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Abbreviation : MAPKs
Long Form : mitogen-activated protein kinases
No. Year Title Co-occurring Abbreviation
2021 (3α)-3-(tiglinoyloxy)-ent-kaur-16-en-19-oic acid, isolated from Wedelia trilobata L., exerts an anti-inflammatory effect via the modulation of NF-κB, MAPK and mTOR pathway and autophagy in LPS-stimulated macrophages. COX-2, IL-6, iNOS, LPS, NF-kappaB, NO, PGE2, ROS, TNF-alpha
2021 2,4-Dimethoxy-6-Methylbenzene-1,3-diol, a Benzenoid From Antrodia cinnamomea, Mitigates Psoriasiform Inflammation by Suppressing MAPK/NF-κB Phosphorylation and GDAP1L1/Drp1 Translocation. DMD, IMQ
2021 3,5-Dimethoxy-4-hydroxy myricanol attenuated oxidative stress-induced toxicity on cardiomyoblast cells. DHM, ELISA, HO-1, NF-kappaB
2021 6,8-Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53. NAC, ROS
2021 A Crosstalk Between Dual-Specific Phosphatases and Dual-Specific Protein Kinases Can Be A Potential Therapeutic Target for Anti-cancer Therapy. CDK, CLK, DUSPs, DYRKs, MKPs, mTOR, mTORC1, PI3K, PTKs, PTPs
2021 A new synthetic antitumor naphthoquinone induces ROS-mediated apoptosis with activation of the JNK and p38 signaling pathways. JNK
2021 A Novel Cyclic Pentadepsipeptide, N-Methylsansalvamide, Suppresses Angiogenic Responses and Exhibits Antitumor Efficacy against Bladder Cancer. MMP-9, MSSV, VEGF
2021 A Phase 1/2 Study of Flavocoxid, an Oral NF-κB Inhibitor, in Duchenne Muscular Dystrophy. 10MWT, 5-LOX, COX, DMD, GPx, IL, NF-kappaB, TNF
2021 A walk-through MAPK structure and functionality with the 30-year-old yeast MAPK Slt2. CWI
10  2021 Acetate stimulates lipogenesis via AMPKα signaling in rabbit adipose-derived stem cells. ADSCs, AMPK, ERK, JNK
11  2021 An Antioxidant Sesquiterpene Inhibits Osteoclastogenesis Via Blocking IPMK/TRAF6 and Counteracts OVX-Induced Osteoporosis in Mice. ASBMR, CUL, IPMK, NF-kappaB, ROS
12  2021 Anti-Inflammatory and Anti-Oxidant Effects of Korean Ginseng Berry Extract in LPS-Activated RAW264.7 Macrophages. CAT, COX-2, GSH-Px, IL, iNOS, JNK, KGB, LPS, NO, ROS, SOD
13  2021 Anti-Metastatic and Anti-Inflammatory Effects of Matrix Metalloproteinase Inhibition by Ginsenosides. ECM, ERK, JNK, MMPs
14  2021 Anti-Neuroinflammatory Effects and Mechanism of Action of Fructus ligustri lucidi Extract in BV2 Microglia. FLL, FLLE, HO, IL-6, LPS, NF-kappaB, NO, TNF-alpha
15  2021 Anti-thrombotic effects mediated by dihydromyricetin involve both platelet inhibition and endothelial protection. DHM
16  2021 Antitumor and antimigration effects of Salvia clandestina L. extract on osteosarcoma cells. ---
17  2021 Ascorbic Acid Suppresses House Dust Mite-Induced Expression of Interleukin-8 in Human Respiratory Epithelial Cells. HDM, IL-8, ROS
18  2021 Assessment on the adverse effects on different kinds of fish induced by methamphetamine during the natural attenuation process based on adverse outcome pathway. AOP, DFw, METH
19  2021 BC and 1,4NQ-BC up-regulate the cytokines and enhance IL-33 expression in LPS pretreatment of human bronchial epithelial cells☆. BC, LPS, PI3K
20  2021 Chromatin phosphoproteomics unravels a function for AT-hook motif nuclear localized protein AHL13 in PAMP-triggered immunity. AHL, PAMP
21  2021 Combined Toxicity of Metal Nanoparticles: Comparison of Individual and Mixture Particles Effect. DEP, NPs, QSAR, ROS
22  2021 Constitutive activation of mitogen-activated protein kinase kinase (MEK1) in ileal enterocytes leads to dysplasia and a predisposition to cancer. CA-MEK1
23  2021 Corneal Collagen as a Potential Therapeutic Target in Dry Eye Disease. DED, MMPs
24  2021 CQMUH-011 Inhibits LPS-Induced Microglia Activation and Ameliorates Brain Ischemic Injury in Mice. ERK, I/R, IkappaBalpha, IL, LPS, MyD88, PCNA, TLR4, tMCAO, TNF
25  2021 Cyclooxygenase inhibition attenuates brain angiogenesis and independently decreases mouse survival under hypoxia. BBB, COX, CXCR4, VEGFR2
26  2021 Cytotoxic Fractions from Hechtia glomerata Extracts and p-Coumaric Acid as MAPK Inhibitors. pCA, ROS
27  2021 Dietary polyphenols suppress chronic inflammation by modulation of multiple inflammation-associated cell signaling pathways. NF-kappaB
28  2021 Downregulation of Snail by DUSP1 Impairs Cell Migration and Invasion through the Inactivation of JNK and ERK and Is Useful as a Predictive Factor in the Prognosis of Prostate Cancer. DUSP1, ERK, JNK, PC
29  2021 Dual Activity of Ginsenoside Rb1 in Hypertrophic Cardiomyocytes and Activated Macrophages: Implications for the Therapeutic Intervention of Cardiac Hypertrophy. Ang II, IL, LPS, miR-155, TNF
30  2021 Effect of Cone of Pinus densiflora on DNCB-Induced Allergic Contact Dermatitis-Like Skin Lesion in Balb/c Mice. ACD, CP
31  2021 Effects of trans-resveratrol on type 1 diabetes-induced up-regulation of apoptosis and mitogen-activated protein kinase signaling in retinal pigment epithelium of Dark Agouti rats. Bcl-2, CASP3, ERK1, JNK1, RPE
32  2021 EGCG Induces Pro-inflammatory Response in Macrophages to Prevent Bacterial Infection through the 67LR/p38/JNK Signaling Pathway. EGCG, IL-1beta, MCP-1, TNF-alpha
33  2021 Enhancement of skin barrier and hydration-related molecules by protopanaxatriol in human keratinocytes. FLG, HAS, PPT, TGM
34  2021 Hsp90 modulates human sperm capacitation via the Erk1/2 and p38 MAPK signaling pathways. 17-AAG, CASA, Cdc37, Co-IP, Hsp90
35  2021 Hypoxic Jumbo Squid Activate Neuronal Apoptosis but Not MAPK or Antioxidant Enzymes during Oxidative Stress. ---
36  2021 Identification of 4'-Demethyltangeretin as a Major Urinary Metabolite of Tangeretin in Mice and Its Anti-inflammatory Activities. 4DT, LPS, NF-kappaB, TAN
37  2021 Imipramine alleviates memory impairment and hippocampal apoptosis in STZ-induced sporadic Alzheimer's rat model: Possible contribution of MAPKs and insulin signaling. AD, IRS1, Ser307, MWM, STZ
38  2021 Immunomodulatory Effects of Curcumin in Rheumatoid Arthritis: Evidence from Molecular Mechanisms to Clinical Outcomes. AP-1, NF-kappaB, RA, Th
39  2021 Interaction of RIPK1 and A20 modulates MAPK signaling in murine acetaminophen toxicity. ASK1, Co-IP, RCD, RIPK1
40  2021 Interplay Between CMGC Kinases Targeting SR Proteins and Viral Replication: Splicing and Beyond. CDKs, CLKs, GSKs, SR
41  2021 Intrinsic apoptosis and cytokine induction regulated in human tonsillar epithelial cells infected with enterovirus A71. EV-A71
42  2021 Ishige okamurae Suppresses Trimethyltin-Induced Neurodegeneration and Glutamate-Mediated Excitotoxicity by Regulating MAPKs/Nrf2/HO-1 Antioxidant Pathways. HO-1, IOE, Nrf2, TMT
43  2021 Lipopolysaccharide-Induced Nitric Oxide and Prostaglandin E2 Production Is Inhibited by Tellimagrandin II in Mouse and Human Macrophages. COX-2, LPS, NF-kappaB, NO, PGE2, TGII
44  2021 Literature-Based Drug Repurposing in Traditional Chinese Medicine: Reduced Inflammatory M1 Macrophage Polarization by Jisil Haebaek Gyeji-Tang Alleviates Cardiovascular Disease In Vitro and Ex Vivo. CVD, JHGT
45  2021 Mechanical stretching of the pulmonary vein mediates pulmonary hypertension due to left heart disease by regulating SAC/MAPK pathway and the expression of IL-6 and TNF-α. IL-6, SAC, TNF-alpha
46  2021 Mechanistic insights and perspectives involved in nfeuroprotective action of quercetin. JNK, NDDs, Nrf2, PGC-1alpha, PON2, TNF-alpha
47  2021 Mitogen-activated protein kinase 11 (MAPK11) maintains growth and photosynthesis of potato plant under drought condition. MAPK11
48  2021 MNK as a potential pharmacological target for suppressing LPS-induced acute lung injury in mice. ALI, ARDS, BALF, BMDMs, eIF4E, IL-6, KC, TNF-alpha
49  2021 Mogroside V Alleviates Lipopolysaccharide-Induced Neuroinflammation via Inhibition of TLR4-MyD88 and Activation of AKT/AMPK-Nrf2 Signaling Pathway. AD, CNS, COX-2, GCLC, HD, HMGB1, HO-1, IL-1beta, iNOS, Mog, MyD88, NF-kappaB, Nrf2, TLR4, TNF-alpha
50  2021 Orexin-A Attenuates Inflammatory Responses in Lipopolysaccharide-Induced Neural Stem Cells by Regulating NF-KB and Phosphorylation of MAPK/P38/Erk Pathways. CCK-8, HE, LPS, NF-kB, NSCs
51  2021 Potato StMPK7 is a downstream component of StMKK1 and promotes resistance to the oomycete pathogen Phytophthora infestans. CA-StMKK1, SA, StMKK1
52  2021 Potentiated Response of ERK/MAPK Signaling is Associated with Prolonged Withdrawal from Cocaine Behavioral Sensitization. BS, ERK, NAc
53  2021 PPARγ Attenuates Interleukin-1β-Induced Cell Apoptosis by Inhibiting NOX2/ROS/p38MAPK Activation in Osteoarthritis Chondrocytes. COX-2, NAC, NOX, OA, PGE2, PPARgamma, ROS
54  2021 Prostaglandin E2 induces dual-specificity phosphatase-1, thereby attenuating inflammatory genes expression in human osteoarthritic synovial fibroblasts. DUSP, MMPs, NGF, OA, PG
55  2021 Prostaglandin E2 receptor PTGER4-expressing macrophages promote intestinal epithelial barrier regeneration upon inflammation. DSS, IBD, PGE2
56  2021 Protective Effect of Osmundacetone against Neurological Cell Death Caused by Oxidative Glutamate Toxicity. ERK, HO-1, HSP70, JNK, OAC, ROS
57  2021 Retinoprotective effect of agmatine in streptozotocin-induced diabetic rat model: avenues for vascular and neuronal protection : Agmatine in diabetic retinopathy. DR, GFAP, GLAST, GS, NF-kappaB, NMDAR1, NO, NOS, VEGF
58  2021 Rice Transcription Factor OsWRKY55 Is Involved in the Drought Response and Regulation of Plant Growth. ABA, TFs, WT
59  2021 Role of copper in the enhancement of astaxanthin and lipid coaccumulation in Haematococcus pluvialis exposed to abiotic stress conditions. CDPKs, HL, ND, ROS
60  2021 Role of p38 mitogen-activated protein kinase signalling in virus replication and potential for developing broad spectrum antiviral drugs. ERK
61  2021 Scorpion venom peptide SVHRSP ameliorates 6-OHDA-induced neurotoxicity and neuroinflammation: potential role of Nav 1.6 inhibition in microglia. LPS, PD, SVHRSP, VGSCs
62  2021 Serum deprivation-response protein induces apoptosis in hepatocellular carcinoma through ASK1-JNK/p38 MAPK pathways. ASK1, GSEA, HCC, LIHC, SDPR
63  2021 Sestrin2 Regulates Osteoclastogenesis via the p62-TRAF6 Interaction. BMMs, KO, NFATc1, RANKL, ROS, Sesn2, TNF, WT
64  2021 SUMO enables substrate selectivity by mitogen-activated protein kinases to regulate immunity in plants. SIM, SPF1, SUMO
65  2021 TALEN-Based HvMPK3 Knock-Out Attenuates Proteome and Root Hair Phenotypic Responses to flg22 in Barley. ---
66  2021 Targeting macrophage polarization by Nrf2 agonists for treating various xenobiotics-induced toxic responses. NF-kappaB, Nrf2, PPARgamma
67  2021 Targeting oxidative stress with amobarbital to prevent intervertebral disc degeneration: Part I. in vitro and ex vivo studies. Amo, DHE, ERK, IVD, JNK, NAC, NP, ROS, TBHP
68  2021 Tat‑aldose reductase prevents dopaminergic neuronal cell death by inhibiting oxidative stress and MAPK activation. AR, PD, SN
69  2021 TGF-β1-induced EMT activation via both Smad-dependent and MAPK signaling pathways in Cu-induced pulmonary fibrosis. alpha-SMA, EMT, TGF-beta1
70  2021 Titanium Dioxide Presents a Different Profile in Dextran Sodium Sulphate-Induced Experimental Colitis in Mice Lacking the IBD Risk Gene Ptpn2 in Myeloid Cells. BMDMs, DSS, IBD, PTPN2
71  2021 Uric acid can enhance MAPK pathway-mediated proliferation in rat primary vascular smooth muscle cells via controlling of mitochondria and caspase-dependent cell death. Bcl-xL, VSMCs
72  2021 Zinc Sulfate Stimulates Osteogenic Phenotypes in Periosteum-Derived Cells and Co-Cultures of Periosteum-Derived Cells and THP-1 Cells. ERK, hPDCs, OPG, RANKL
73  2020 (-)-Epicatechin and the colonic metabolite 2,3-dihydroxybenzoic acid protect against high glucose and lipopolysaccharide-induced inflammation in renal proximal tubular cells through NOX-4/p38 signalling. DHBA, DHPAA, EC, ERK, HPPA, ICAM-1, IL-6, LPS, MCP-1, NOX4, TNF-alpha, VCAM-1
74  2020 (Z)-7,4'-dimethoxy-6-hydroxy-aurone-4-O-β-glucopyranoside attenuates lipoteichoic acid-induced damage in rat cardiomyoblast cells. DHAG, LTA, NF-kappaB
75  2020 3,5-Dicaffeoyl-epi-quinic acid inhibits the PMA-stimulated activation and expression of MMP-9 but not MMP-2 via downregulation of MAPK pathway. DCEQA, MMPs, PMA
76  2020 3-Hydroxyolean-12-en-27-oic Acids Inhibit RANKL-Induced Osteoclastogenesis in Vitro and Inflammation-Induced Bone Loss in Vivo. AR-1, CtsK, LPS, NFATc1, RANKL, TRAP
77  2020 3α-Angeloyloxy-ent-kaur-16-en-19-oic Acid Isolated from Wedelia trilobata L. Alleviates Xylene-Induced Mouse Ear Edema and Inhibits NF-κB and MAPK Pathway in LPS-Stimulated Macrophages. COX-2, NO, PGE2, ROS
78  2020 7-HYB, a Phenolic Compound Isolated from Myristica fragrans Houtt Increases Cell Migration, Osteoblast Differentiation, and Mineralization through BMP2 and β-catenin Signaling. 7-HYB, BMMs, RANKL
79  2020 A Radioactive in vitro ERK3 Kinase Assay. ERK3, MBP, SRC-3
80  2020 A selective p38alpha/beta MAPK inhibitor alleviates neuropathology and cognitive impairment, and modulates microglia function in 5XFAD mouse. AD
81  2020 A study on the protective effects of taxifolin on human umbilical vein endothelial cells and THP-1 cells damaged by hexavalent chromium: a probable mechanism for preventing cardiovascular disease induced by heavy metals. CVD, HUVECs, NF-kappaB
82  2020 Activation of JNK and p38 in MCF-7 Cells and the In Vitro Anticancer Activity of Alnus hirsuta Extract. ELISA
83  2020 Activation of RAW264.7 macrophage by Exopolysaccharide from Aphanothece halaphytica (EPSAH) and the underlying mechanisms. EPSAH
84  2020 Altered paracellular permeability in intestinal cell monolayer challenged with lipopolysaccharide: Modulatory effects of pterostilbene metabolites. ---
85  2020 Ameliorative effects of Qingganjiuwei powder, a traditional Mongolian medicine, against CCl4-induced liver fibrosis in rats. alpha-SMA, ERK, JNKs, MMP-2, SIL, TIMP1
86  2020 An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling. ---
87  2020 Angiotensin Converting Enzyme Inhibitors (ACEIs) Decrease the Progression of Cardiac Fibrosis in Rheumatic Heart Disease Through the Inhibition of IL-33/sST2. ACEIs, APC, DCs, GAS, RHD, TGF-beta
88  2020 Angiotensin III induces p38 Mitogen-activated protein kinase leading to proliferation of vascular smooth muscle cells. Ang, AT1, RAAS, SHRs, VSMCs
89  2020 Anti-inflammatory action of physalin A by blocking the activation of NF-κB signaling pathway. COX-2, ELISA, ERK, IkappaB-alpha, iNOS, JNK, LPS, NF-kappaB, NO, PGE2, TCM, TNF-alpha
90  2020 Anti-Inflammatory and Anti-Migratory Activities of Isoquinoline-1-Carboxamide Derivatives in LPS-Treated BV2 Microglial Cells via Inhibition of MAPKs/NF-κB Pathway. IL, LPS, NO
91  2020 Anti-inflammatory effect of IGF-1 is mediated by IGF-1R cross talk with GPER in MPTP/MPP+-induced astrocyte activation. COX-2, GPER, IGF-1, IGF-1R, iNOS, MPTP, PI3K
92  2020 Antitumor effects of icaritin and the molecular mechanisms. STAT3, TCM
93  2020 Argania Spinosa Fruit Shell Extract-Induced Melanogenesis via cAMP Signaling Pathway Activation. AFSEE, cAMP, DCT, ERK, MITF, TRP1, TRY
94  2020 Astragaloside IV protects against retinal iron overload toxicity through iron regulation and the inhibition of MAPKs and NF-κB activation. AS-IV, NF-kappaB
95  2020 Attenuation of Inflammatory Symptoms by Icariside B2 in Carrageenan and LPS-Induced Inflammation Models via Regulation of MAPK/NF-κB Signaling Cascades. CA, COX-2, ERK, IkappaBalpha, iNOS, NF-kappaB, NO, PGE2, RT-PCR
96  2020 Attenuation of paraquat-induced inflammation by inhibitors of phosphorylation of mitogen-activated protein kinases in BV2 microglial cells. PD, TLR4
97  2020 Bacteroides fragilis Enterotoxin Induces Sulfiredoxin-1 Expression in Intestinal Epithelial Cell Lines Through a Mitogen-Activated Protein Kinases- and Nrf2-Dependent Pathway, Leading to the Suppression of Apoptosis. IECs, Srx
98  2020 Bromosulfophthalein suppresses inflammatory effects in lipopolysaccharide-stimulated RAW264.7 macrophages. BSP, FOXO1, IL-1beta, IL-6, iNOS, LPS, TLR4, TNF-alpha
99  2020 Camellioside A, isolated from Camellia japonica flowers, attenuates UVA-induced production of MMP-1 in HaCaT keratinocytes via suppression of MAPK activation. CMDA, MMP-1, UV
100  2020 CaMKII(δ) regulates osteoclastogenesis through ERK, JNK, and p38 MAPKs and CREB signalling pathway. CaMKs, NFATc1, TRAP