx, I/R, MDA, OGD/R, ROS, SOD
51  2020 JZL184, A Monoacylglycerol Lipase Inhibitor, Induces Bone Loss in a Multiple Myeloma Model of Immunocompetent Mice. 2-AG, MM
52  2020 Monoacylglycerol lipase alpha inhibition alters prefrontal cortex excitability and blunts the consequences of traumatic stress in rat. 2-AG, E/I, eCB, IS, vmPFC
53  2020 Monoacylglycerol lipase inhibitors: modulators for lipid metabolism in cancer malignancy, neurological and metabolic disorders. ---
54  2020 Organophosphate Agent Induces ADHD-Like Behaviors via Inhibition of Brain Endocannabinoid-Hydrolyzing Enzyme(s) in Adolescent Male Rats. ADHD, EOPF, FAAH, OP
55  2020 Peripheral deficiency and antiallodynic effects of 2-arachidonoyl glycerol in a mouse model of paclitaxel-induced neuropathic pain. 2-AG, CB1, NAEs, OEA, PEA, s.c
56  2020 Potential application of endocannabinoid system agents in neuropsychiatric and neurodegenerative diseases-focusing on FAAH/MAGL inhibitors. AD, ECS, FAAH, PD
57  2020 Role of endocannabinoid signaling in a septohabenular pathway in the regulation of anxiety- and depressive-like behavior. 2-AG, CB1, DSI, MHb, MSDB
58  2020 Targeting Endocannabinoid Signaling: FAAH and MAG Lipase Inhibitors. FAAH, THC
59  2020 Termination of acute stress response by the endocannabinoid system is regulated through lysine-specific demethylase 1-mediated transcriptional repression of 2-AG hydrolases ABHD6 and MAGL. 2-AG, ABHD6, CB1, eCB, ECS, LSD1
60  2020 The Antimalarial Natural Product Salinipostin A Identifies Essential α/β Serine Hydrolases Involved in Lipid Metabolism in P. falciparum Parasites. Sal A
61  2020 The discovery of azetidine-piperazine di-amides as potent, selective and reversible monoacylglycerol lipase (MAGL) inhibitors. 2-AG, AA, CFA
62  2020 The discovery of diazetidinyl diamides as potent and reversible inhibitors of monoacylglycerol lipase (MAGL). 2-AG, AA
63  2020 The effects of fatty acid amide hydrolase and monoacylglycerol lipase inhibitor treatments on lipopolysaccharide-induced airway inflammation in mice. 2-AG, 5-HT, AEA, BAL, FAAH, i.n, i.p, LPS
64  2020 The endocannabinoid 2-arachidonoylglycerol inhibits endothelial function and repair. 2-AG, HCAEC
65  2020 The Endocannabinoid System Alleviates Pain in a Murine Model of Cancer-Induced Bone Pain. ---
66  2019 Brain structural changes in cannabis dependence: association with MAGL. CD
67  2019 Comparative Proteome Analysis of Breast Cancer Tissues Highlights the Importance of Glycerol-3-phosphate Dehydrogenase 1 and Monoacylglycerol Lipase in Breast Cancer Metabolism. BC, DIGE, GPD1, TAG
68  2019 Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors. CD
69  2019 Design, Synthesis, and Evaluation of (4 R)-1-{3-[2-(18F)Fluoro-4-methylpyridin-3-yl]phenyl}-4-[4-(1,3-thiazol-2-ylcarbonyl)piperazin-1-yl]pyrrolidin-2-one ([18F]T-401) as a Novel Positron-Emission Tomography Imaging Agent for Monoacylglycerol Lipase. PET
70  2019 Design, Synthesis, and Evaluation of 18F-Labeled Monoacylglycerol Lipase Inhibitors as Novel Positron Emission Tomography Probes. PET, SCIDY
71  2019 Design, Synthesis, and Evaluation of Reversible and Irreversible Monoacylglycerol Lipase Positron Emission Tomography (PET) Tracers Using a "Tail Switching" Strategy on a Piperazinyl Azetidine Skeleton. 2-AG, eCB, PET
72  2019 Disturbance in biosynthesis of arachidonic acid impairs the sexual development of the onion blight pathogen Stemphylium eturmiunum. 5-AC, AA
73  2019 Dual pharmacological inhibitor of endocannabinoid degrading enzymes reduces depressive-like behavior in female rats. 2-AG, AEA, BDNF, FAAH, MDD, WKY
74  2019 Effect of monoacylglycerol lipase on the tumor growth in endometrial cancer. EC, mRNA, siRNA
75  2019 Effects of Fatty Acid Amide Hydrolase Inhibitors Acute Administration on the Positive and Cognitive Symptoms of Schizophrenia in Mice. 2-AG, AEA, CB, ECS, FAAH, NMDA, PA
76  2019 Elevation of endocannabinoids in the brain by synthetic cannabinoid JWH-018: mechanism and effect on learning and memory. 2-AG, AEA, BDNF, FAAH
77  2019 Endocannabinoid system imbalance in the postmortem prefrontal cortex of subjects with schizophrenia. CB1, FAAH
78  2019 FABP5 coordinates lipid signaling that promotes prostate cancer metastasis. FABP5, FASN, PCa
79  2019 Formation of HETE-EAs and dihydroxy derivatives in mouse kidney tissue and analysis by high-performance liquid chromatography tandem mass spectrometry. 2-AG, AEA, DiHETE-EA, FAAH, OEA, PEA
80  2019 Forsythiaside prevents beta-amyloid-induced hippocampal slice injury by upregulating 2-arachidonoylglycerol via cannabinoid receptor 1-dependent NF-kappaB pathway. 2-AG, AD, CB1R, COX-2, LTP, NF-kappaB
81  2019 Hemisphere-dependent endocannabinoid system activity in prefrontal cortex and hippocampus of the Flinders Sensitive Line rodent model of depression. 2-AG, AEA, CB1R, CNR1, eCB, FAAH, FRL, FSL, LC/MRM
82  2019 Identification and Development of an Irreversible Monoacylglycerol Lipase (MAGL) Positron Emission Tomography (PET) Radioligand with High Specificity. PET
83  2019 Intermittent ethanol exposure during adolescence impairs cannabinoid type 1 receptor-dependent long-term depression and recognition memory in adult mice. CB1, DG-ML, DID, eCB, EtOH, fEPSPs, MPP
84  2019 Low mRNA expression and activity of monoacylglycerol lipase in human SH-SY5Y neuroblastoma cells. ---
85  2019 Monoacylglycerol lipase blockade impairs fine motor coordination and triggers cerebellar neuroinflammation through cyclooxygenase-2. 2-AG, AA, COX-2, KO, PGs
86  2019 Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor. ---
87  2019 Paradoxical effects of JZL184, an inhibitor of monoacylglycerol lipase, on bone remodelling in healthy and cancer-bearing mice. 2-AG
88  2019 Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor. 2-AG, CBs
89  2019 Phenolic compounds from nutmeg (Myristica fragrans Houtt.) inhibit the endocannabinoid-modulating enzyme fatty acid amide hydrolase. EPM, FAAH
90  2019 Potential of Cannabinoid Receptor Ligands as Treatment for Substance Use Disorders. CB1R, FAAH, FABP, SUD
91  2019 Radiosynthesis and evaluation of a novel monoacylglycerol lipase radiotracer: 1,1,1,3,3,3-hexafluoropropan-2-yl-3-(1-benzyl-1H-pyrazol-3-yl)azetidine-1-[11C]carboxylate. 2-AG, AA, PET
92  2019 Regulating membrane lipid levels at the synapse by small-molecule inhibitors of monoacylglycerol lipase: new developments in therapeutic and PET imaging applications. ---
93  2019 Roles of Toll-like receptor 2/4, monoacylglycerol lipase, and cyclooxygenase in social defeat stress-induced prostaglandin E2 synthesis in the brain and their behavioral relevance. COX, PG, SDS, TLR
94  2019 Set-Up and Validation of a High Throughput Screening Method for Human Monoacylglycerol Lipase (MAGL) Based on a New Red Fluorescent Probe. 2-AG, HTS, MAFP
95  2019 Tapetal Expression of BnaC.MAGL8.a Causes Male Sterility in Arabidopsis. MAG
96  2019 The Endocannabinoid System Is Present in Rod Outer Segments from Retina and Is Modulated by Light. 2-AG, DAGL, LPAP, PLCbeta1, ROS
97  2019 The endocannabinoid system: Novel targets for treating cancer induced bone pain. CIBP, ECS, FAAH
98  2019 The novel MAGL inhibitor MJN110 enhances responding to reward-predictive incentive cues by activation of CB1 receptors. 2-AG, IC
99  2019 [Effect of monoacylglycerol lipase with proliferation of MHCC97H human liver cancer cells in vivo]. TAMs
100  2019 [Monoacylglycerol lipase high expression as an independent indicator of survival for patients with hepatocellular carcinoma]. HCC, TMA